In vivo methods for drug absorption - comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects.

[1]  P. Augustijns,et al.  Resolving intraluminal drug and formulation behavior: Gastrointestinal concentration profiling in humans. , 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[2]  Qiang Zhang,et al.  Investigation of the mechanisms of improved oral bioavailability of bergenin using bergenin–phospholipid complex , 2014, Drug development and industrial pharmacy.

[3]  P. Boesiger,et al.  Real‐Time Multipoint Gastrointestinal 19‐Fluorine Catheter Tracking , 2014, Magnetic resonance in medicine.

[4]  A. Paulick,et al.  LC-MS/MS-based quantification of clinically relevant intestinal uptake and efflux transporter proteins. , 2013, Journal of pharmaceutical and biomedical analysis.

[5]  M. Finel,et al.  A high throughput assay for the glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin by recombinant human UDP-glucuronosyltransferases and liver microsomes , 2013, Xenobiotica; the fate of foreign compounds in biological systems.

[6]  A. Müllertz,et al.  Bile salts and their importance for drug absorption. , 2013, International journal of pharmaceutics.

[7]  M. Brewster,et al.  Evaluation of gastrointestinal drug supersaturation and precipitation: strategies and issues. , 2013, International journal of pharmaceutics.

[8]  C. Gröer,et al.  Mass Spectrometry-Based Targeted Proteomics as a Tool to Elucidate the Expression and Function of Intestinal Drug Transporters , 2013, The AAPS Journal.

[9]  G. Radda,et al.  Gastrointestinal transit measurements in mice with 99mTc-DTPA-labeled activated charcoal using NanoSPECT-CT , 2013, EJNMMI Research.

[10]  J. Dressman,et al.  Dissolution media simulating the proximal canine gastrointestinal tract in the fasted state. , 2013, European journal of pharmaceutics and biopharmaceutics.

[11]  W. Weitschies,et al.  Simulating the Postprandial Stomach: Biorelevant Test Methods for the Estimation of Intragastric Drug Dissolution , 2013 .

[12]  Erik Sjögren,et al.  In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: application of the mechanistic absorption model GI-Sim. , 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[13]  Mei Hong,et al.  Cloning and functional characterization of the pig (Sus scrofa) organic anion transporting polypeptide 1a2 , 2013, Xenobiotica; the fate of foreign compounds in biological systems.

[14]  G. K. Jani,et al.  Raft forming system-an upcoming approach of gastroretentive drug delivery system. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[15]  R. Holm,et al.  In vitro, ex vivo and in vivo examination of buccal absorption of metoprolol with varying pH in TR146 cell culture, porcine buccal mucosa and Göttingen minipigs. , 2013, European Journal of Pharmaceutical Sciences.

[16]  A. Müllertz,et al.  Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations, Part 3: Understanding Supersaturation Versus Precipitation Potential During the In Vitro Digestion of Type I, II, IIIA, IIIB and IV Lipid-Based Formulations , 2013, Pharmaceutical Research.

[17]  Yasuyoshi Watanabe,et al.  Dynamic analysis of fluid distribution in the gastrointestinal tract in rats: positron emission tomography imaging after oral administration of nonabsorbable marker, [(18)F]Deoxyfluoropoly(ethylene glycol). , 2013, Molecular pharmaceutics.

[18]  W. Weitschies,et al.  Simulating the postprandial stomach: physiological considerations for dissolution and release testing. , 2013, Molecular pharmaceutics.

[19]  Hannah M Jones,et al.  Predicting pharmacokinetic profiles using in silico derived parameters. , 2013, Molecular pharmaceutics.

[20]  F. Gonzalez,et al.  PXR/CYP3A4-humanized mice for studying drug-drug interactions involving intestinal P-glycoprotein. , 2013, Molecular pharmaceutics.

[21]  Yvonne S. Lin,et al.  Interindividual variability in the hepatic expression of the human breast cancer resistance protein (BCRP/ABCG2): effect of age, sex, and genotype. , 2013, Journal of pharmaceutical sciences.

[22]  M. Jamei,et al.  Predicting drug–drug interactions: application of physiologically based pharmacokinetic models under a systems biology approach , 2013, Expert review of clinical pharmacology.

[23]  Christer Tannergren,et al.  Comprehensive study on regional human intestinal permeability and prediction of fraction absorbed of drugs using the Ussing chamber technique. , 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[24]  M. Swindle,et al.  Animal models of toxicology testing: the role of pigs , 2013, Expert opinion on drug metabolism & toxicology.

[25]  A. Pullan,et al.  The effect of luminal content and rate of occlusion on the interpretation of colonic manometry , 2013, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[26]  K. Regulska,et al.  Effect of pharmaceutical excipients on the stability of angiotensin-converting enzyme inhibitors in their solid dosage formulations , 2013, Drug development and industrial pharmacy.

[27]  N. Oberlies,et al.  Mechanisms underlying food-drug interactions: inhibition of intestinal metabolism and transport. , 2012, Pharmacology & therapeutics.

[28]  G. Knipp,et al.  Comparative pharmacokinetics studies of immediate- and modified-release formulations of glipizide in pigs and dogs. , 2012, Journal of pharmaceutical sciences.

[29]  N. Rapin,et al.  Intestinal transporters for endogenic and pharmaceutical organic anions: the challenges of deriving in‐vitro kinetic parameters for the prediction of clinically relevant drug–drug interactions , 2012, The Journal of pharmacy and pharmacology.

[30]  N. Ganderup,et al.  The Minipig as Nonrodent Species in Toxicology—Where Are We Now? , 2012, International journal of toxicology.

[31]  X. Sala,et al.  Single-pass intestinal perfusion to establish the intestinal permeability of model drugs in mouse. , 2012, International journal of pharmaceutics.

[32]  K. Pang,et al.  Commentary: Theoretical Predictions of Flow Effects on Intestinal and Systemic Availability in Physiologically Based Pharmacokinetic Intestine Models: The Traditional Model, Segregated Flow Model, and QGut Model , 2012, Drug Metabolism and Disposition.

[33]  G. Amidon,et al.  In silico prediction of drug dissolution and absorption with variation in intestinal pH for BCS class II weak acid drugs: ibuprofen and ketoprofen , 2012, Biopharmaceutics & drug disposition.

[34]  Yusuke Tanaka,et al.  Regional differences in the components of luminal water from rat gastrointestinal tract and comparison with other species. , 2012, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[35]  Kimberly A. Foster,et al.  Utility of in situ sodium alginate/karaya gum gels to facilitate gastric retention in rodents. , 2012, International journal of pharmaceutics.

[36]  J. Dressman,et al.  An In Vitro Methodology for Forecasting Luminal Concentrations and Precipitation of Highly Permeable Lipophilic Weak Bases in the Fasted Upper Small Intestine , 2012, Pharmaceutical Research.

[37]  H. Lennernäs,et al.  Extensive intestinal glucuronidation of raloxifene in vivo in pigs and impact for oral drug delivery , 2012, Xenobiotica; the fate of foreign compounds in biological systems.

[38]  S. Lazic,et al.  Expression Profiles of Metabolic Enzymes and Drug Transporters in the Liver and along the Intestine of Beagle Dogs , 2012, Drug Metabolism and Disposition.

[39]  J. Ware,et al.  Drug Absorption Interactions Between Oral Targeted Anticancer Agents and PPIs: Is pH‐Dependent Solubility the Achilles Heel of Targeted Therapy? , 2012, Clinical pharmacology and therapeutics.

[40]  R. Coatney,et al.  Gastric pH and gastric residence time in fasted and fed conscious beagle dogs using the Bravo pH system. , 2012, Journal of pharmaceutical sciences.

[41]  A. Narang,et al.  Impact of Excipient Interactions on Drug Bioavailability from Solid Dosage Forms , 2012, Pharmaceutical Research.

[42]  John P. Rose,et al.  Developability assessment of clinical drug products with maximum absorbable doses. , 2012, International journal of pharmaceutics.

[43]  J. Cardot,et al.  In vitro–In Vivo Correlations: Tricks and Traps , 2012, The AAPS Journal.

[44]  K. Mohsin.  Design of Lipid-Based Formulations for Oral Administration of Poorly Water-Soluble Drug Fenofibrate: Effects of Digestion , 2012, AAPS PharmSciTech.

[45]  C. Reppas,et al.  Luminal lipid phases after administration of a triglyceride solution of danazol in the fed state and their contribution to the flux of danazol across Caco-2 cell monolayers. , 2012, Molecular pharmaceutics.

[46]  J. Boullata,et al.  Drug-nutrient interactions: a broad view with implications for practice. , 2012, Journal of the Academy of Nutrition and Dietetics.

[47]  George Zografi,et al.  Assessing the performance of amorphous solid dispersions. , 2012, Journal of pharmaceutical sciences.

[48]  D. Bindra,et al.  Reversible and pH‐dependent weak drug‐excipient binding does not affect oral bioavailability of high dose drugs , 2012, The Journal of pharmacy and pharmacology.

[49]  H. Lennernäs,et al.  Assessment of enzymatic prodrug stability in human, dog and simulated intestinal fluids. , 2012, European journal of pharmaceutics and biopharmaceutics.

[50]  S. Wolffram,et al.  Chronic quercetin feeding decreases plasma concentrations of salicylamide phase II metabolites in pigs following oral administration , 2012, Xenobiotica; the fate of foreign compounds in biological systems.

[51]  H. Lennernäs,et al.  The pharmacokinetics and hepatic disposition of repaglinide in pigs: mechanistic modeling of metabolism and transport. , 2012, Molecular pharmaceutics.

[52]  F. Clubb,et al.  Swine as Models in Biomedical Research and Toxicology Testing , 2012, Veterinary pathology.

[53]  P. Cutler,et al.  Mass Spectrometry-Based Quantification of CYP Enzymes to Establish In Vitro/In Vivo Scaling Factors for Intestinal and Hepatic Metabolism in Beagle Dog , 2012, Pharmaceutical Research.

[54]  Akash Jain,et al.  Selection of oral bioavailability enhancing formulations during drug discovery , 2012, Drug development and industrial pharmacy.

[55]  M. Coughtrie,et al.  Absolute immunoquantification of the expression of ABC transporters P-glycoprotein, breast cancer resistance protein and multidrug resistance-associated protein 2 in human liver and duodenum. , 2012, Biochemical pharmacology.

[56]  Takashi Baba,et al.  Quantification of human uridine-diphosphate glucuronosyl transferase 1A isoforms in liver, intestine, and kidney using nanobore liquid chromatography-tandem mass spectrometry. , 2012, Analytical chemistry.

[57]  A. Mrhar,et al.  Raloxifene Glucuronidation in Human Intestine, Kidney, and Liver Microsomes and in Human Liver Microsomes Genotyped for the UGT1A1*28 Polymorphism , 2011, Drug Metabolism and Disposition.

[58]  B. Burchell,et al.  A Novel Method for the Immunoquantification of UDP-Glucuronosyltransferases in Human Tissue , 2011, Drug Metabolism and Disposition.

[59]  J. Tack,et al.  Effect of pH and Comedication on Gastrointestinal Absorption of Posaconazole , 2011, Clinical pharmacokinetics.

[60]  Shunsuke Ozaki,et al.  Solvent shift method for anti-precipitant screening of poorly soluble drugs using biorelevant medium and dimethyl sulfoxide. , 2011, International journal of pharmaceutics.

[61]  Masahiro Iwaki,et al.  In vitro and in vivo small intestinal metabolism of CYP3A and UGT substrates in preclinical animals species and humans: species differences , 2011, Drug metabolism reviews.

[62]  Xinyuan Zhang,et al.  The role of predictive biopharmaceutical modeling and simulation in drug development and regulatory evaluation. , 2011, International journal of pharmaceutics.

[63]  N. Rapin,et al.  Simulating kinetic parameters in transporter mediated permeability across Caco-2 cells. A case study of estrone-3-sulfate. , 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[64]  Malcolm Rowland,et al.  PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: prediction of plasma concentration-time profiles in human by using the physiologically-based pharmacokinetic modeling approach. , 2011, Journal of pharmaceutical sciences.

[65]  C. Hilmas,et al.  The safety and regulation of natural products used as foods and food ingredients. , 2011, Toxicological Sciences.

[66]  Clive G. Wilson,et al.  In vivo imaging of drug delivery systems in the gastrointestinal tract. , 2011, International journal of pharmaceutics.

[67]  T. Terasaki,et al.  Quantitative targeted absolute proteomics-based ADME research as a new path to drug discovery and development: methodology, advantages, strategy, and prospects. , 2011, Journal of pharmaceutical sciences.

[68]  Michael Gertz,et al.  Physiologically Based Pharmacokinetic Modeling of Intestinal First-Pass Metabolism of CYP3A Substrates with High Intestinal Extraction , 2011, Drug Metabolism and Disposition.

[69]  P. Boesiger,et al.  Visualization and quantification of intestinal transit and motor function by real‐time tracking of 19F labeled capsules in humans , 2011, Magnetic resonance in medicine.

[70]  R. Singh,et al.  Computational modeling of gastric digestion and the role of food material properties , 2011 .

[71]  B. Steffansen,et al.  Interactions between organic anions on multiple transporters in Caco-2 cells. , 2011, Journal of pharmaceutical sciences.

[72]  Johan Martens,et al.  Evaluation of ordered mesoporous silica as a carrier for poorly soluble drugs: influence of pressure on the structure and drug release. , 2011, Journal of pharmaceutical sciences.

[73]  Jörg Keldenich,et al.  Volume to dissolve applied dose (VDAD) and apparent dissolution rate (ADR): tools to predict in vivo bioavailability from orally applied drug suspensions. , 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[74]  P. Mura,et al.  Improvement of oxaprozin solubility and permeability by the combined use of cyclodextrin, chitosan, and bile components. , 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[75]  G. Bonn,et al.  Thiolated polycarbophil/glutathione: Defining its potential as a permeation enhancer for oral drug administration in comparison to sodium caprate , 2011, Drug delivery.

