Journal of Neuroinflammation BioMed Central

[1]  N. Rothwell,et al.  Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage. , 2008, British journal of clinical pharmacology.

[2]  N. Rothwell,et al.  Interleukin-1 Receptor Antagonist Penetrates Human Brain at Experimentally Therapeutic Concentrations , 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[3]  M. O’Banion,et al.  Chronic Interleukin-1β Expression in Mouse Brain Leads to Leukocyte Infiltration and Neutrophil-Independent Blood–Brain Barrier Permeability without Overt Neurodegeneration , 2007, The Journal of Neuroscience.

[4]  Michal Schwartz,et al.  Selective ablation of bone marrow‐derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model , 2007, The European journal of neuroscience.

[5]  M. O’Banion,et al.  Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. , 2007, The Journal of clinical investigation.

[6]  R. Green,et al.  Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial , 2007, Neurology.

[7]  Patrick L. McGeer,et al.  NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies , 2007, Neurobiology of Aging.

[8]  S. Rivest,et al.  Role of IL-1 and TNF in the brain: Twenty years of progress on a Dr. Jekyll/Mr. Hyde duality of the innate immune system , 2007, Brain, Behavior, and Immunity.

[9]  Michael T. Heneka,et al.  Inflammatory processes in Alzheimer's disease , 2007, Journal of Neuroimmunology.

[10]  Bin Zhang,et al.  Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model , 2007, Neuron.

[11]  H. Soininen,et al.  Long-Term Efficacy and Safety of Celecoxib in Alzheimer’s Disease , 2006, Dementia and Geriatric Cognitive Disorders.

[12]  C. Ferrari,et al.  Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1β in the substantia nigra , 2006, Neurobiology of Disease.

[13]  B. Melchior,et al.  CNS immune privilege: hiding in plain sight , 2006, Immunological reviews.

[14]  Tony Wyss-Coray,et al.  Inflammation in Alzheimer disease: driving force, bystander or beneficial response? , 2006, Nature Medicine.

[15]  T. Golde,et al.  Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Aβ immunotherapy , 2006, Journal of Neuroinflammation.

[16]  N. Rothwell,et al.  Interleukin‐1‐induced neurotoxicity is mediated by glia and requires caspase activation and free radical release , 2006, Journal of neurochemistry.

[17]  S. Levison,et al.  Astrogliosis is delayed in type 1 interleukin-1 receptor-null mice following a penetrating brain injury , 2006, Journal of Neuroinflammation.

[18]  C. Lemere,et al.  Minocycline affects microglia activation, Aβ deposition, and behavior in APP‐tg mice , 2006, Glia.

[19]  S. Rivest,et al.  Neuroprotective properties of the innate immune system and bone marrow stem cells in Alzheimer's disease , 2006, Molecular Psychiatry.

[20]  N. Rothwell,et al.  Gene regulation by IL‐1β independent of IL‐1R1 in the mouse brain , 2006, Glia.

[21]  N. Rothwell,et al.  Neuroprotective actions of endogenous interleukin‐1 receptor antagonist (IL‐1ra) are mediated by glia , 2006, Glia.

[22]  S. Barger,et al.  Journal of Neuroinflammation Interleukin-1 Mediates Alzheimer and Lewy Body Pathologies , 2022 .

[23]  Carl Nathan,et al.  Neutrophils and immunity: challenges and opportunities , 2006, Nature Reviews Immunology.

[24]  S. Shioda,et al.  Lipopolysaccharide‐induced microglial activation induces learning and memory deficits without neuronal cell deathin rats , 2006, Journal of neuroscience research.

[25]  J. Julien,et al.  Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease , 2006, Neuron.

[26]  T. Montine,et al.  Deletion of the Prostaglandin E2 EP2 Receptor Reduces Oxidative Damage and Amyloid Burden in a Model of Alzheimer's Disease , 2005, The Journal of Neuroscience.

[27]  C. Ferrari,et al.  Differential effects of interleukin-1β on neurotoxicity, cytokine induction and glial reaction in specific brain regions , 2005, Journal of Neuroimmunology.

[28]  F. LaFerla,et al.  Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice , 2022 .

[29]  F. LaFerla,et al.  Lipopolysaccharide-Induced Inflammation Exacerbates Tau Pathology by a Cyclin-Dependent Kinase 5-Mediated Pathway in a Transgenic Model of Alzheimer's Disease , 2005, The Journal of Neuroscience.