[76]  G. Derbin,et al.  Development of a canine model to enable the preclinical assessment of pH-dependent absorption of test compounds. , 2011, Journal of pharmaceutical sciences.

[77]  P. Gervasi,et al.  Xenobiotic metabolizing cytochrome P450 in pig, a promising animal model. , 2011, Current drug metabolism.

[78]  K. Goumas,et al.  Precipitation in and Supersaturation of Contents of the Upper Small Intestine After Administration of Two Weak Bases to Fasted Adults , 2011, Pharmaceutical Research.

[79]  H. Lennernäs,et al.  Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans. , 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[80]  K. Alton,et al.  Intestinal lymphatic transport for drug delivery☆ , 2011, Advanced Drug Delivery Reviews.

[81]  Xi Ma,et al.  Dietary grape-seed procyanidins decreased postweaning diarrhea by modulating intestinal permeability and suppressing oxidative stress in rats. , 2011, Journal of agricultural and food chemistry.

[82]  S. Burchiel,et al.  Potential risks resulting from fruit/vegetable-drug interactions: effects on drug-metabolizing enzymes and drug transporters. , 2011, Journal of food science.

[83]  L. Marciani,et al.  Assessment of gastrointestinal motor functions by MRI: a comprehensive review , 2011, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[84]  Werner Weitschies,et al.  Effects of non-ionic surfactants on cytochrome P450-mediated metabolism in vitro. , 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[85]  Oswaldo Baffa,et al.  Biomagnetic Methods: Technologies Applied to Pharmaceutical Research , 2011, Pharmaceutical Research.

[86]  G. Duchateau,et al.  Food-dependent disintegration of immediate release fosamprenavir tablets: in vitro evaluation using magnetic resonance imaging and a dynamic gastrointestinal system. , 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[87]  A. Basit,et al.  Assessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug development. , 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[88]  S. Bharate,et al.  Incompatibilities of Pharmaceutical Excipients with Active Pharmaceutical Ingredients: A Comprehensive Review , 2010 .

[89]  Jennifer B Dressman,et al.  The developability classification system: application of biopharmaceutics concepts to formulation development. , 2010, Journal of pharmaceutical sciences.

[90]  J. Qiu,et al.  Inhibitive effect of cremophor RH40 or tween 80-based self-microemulsiflying drug delivery system on cytochrome P450 3A enzymes in murine hepatocytes , 2010, Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.

[91]  Dallas B. Warren,et al.  Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: A mechanistic basis for utility , 2010, Journal of drug targeting.

[92]  A. Rostami-Hodjegan,et al.  Determination of a quantitative relationship between hepatic CYP3A5*1/*3 and CYP3A4 expression for use in the prediction of metabolic clearance in virtual populations , 2010, Biopharmaceutics & drug disposition.

[93]  N. Oberlies,et al.  Influence of dietary substances on intestinal drug metabolism and transport. , 2010, Current drug metabolism.

[94]  D. Bailey.  Fruit juice inhibition of uptake transport: a new type of food-drug interaction. , 2010, British journal of clinical pharmacology.

[95]  M. Fredholm,et al.  The minipig as a platform for new technologies in toxicology. , 2010, Journal of pharmacological and toxicological methods.

[96]  H. Simianer,et al.  Genetic management of the Göttingen Minipig population. , 2010, Journal of pharmacological and toxicological methods.

[97]  J. W. van der Laan,et al.  Regulatory acceptability of the minipig in the development of pharmaceuticals, chemicals and other products. , 2010, Journal of pharmacological and toxicological methods.

[98]  J. Sims,et al.  The utility of the minipig as an animal model in regulatory toxicology. , 2010, Journal of pharmacological and toxicological methods.

[99]  M. Varma,et al.  Targeting intestinal transporters for optimizing oral drug absorption. , 2010, Current drug metabolism.

[100]  A Rostami-Hodjegan,et al.  Interplay of metabolism and transport in determining oral drug absorption and gut wall metabolism: a simulation assessment using the "Advanced Dissolution, Absorption, Metabolism (ADAM)" model. , 2010, Current drug metabolism.

[101]  G. Amidon,et al.  Physiological parameters for oral delivery and in vitro testing. , 2010, Molecular pharmaceutics.

[102]  P. Holm,et al.  IVIVR in oral absorption for fenofibrate immediate release tablets using dissolution and dissolution permeation methods. , 2010, Die Pharmazie.

[103]  U. Kolb,et al.  IVIVC for fenofibrate immediate release tablets using solubility and permeability as in vitro predictors for pharmacokinetics. , 2010, Journal of pharmaceutical sciences.

[104]  S. Tajiri,et al.  The relationship between the drug concentration profiles in plasma and the drug doses in the colon. , 2010, Chemical & pharmaceutical bulletin.

[105]  David C. Sperry,et al.  Relative bioavailability of three different solid forms of PNU-141659 as determined with the artificial stomach-duodenum model. , 2010, Journal of pharmaceutical sciences.

[106]  J Michael Newton,et al.  Gastric emptying of multi-particulate dosage forms. , 2010, International journal of pharmaceutics.

[107]  A. Basit,et al.  Oral modified-release formulations in motion: the relationship between gastrointestinal transit and drug absorption. , 2010, International journal of pharmaceutics.

[108]  K. Yuen.  The transit of dosage forms through the small intestine. , 2010, International journal of pharmaceutics.

[109]  Clive G. Wilson.  The transit of dosage forms through the colon. , 2010, International journal of pharmaceutics.

[110]  R. Saito,et al.  Quantitative analysis of the effect of supersaturation on in vivo drug absorption. , 2010, Molecular pharmaceutics.

[111]  Li Di,et al.  Coexistence of passive and carrier-mediated processes in drug transport , 2010, Nature Reviews Drug Discovery.

[112]  J. Dressman,et al.  Biorelevant Media to Simulate Fluids in the Ascending Colon of Humans and Their Usefulness in Predicting Intracolonic Drug Solubility , 2010, Pharmaceutical Research.

[113]  Jean-Michel Kauffmann,et al.  The effects of excipients on transporter mediated absorption. , 2010, International journal of pharmaceutics.

[114]  S. Tajiri,et al.  Colonoscopic method for estimating the colonic absorption of extended-release dosage forms in dogs. , 2010, European journal of pharmaceutics and biopharmaceutics.

[115]  J. Polli,et al.  Effects of Commonly Used Excipients on the Expression of CYP3A4 in Colon and Liver Cells , 2010, Pharmaceutical Research.

[116]  E. Squires,et al.  Chlorzoxazone Metabolism by Porcine Cytochrome P450 Enzymes and the Effect of Cytochrome b5 , 2010, Drug Metabolism and Disposition.

[117]  Ciprian Catana,et al.  Small-Animal Molecular Imaging Methods , 2010, Journal of Nuclear Medicine.

[118]  T. Prueksaritanont,et al.  Use of In Vivo Animal Models to Assess Pharmacokinetic Drug-Drug Interactions , 2010, Pharmaceutical Research.

[119]  D. Archambault,et al.  Carboxymethyl-starch excipients for gastrointestinal stable oral protein formulations containing protease inhibitors. , 2010, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[120]  J. Dressman,et al.  Modification of gastric pH in the fasted dog , 2010, The Journal of pharmacy and pharmacology.

[121]  S. Rossi,et al.  Insulin-Loaded Nanoparticles Based on N-Trimethyl Chitosan: In Vitro (Caco-2 Model) and Ex Vivo (Excised Rat Jejunum, Duodenum, and Ileum) Evaluation of Penetration Enhancement Properties , 2010, AAPS PharmSciTech.

[122]  Takuya Suzuki,et al.  Dietary fat and bile juice, but not obesity, are responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats , 2010, Nutrition & metabolism.

[123]  P. Bork,et al.  A human gut microbial gene catalogue established by metagenomic sequencing , 2010, Nature.

[124]  Jan Van Humbeeck,et al.  Influence of Preparation Methods on Solid State Supersaturation of Amorphous Solid Dispersions: A Case Study with Itraconazole and Eudragit E100 , 2010, Pharmaceutical Research.

[125]  A. Nokhodchi,et al.  To enhance dissolution rate of poorly water-soluble drugs: glucosamine hydrochloride as a potential carrier in solid dispersion formulations. , 2010, Colloids and surfaces. B, Biointerfaces.

[126]  M. Niemi,et al.  Membrane transporters in drug development , 2010, Nature Reviews Drug Discovery.

[127]  R. R. Walters,et al.  Current Cytochrome P450 Phenotyping Methods Applied to Metabolic Drug-Drug Interaction Prediction in Dogs , 2010, Drug Metabolism and Disposition.

[128]  Erik C von Rosenvinge,et al.  Gastrointestinal peptides and regulation of gastric acid secretion , 2010, Current opinion in endocrinology, diabetes, and obesity.

[129]  H. Bianco-Peled,et al.  Mucoadhesion: a review of characterization techniques , 2010, Expert opinion on drug delivery.

[130]  T. Nakanishi,et al.  Species Difference in the Effect of Grapefruit Juice on Intestinal Absorption of Talinolol between Human and Rat , 2010, Journal of Pharmacology and Experimental Therapeutics.

[131]  H. Lennernäs,et al.  Enterohepatic Disposition of Rosuvastatin in Pigs and the Impact of Concomitant Dosing with Cyclosporine and Gemfibrozil , 2009, Drug Metabolism and Disposition.

[132]  Leslie Z Benet,et al.  The drug transporter-metabolism alliance: uncovering and defining the interplay. , 2009, Molecular pharmaceutics.

[133]  H. Lennernäs,et al.  Different Effects of Ketoconazole on the Stereoselective First-Pass Metabolism of R/S-Verapamil in the Intestine and the Liver: Important for the Mechanistic Understanding of First-Pass Drug-Drug Interactions , 2009, Drug Metabolism and Disposition.

[134]  P. Boesiger,et al.  Effect of meal volume and calorie load on postprandial gastric function and emptying: studies under physiological conditions by combined fiber-optic pressure measurement and MRI. , 2009, American Journal of Physiology - Gastrointestinal and Liver Physiology.

[135]  S. Yamashita,et al.  The species differences of intestinal drug absorption and first-pass metabolism between cynomolgus monkeys and humans. , 2009, Journal of pharmaceutical sciences.

[136]  Jackie C Bloomer,et al.  Quantitative Evaluation of the Expression and Activity of Five Major Sulfotransferases (SULTs) in Human Tissues: The SULT “Pie” , 2009, Drug Metabolism and Disposition.

[137]  M. Schubert.  Gastric exocrine and endocrine secretion , 2009, Current opinion in gastroenterology.

[138]  M. Roberts,et al.  Compatibility studies of acyclovir and lactose in physical mixtures and commercial tablets. , 2009, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[139]  Y. Lai,et al.  Identification of interspecies difference in hepatobiliary transporters to improve extrapolation of human biliary secretion , 2009, Expert opinion on drug metabolism & toxicology.

[140]  K. Kawakami,et al.  Current status of amorphous formulation and other special dosage forms as formulations for early clinical phases. , 2009, Journal of pharmaceutical sciences.

[141]  Yuming Guo,et al.  Supplemental zinc reduced intestinal permeability by enhancing occludin and zonula occludens protein-1 (ZO-1) expression in weaning piglets , 2009, British Journal of Nutrition.

[142]  Steven C Sutton,et al.  The use of gastrointestinal intubation studies for controlled release development. , 2009, British journal of clinical pharmacology.

[143]  Patrick Augustijns,et al.  Supersaturating drug delivery systems: the answer to solubility-limited oral bioavailability? , 2009, Journal of pharmaceutical sciences.

[144]  K. Shoghi,et al.  Quantitative small animal PET. , 2009, The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of....

[145]  P. Boesiger,et al.  The effect of gastric secretion on gastric physiology and emptying in the fasted and fed state assessed by magnetic resonance imaging , 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[146]  Fasheng Li,et al.  Fed and fasted gastric pH and gastric residence time in conscious beagle dogs. , 2009, Journal of pharmaceutical sciences.

[147]  L. Lim,et al.  Dietary regulation of P-gp function and expression , 2009, Expert opinion on drug metabolism & toxicology.

[148]  A. Galetin,et al.  Methodology for development of a physiological model incorporating CYP3A and P-glycoprotein for the prediction of intestinal drug absorption. , 2009, Journal of Pharmacy and Science.

[149]  V. Saxena,et al.  Developability assessment in pharmaceutical industry: An integrated group approach for selecting developable candidates. , 2009, Journal of pharmaceutical sciences.

[150]  C. Telang,et al.  Improved physical stability of amorphous state through acid base interactions. , 2009, Journal of pharmaceutical sciences.

[151]  M. Kataoka,et al.  IVIVC in oral absorption for fenofibrate immediate release tablets using a dissolution/permeation system. , 2009, Journal of Pharmacy and Science.

[152]  Michael J. McKenna,et al.  Oral administration of the GnRH antagonist acyline, in a GIPET®-enhanced tablet form, acutely suppresses serum testosterone in normal men: single-dose pharmacokinetics and pharmacodynamics , 2009, Cancer Chemotherapy and Pharmacology.

[153]  Michael B. Bolger,et al.  Simulations of the Nonlinear Dose Dependence for Substrates of Influx and Efflux Transporters in the Human Intestine , 2009, The AAPS Journal.

[154]  J. Dressman,et al.  Cytochrome P450-mediated metabolism in the human gut wall. , 2009, The Journal of pharmacy and pharmacology.

[155]  V. Bhargava,et al.  Effect of proton pump inhibition on the gastric volume: assessed by magnetic resonance imaging , 2009, Alimentary pharmacology & therapeutics.

[156]  S. Panunzi,et al.  A Simple, Realistic Stochastic Model of Gastric Emptying , 2009, Pharmaceutical Research.

[157]  Yue Weng,et al.  Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding , 2009, Science.

[158]  C. Locuson,et al.  Evaluation of Escherichia coli Membrane Preparations of Canine CYP1A1, 2B11, 2C21, 2C41, 2D15, 3A12, and 3A26 with Coexpressed Canine Cytochrome P450 Reductase , 2009, Drug Metabolism And Disposition.

[159]  J. Crison,et al.  Investigation of some factors contributing to negative food effects , 2009, Biopharmaceutics & drug disposition.

[160]  Jun Qiu,et al.  Nonionic surfactants are strong inhibitors of cytochrome P450 3A biotransformation activity in vitro and in vivo. , 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[161]  M. Papich,et al.  Factors influencing the gastric residence of dosage forms in dogs. , 2009, Journal of pharmaceutical sciences.

[162]  Hans Lennernäs,et al.  Toward an increased understanding of the barriers to colonic drug absorption in humans: implications for early controlled release candidate assessment. , 2009, Molecular pharmaceutics.

[163]  Qing Yang,et al.  Lymphatic and portal vein absorption of organochlorine compounds in rats. , 2009, American journal of physiology. Gastrointestinal and liver physiology.

[164]  Kairui Feng,et al.  The Simcyp® Population-based ADME Simulator , 2009 .

[165]  Emma L. McConnell,et al.  Meal-Induced Acceleration of Tablet Transit Through the Human Small Intestine , 2009, Pharmaceutical Research.

[166]  A. Basit,et al.  Gut instincts: explorations in intestinal physiology and drug delivery. , 2008, International journal of pharmaceutics.

[167]  E. Björk,et al.  Physicochemical interactions between drugs and superdisintegrants. , 2008, The Journal of pharmacy and pharmacology.

[168]  Abdul W Basit,et al.  The gastrointestinal microbiota as a site for the biotransformation of drugs. , 2008, International journal of pharmaceutics.

[169]  P. Arhan,et al.  Interactions between ethylenediaminetetraacetic acid (EDTA) and iron absorption pathways, in the Caco-2 model. , 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[170]  J. Akey,et al.  Differential expression of CYP3A12 and CYP3A26 mRNAs in canine liver and intestine , 2008 .

[171]  Y. Lai,et al.  Absolute quantification of multidrug resistance-associated protein 2 (MRP2/ABCC2) using liquid chromatography tandem mass spectrometry. , 2008, Analytical biochemistry.

[172]  M. Rouini,et al.  Investigation on different levels of in vitro–in vivo correlation: gemfibrozil immediate release capsule , 2008, Biopharmaceutics & drug disposition.

[173]  X. Mao,et al.  Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. , 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[174]  Paul A. Dickinson,et al.  Clinical Relevance of Dissolution Testing in Quality by Design , 2008, The AAPS Journal.

[175]  H. Lennernäs,et al.  Intestinal and Hepatobiliary Transport of Ximelagatran and Its Metabolites in Pigs , 2008, Drug Metabolism And Disposition.

[176]  Isadore Kanfer,et al.  Physicochemical characterization of five glyburide powders: a BCS based approach to predict oral absorption. , 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[177]  D. P. Santana,et al.  Application of thermal analysis in study of binary mixtures with metformin , 2008 .

[178]  A. Dokoumetzidis,et al.  IVIVC of controlled release formulations: physiological-dynamical reasons for their failure. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[179]  Arik Dahan,et al.  Rationalizing the selection of oral lipid based drug delivery systems by an in vitro dynamic lipolysis model for improved oral bioavailability of poorly water soluble drugs. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[180]  S. Benita,et al.  A Novel Nanocapsule Delivery System to Overcome Intestinal Degradation and Drug Transport Limited Absorption of P-glycoprotein Substrate Drugs , 2008, Pharmaceutical Research.

[181]  Raimar Löbenberg,et al.  Dynamic Dissolution Testing To Establish In Vitro/In Vivo Correlations for Montelukast Sodium, a Poorly Soluble Drug , 2008, Pharmaceutical Research.

[182]  R. Singh,et al.  Disintegration of solid foods in human stomach. , 2008, Journal of food science.

[183]  Jiunn H. Lin,et al.  Applications and limitations of genetically modified mouse models in drug discovery and development. , 2008, Current drug metabolism.

[184]  Masoud Jamei,et al.  Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions. , 2008, Current drug metabolism.

[185]  Kimberley A. Lentz,et al.  Current Methods for Predicting Human Food Effect , 2008, The AAPS Journal.

[186]  H. Lennernäs,et al.  Improved understanding of the effect of food on drug absorption and bioavailability for lipophilic compounds using an intestinal pig perfusion model. , 2008, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[187]  M. Iwaki,et al.  Species differences in in vitro and in vivo small intestinal metabolism of CYP3A substrates. , 2008, Journal of pharmaceutical sciences.

[188]  H. Stevens,et al.  In Vivo Performance of an Oral MR Matrix Tablet Formulation in the Beagle Dog in the Fed and Fasted State: Assessment of Mechanical Weakness , 2008, Pharmaceutical Research.

[189]  S. Grube,et al.  Characterization of the epithelial permeation enhancing effect of basic butylated methacrylate copolymer--in vitro studies. , 2008, Biomacromolecules.

[190]  M. Sherry Ku,et al.  Use of the Biopharmaceutical Classification System in Early Drug Development , 2008, The AAPS Journal.

[191]  A. Kong,et al.  Liquid microjunction surface sampling probe electrospray mass spectrometry for detection of drugs and metabolites in thin tissue sections. , 2008, Journal of mass spectrometry : JMS.

[192]  R. Fisher,et al.  Gastric emptying of a non‐digestible solid: assessment with simultaneous SmartPill pH and pressure capsule, antroduodenal manometry, gastric emptying scintigraphy , 2008, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[193]  D. Greenblatt,et al.  Influence of fruit juices on drug disposition: discrepancies between in vitro and clinical studies , 2008 .

[194]  Marloes A. A. Schepens,et al.  M1739 Dietary Calcium Decreases But Fructo-Oligosaccharides Increase Intestinal Permeability in Colon of Rats , 2008 .

[195]  Leslie Z Benet,et al.  Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption. , 2008, Advanced drug delivery reviews.

[196]  B. Medhi,et al.  Natural product and drugs interactions, its clinical implication in drug therapy management. , 2008, Saudi medical journal.

[197]  D. Genser.  Food and Drug Interaction: Consequences for the Nutrition/Health Status , 2008, Annals of Nutrition and Metabolism.

[198]  H. Saji,et al.  Influence of various combinations of mucolytic agent and non-ionic surfactant on intestinal absorption of poorly absorbed hydrophilic compounds. , 2008, International journal of pharmaceutics.

[199]  Tetsuya Terasaki,et al.  Quantitative Atlas of Membrane Transporter Proteins: Development and Application of a Highly Sensitive Simultaneous LC/MS/MS Method Combined with Novel In-silico Peptide Selection Criteria , 2008, Pharmaceutical Research.

[200]  A. Basit,et al.  Measurements of rat and mouse gastrointestinal pH, fluid and lymphoid tissue, and implications for in‐vivo experiments , 2008, The Journal of pharmacy and pharmacology.

[201]  Timothy J Muldoon,et al.  Subcellular-resolution molecular imaging within living tissue by fiber microendoscopy. , 2007, Optics express.

[202]  O Pelkonen,et al.  Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: A comparative study in vitro , 2007, Xenobiotica; the fate of foreign compounds in biological systems.

[203]  M. Landín,et al.  Compatibility of the antitumoral beta-lapachone with different solid dosage forms excipients. , 2007, Journal of pharmaceutical and biomedical analysis.

[204]  Christopher J H Porter,et al.  Lipid-based delivery systems and intestinal lymphatic drug transport: A mechanistic update☆ , 2007, Advanced Drug Delivery Reviews.

[205]  Fridrun Podczeck,et al.  The gastric emptying of food as measured by gamma‐scintigraphy and electrical impedance tomography (EIT) and its influence on the gastric emptying of tablets of different dimensions , 2007, The Journal of pharmacy and pharmacology.

[206]  Roberto Canaparo,et al.  EXPRESSION OF CYP3A ISOFORMS AND P‐GLYCOPROTEIN IN HUMAN STOMACH, JEJUNUM AND ILEUM , 2007, Clinical and experimental pharmacology & physiology.

[207]  Ayman El-Kattan,et al.  Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bioavailability of rats and humans. , 2007, Expert opinion on drug metabolism & toxicology.

[208]  A Philip Plumb,et al.  A decision-support tool for the formulation of orally active, poorly soluble compounds. , 2007, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[209]  H Lennernäs,et al.  Intestinal permeability and its relevance for absorption and elimination , 2007, Xenobiotica; the fate of foreign compounds in biological systems.

[210]  H. Lennernäs.  Animal data: the contributions of the Ussing Chamber and perfusion systems to predicting human oral drug delivery in vivo. , 2007, Advanced drug delivery reviews.

[211]  Hans Lennernäs,et al.  Modeling gastrointestinal drug absorption requires more in vivo biopharmaceutical data: experience from in vivo dissolution and permeability studies in humans. , 2007, Current drug metabolism.

[212]  Masoud Jamei,et al.  Prediction of intestinal first-pass drug metabolism. , 2007, Current drug metabolism.

[213]  Hu Liu,et al.  Reversal of P-glycoprotein-mediated multidrug resistance by cholesterol derived from low density lipoprotein in a vinblastine-resistant human lymphoblastic leukemia cell line. , 2007, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[214]  Geert Verreck,et al.  Use of a screening method to determine excipients which optimize the extent and stability of supersaturated drug solutions and application of this system to solid formulation design. , 2007, International journal of pharmaceutics.

[215]  C. Friis,et al.  Is bupropion a more specific substrate for porcine CYP2E than chlorzoxazone and p-nitrophenol? , 2007, Basic & clinical pharmacology & toxicology.

[216]  Ping Li,et al.  Developing early formulations: practice and perspective. , 2007, International journal of pharmaceutics.

[217]  Per Artursson,et al.  Expression of Thirty-six Drug Transporter Genes in Human Intestine, Liver, Kidney, and Organotypic Cell Lines , 2007, Drug Metabolism and Disposition.

[218]  Todd J. McWhorter,et al.  Mechanistic bases for differences in passive absorption , 2007, Journal of Experimental Biology.

[219]  D. Hauss.  Oral lipid-based formulations. , 2007, Advanced drug delivery reviews.

[220]  A. Wilfart,et al.  Digesta transit in different segments of the gastrointestinal tract of pigs as affected by insoluble fibre supplied by wheat bran , 2007, British Journal of Nutrition.

[221]  J. Tack,et al.  In vitro behavior of a phosphate ester prodrug of amprenavir in human intestinal fluids and in the Caco-2 system: illustration of intraluminal supersaturation. , 2007, International journal of pharmaceutics.

[222]  A. Müllertz,et al.  Bioavailability of seocalcitol III. Administration of lipid-based formulations to minipigs in the fasted and fed state. , 2007, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[223]  H. Koepsell,et al.  Polyspecific Organic Cation Transporters: Structure, Function, Physiological Roles, and Biopharmaceutical Implications , 2007, Pharmaceutical Research.

[224]  C. Xia,et al.  Evaluation of drug-transporter interactions using in vitro and in vivo models. , 2007, Current drug metabolism.

[225]  J. Tack,et al.  Parallel Monitoring of Plasma and Intraluminal Drug Concentrations in Man After Oral Administration of Fosamprenavir in the Fasted and Fed State , 2007, Pharmaceutical Research.

[226]  Jochen Maas,et al.  An integrated early formulation strategy--from hit evaluation to preclinical candidate profiling. , 2007, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[227]  Y. Masaoka,et al.  Effect of administration site in the gastrointestinal tract on bioavailability of poorly absorbed drugs taken after a meal. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[228]  M. Thanou,et al.  N-sulfonato-N,O-carboxymethylchitosan: a novel polymeric absorption enhancer for the oral delivery of macromolecules. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[229]  J. Ayres,et al.  Bioavailability of riboflavin from a gastric retention formulation. , 2007, International journal of pharmaceutics.

[230]  J. Ritter.  Intestinal UGTs as potential modifiers of pharmacokinetics and biological responses to drugs and xenobiotics , 2007, Expert opinion on drug metabolism & toxicology.

[231]  P. Marathe,et al.  Development and validation of a preclinical food effect model. , 2007, Journal of pharmaceutical sciences.

[232]  M. Lavine,et al.  Optical imaging and analysis of human vaginal coating by drug delivery gels. , 2007, Contraception.

[233]  H. Lennernäs,et al.  Gene and protein expression of P-glycoprotein, MRP1, MRP2, and CYP3A4 in the small and large human intestine. , 2007, Molecular pharmaceutics.

[234]  M. Islam,et al.  Sorbitol-based osmotic diarrhea: possible causes and mechanism of prevention investigated in rats. , 2006, World journal of gastroenterology.

[235]  R. de Kanter,et al.  Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction , 2006, Expert opinion on drug metabolism & toxicology.

[236]  H. Lennernäs,et al.  The effect of pancreatic and biliary depletion on the in vivo pharmacokinetics of digoxin in pigs. , 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[237]  A. Hussain,et al.  A Modern View of Excipient Effects on Bioequivalence: Case Study of Sorbitol , 2006, Pharmaceutical Research.

[238]  Seshadri Neervannan,et al.  Preclinical formulations for discovery and toxicology: physicochemical challenges , 2006, Expert opinion on drug metabolism & toxicology.

[239]  H. Tanabe,et al.  Increased luminal mucin does not disturb glucose or ovalbumin absorption in rats fed insoluble dietary fiber. , 2006, The Journal of nutrition.

[240]  J. Donnelly,et al.  Pharmacokinetics of Itraconazole and Hydroxyitraconazole in Healthy Subjects after Single and Multiple Doses of a Novel Formulation , 2006, Antimicrobial Agents and Chemotherapy.

[241]  A. Hila,et al.  Postprandial Stomach Contents Have Multiple Acid Layers , 2006, Journal of clinical gastroenterology.