[30]  N. Rothwell,et al.  A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[31]  N. Rothwell,et al.  Interleukin-1 and neuronal injury , 2005, Nature Reviews Immunology.

[32]  L. V. Van Eldik,et al.  Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human β-amyloid , 2005, Journal of Neuroinflammation.

[33]  P. Carvey,et al.  Intra-parenchymal injection of tumor necrosis factor-α and interleukin 1-β produces dopamine neuron loss in the rat , 2005, Journal of Neural Transmission.

[34]  N. Quan,et al.  IL-1 type I receptor plays a key role in mediating the recruitment of leukocytes into the central nervous system , 2005, Brain, Behavior, and Immunity.

[35]  R. Mrak,et al.  Glia and their cytokines in progression of neurodegeneration , 2005, Neurobiology of Aging.

[36]  V. Perry,et al.  Differential regulation of type I and type II interleukin‐1 receptors in focal brain inflammation , 2005, The European journal of neuroscience.

[37]  H. Arias,et al.  The role of inflammation in Alzheimer's disease. , 2005, The international journal of biochemistry & cell biology.

[38]  S. Karlsson,et al.  Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to β-amyloid deposition in APP/PS1 double transgenic Alzheimer mice , 2005, Neurobiology of Disease.

[39]  J. Tichelaar,et al.  Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung. , 2005, American journal of respiratory cell and molecular biology.

[40]  T. Baram,et al.  Interleukin‐1β contributes to the generation of experimental febrile seizures , 2005, Annals of neurology.

[41]  M. Wolfe,et al.  Tumor Necrosis Factor-α, Interleukin-1β, and Interferon-γ Stimulate γ-Secretase-mediated Cleavage of Amyloid Precursor Protein through a JNK-dependent MAPK Pathway* , 2004, Journal of Biological Chemistry.

[42]  V. Perry,et al.  Reversible demyelination, blood-brain barrier breakdown, and pronounced neutrophil recruitment induced by chronic IL-1 expression in the brain. , 2004, The American journal of pathology.

[43]  N. Rothwell,et al.  CNS injury: the role of the cytokine IL-1. , 2004, Veterinary journal.

[44]  D. Morgan,et al.  Time-dependent reduction in Aβ levels after intracranial LPS administration in APP transgenic mice , 2004, Experimental Neurology.

[45]  S. Levison,et al.  Interleukin‐1: A master regulator of neuroinflammation , 2004, Journal of neuroscience research.

[46]  S. Goodman,et al.  Nonsteroidal Anti-Inflammatory Drugs for the Prevention of Alzheimer’s Disease: A Systematic Review , 2004, Neuroepidemiology.

[47]  R. Mrak,et al.  Trisomy 21 and the Brain , 2004, Journal of neuropathology and experimental neurology.

[48]  G. Cole,et al.  The microglial phagocytic role with specific plaque types in the Alzheimer disease brain , 2004, Neurobiology of Aging.

[49]  M. O’Banion,et al.  Intraparenchymal administration of interleukin-1β induces cyclooxygenase-2-mediated expression of membrane- and cytosolic-associated prostaglandin E synthases in mouse brain , 2004, Journal of Neuroimmunology.

[50]  D. Wilcock,et al.  Microglial activation facilitates Aβ plaque removal following intracranial anti-Aβ antibody administration , 2004, Neurobiology of Disease.

[51]  C. Lines,et al.  Rofecoxib , 2004, Neurology.

[52]  F. Dhabhar,et al.  Neurotoxic effects of polymorphonuclear granulocytes on hippocampal primary cultures , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[53]  D. Borchelt,et al.  Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice , 2003, Neurobiology of Disease.

[54]  R. Ransohoff,et al.  Three or more routes for leukocyte migration into the central nervous system , 2003, Nature Reviews Immunology.

[55]  K. Davis,et al.  Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. , 2003, JAMA.

[56]  N. Rothwell.  Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential , 2003, Brain, Behavior, and Immunity.

[57]  S. Allan,et al.  Interleukin‐1 in the Brain , 2003 .

[58]  T. Montine,et al.  Inflammation and cerebral amyloidosis are disconnected in an animal model of Alzheimer's disease , 2003, Journal of Neuroimmunology.