[242]  D. Mishra,et al.  Preparation, characterization and in vitro dissolution studies of solid dispersion of meloxicam with PEG 6000. , 2006, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[243]  S. Mandlekar,et al.  Modulation of metabolic enzymes by dietary phytochemicals: a review of mechanisms underlying beneficial versus unfavorable effects. , 2006, Current drug metabolism.

[244]  Ho-Chul Shin,et al.  Why is it Challenging to Predict Intestinal Drug Absorption and Oral Bioavailability in Human Using Rat Model , 2006, Pharmaceutical Research.

[245]  H. Lennernäs,et al.  FIRST-PASS EFFECTS OF VERAPAMIL ON THE INTESTINAL ABSORPTION AND LIVER DISPOSITION OF FEXOFENADINE IN THE PORCINE MODEL , 2006, Drug Metabolism and Disposition.

[246]  J. M. McCarthy,et al.  Dog Colonoscopy Model for Predicting Human Colon Absorption , 2006, Pharmaceutical Research.

[247]  H. Yamahara,et al.  Synergistic absorption enhancement of salmon calcitonin and reversible mucosal injury by applying a mucolytic agent and a non-ionic surfactant. , 2006, International journal of pharmaceutics.

[248]  J. Dressman,et al.  Canine Intestinal Contents vs. Simulated Media for the Assessment of Solubility of Two Weak Bases in the Human Small Intestinal Contents , 2006, Pharmaceutical Research.

[249]  Mary F Paine,et al.  THE HUMAN INTESTINAL CYTOCHROME P450 “PIE” , 2006, Drug Metabolism and Disposition.

[250]  M. Ronis,et al.  Metabolic phenotype of isoflavones differ among female rats, pigs, monkeys, and women. , 2006, The Journal of nutrition.

[251]  Alessio Fasano,et al.  Tight junction modulation and its relationship to drug delivery. , 2006, Advanced drug delivery reviews.

[252]  G. Fahey,et al.  Dietary fibers affect viscosity of solutions and simulated human gastric and small intestinal digesta. , 2006, The Journal of nutrition.

[253]  J. Wishart,et al.  Effects of load, and duration, of duodenal lipid on antropyloroduodenal motility, plasma CCK and PYY, and energy intake in healthy men. , 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

[254]  O. Corrigan,et al.  Effect of intestinal fluid flux on ibuprofen absorption in the rat intestine. , 2006, International journal of pharmaceutics.

[255]  Patrick Augustijns,et al.  Intraluminal drug and formulation behavior and integration in in vitro permeability estimation: a case study with amprenavir. , 2006, Journal of pharmaceutical sciences.

[256]  J. A. D. Leeuw,et al.  An Animal Model to Study Digesta Passage in Different Compartments of the Gastro-Intestinal Tract (GIT) as Affected by Dietary Composition , 2006 .

[257]  A. Watson,et al.  Dietary constituents are able to play a beneficial role in canine epidermal barrier function , 2006, Experimental dermatology.

[258]  M. Fox,et al.  Magnetic resonance imaging for the assessment of gastrointestinal function , 2006, Scandinavian journal of gastroenterology.

[259]  R. Fisher,et al.  Regional Postprandial Differences in pH Within the Stomach and Gastroesophageal Junction , 2005, Digestive Diseases and Sciences.

[260]  P. Dawson,et al.  OSTα‐OSTβ: A major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia , 2005 .

[261]  N. Hosten,et al.  Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging , 2005, Alimentary pharmacology & therapeutics.

[262]  N. Fotaki,et al.  Canine versus in vitro data for predicting input profiles of L-sulpiride after oral administration. , 2005, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[263]  Hans Lennernäs,et al.  The Effects of Food on the Dissolution of Poorly Soluble Drugs in Human and in Model Small Intestinal Fluids , 2005, Pharmaceutical Research.

[264]  Rajeswari Challa,et al.  Cyclodextrins in drug delivery: An updated review , 2005, AAPS PharmSciTech.

[265]  G. Guyatt,et al.  Natural Health Product-Drug Interactions: A Systematic Review of Clinical Trials , 2005, Therapeutic drug monitoring.

[266]  Jing-Tao Wu,et al.  Strategy of utilizing in vitro and in vivo ADME tools for lead optimization and drug candidate selection. , 2005, Current topics in medicinal chemistry.

[267]  J. Brasseur,et al.  A Novel in Vitro and Numerical Analysis of Shear-Induced Drug Release from Extended-Release Tablets in the Fed Stomach , 2005, Pharmaceutical Research.

[268]  C. Friis,et al.  Porcine CYP2A polymorphisms and activity. , 2005, Basic & clinical pharmacology & toxicology.

[269]  M. Camilleri,et al.  Relationship of gastric emptying and volume changes after a solid meal in humans. , 2005, American journal of physiology. Gastrointestinal and liver physiology.

[270]  J. Tack,et al.  Determination of intraluminal theophylline concentrations after oral intake of an immediate‐and a slow‐release dosage form , 2005, The Journal of pharmacy and pharmacology.

[271]  S. Frokjaer,et al.  Delivery aspects of small peptides and substrates for peptide transporters. , 2005, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[272]  I. Toth,et al.  Gastrointestinal absorption of heparin by lipidization or coadministration with penetration enhancers. , 2005, Current drug delivery.

[273]  Lutz Trahms,et al.  Magnetic Marker Monitoring: An application of biomagnetic measurement instrumentation and principles for the determination of the gastrointestinal behavior of magnetically marked solid dosage forms. , 2005, Advanced drug delivery reviews.

[274]  H. Parkman,et al.  The effect of rabeprazole on regional gastric acidity and the postprandial cardia/gastro‐oesophageal junction acid layer in normal subjects: a randomized, double‐blind, placebo‐controlled study , 2005, Alimentary pharmacology & therapeutics.

[275]  R. Neubert,et al.  The influence of bile salts and mixed micelles on the pharmacokinetics of quinine in rabbits. , 2005, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[276]  P. Boesiger,et al.  Effect of ingestion order of the fat component of a solid meal on intragastric fat distribution and gastric emptying assessed by MRI , 2005, Journal of magnetic resonance imaging : JMRI.

[277]  A. Hoffman,et al.  Evaluation of a chylomicron flow blocking approach to investigate the intestinal lymphatic transport of lipophilic drugs. , 2005, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[278]  Anette Müllertz,et al.  Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug. , 2005, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[279]  S. Davis,et al.  Formulation strategies for absorption windows. , 2005, Drug discovery today.

[280]  Minoru Ishikawa,et al.  Interaction of Modified Cyclodextrins with Cytochrome P-450 , 2005, Bioscience, biotechnology, and biochemistry.

[281]  F. Ahsan,et al.  Tetradecylmaltoside (TDM) enhances in vitro and in vivo intestinal absorption of enoxaparin, a low molecular weight heparin , 2005, Journal of drug targeting.

[282]  James G Brasseur,et al.  Gastric flow and mixing studied using computer simulation , 2004, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[283]  Mark E. Davis,et al.  Cyclodextrin-based pharmaceutics: past, present and future , 2004, Nature Reviews Drug Discovery.

[284]  Gloria Kwei,et al.  The role of biopharmaceutics in the development of a clinical nanoparticle formulation of MK-0869: a Beagle dog model predicts improved bioavailability and diminished food effect on absorption in human. , 2004, International journal of pharmaceutics.

[285]  Z. Değim,et al.  The effect of various liposome formulations on insulin penetration across Caco-2 cell monolayer. , 2004, Life sciences.

[286]  H. Lennernäs,et al.  Regional intestinal absorption and biliary excretion of fluvastatin in the rat: possible involvement of mrp2. , 2004, Molecular pharmaceutics.

[287]  Ben J. Boyd,et al.  Susceptibility to Lipase-Mediated Digestion Reduces the Oral Bioavailability of Danazol After Administration as a Medium-Chain Lipid-Based Microemulsion Formulation , 2004, Pharmaceutical Research.

[288]  H. Dumon,et al.  Gastric emptying rate is inversely related to body weight in dog breeds of different sizes. , 2004, The Journal of nutrition.

[289]  Steven C Sutton,et al.  Companion animal physiology and dosage form performance. , 2004, Advanced drug delivery reviews.

[290]  Georges Houin,et al.  Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivo. , 2004, International journal of pharmaceutics.

[291]  B. Abrahamsson,et al.  Food effects on tablet disintegration. , 2004, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[292]  A. Glukhovsky,et al.  The development and application of wireless capsule endoscopy , 2004, The international journal of medical robotics + computer assisted surgery : MRCAS.

[293]  Kim L. R. Brouwer,et al.  The Complexities of Hepatic Drug Transport: Current Knowledge and Emerging Concepts , 2004, Pharmaceutical Research.

[294]  Akira Yamamoto,et al.  Modulation of intestinal P-glycoprotein function by cremophor EL and other surfactants by an in vitro diffusion chamber method using the isolated rat intestinal membranes. , 2004, Journal of pharmaceutical sciences.

[295]  T. Sakata,et al.  Viscous properties of pig cecal contents and the contribution of solid particles to viscosity. , 2004, Nutrition.

[296]  H. Lennernäs,et al.  St John's Wort Decreases the Bioavailability of R‐ and S‐verapamil Through Induction of the First‐pass Metabolism , 2004, Clinical pharmacology and therapeutics.

[297]  W. Wahli,et al.  Regional variations in ABC transporter expression along the mouse intestinal tract. , 2004, Physiological genomics.

[298]  Oliver Burk,et al.  Cytochrome P450 3A4 and P‐glycoprotein Expression in Human Small Intestinal Enterocytes and Hepatocytes: A Comparative Analysis in Paired Tissue Specimens , 2004, Clinical pharmacology and therapeutics.

[299]  W. Curatolo,et al.  Drug polymorphism and dosage form design: a practical perspective. , 2004, Advanced drug delivery reviews.

[300]  A. van der Bilt,et al.  Chewing behavior and salivary secretion. , 2004, European journal of oral sciences.

[301]  G. Tucker,et al.  Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors , 2004, Xenobiotica; the fate of foreign compounds in biological systems.

[302]  A. Bernkop‐Schnürch,et al.  Thiolated chitosans: development and in vitro evaluation of a mucoadhesive, permeation enhancing oral drug delivery system. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[303]  M. Al-omari,et al.  Amlodipine Besylate–Excipients Interaction in Solid Dosage Form , 2004, Pharmaceutical development and technology.

[304]  J. Dressman,et al.  Predicting the precipitation of poorly soluble weak bases upon entry in the small intestine , 2004, The Journal of pharmacy and pharmacology.

[305]  Abdul W. Basit,et al.  Concentration-Dependent Effects of Polyethylene Glycol 400 on Gastrointestinal Transit and Drug Absorption , 2003, Pharmaceutical Research.

[306]  H. Lennernäs,et al.  Multiple transport mechanisms involved in the intestinal absorption and first‐pass extraction of fexofenadine , 2003, Clinical pharmacology and therapeutics.

[307]  D. Dunbar,et al.  Characterization of mouse small intestinal cytochrome P450 expression. , 2003, Drug metabolism and disposition: the biological fate of chemicals.

[308]  T. Ōsawa,et al.  Suitability of the cynomolgus monkey as an animal model for drug absorption studies of oral dosage forms from the viewpoint of gastrointestinal physiology. , 2003, Biological & pharmaceutical bulletin.

[309]  Christopher J. H. Porter,et al.  Intestinal Lymphatic Transport of Halofantrine Occurs After Oral Administration of a Unit-Dose Lipid-Based Formulation to Fasted Dogs , 2003, Pharmaceutical Research.

[310]  David M. Shackleford,et al.  Contribution of Lymphatically Transported Testosterone Undecanoate to the Systemic Exposure of Testosterone after Oral Administration of Two Andriol Formulations in Conscious Lymph Duct-Cannulated Dogs , 2003, Journal of Pharmacology and Experimental Therapeutics.

[311]  T. Fushiki,et al.  Effects of oral stimulation with fats on the cephalic phase of pancreatic enzyme secretion in esophagostomized rats , 2003, Physiology & Behavior.

[312]  D. Greenblatt,et al.  Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice , 2003, Clinical pharmacology and therapeutics.

[313]  David Attwood,et al.  Oral sustained delivery of paracetamol from in situ-gelling gellan and sodium alginate formulations. , 2003, International journal of pharmaceutics.

[314]  G. Williamson,et al.  Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo. , 2003, Drug metabolism and disposition: the biological fate of chemicals.

[315]  G. Amidon,et al.  Human Jejunal Permeability of Cyclosporin A: Influence of Surfactants on P-Glycoprotein Efflux in Caco-2 Cells , 2003, Pharmaceutical Research.

[316]  J. Watanabe,et al.  Effect of food on gastrointestinal transit of liquids in cynomolgus monkeys , 2003, Biopharmaceutics & drug disposition.

[317]  Gerd Mikus,et al.  Pharmacokinetic and pharmaceutic interaction between digoxin and Cremophor RH40 , 2003, Clinical pharmacology and therapeutics.

[318]  C Michael Stein,et al.  “Inactive” excipients such as Cremophor can affect in vivo drug disposition , 2003, Clinical pharmacology and therapeutics.

[319]  N. Houwing,et al.  Important Effect of Food on the Bioavailability of Oral Testosterone Undecanoate , 2003, Pharmacotherapy.

[320]  H. Glaeser,et al.  P‐glycoprotein‐mediated intestinal and biliary digoxin transport in humans , 2003, Clinical pharmacology and therapeutics.

[321]  H. Lennernäs,et al.  The effect of ketoconazole on the in vivo intestinal permeability of fexofenadine using a regional perfusion technique. , 2003, British journal of clinical pharmacology.

[322]  P. Augustijns,et al.  The effect of food components on the absorption of P‐gp substrates: a review , 2003, The Journal of pharmacy and pharmacology.

[323]  F. Bosman,et al.  The relation between saliva flow after different stimulations and the perception of flavor and texture attributes in custard desserts , 2003, Physiology & Behavior.

[324]  T. Shinoda,et al.  Characteristics of the gastric pH profiles of unfed and fed cynomolgus monkeys as pharmaceutical product development subjects , 2003, Biopharmaceutics & drug disposition.

[325]  Paul S Price,et al.  Modeling Interindividual Variation in Physiological Factors Used in PBPK Models of Humans , 2003, Critical reviews in toxicology.

[326]  H. Yamazaki,et al.  Catalytic activities of cytochrome P450 enzymes and UDP-glucuronosyltransferases involved in drug metabolism in rat everted sacs and intestinal microsomes , 2003, Xenobiotica; the fate of foreign compounds in biological systems.

[327]  Christopher J. H. Porter,et al.  An in vitro examination of the impact of polyethylene glycol 400, pluronic P85, and vitamin E d-a-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein efflux and enterocyte-based metabolism in excised rat intestine , 2002, AAPS PharmSci.

[328]  P. Augustijns,et al.  Apricot extract inhibits the P-gp-mediated efflux of talinolol. , 2002, Journal of pharmaceutical sciences.

[329]  J. DeSesso,et al.  Response to the Commentary of Wu et al. , 2002 .

[330]  G. Hardee,et al.  Effect of sodium caprate on the intestinal absorption of two modified antisense oligonucleotides in pigs. , 2002, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[331]  G. Amidon,et al.  Applying the biopharmaceutics classification system to veterinary pharmaceutical products. Part II. Physiological considerations. , 2002, Advanced drug delivery reviews.

[332]  A. Hoffman,et al.  Novel Gastroretentive Dosage Forms: Evaluation of Gastroretentivity and Its Effect on Riboflavin Absorption in Dogs , 2002, Pharmaceutical Research.

[333]  Gordon L. Amidon,et al.  Comparison of Human Duodenum and Caco-2 Gene Expression Profiles for 12,000 Gene Sequences Tags and Correlation with Permeability of 26 Drugs , 2002, Pharmaceutical Research.

[334]  C. Friis,et al.  Is cytochrome P450 CYP2D activity present in pig liver? , 2002, Pharmacology & toxicology.

[335]  J. Huwyler,et al.  Improved oral bioavailability of cyclosporin A in male Wistar rats. Comparison of a Solutol HS 15 containing self-dispersing formulation and a microsuspension. , 2002, International journal of pharmaceutics.

[336]  Fridrun Podczeck,et al.  Influence of Polyethylene Glycol 400 on the Gastrointestinal Absorption of Ranitidine , 2002, Pharmaceutical Research.

[337]  K. Audus,et al.  Effects of poly(ethylene glycol) on efflux transporter activity in Caco-2 cell monolayers. , 2002, Journal of pharmaceutical sciences.

[338]  Ronald T Borchardt,et al.  A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro. , 2002, Journal of pharmaceutical sciences.

[339]  James E Polli,et al.  Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers. , 2002, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[340]  Alberto Guenzi,et al.  Improvement of the Bioavailability of Colchicine in Rats by Co-administration of D-α-Tocopherol Polyethylene Glycol 1000 Succinate and a Polyethoxylated Derivative of 12-Hydroxy-Stearic Acid , 2002, Arzneimittelforschung.

[341]  F. Kadlubar,et al.  Interindividual variation and organ-specific patterns of glutathione S-transferase alpha, mu, and pi expression in gastrointestinal tract mucosa of normal individuals. , 2002, Archives of biochemistry and biophysics.

[342]  C. O’Driscoll.  Lipid-based formulations for intestinal lymphatic delivery. , 2002, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[343]  D. Burton,et al.  A nutrient drink test to assess maximum tolerated volume and postprandial symptoms: effects of gender, body mass index and age in health , 2002, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[344]  L. Chan.  Drug-nutrient interaction in clinical nutrition , 2002, Current opinion in clinical nutrition and metabolic care.

[345]  M. Eichelbaum,et al.  Tissue-specific regulation of canine intestinal and hepatic phenol and morphine UDP-glucuronosyltransferases by beta-naphthoflavone in comparison with humans. , 2002, Biochemical pharmacology.

[346]  A. Pedersen,et al.  Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion. , 2002, Oral diseases.

[347]  T. Sakata,et al.  Large particles increase viscosity and yield stress of pig cecal contents without changing basic viscoelastic properties. , 2002, The Journal of nutrition.

[348]  Y. Seta,et al.  Comparison of the mechanical destructive force in the small intestine of dog and human. , 2002, International journal of pharmaceutics.

[349]  G. Amidon,et al.  The effect of amiloride on the in vivo effective permeability of amoxicillin in human jejunum: experience from a regional perfusion technique. , 2002, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[350]  G. Edwards,et al.  A physicochemical basis for the extensive intestinal lymphatic transport of a poorly lipid soluble antimalarial, halofantrine hydrochloride, after postprandial administration to dogs. , 2002, Journal of pharmaceutical sciences.

[351]  E. Scharrer,et al.  Characteristics of Na+-dependent intestinal nucleoside transport in the pig , 2002, Journal of Comparative Physiology B.

[352]  L. Emara,et al.  Improving the Dissolution and Bioavailability of Nifedipine Using Solid Dispersions and Solubilizers , 2002, Drug development and industrial pharmacy.

[353]  Allan Geliebter,et al.  Gastric capacity in normal, obese, and bulimic women , 2001, Physiology & Behavior.

[354]  Lawrence X. Yu,et al.  Effect of common excipients on Caco-2 transport of low-permeability drugs. , 2001, Journal of pharmaceutical sciences.

[355]  P Boesiger,et al.  Pressure-geometry relationship in the antroduodenal region in humans. , 2001, American journal of physiology. Gastrointestinal and liver physiology.

[356]  Y. Seta,et al.  Evaluation of the mechanical destructive force in the stomach of dog. , 2001, International journal of pharmaceutics.

[357]  H. Junginger,et al.  Chitosan and its derivatives as intestinal absorption enhancers. , 2001, Advanced drug delivery reviews.

[358]  G. Edwards,et al.  A conscious dog model for assessing the absorption, enterocyte-based metabolism, and intestinal lymphatic transport of halofantrine. , 2001, Journal of pharmaceutical sciences.

[359]  M. Fromm,et al.  Determination of in vivo absorption, metabolism, and transport of drugs by the human intestinal wall and liver with a novel perfusion technique , 2001, Clinical pharmacology and therapeutics.

[360]  C. Porter,et al.  Intestinal lymphatic drug transport: an update. , 2001, Advanced drug delivery reviews.

[361]  G. Edwards,et al.  Animal models for the study of intestinal lymphatic drug transport. , 2001, Advanced drug delivery reviews.

[362]  J. Newton,et al.  The Effect of Polyethylene Glycol 400 on Gastrointestinal Transit: Implications for the Formulation of Poorly-Water Soluble Drugs , 2001, Pharmaceutical Research.

[363]  Y. Moriwaki,et al.  Widespread cellular distribution of aldehyde oxidase in human tissues found by immunohistochemistry staining. , 2001, Histology and histopathology.

[364]  G. Amidon,et al.  Human Jejunal Permeability of Two Polar Drugs: Cimetidine and Ranitidine , 2001, Pharmaceutical Research.

[365]  H. Junginger,et al.  Intestinal Absorption of Octreotide Using Trimethyl Chitosan Chloride: Studies in Pigs , 2001, Pharmaceutical Research.

[366]  D. Farrell,et al.  Identification of multiple constitutive and inducible hepatic cytochrome P450 enzymes in market weight swine. , 2001, Drug metabolism and disposition: the biological fate of chemicals.

[367]  L. Marciani,et al.  Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI. , 2001, American journal of physiology. Gastrointestinal and liver physiology.

[368]  A. Li,et al.  Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog. , 2001, Chemico-biological interactions.

[369]  T. Baba,et al.  Induction of intestinal cytochrome P450 (CYP3A) by rifampicin in beagle dogs. , 2001, Chemico-biological interactions.

[370]  L. Marciani,et al.  Assessment of antral grinding of a model solid meal with echo-planar imaging. , 2001, American journal of physiology. Gastrointestinal and liver physiology.

[371]  M. Vaughn,et al.  Pharmacokinetics of celecoxib after oral administration in dogs and humans: effect of food and site of absorption. , 2001, The Journal of pharmacology and experimental therapeutics.

[372]  J. DeSesso,et al.  Anatomical and physiological parameters affecting gastrointestinal absorption in humans and rats. , 2001, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[373]  I. Wilding,et al.  Oral drug absorption studies: the best model for man is man! , 2001, Drug discovery today.

[374]  Samuel H. Yalkowsky,et al.  Prediction of Drug Solubility by the General Solubility Equation (GSE) , 2001, J. Chem. Inf. Comput. Sci..

[375]  D. Schrenk,et al.  Sequencing and tissue distribution of the canine MRP2 gene compared with MRP1 and MDR1. , 2001, Toxicology.

[376]  S. S. Davis,et al.  Gastrointestinal transit of dosage forms in the pig , 2001, The Journal of pharmacy and pharmacology.

[377]  Y. Seta,et al.  A unique dosage form to evaluate the mechanical destructive force in the gastrointestinal tract. , 2000, International journal of pharmaceutics.

[378]  C. Friis,et al.  Expression changes of CYP2A and CYP3A in microsomes from pig liver and cultured hepatocytes. , 2000, Pharmacology & toxicology.

[379]  S. Bhatia,et al.  Xenobiotic metabolism by cultured primary porcine hepatocytes. , 2000, Tissue engineering.

[380]  M. Grøndahl,et al.  Transport of neutral, cationic and anionic amino acids by systems B, b(o,+), X(AG), and ASC in swine small intestine. , 2000, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

[381]  M. Kool,et al.  Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-, MRP1- and MRP2-mediated transport , 2000, British Journal of Cancer.

[382]  K. Yuen,et al.  Gamma-scintigraphic study of the gastrointestinal transit and in vivo dissolution of a controlled release diclofenac sodium formulation in xanthan gum matrices. , 2000, International journal of pharmaceutics.

[383]  O. Pelkonen,et al.  CYP2A6: a human coumarin 7-hydroxylase. , 2000, Toxicology.

[384]  Bruno C. Hancock,et al.  What is the True Solubility Advantage for Amorphous Pharmaceuticals? , 2000, Pharmaceutical Research.

[385]  S. Higuchi,et al.  Gastric pH profiles of beagle dogs and their use as an alternative to human testing. , 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[386]  Hyunyoung Jeong,et al.  Evaluation of Using Dog as an Animal Model to Study the Fraction of Oral Dose Absorbed of 43 Drugs in Humans , 2000, Pharmaceutical Research.

[387]  S. Kawashima,et al.  Modification of ceftibuten transport by the addition of non-ionic surfactants. , 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[388]  E. Näslund.  Gastric Emptying: Comparison of Scintigraphic, Polyethylene Glycol Dilution, and Paracetamol Tracer Assessment Techniques , 2000, Scandinavian journal of gastroenterology.

[389]  R. Weaver,et al.  Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man , 2000, Xenobiotica; the fate of foreign compounds in biological systems.

[390]  T. Hansen,et al.  Primary porcine enterocyte and hepatocyte cultures to study drug oxidation reactions , 2000, British journal of pharmacology.

[391]  C. Friis,et al.  Cytochrome P450 sex differences in minipigs and conventional pigs. , 1999, Pharmacology & toxicology.

[392]  L. Corcos,et al.  Detoxifying activity in pig livers and hepatocytes intended for xenotherapy. , 1999, Transplantation.

[393]  Engelen Jgm van,et al.  Anatomical and physiological differences betweenvarious species used in studies on the pharmacokinetics and toxicology of xenobiotics. A review ofliterature , 1999 .

[394]  J. Silverman,et al.  Inhibition of P-Glycoprotein by D-α-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS) , 1999, Pharmaceutical Research.

[395]  C. Winckler,et al.  Characteristics of dipeptide transport in pig jejunum in vitro , 1999, Journal of Comparative Physiology B.

[396]  A. Kabanov,et al.  Fundamental Relationships Between the Composition of Pluronic Block Copolymers and Their Hypersensitization Effect in MDR Cancer Cells , 1999, Pharmaceutical Research.

[397]  Alexander V. Kabanov,et al.  Pluronic P85 Increases Permeability of a Broad Spectrum of Drugs in Polarized BBMEC and Caco-2 Cell Monolayers , 1999, Pharmaceutical Research.

[398]  N. Horiuchi,et al.  Regulation of Small Intestinal Transit by Central Nervous Calcitonin Receptor , 1999, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[399]  Brahma N. Singh.  Effects of Food on Clinical Pharmacokinetics , 1999, Clinical pharmacokinetics.

[400]  H. Lennernäs,et al.  The effect of ketoconazole on the jejunal permeability and CYP3A metabolism of (R/S)-verapamil in humans. , 1999, British journal of clinical pharmacology.

[401]  D. Dunbar,et al.  Characterization of human small intestinal cytochromes P-450. , 1999, Drug Metabolism And Disposition.

[402]  D M Barends,et al.  In vitro/in vivo correlations of dissolution data of carbamazepine immediate release tablets with pharmacokinetic data obtained in healthy volunteers. , 1999, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[403]  H. Kubo,et al.  Evaluation of colonic absorbability of drugs in dogs using a novel colon-targeted delivery capsule (CTDC). , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[404]  D. Fleisher,et al.  Meal Composition Effects on the Oral Bioavailability of Indinavir in HIV-Infected Patients , 1999, Pharmaceutical Research.

[405]  Newman,et al.  Imaging techniques for assessing drug delivery in man. , 1999, Pharmaceutical science & technology today.

[406]  H Lennernäs,et al.  Jejunal permeability in humans in vivo and rats in situ: investigation of molecular size selectivity and solvent drag. , 1999, Acta physiologica Scandinavica.

[407]  D. Fleisher,et al.  Drug, Meal and Formulation Interactions Influencing Drug Absorption After Oral Administration , 1999, Clinical pharmacokinetics.