[59]  S. Barger,et al.  Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway , 2003, The Journal of Neuroscience.

[60]  S. DeKosky,et al.  The Type 1 Interleukin-1 Receptor Is Essential for the Efficient Activation of Microglia and the Induction of Multiple Proinflammatory Mediators in Response to Brain Injury , 2002, The Journal of Neuroscience.

[61]  M. Herkenham,et al.  Intracerebroventricular but not intravenous interleukin-1β induces widespread vascular-mediated leukocyte infiltration and immune signal mRNA expression followed by brain-wide glial activation , 2002, Neuroscience.

[62]  G. Almazan,et al.  Interleukin-1 Regulates Proliferation and Differentiation of Oligodendrocyte Progenitor Cells , 2002, Molecular and Cellular Neuroscience.

[63]  P. Aisen,et al.  Randomized pilot study of nimesulide treatment in Alzheimer’s disease , 2002, Neurology.

[64]  M. Morganti-Kossmann,et al.  Inflammatory response in acute traumatic brain injury: a double-edged sword , 2002, Current opinion in critical care.

[65]  D. Coppola,et al.  Microglial Activation and β-Amyloid Deposit Reduction Caused by a Nitric Oxide-Releasing Nonsteroidal Anti-Inflammatory Drug in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mice , 2002, The Journal of Neuroscience.

[66]  P. Cras,et al.  The role of cytokines, astrocytes, microglia and apoptosis in Creutzfeldt-Jakob disease , 2002, Neurobiology of Aging.

[67]  R. Bartus,et al.  The Role of Leukocytes Following Cerebral Ischemia: Pathogenic Variable or Bystander Reaction to Emerging Infarct? , 2002, Experimental Neurology.

[68]  N. Rothwell,et al.  Interleukin-1 Influences Ischemic Brain Damage in the Mouse Independently of the Interleukin-1 Type I Receptor , 2002, The Journal of Neuroscience.

[69]  Soumaya Bennouna,et al.  CXCR2 Deficiency Confers Impaired Neutrophil Recruitment and Increased Susceptibility During Toxoplasma gondii Infection1 , 2001, The Journal of Immunology.

[70]  D. Wilcock,et al.  Intrahippocampal LPS injections reduce Aβ load in APP+PS1 transgenic mice , 2001, Neurobiology of Aging.

[71]  P. Mcgeer,et al.  Polymorphisms in inflammatory genes and the risk of Alzheimer disease. , 2001, Archives of neurology.

[72]  Damijana M. Jurič,et al.  Interleukin-1β, but not IL-1α, mediates nerve growth factor secretion from rat astrocytes via type I IL-1 receptor , 2001, International Journal of Developmental Neuroscience.

[73]  D. Chaplin,et al.  Interleukin-1β Promotes Repair of the CNS , 2001, The Journal of Neuroscience.

[74]  S. Paul,et al.  Neuroinflammation‐induced acceleration of amyloid deposition in the APPV717F transgenic mouse , 2001, The European journal of neuroscience.

[75]  L. Mucke,et al.  TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice , 2001, Nature Medicine.

[76]  Sunhee C. Lee,et al.  Expression of inducible nitric oxide synthase, interleukin-1 and caspase-1 in HIV-1 encephalitis , 2001, Journal of Neuroimmunology.

[77]  C. Lemere,et al.  Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease. , 2001, The American journal of pathology.

[78]  W. Hickey,et al.  CXC Chemokine Receptor-2 Ligands Are Required for Neutrophil-Mediated Host Defense in Experimental Brain Abscesses1 , 2001, The Journal of Immunology.

[79]  T. Standiford,et al.  Chemokine-Dependent Neutrophil Recruitment in a Murine Model of Legionella Pneumonia: Potential Role of Neutrophils as Immunoregulatory Cells , 2001, Infection and Immunity.

[80]  Brian J. Bacskai,et al.  Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy , 2001, Nature Medicine.

[81]  J. W. Rudy,et al.  The immune system and memory consolidation: a role for the cytokine IL-1β , 2001, Neuroscience & Biobehavioral Reviews.

[82]  K. Ashe,et al.  Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease , 2000, The Journal of Neuroscience.

[83]  R. Motter,et al.  Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease , 2000, Nature Medicine.