[408]  Alan F. Parr,et al.  Evaluation of the Feasibility and Use of a Prototype Remote Drug Delivery Capsule (RDDC) for Non-Invasive Regional Drug Absorption Studies in the GI Tract of Man and Beagle Dog , 1999, Pharmaceutical Research.

[409]  P. Bampton,et al.  Basal pressure patterns and reflexive motor responses in the human ileocolonic junction. , 1999, American journal of physiology. Gastrointestinal and liver physiology.

[410]  Gowland,et al.  Fat delays emptying but increases forward and backward antral flow as assessed by flow‐sensitive magnetic resonance imaging , 1999, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[411]  R. Witkamp,et al.  Characterization of cytochrome P450 isoenzymes in primary cultures of pig hepatocytes. , 1998, Toxicology in vitro : an international journal published in association with BIBRA.

[412]  H Lennernäs,et al.  Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach. , 1998, Journal of medicinal chemistry.

[413]  A. Barve,et al.  Linear Correlation of the Fraction of Oral Dose Absorbed of 64 Drugs Between Humans and Rats , 1998, Pharmaceutical Research.

[414]  K. Järvinen,et al.  Co-Administration of a Water-Soluble Polymer Increases the Usefulness of Cyclodextrins in Solid Oral Dosage Forms , 1998, Pharmaceutical Research.

[415]  B. G. Campbell,et al.  Effect of food on absorption of cefadroxil and cephalexin in dogs. , 1998, Journal of veterinary pharmacology and therapeutics.

[416]  J. Groten,et al.  Absorption enhancement, structural changes in tight junctions and cytotoxicity caused by palmitoyl carnitine in Caco-2 and IEC-18 cells. , 1998, The Journal of pharmacology and experimental therapeutics.

[417]  Hans Lennernäs,et al.  Jejunal Absorption and Metabolism of R/S-Verapamil in Humans , 1998, Pharmaceutical Research.

[418]  G. Edwards,et al.  Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine , 1998 .

[419]  R. Havenaar,et al.  A review of the physiology of the canine digestive tract related to the development of in vitro systems , 1998, Nutrition Research Reviews.

[420]  J. Mcrorie,et al.  Characterization of Propagating Contractions in Proximal Colon of Ambulatory Mini Pigs , 1998, Digestive Diseases and Sciences.

[421]  M Rowland,et al.  Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides. , 1998, Journal of pharmaceutical sciences.

[422]  P. Boesiger,et al.  Relative contributions of "pressure pump" and "peristaltic pump" to gastric emptying. , 1998, American journal of physiology. Gastrointestinal and liver physiology.

[423]  U. Fuhr.  Drug Interactions with Grapefruit Juice , 1998, Drug safety.

[424]  J. Dressman,et al.  Effect of elevated viscosity in the upper gastrointestinal tract on drug absorption in dogs. , 1998, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[425]  H Lennernäs,et al.  Human intestinal permeability. , 1998, Journal of pharmaceutical sciences.

[426]  A. Karim,et al.  Mechanism of Compound- and Species-Specific Food Effects of Structurally Related Antiarrhythmic Drugs, Disopyramide and Bidisomide , 1998, Pharmaceutical Research.

[427]  R. Wanke,et al.  Intestinal dimensions of mice divergently selected for body weight , 1998, The Anatomical record.

[428]  H Lennernäs,et al.  Membrane transport of drugs in different regions of the intestinal tract of the rat. , 1998, Journal of pharmaceutical sciences.

[429]  Carol F. Kirchhoff,et al.  Reduced Systemic Availability of an Antiarrhythmic Drug, Bidisomide, with Meal Co-administration: Relationship with Region-Dependent Intestinal Absorption , 1998, Pharmaceutical Research.

[430]  R. A. Lipper,et al.  In Vivo Evaluation of the Absorption and Gastrointestinal Transit of Avitriptan in Fed and Fasted Subjects Using Gamma Scintigraphy , 1998, Journal of Pharmacokinetics and Biopharmaceutics.

[431]  H. Junginger,et al.  Chitosans for enhanced delivery of therapeutic peptides across intestinal epithelia: in vitro evaluation in Caco-2 cell monolayers , 1997 .

[432]  D. Shen,et al.  Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism. , 1997, The Journal of pharmacology and experimental therapeutics.

[433]  J. Halpert,et al.  Isolation, heterologous expression and functional characterization of a novel cytochrome P450 3A enzyme from a canine liver cDNA library. , 1997, The Journal of pharmacology and experimental therapeutics.

[434]  P. Watkins,et al.  Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins. , 1997, Drug metabolism and disposition: the biological fate of chemicals.

[435]  D. R. L. Snipes.  Intestinal Absorptive Surface in Mammals of Different Sizes , 1997, Advances in Anatomy Embryology and Cell Biology.

[436]  G. Amidon,et al.  Human Intestinal Permeability of Piroxicam, Propranolol, Phenylalanine, and PEG 400 Determined by Jejunal Perfusion , 1997, Pharmaceutical Research.

[437]  P. Artursson,et al.  Mechanism of Absorption Enhancement in Humans After Rectal Administration of Ampicillin in Suppositories Containing Sodium Caprate , 1997, Pharmaceutical Research.

[438]  H. Lennernäs,et al.  Regional Intestinal Permeability in Rats of Compounds with Different Physicochemical Properties and Transport Mechanisms , 1997, The Journal of pharmacy and pharmacology.

[439]  A. Peregrina,et al.  The influence of coffee with milk and tea with milk on the bioavailability of tetracycline. , 1997, Biopharmaceutics & drug disposition.

[440]  H Lennernäs,et al.  Human Jejunal Effective Permeability and Its Correlation with Preclinical Drug Absorption Models , 1997, The Journal of pharmacy and pharmacology.

[441]  M. Rowland,et al.  Influence of Morphometric Factors on Quantitation of Paracellular Permeability of Intestinal Epithelia In Vitro , 1997, Pharmaceutical Research.

[442]  S. Nylander,et al.  Jejunal Permeability: A Comparison Between the Ussing Chamber Technique and the Single-Pass Perfusion in Humans , 1997, Pharmaceutical Research.

[443]  W. Craig,et al.  Sorbitol is a possible risk factor for diarrhea in young children. , 1997, Journal of the American Dietetic Association.

[444]  G. Olaison,et al.  Absorption Profiles for Polyethylene Glycols After Regional Jejunal Perfusion and Oral Load in Healthy Humans , 1997, Digestive Diseases and Sciences.

[445]  J. Dressman,et al.  Physiochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH. , 1997, Journal of pharmaceutical sciences.

[446]  Hans E. Junginger,et al.  Mucoadhesive Polymers in Peroral Peptide Drug Delivery. VI. Carbomer and Chitosan Improve the Intestinal Absorption of the Peptide Drug Buserelin In Vivo , 1996, Pharmaceutical Research.

[447]  H Lennernäs,et al.  Jejunal permeability and hepatic extraction of fluvastatin in humans , 1996, Clinical pharmacology and therapeutics.

[448]  S K Balani,et al.  Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor. , 1996, Drug metabolism and disposition: the biological fate of chemicals.

[449]  M. Horowitz,et al.  Effects of increasing solid component size of a mixed solid/liquid meal on solid and liquid gastric emptying. , 1996, The American journal of physiology.

[450]  Hans Lennernäs,et al.  Comparison Between Permeability Coefficients in Rat and Human Jejunum , 1996, Pharmaceutical Research.

[451]  M. Alpsten,et al.  Gastro-intestinal transit of a multiple-unit formulation (metoprolol CR/ZOK) and a non-disintegrating tablet with the emphasis on colon , 1996 .

[452]  C. Porter,et al.  A physicochemical basis for the effect of food on the absolute oral bioavailability of halofantrine. , 1996, Journal of pharmaceutical sciences.

[453]  P. Langguth,et al.  Evidence for Intestinal Secretion as an Additional Clearance Pathway of Talinolol Enantiomers: Concentration- and Dose-dependent Absorption in Vitro and in Vivo , 1996, Pharmaceutical Research.

[454]  N. Maekawa,et al.  A Comparison of Lansoprazole, Omeprazole, and Ranitidine for Reducing Preoperative Gastric Secretion in Adult Patients Undergoing Elective Surgery , 1996, Anesthesia and analgesia.

[455]  C. Porter,et al.  Lymphatic transport of halofantrine in the triple-cannulated anesthetized rat model: effect of lipid vehicle dispersion. , 1996, Journal of pharmaceutical sciences.

[456]  U. Christians,et al.  Drug interactions and interindividual variability of ciclosporin metabolism in the small intestine. , 1996, Pharmacology.

[457]  U. Christians,et al.  Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability. , 1995, Drug metabolism and disposition: the biological fate of chemicals.

[458]  I. Wilding,et al.  The effect of mannitol on the oral bioavailability of cimetidine. , 1995, Journal of pharmaceutical sciences.

[459]  Hans Lennernäs,et al.  Does Fluid Flow Across the Intestinal Mucosa Affect Quantitative Oral Drug Absorption? Is It Time for a Reevaluation? , 1995, Pharmaceutical Research.

[460]  Hans Lennernäs,et al.  EXPERIMENTAL ESTIMATION OF THE EFFECTIVE UNSTIRRED WATER LAYER THICKNESS IN THE HUMAN JEJUNUM, AND ITS IMPORTANCE IN ORAL-DRUG ABSORPTION , 1995 .

[461]  M. Grøndahl,et al.  beta-Amino acid transport in pig small intestine in vitro by a high-affinity, chloride-dependent carrier. , 1995, Biochimica et biophysica acta.

[462]  M. Jimenez,et al.  Intraluminal lipids modulate avian gastrointestinal motility. , 1995, The American journal of physiology.

[463]  T. Kararli.  Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals , 1995, Biopharmaceutics & drug disposition.

[464]  M. Akimoto,et al.  Evaluation of gastrointestinal transit controlled-beagle dog as a suitable animal model for bioavailability testing of sustained-release acetaminophen dosage form , 1995 .

[465]  V. Casabó,et al.  Experimental studies on the influence of surfactants on intestinal absorption of drugs. Cefadroxil as model drug and sodium lauryl sulfate as model surfactant: studies in rat duodenum. , 1995, Arzneimittel-Forschung.

[466]  M. Akimoto,et al.  Release and absorption characteristics of chlorphenesin carbamate sustained-release formulations: In vitro-in vivo and in vivo dog-human correlations , 1995 .

[467]  I. Wilding,et al.  The effect of food on the gastrointestinal transit and systemic absorption of naproxen from a novel sustained release formulation , 1995 .

[468]  I. Wilding,et al.  The effects of pharmaceutical excipients on small intestinal transit. , 1995, British journal of clinical pharmacology.

[469]  H. Lennernäs,et al.  Regional Jejunal Perfusion, a New in Vivo Approach to Study Oral Drug Absorption in Man , 1995, Pharmaceutical Research.

[470]  Valentino J. Stella,et al.  β‐Cyclodextrin Derivatives, SBE4‐β‐CD and HP–β‐CD, Increase the Oral Bioavailability of Cinnarizine in Beagle Dogs , 1995 .

[471]  Nobuo Aoyagi,et al.  Estimation of Agitation Intensity in the GI Tract in Humans and Dogs Based on in Vitro/in Vivo Correlation , 1995, Pharmaceutical Research.

[472]  G. Amidon,et al.  Variable gastric emptying and discontinuities in drug absorption profiles: Dependence of rates and extent of cimetidine absorption on motility phase and pH , 1994, Biopharmaceutics & drug disposition.

[473]  T. Gramatté.  Griseofulvin absorption from different sites in the human small intestine , 1994, Biopharmaceutics & drug disposition.

[474]  H. Lennernäs,et al.  The Influence of Net Water Absorption on the Permeability of Antipyrine and Levodopa in the Human Jejunum , 1994, Pharmaceutical Research.

[475]  J. Remon,et al.  In Vitro and in Vivo Evaluation in Dogs and Pigs of a Hydrophilic Matrix Containing Propylthiouracil , 1994, Pharmaceutical Research.

[476]  L. Maerz,et al.  Effect of caloric content and composition of a liquid meal on gastric emptying in the rat. , 1994, American Journal of Physiology.

[477]  J. Dressman,et al.  Absorption of ACE inhibitors from small intestine and colon. , 1994, Journal of pharmaceutical sciences.

[478]  W. Curatolo,et al.  Intestinal Permeability Enhancement: Efficacy, Acute Local Toxicity, and Reversibility , 1994, Pharmaceutical Research.

[479]  H. Yamazaki,et al.  Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. , 1994, The Journal of pharmacology and experimental therapeutics.

[480]  J. Elashoff,et al.  Control of canine gastric emptying of fat by lipolytic products. , 1994, The American journal of physiology.

[481]  H. Lennernäs,et al.  Intestinal drug absorption during induced net water absorption in man; a mechanistic study using antipyrine, atenolol and enalaprilat. , 1994, British journal of clinical pharmacology.

[482]  S. Sarna,et al.  Contractile mechanisms of gallbladder filling and emptying in dogs. , 1994, Gastroenterology.

[483]  M. Tomita,et al.  Comparison of absorption-enhancing effect between sodium caprate and disodium ethylenediaminetetraacetate in Caco-2 cells. , 1994, Biological & pharmaceutical bulletin.

[484]  J. R. Sportsman,et al.  Association of intestinal peptide transport with a protein related to the cadherin superfamily. , 1994, Science.

[485]  T. Ma,et al.  Mechanisms and sites of mannitol permeability of small and large intestine in the rat , 1994, Digestive Diseases and Sciences.

[486]  R. Oberle,et al.  Variability in Gastric pH and Delayed Gastric Emptying in Yucatan Miniature Pigs , 1994, Pharmaceutical Research.

[487]  M. Karpeisky,et al.  Formation and properties of S‐protein complex with S‐peptide‐containing fusion protein , 1994, FEBS letters.

[488]  D. Cederberg,et al.  Pharmacokinetics of the acyclovir pro‐drug valaciclovir after escalating single‐and multiple‐dose administration to normal volunteers , 1993, Clinical pharmacology and therapeutics.

[489]  E. LeCluyse,et al.  Enhanced Bioavailability of Cefoxitin Using Palmitoylcarnitine. II. Use of Directly Compressed Tablet Formulations in the Rat and Dog , 1993, Pharmaceutical Research.

[490]  J. Elashoff,et al.  Nutrient feedback inhibition of gastric emptying plays a larger role than osmotically dependent duodenal resistance. , 1993, The American journal of physiology.

[491]  K. D. Fine,et al.  Effect of D-glucose on intestinal permeability and its passive absorption in human small intestine in vivo. , 1993, Gastroenterology.

[492]  K. Soergel.  Showdown at the tight junction. , 1993, Gastroenterology.

[493]  J. Newton,et al.  Gastrointestinal transit and absorption of theophylline from a multiparticulate controlled release formulation , 1993 .

[494]  Tim Morris,et al.  Physiological Parameters in Laboratory Animals and Humans , 1993, Pharmaceutical Research.

[495]  R. Cargill,et al.  Controlled Gastric Emptying. III. Gastric Residence Time of a Nondisintegrating Geometric Shape in Human Volunteers , 1993, Pharmaceutical Research.

[496]  A. Parr,et al.  Effect of Sodium Acid Pyrophosphate on Ranitidine Bioavailability and Gastrointestinal Transit Time , 1993, Pharmaceutical Research.

[497]  P. Bass,et al.  Nutrient-induced changes in the permeability of the rat jejunal mucosa. , 1993, Journal of pharmaceutical sciences.

[498]  R. Hatz,et al.  Intestinal adaptation during lactation in the mouse. II. Altered intestinal processing of a dietary protein. , 1993, The American journal of physiology.

[499]  M. Rogge,et al.  Effect of Food and a Monoglyceride Emulsion Formulation on Danazol Bioavailability , 1993, Journal of clinical pharmacology.

[500]  H. Lennernäs,et al.  The effect of L-leucine on the absorption of levodopa, studied by regional jejunal perfusion in man. , 1993, British journal of clinical pharmacology.

[501]  N. Kaniwa,et al.  Gastric emptying of tablets and granules in humans, dogs, pigs, and stomach-emptying-controlled rabbits. , 1992, Journal of pharmaceutical sciences.

[502]  J. Patience,et al.  L-threonine transport in pig jejunal brush border membrane vesicles. Functional characterization of the unique system B in the intestinal epithelium. , 1992, The Journal of biological chemistry.

[503]  Takahiro Ogawa,et al.  Differences in the Enhancing Effects of Sodium Caprate on Colonic and Jejimal Drug Absorption , 1992, Pharmaceutical Research.

[504]  J. Elashoff,et al.  Gastric emptying of solid food is most potently inhibited by carbohydrate in the canine distal ileum. , 1992, Gastroenterology.

[505]  P. Neuvonen,et al.  Interference of dairy products with the absorption of ciprofloxacin , 1991, Clinical pharmacology and therapeutics.

[506]  P. Tso,et al.  Jejunal mucosal injury and restitution: role of hydrolytic products of food digestion. , 1991, The American journal of physiology.

[507]  M. Marvola,et al.  Bioavailability of Erythromycin Acistrate from Hard Gelatin Capsules Containing Sodium Bicarbonate , 1991, Pharmaceutical Research.

[508]  I. Wilding,et al.  The role of γ-scintigraphy in oral drug delivery , 1991 .

[509]  J. Meyer,et al.  Effect of hydroxypropylmethylcellulose on gastrointestinal transit and luminal viscosity in dogs. , 1991, Gastroenterology.

[510]  D. Crommelin,et al.  Intestinal Absorption of Drugs. The Influence of Mixed Micelles on on the Disappearance Kinetics of Drugs from the Small Intestine of the Rat , 1991, The Journal of pharmacy and pharmacology.

[511]  D. G. White,et al.  An experimental animal model for studying the effects of a novel lymphatic drug delivery system for propranolol , 1991 .

[512]  B. Abrahamsson,et al.  Influence of dissolution rate on the extent and rate of bioavailability of metoprolol , 1991 .

[513]  M. Hossain,et al.  Gastrointestinal Transit of Nondisintegrating, Nonerodible Oral Dosage Forms in Pigs , 1990, Pharmaceutical Research.

[514]  G L Amidon,et al.  The influence of the interdigestive migrating myoelectric complex on the gastric emptying of liquids. , 1990, Gastroenterology.

[515]  D. Levitt,et al.  Physiological measurements of luminal stirring in the dog and human small bowel. , 1990, The Journal of clinical investigation.

[516]  R. Khosla,et al.  The effect of tablet size on the gastric emptying of non-disintegrating tablets , 1990 .

[517]  J. Dressman,et al.  Upper Gastrointestinal (GI) pH in Young, Healthy Men and Women , 1990, Pharmaceutical Research.

[518]  M. Rongier,et al.  Intestinal Absorption of Amiodarone in Man , 1990, Journal of clinical pharmacology.

[519]  K. Kowalski,et al.  Suitability of the dog as an animal model for evaluating theophylline absorption and food effects from different formulations , 1990 .

[520]  P. Beaune,et al.  Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues. , 1990, The Journal of pharmacology and experimental therapeutics.

[521]  L. C. Feely,et al.  Gastrointestinal transit of non-disintegrating tablets in fed subjects , 1989 .

[522]  T. Bamba,et al.  Effects of pectin on fatty acid and glucose absorption and on thickness of unstirred water layer in rat and human intestine , 1989, Digestive Diseases and Sciences.

[523]  P. Watkins,et al.  Identification of a polymorphically expressed member of the human cytochrome P-450III family. , 1989, Molecular pharmacology.

[524]  A. Breckenridge,et al.  Pharmacokinetics of halofantrine in man: effects of food and dose size. , 1989, British journal of clinical pharmacology.

[525]  D. Staniforth.  Comparison of orocaecal transit times assessed by the lactulose/breath hydrogen and the sulphasalazine/sulphapyridine methods. , 1989, Gut.

[526]  S. Salminen,et al.  Xylitol vs glucose: effect on the rate of gastric emptying and motilin, insulin, and gastric inhibitory polypeptide release. , 1989, The American journal of clinical nutrition.

[527]  J. Misiewicz,et al.  Increased segmental activity and intraluminal pressures in the sigmoid colon of patients with the irritable bowel syndrome. , 1989, Gut.

[528]  J. Reynolds,et al.  Caloric content of a meal affects duration but not contractile pattern of duodenal motility in man , 1989, Digestive Diseases and Sciences.

[529]  K. Ling,et al.  Polyethylene glycol 900 permeability of rat intestinal and colonic segments in vivo and brush border membrane vesicles in vitro. , 1989, The Journal of laboratory and clinical medicine.

[530]  A. Geliebter.  Gastric distension and gastric capacity in relation to food intake in humans , 1988, Physiology & Behavior.

[531]  N. Kaniwa,et al.  Gastric emptying rates of drug preparations. II. Effects of size and density of enteric-coated drug preparations and food on gastric emptying rates in humans. , 1988, Journal of pharmacobio-dynamics.

[532]  N. Kaniwa,et al.  Gastric emptying rates of drug preparations. I. Effects of size of dosage forms, food and species on gastric emptying rates. , 1988, Journal of pharmacobio-dynamics.

[533]  J. Robinson,et al.  Gastric emptying of liquids in the fasted dog , 1988 .

[534]  B. Krevsky,et al.  Biphasic nature of gastric emptying. , 1988, Gut.

[535]  C. Beattie,et al.  Inheritance of Sinclair swine cutaneous malignant melanoma. , 1987, Cancer research.

[536]  M. Gouda,et al.  Effect of dosage form, food, and an anticholinergic drug on the bioavailability of sulphide , 1987 .

[537]  J. Robinson,et al.  Gastric emptying of nondigestible solids in the fasted dog. , 1987, Journal of pharmaceutical sciences.

[538]  V. Stella,et al.  Testing potential dosage form strategies for intestinal lymphatic drug transport: studies in the rat , 1986 .

[539]  S. Davis,et al.  Transit of pharmaceutical dosage forms through the small intestine. , 1986, Gut.

[540]  T Kurihara-Bergstrom,et al.  Characterization of the Yucatan miniature pig skin and small intestine for pharmaceutical applications. , 1986, Laboratory animal science.

[541]  J. Dressman,et al.  Comparison of Canine and Human Gastrointestinal Physiology , 1986, Pharmaceutical Research.

[542]  M. Schemann,et al.  Postprandial patterns of canine jejunal motility and transit of luminal content. , 1986, Gastroenterology.

[543]  G. Amidon,et al.  Comparison of gastrointestinal pH in dogs and humans: implications on the use of the beagle dog as a model for oral absorption in humans. , 1986, Journal of pharmaceutical sciences.

[544]  S. Sarna.  Cyclic motor activity; migrating motor complex: 1985. , 1985, Gastroenterology.

[545]  G. Amidon,et al.  Effect of size and density on canine gastric emptying of nondigestible solids. , 1985, Gastroenterology.

[546]  J. Robinson,et al.  Bioadhesive polymers as platforms for oral controlled drug delivery III: oral delivery of chlorothiazide using a bioadhesive polymer. , 1985, Journal of pharmaceutical sciences.

[547]  S. Kitazawa,et al.  Segmental difference and effect of glucose on drug exsorption across the small intestine of rats. , 1985, Journal of pharmaceutical sciences.

[548]  S. Keipert,et al.  [Comparative studies on the study of drug-excipient interactions with vapor pressure osmometry and equilibrium dialysis]. , 1984, Die Pharmazie.

[549]  M. Schemann,et al.  Mechanical factors regulating gastric emptying of viscous nutrient meals in dogs. , 1984, Quarterly journal of experimental physiology.

[550]  C. Juste,et al.  Response of bile flow, biliary lipids and bile acid pool in the pig to quantitative variations in dietary fat. , 1983, The Journal of nutrition.

[551]  P. McHugh,et al.  Regulation of the gastric emptying of glucose. , 1983, Gastroenterology.

[552]  W. Arossa,et al.  Diagnostic value of serum bile acids and routine liver function tests in hepatobiliary diseases , 1983, Digestive Diseases and Sciences.

[553]  E. Wright,et al.  Multiple transport pathways for neutral amino acids in rabbit jejunal brush border vesicles , 1982, The Journal of Membrane Biology.

[554]  S. Frost,et al.  Studies on fat digestion, absorption, and transport in the suckling rat. III. Composition of bile and evidence for enterohepatic circulation of bile salts. , 1982, Journal of lipid research.

[555]  N. Read,et al.  Is the transit time of a meal through the small intestine related to the rate at which it leaves the stomach? , 1982, Gut.

[556]  H. Ehrlein,et al.  Effect of viscosity of test meals on gastric emptying in dogs. , 1982, Quarterly journal of experimental physiology.

[557]  A. Zinsmeister,et al.  Relationship of motility to flow of contents in the human small intestine. , 1982, Gastroenterology.

[558]  M. Chusid,et al.  Diarrhea induced by sorbitol. , 1981, Jornal de Pediatria.

[559]  James H. Meyer,et al.  Size of liver particles emptied from the human stomach , 1981 .

[560]  J G Hardy,et al.  Radionuclide imaging in pharmaceutical, physiological and pharmacological research. , 1981, Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics.

[561]  I. Takahashi,et al.  Periodic contractions of the canine gallbladder during the interdigestive state. , 1981, The American journal of physiology.

[562]  B. Carter,et al.  Effect of calcium and antacids on phenytoin bioavailability. , 1980, Archives of Neurology.

[563]  H. Frey,et al.  Bioavailability of oral testosterone in males , 1979, European Journal of Clinical Pharmacology.

[564]  D C Hohnadel,et al.  Effect of calcium and antacids on phenytoin bioavailability. , 1979, Archives of neurology.

[565]  M. Cohen,et al.  Sieving of solid food by the canine stomach and sieving after gastric surgery. , 1979, Gastroenterology.

[566]  T Nagai,et al.  Bioavailability of powdered inclusion compounds of nonsteroidal antiinflammatory drugs with beta-cyclodextrin in rabbits and dogs. , 1978, Chemical & pharmaceutical bulletin.

[567]  Zak Af,et al.  Bioavailability of tetracycline hydrochloride capsules (an in vivo study) , 1978 .

[568]  S. Kitazawa,et al.  Generality in effects of transmucosal fluid movement and glucose on drug absorption from the rat small intestine. , 1978, Chemical & pharmaceutical bulletin.

[569]  R. Hinder,et al.  Canine gastric emptying of solids and liquids. , 1977, The American journal of physiology.

[570]  P. Welling,et al.  Influence of food and diet on gastrointestinal drug absorption: A review , 1977, Journal of Pharmacokinetics and Biopharmaceutics.

[571]  A. Hofmann,et al.  Measurements of intestinal permeability using low molecular weight polyethylene glycols (PEG 400). I. Chemical analysis and biological properties of PEG 400. , 1977, Gastroenterology.

[572]  A. Hofmann,et al.  Measurements of intestinal permeability using low molecular weight polyethylene glycols (PEG 400). II. Application to normal and abnormal permeability states in man and animals. , 1977, Gastroenterology.

[573]  J Hellemans,et al.  The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. , 1977, The Journal of clinical investigation.

[574]  J. Barrowman,et al.  Intestinal lymph flow and lymphatic transport of protein during fat absorption. , 1977, Quarterly journal of experimental physiology and cognate medical sciences.

[575]  Rosemary J. Fulford,et al.  Studies on digestion and absorption in the intestines of growing pigs. Measurements of the flow of digesta and pH , 1976, British Journal of Nutrition.

[576]  L. Buéno,et al.  The effect of feeding on the motility of the stomach and small intestine in the pig , 1976, British Journal of Nutrition.