[84]  L. Grimaldi,et al.  The pervasiveness of interleukin-1 in Alzheimer pathogenesis: a role for specific polymorphisms in disease risk , 2000, Experimental Gerontology.

[85]  W. Griffin,et al.  Interleukin-1 Promotes Expression and Phosphorylation of Neurofilament and tau Proteins in Vivo , 2000, Experimental Neurology.

[86]  C. Plata-salamán,et al.  Inflammation and Alzheimer’s disease , 2000, Neurobiology of Aging.

[87]  A. Dunn.  Cytokine Activation of the HPA Axis , 2000, Annals of the New York Academy of Sciences.

[88]  W. Griffin,et al.  Overexpression of the Neuritotrophic Cytokine S100β Precedes the Appearance of Neuritic β‐Amyloid Plaques in APPV717F Mice , 2000 .

[89]  T. Standiford,et al.  CXC chemokine receptor-2 ligands are necessary components of neutrophil-mediated host defense in invasive pulmonary aspergillosis. , 1999, Journal of immunology.

[90]  W. Benzing,et al.  Evidence for glial-mediated inflammation in aged APPSW transgenic mice , 1999, Neurobiology of Aging.

[91]  S. Rogers,et al.  Inflammatory Cytokines IL-1α, IL-1β, IL-6, and TNF-α Impart Neuroprotection to an Excitotoxin Through Distinct Pathways , 1999, The Journal of Immunology.

[92]  B. Winblad,et al.  Immunohistochemical localization of interleukin-1β, interleukin-1 receptor antagonist and interleukin-1β converting enzyme/caspase-1 in the rat brain after peripheral administration of kainic acid , 1999, Neuroscience.

[93]  A. Coogan,et al.  Actions of the Pro‐Inflammatory Cytokine Il‐1[beta] on Central Synaptic Transmission , 1999, Experimental physiology.

[94]  Šimon Scharf,et al.  A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer’s disease , 1999, Neurology.

[95]  C. Cahill,et al.  Translation of the Alzheimer Amyloid Precursor Protein mRNA Is Up-regulated by Interleukin-1 through 5′-Untranslated Region Sequences* , 1999, The Journal of Biological Chemistry.

[96]  A. Betz,et al.  Expression of intercellular adhesion molecule 1 (ICAM-1) is reduced in permanent focal cerebral ischemic mouse brain using an adenoviral vector to induce overexpression of interleukin-1 receptor antagonist. , 1999, Brain research. Molecular brain research.

[97]  E. Scarpini,et al.  Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with β-amyloid[25–35] , 1999, Journal of Neuroimmunology.

[98]  B. Davidson,et al.  Attenuation of Ischemic Inflammatory Response in Mouse Brain Using an Adenoviral Vector to Induce Overexpression of Interleukin-1 Receptor Antagonist , 1998, Journal of Cerebral Blood Flow and Metabolism.

[99]  N. Delanty,et al.  Risk of Alzheimer's disease and duration of NSAID use , 1998, Neurology.

[100]  R. P. Stroemer,et al.  Exacerbation of Ischemic Brain Damage by Localized Striatal Injection of Interleukin-1β in the Rat , 1998, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[101]  W. Griffin,et al.  Distribution of interleukin‐1‐immunoreactive microglia in cerebral cortical layers: implications for neuritic plaque formation in Alzheimer’s disease , 1998, Neuropathology and applied neurobiology.

[102]  V. Perry,et al.  CXC chemokines generate age-related increases in neutrophil-mediated brain inflammation and blood–brain barrier breakdown , 1998, Current Biology.

[103]  Detlef Balschun,et al.  A neuromodulatory role of interleukin-1β in the hippocampus , 1998 .

[104]  W. Griffin,et al.  Glial‐Neuronal Interactions in Alzheimer's Disease: The Potential Role of a ‘Cytokine Cycle’ in Disease Progression , 1998, Brain pathology.

[105]  P. Feng,et al.  IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. , 1997, Science.

[106]  P. Morrissey,et al.  Phenotypic and functional characterization of mice that lack the type I receptor for IL-1. , 1997, Journal of immunology.

[107]  S. McColl,et al.  Chemokine networks in vivo: involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-alpha. , 1997, Journal of immunology.

[108]  S. Barger,et al.  Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E , 1997, Nature.

[109]  R. Mrak,et al.  Neuritic plaque evolution in Alzheimer’s disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms , 1997, Acta Neuropathologica.

[110]  M. Wong,et al.  Endogenous interleukin-1 receptor antagonist is neuroprotective. , 1997, Biochemical and biophysical research communications.

[111]  K. Smith,et al.  Human leukocyte antigens and cytokine expression in cerebral inflammatory demyelinative lesions of X-linked adrenoleukodystrophy and multiple sclerosis , 1997, Journal of Neuroimmunology.

[112]  V. Perry,et al.  Age-related effects of interleukin-1 beta on polymorphonuclear neutrophil-dependent increases in blood-brain barrier permeability in rats. , 1997, Brain : a journal of neurology.

[113]  R. Mrak,et al.  Glial‐Neuronal Interactions in Alzheimer Disease: Progressive Association of IL‐1α+ Microglia and S100β+ Astrocytes with Neurofibrillary Tangle Stages , 1997, Journal of neuropathology and experimental neurology.

[114]  D. Wallach,et al.  MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1 , 1997, Nature.

[115]  V. Perry,et al.  OVERRIDING THE BRAIN'S INTRINSIC RESISTANCE TO LEUKOCYTE RECRUITMENT WITH INTRAPARENCHYMAL INJECTIONS OF RECOMBINANT CHEMOKINES , 1996, Neuroscience.

[116]  R. Skinner,et al.  In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis , 1996, Neurobiology of Aging.

[117]  B. Trapp,et al.  Neutrophil infiltration, glial reaction, and neurological disease in transgenic mice expressing the chemokine N51/KC in oligodendrocytes. , 1996, The Journal of clinical investigation.

[118]  T. Nagatsu,et al.  Interleukin (IL)-1β, IL-2, IL-4, IL-6 and transforming growth factor-α levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease , 1996, Neuroscience Letters.

[119]  Julia W. Chang,et al.  Interleukin‐1β Induces Prostaglandin G/H Synthase‐2 (Cyclooxygenase‐2) in Primary Murine Astrocyte Cultures , 1996, Journal of neurochemistry.

[120]  M. Bukrinsky,et al.  Cytokine‐stimulated astrocytes damage human neurons via a nitric oxide mechanism , 1996, Glia.

[121]  J. Garcìa,et al.  Interleukin-1 receptor antagonist decreases the number of necrotic neurons in rats with middle cerebral artery occlusion. , 1995, The American journal of pathology.

[122]  W. Wood,et al.  Chemokine binding and activities mediated by the mouse IL-8 receptor. , 1995, Journal of immunology.

[123]  N. Rothwell,et al.  Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[124]  Y. L. Dubreuil,et al.  Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[125]  R. Mrak,et al.  Interleukin‐1 Expression in Different Plaque Types in Alzheimer's Disease: Significance in Plaque Evalution , 1995, Journal of neuropathology and experimental neurology.

[126]  N. Rothwell,et al.  Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat , 1995, Brain Research.

[127]  R. Mrak,et al.  Increased Neuronal β‐Amyloid Precursor Protein Expression in Human Temporal Lobe Epilepsy: Association with Interleukin‐1α Immunoreactivity , 1994 .

[128]  D. Graham,et al.  Microglial interleukin-lα expression in human head injury: Correlations with neuronal and neuritic β-amyloid precursor protein expression , 1994, Neuroscience Letters.

[129]  R. Mrak,et al.  Glial Cytokines as Neuropathogenic Factors in HIV Infection: Pathogenic Similarities to Alzheimer's Disease , 1994, Journal of neuropathology and experimental neurology.

[130]  W. McDonald,et al.  Inverse association of anti‐inflammatory treatments and Alzheimer's disease , 1994, Neurology.

[131]  C. Dijkstra,et al.  Demonstration of interleukin-1β in Lewis rat brain during experimental allergic encephalomyelitis by immunocytochemistry at the light and ultrastructural level , 1993, Journal of Neuroimmunology.

[132]  A. Kaszniak,et al.  Clinical trial of indomethacin in Alzheimer's disease , 1993, Neurology.

[133]  C. Gray,et al.  Regulation of β-amyloid precursor protein isoform mRNAs by transforming growth factor-β1 and interleukin-1β in astrocytes , 1993 .

[134]  K. Mohler,et al.  Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. , 1992, Journal of immunology.