[577]  J. Lach,et al.  Drug diffusion and bioavailability: tetracycline metallic chelation. , 1975, American journal of hospital pharmacy.

[578]  R. Modigliani,et al.  The method of intraluminal perfusion of the human small intestine. II. Absorption studies in health. , 1973, Digestion.

[579]  R. Modigliani,et al.  The method of intraluminal perfusion of the human small intestine. 3. Absorption studies in disease. , 1973, Digestion.

[580]  F. Bochner,et al.  Factors involved in an outbreak of phenytoin intoxication. , 1972, Journal of the neurological sciences.

[581]  M. Nakano.  Effects of interaction with surfactants, adsorbents, and other substances on the permeation of chlorpromazine through a dimethyl polysiloxane membrane. , 1971, Journal of pharmaceutical sciences.

[582]  J. Szurszewski.  A migrating electric complex of canine small intestine. , 1969, The American journal of physiology.

[583]  F. Nakayama.  Composition of gallstone and bile: species difference. , 1969, The Journal of laboratory and clinical medicine.

[584]  I. Beck,et al.  Gastric emptying rate of the water and fat phases of a mixed test meal in man. , 1968, Gut.

[585]  J. Wilson,et al.  Surface area of the small intestine in man. , 1967, Gut.

[586]  W. Russell,et al.  The Principles of Humane Experimental Technique , 1960 .

[587]  Anna Tostevin,et al.  An observational multi-cohort study on the use and safety of Combivir scored tablets among HIV-infected children and adolescents. Report to the European Medicines Agency (EMA)/ Committee for Medicinal Products for Human Use (CHMP) , 2014 .

[588]  Y. Lai,et al.  Membrane Protein Quantification by Peptide-Based Mass Spectrometry Approaches: Studies on the Organic Anion-Transporting Polypeptide Family , 2013 .

[589]  A Rostami-Hodjegan,et al.  Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanistic in vitro-in vivo extrapolation of oral drug absorption. , 2013, Biopharmaceutics & drug disposition.

[590]  M. Fromm,et al.  Sodium caprate as an enhancer of macromolecule permeation across tricellular tight junctions of intestinal cells. , 2013, Biomaterials.

[591]  G. Murtaza,et al.  Pharmacokinetic study of hydroxypropylmethylcellulose microparticles loaded with cimetidine. , 2013, Advances in Clinical and Experimental Medicine.

[592]  G. Cheng,et al.  Effect of the timing of food intake on the absorption and bioavailability of carbamazepine immediate-release tablets in beagle dogs. , 2012, Biopharmaceutics & drug disposition.

[593]  K. Dalhoff,et al.  Food-Drug Interactions , 2012, Drugs.

[594]  N. Parrott,et al.  A Physiologically Based Pharmacokinetic Model of the Minipig: Data Compilation and Model Implementation , 2012, Pharmaceutical Research.

[595]  Sheng Qi,et al.  Physicochemical properties of the amorphous drug, cast films, and spray dried powders to predict formulation probability of success for solid dispersions: etravirine. , 2011, Journal of pharmaceutical sciences.

[596]  S. Yamashita,et al.  Investigation of the intestinal permeability and first-pass metabolism of drugs in cynomolgus monkeys using single-pass intestinal perfusion. , 2010, Biological & pharmaceutical bulletin.

[597]  Alain Bousquet-Mélou,et al.  Species differences in pharmacokinetics and pharmacodynamics. , 2010, Handbook of experimental pharmacology.

[598]  H. Mönnikes,et al.  Magnetic marker monitoring: high resolution real-time tracking of oral solid dosage forms in the gastrointestinal tract. , 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[599]  Jelena Parojcić,et al.  Justification of biowaiver for carbamazepine, a low soluble high permeable compound, in solid dosage forms based on IVIVC and gastrointestinal simulation. , 2009, Molecular pharmaceutics.

[600]  C. Teng,et al.  Systematic studies on the paracellular permeation of model permeants and oligonucleotides in the rat small intestine with chenodeoxycholate as enhancer. , 2008, Journal of pharmaceutical sciences.

[601]  David J Brayden,et al.  Cracking the junction: update on the progress of gastrointestinal absorption enhancement in the delivery of poorly absorbed drugs. , 2008, Critical reviews in therapeutic drug carrier systems.

[602]  Karen Twomey,et al.  Swallowable-Capsule Technology , 2008, IEEE Pervasive Computing.

[603]  James G Brasseur,et al.  A stomach road or "Magenstrasse" for gastric emptying. , 2007, Journal of biomechanics.

[604]  M. Brewster,et al.  The Use of Solubilizing Excipients and Approaches to GenerateToxicology Vehicles for Contemporary Drug Pipelines , 2007 .

[605]  U. Hofmann,et al.  Increased Absorption of Digoxin from the Human Jejunum Due to Inhibition of Intestinal Transporter-Mediated Efflux , 2007, Clinical pharmacokinetics.

[606]  M. Swindle,et al.  Swine in the laboratory: surgery, anesthesia, imaging, and experimental techniques , 2007 .

[607]  R. Coatney,et al.  Gastric pH and Gastric Residence Time in Fasted and Fed Conscious Cynomolgus Monkeys Using the Bravo® pH System , 2007, Pharmaceutical Research.

[608]  Yu-Hsin Lin,et al.  Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery. , 2007, Biomacromolecules.

[609]  C. Porter,et al.  Oral lipid-based formulations: using preclinical data to dictate formulation strategies for poorly water-soluble drugs , 2007 .

[610]  P. Hockings.  Magnetic Resonance Imaging in Pharmaceutical Safety Assessment , 2006 .

[611]  J. G. Eley,et al.  Permeability enhancing effects of the alkylglycoside, octylglucoside, on insulin permeation across epithelial membrane in vitro. , 2006, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[612]  Martin Kuentz,et al.  A strategy for preclinical formulation development using GastroPlus as pharmacokinetic simulation tool and a statistical screening design applied to a dog study. , 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[613]  L. Granero,et al.  Intestinal absorption enhancement via the paracellular route by fatty acids, chitosans and others: a target for drug delivery. , 2005, Current drug delivery.

[614]  J. Pappenheimer,et al.  Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the rat , 2005, The Journal of Membrane Biology.

[615]  I. Wilding,et al.  The Effect of Oleic Acid on the Human Ileal Brake and Its Implications for Small Intestinal Transit of Tablet Formulations , 2004, Pharmaceutical Research.

[616]  R. Yeates,et al.  Influence of concomitant food intake on the oral absorption of two triazole antifungal agents, itraconazole and fluconazole , 2004, European Journal of Clinical Pharmacology.

[617]  Huadong Tang,et al.  Protein expression pattern of P–glycoprotein along the gastrointestinal tract of the yucatan micropig , 2004, Journal of biochemical and molecular toxicology.

[618]  R. Huupponen,et al.  Effect of guar gum, a fibre preparation, on digoxin and penicillin absorption in man , 2004, European Journal of Clinical Pharmacology.

[619]  H. Lennernäs,et al.  Regional Gastrointestinal Absorption of the Beta-Blocker Pafenolol in the Rat and Intestinal Transit Rate Determined by Movement of 14C-Polyethylene Glycol (PEG) 4000 , 2004, Pharmaceutical Research.

[620]  Leslie Z. Benet,et al.  Predicting Drug Disposition via Application of BCS: Transport/Absorption/ Elimination Interplay and Development of a Biopharmaceutics Drug Disposition Classification System , 2004, Pharmaceutical Research.

[621]  R. van der Meer,et al.  UvA-DARE ( Digital Academic Repository ) Differential in vivo and in vitro intestinal permeability to lactulose and mannitol in animals and humans : a hypothesis , 2004 .

[622]  Anders Karlén,et al.  Hydrogen bonding descriptors in the prediction of human in vivo intestinal permeability. , 2003, Journal of molecular graphics & modelling.

[623]  M. Dacasto,et al.  Comparative expression of liver cytochrome P450-dependent monooxygenases in the horse and in other agricultural and laboratory species. , 2003, Veterinary journal.

[624]  David V. Prior,et al.  Remote controlled capsules in human drug absorption (HDA) studies. , 2003, Critical reviews in therapeutic drug carrier systems.

[625]  S. Leucuţa,et al.  Oxprenolol-loaded bioadhesive microspheres: preparation and in vitro/in vivo characterization. , 2003, Journal of microencapsulation.

[626]  K. Romański,et al.  [The kinetics of canine gallbladder before and after feeding and cerulein administration]. , 2003, Folia medica Cracoviensia.

[627]  John-Michael Sauer,et al.  Disposition and metabolic fate of atomoxetine hydrochloride: pharmacokinetics, metabolism, and excretion in the Fischer 344 rat and beagle dog. , 2003, Drug metabolism and disposition: the biological fate of chemicals.

[628]  D. Fleisher,et al.  Regional-dependent intestinal absorption and meal composition effects on systemic availability of LY303366, a lipopeptide antifungal agent, in dogs. , 2001, Journal of pharmaceutical sciences.

[629]  U. Kühn.  Vergleichende anatomische Untersuchungen des Darmtraktes und des darmassoziierten lymphatischen Gewebes (GALT) bei alten Hausschweinrassen und einer modernen Fleischrasse , 2001 .

[630]  A. Y. Lu,et al.  Interindividual variability in inhibition and induction of cytochrome P450 enzymes. , 2001, Annual review of pharmacology and toxicology.

[631]  H. Junginger,et al.  Mono-N-carboxymethyl chitosan (MCC), a polyampholytic chitosan derivative, enhances the intestinal absorption of low molecular weight heparin across intestinal epithelia in vitro and in vivo. , 2001, Journal of pharmaceutical sciences.

[632]  J. Polli.  IVIVR versus IVIVC , 2000 .

[633]  M. Ekelund,et al.  Mucosal in vitro permeability in the intestinal tract of the pig, the rat, and man: species- and region-related differences. , 2000, Scandinavian journal of gastroenterology.

[634]  L. Marciani,et al.  Gastric response to increased meal viscosity assessed by echo-planar magnetic resonance imaging in humans. , 2000, The Journal of nutrition.

[635]  H. Yoshino,et al.  In vivo drug release behavior in dogs from a new colon-targeted delivery system. , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[636]  T. Brewer,et al.  Absolute Bioavailability of Halofantrine-Hcl: Effect of Ranitidine and Pentagastrin Treatment , 1999 .

[637]  S. Alsaidan,et al.  Improved dissolution rate of indomethacin by adsorbents. , 1998, Drug development and industrial pharmacy.

[638]  K. S. Kumaran,et al.  Enhancement of bioavailability of griseofulvin by its complexation with beta-cyclodextrin. , 1998, Drug development and industrial pharmacy.

[639]  J Kvĕtina,et al.  Presence and activity of cytochrome P450 isoforms in minipig liver microsomes. Comparison with human liver samples. , 1998, Drug metabolism and disposition: the biological fate of chemicals.

[640]  D. Bagchi,et al.  Stress, diet and alcohol‐induced oxidative gastrointestinal mucosal injury in rats and protection by bismuth subsalicylate , 1998, Journal of applied toxicology : JAT.

[641]  O. Corrigan.  The biopharmaceutic drug classification and drugs administered in extended release (ER) formulations. , 1997, Advances in experimental medicine and biology.

[642]  H. Lennernäs,et al.  The lack of effect of induced net fluid absorption on the in vivo permeability of terbutaline in the human jejunum. , 1995, Journal of drug targeting.

[643]  B. Weatherley,et al.  Examination of some factors responsible for a food-induced increase in absorption of atovaquone. , 1994, British journal of clinical pharmacology.

[644]  E. Doelker,et al.  Biopharmaceutical comparison of oral multiple-unit and single-unit sustained-release dosage forms , 1992 .

[645]  D. Fleisher,et al.  Influence of D-glucose-induced water absorption on rat jejunal uptake of two passively absorbed drugs. , 1992, Journal of pharmaceutical sciences.

[646]  J. Dressman,et al.  Animal models for oral drug absorption , 1991 .

[647]  M. Marvola,et al.  Effects of pH regulators used as additives on the bioavailability of ibuprofen from hard gelatin capsules. , 1991, European journal of drug metabolism and pharmacokinetics.

[648]  A. P. Lötter,et al.  Compatiblity Study Between Oxprenolol Hydrochloride, Temazepam and Tablet Excipients using Differential Scanning Calorimetry , 1990 .

[649]  L. Mến,et al.  "A" molasses in diets for growing pigs. , 1990 .

[650]  J. Hardy,et al.  The effect of eating on transit through the small intestine. , 1989, Nuclear medicine communications.

[651]  T. Delahunty,et al.  A comparison of intestinal permeability between humans and three common laboratory animals. , 1987, Comparative biochemistry and physiology. A, Comparative physiology.

[652]  Cacek At.  Review of alterations in oral phenytoin bioavailability associated with formulation, antacids, and food. , 1986, Therapeutic drug monitoring.

[653]  D. Alvaro,et al.  Relationships between bile salts hydrophilicity and phospholipid composition in bile of various animal species. , 1986, Comparative biochemistry and physiology. B, Comparative biochemistry.

[654]  A. Hofmann,et al.  Controlled entry of orally administereddrugs: physiological considerations , 1983 .

[655]  L. Benet,et al.  Effect of inert tablet ingredients on drug absorption. I. Effect of polyethylene glycol 4000 on the intestinal absorption of four barbiturates. , 1966, Journal of pharmaceutical sciences.

[656]  H. Smith,et al.  OBSERVATIONS ON THE FLORA OF THE ALIMENTARY TRACT OF ANIMALS AND FACTORS AFFECTING ITS COMPOSITION. , 1965, The Journal of pathology and bacteriology.

[657]  R. van der Meer,et al.  Nutrient Physiology, Metabolism, and Nutrient-nutrient Interactions Dietary Fructooligosaccharides Affect Intestinal Barrier Function in Healthy Men , 2022 .