[135]  E. Wada,et al.  In situ histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[136]  S. Hauser,et al.  Cytokine accumulations in CSF of multiple sclerosis patients , 1990, Neurology.

[137]  W. Griffin,et al.  Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[138]  H. W. Harris,et al.  Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[139]  S. Styren,et al.  Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease , 1988, Neurobiology of Aging.

[140]  H. Besedovsky,et al.  Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1. , 1987, Science.

[141]  P. Mcgeer,et al.  Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR , 1987, Neuroscience Letters.

[142]  C. Pert,et al.  Visualization and characterization of interleukin 1 receptors in brain. , 1987, Journal of immunology.

[143]  C. Dinarello,et al.  Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. , 1986, Science.

[144]  D. Blacker,et al.  Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database , 2007, Nature Genetics.

[145]  J. Rogers,et al.  Inflammation, anti-inflammatory agents and Alzheimer disease: the last 12 years. , 2006, Journal of Alzheimer's disease : JAD.

[146]  P. Carvey,et al.  Intra-parenchymal injection of tumor necrosis factor-alpha and interleukin 1-beta produces dopamine neuron loss in the rat. , 2005, Journal of neural transmission.

[147]  C. Ferrari,et al.  Learning modulation by endogenous hippocampal IL‐1: Blockade of endogenous IL‐1 facilitates memory formation , 2004, Hippocampus.

[148]  D. Wilcock,et al.  Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration. , 2004, Neurobiology of disease.

[149]  M. Wolfe,et al.  Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway. , 2004, The Journal of biological chemistry.

[150]  I. Goshen,et al.  Impaired interleukin‐1 signaling is associated with deficits in hippocampal memory processes and neural plasticity , 2003, Hippocampus.

[151]  S. Allan,et al.  Interleukin-1 in the brain: mechanisms of action in acute neurodegeneration. , 2003, Annals of the New York Academy of Sciences.

[152]  L. Mucke,et al.  TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice. , 2001, Nature medicine.

[153]  D. Jurič,et al.  Interleukin-1 beta, but not IL-1 alpha, mediates nerve growth factor secretion from rat astrocytes via type I IL-1 receptor. , 2001, International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.

[154]  D. Chaplin,et al.  Interleukin-1beta promotes repair of the CNS. , 2001, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[155]  J. W. Rudy,et al.  The immune system and memory consolidation: a role for the cytokine IL-1beta. , 2001, Neuroscience and biobehavioral reviews.

[156]  S. Paul,et al.  Overexpression of the neuritotrophic cytokine S100beta precedes the appearance of neuritic beta-amyloid plaques in APPV717F mice. , 2000, Journal of neurochemistry.

[157]  S. Rogers,et al.  Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways. , 1999, Journal of immunology.

[158]  B. Hyman,et al.  Microglial response to amyloid plaques in APPsw transgenic mice. , 1998, The American journal of pathology.

[159]  F. Pitossi,et al.  A neuromodulatory role of interleukin-1beta in the hippocampus. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[160]  W. Griffin,et al.  The role of chronic self-propagating glial responses in neurodegeneration: implications for long-lived survivors of human immunodeficiency virus. , 1997, Journal of neurovirology.

[161]  P. Liberski,et al.  Molecular analysis of prion protein (PrP) and glial fibrillary acidic protein (GFAP) transcripts in experimental Creutzfeldt-Jakob disease in mice. , 1997, Acta neurobiologiae experimentalis.

[162]  T. Nagatsu,et al.  Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease. , 1996, Neuroscience letters.

[163]  E. Connolly,et al.  Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke. , 1996, The Journal of clinical investigation.

[164]  R. Mrak,et al.  Increased neuronal beta-amyloid precursor protein expression in human temporal lobe epilepsy: association with interleukin-1 alpha immunoreactivity. , 1994, Journal of neurochemistry.

[165]  D. Graham,et al.  Microglial interleukin-1 alpha expression in human head injury: correlations with neuronal and neuritic beta-amyloid precursor protein expression. , 1994, Neuroscience letters.

[166]  G. Higgins,et al.  Induction of interleukin-1 beta mRNA in adult rat brain. , 1991, Brain research. Molecular brain research.

[167]  G. Higgins,et al.  Induction of interleukin-1β mRNA in adult rat brain , 1991 .

[168]  A. Lbert,et al.  Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease , 2022 .