Pluripotent Very Small Embryonic-Like Stem Cells in Adult Testes – An Alternate Premise to Explain Testicular Germ Cell Tumors

[1]  O. Koca,et al.  Evaluation of germ-cell neoplasia in situ entity in testicular tumors. , 2019, Turkish journal of urology.

[2]  D. Bhartiya,et al.  Novel Insights into Adult and Cancer Stem Cell Biology. , 2018, Stem cells and development.

[3]  J. Koster,et al.  Massive expression of germ cell-specific genes is a hallmark of cancer and a potential target for novel treatment development , 2018, Oncogene.

[4]  R. Huddart,et al.  Large-scale Sequencing of Testicular Germ Cell Tumour (TGCT) Cases Excludes Major TGCT Predisposition Gene. , 2018, European urology.

[5]  R. Skotheim,et al.  Complex Polygenic Nature of Testicular Germ Cell Cancer Suggests Multifactorial Aetiology. , 2018, European urology.

[6]  R. Barbet,et al.  VSELs Maintain their Pluripotency and Competence to Differentiate after Enhanced Ex Vivo Expansion , 2018, Stem Cell Reviews and Reports.

[7]  Jiansheng Xing,et al.  Is testicular dysgenesis syndrome a genetic, endocrine, or environmental disease, or an unexplained reproductive disorder? , 2018, Life sciences.

[8]  A. Bang,et al.  Is the FSHR 2039A>G variant associated with susceptibility to testicular germ cell cancer? , 2018, Andrology.

[9]  D. Bhartiya.  Pluripotent Stem Cells in Adult Tissues: Struggling To Be Acknowledged Over Two Decades , 2017, Stem Cell Reviews and Reports.

[10]  D. Laird,et al.  A pilgrim's progress: Seeking meaning in primordial germ cell migration. , 2017, Stem cell research.

[11]  D. Bhartiya.  Do Adult Somatic Cells Undergo Reprogramming or Endogenous Pluripotent Stem Cells get Activated to Account for Plasticity, Regeneration and Cancer Initiation? , 2017, Stem Cell Reviews and Reports.

[12]  P. Rosenberg,et al.  Future of testicular germ cell tumor incidence in the United States: Forecast through 2026 , 2017, Cancer.

[13]  M. Ratajczak.  Why are hematopoietic stem cells so ‘sexy’? on a search for developmental explanation , 2017, Leukemia.

[14]  J. Bowles,et al.  Germ cell neoplasia in situ: The precursor cell for invasive germ cell tumors of the testis. , 2017, The international journal of biochemistry & cell biology.

[15]  D. Bhartiya,et al.  Underlying Mechanisms that Restore Spermatogenesis on Transplanting Healthy Niche Cells in Busulphan Treated Mouse Testis , 2016, Stem Cell Reviews and Reports.

[16]  D. Bhartiya,et al.  Endogenous, very small embryonic-like stem cells: critical review, therapeutic potential and a look ahead. , 2016, Human reproduction update.

[17]  D. Berney,et al.  Germ cell neoplasia in situ (GCNIS): evolution of the current nomenclature for testicular pre‐invasive germ cell malignancy , 2016, Histopathology.

[18]  D. Bhartiya,et al.  Testicular Stem Cells Express Follicle-Stimulating Hormone Receptors and Are Directly Modulated by FSH , 2016, Reproductive Sciences.

[19]  A. Basiri,et al.  The histologic features of intratubular germ cell neoplasia and its correlation with tumor behavior , 2016, Investigative and clinical urology.

[20]  Virant-KlunIrma.  Very Small Embryonic-Like Stem Cells: A Potential Developmental Link Between Germinal Lineage and Hematopoiesis in Humans. , 2016 .

[21]  D. Bhartiya,et al.  Do Somatic Cells De-differentiate/Trans-differentiate or VSELs Initiate Cancer and Explain Plasticity in Adult Tissues? , 2016 .

[22]  M. De Felici.  The Formation and Migration of Primordial Germ Cells in Mouse and Man. , 2016, Results and problems in cell differentiation.

[23]  P. Kurkure,et al.  Very small embryonic-like stem cells (VSELs) detected in azoospermic testicular biopsies of adult survivors of childhood cancer , 2015, Reproductive Biology and Endocrinology.

[24]  N. Skakkebaek,et al.  Pathogenesis of germ cell neoplasia in testicular dysgenesis and disorders of sex development. , 2015, Seminars in cell & developmental biology.

[25]  T. Walsh,et al.  Infertility with Testicular Cancer. , 2015, The Urologic clinics of North America.

[26]  M. Felici,et al.  Hematopoietic activity in putative mouse primordial germ cell populations , 2015, Mechanisms of Development.

[27]  L. Looijenga,et al.  Etiology and early pathogenesis of malignant testicular germ cell tumors: towards possibilities for preinvasive diagnosis , 2015, Asian journal of andrology.

[28]  N. Hanna,et al.  Testicular cancer--discoveries and updates. , 2014, The New England journal of medicine.

[29]  Dong-Myung Shin,et al.  The Molecular Nature of Very Small Embryonic-Like Stem Cells in Adult Tissues , 2014, International journal of stem cells.

[30]  M. Ratajczak,et al.  Very small embryonic-like stem cells as a novel developmental concept and the hierarchy of the stem cell compartment. , 2014, Advances in medical sciences.

[31]  D. Bhartiya,et al.  Very Small Embryonic-Like Stem Cells Survive and Restore Spermatogenesis after Busulphan Treatment in Mouse Testis , 2014 .

[32]  J. Lortet-Tieulent,et al.  Testicular cancer incidence to rise by 25% by 2025 in Europe? Model-based predictions in 40 countries using population-based registry data. , 2014, European journal of cancer.

[33]  Qi-En Yang,et al.  Spermatogonial stem cell functions in physiological and pathological conditions. , 2014, Current topics in developmental biology.

[34]  J. Toppari,et al.  Testicular Cancer Pathogenesis, Diagnosis and Endocrine Aspects , 2013 .

[35]  S. Rudman,et al.  Global incidence and outcome of testicular cancer , 2013, Clinical epidemiology.

[36]  A. Abbott.  Doubt cast over tiny stem cells , 2013, Nature.

[37]  N. Skakkebæk,et al.  Epigenetic features of testicular germ cell tumours in relation to epigenetic characteristics of foetal germ cells. , 2013, The International journal of developmental biology.

[38]  R. Curi,et al.  Molecular Targets Related to Inflammation and Insulin Resistance and Potential Interventions , 2012, Journal of biomedicine & biotechnology.

[39]  M. Punab,et al.  Combined effects of the variants FSHB -211G>T and FSHR 2039A>G on male reproductive parameters. , 2012, The Journal of clinical endocrinology and metabolism.

[40]  H. Leffers,et al.  A novel double staining strategy for improved detection of testicular carcinoma in situ cells in human semen samples , 2012, Andrologia.

[41]  D. Bhartiya,et al.  Cellular origin of testis-derived pluripotent stem cells: a case for very small embryonic-like stem cells. , 2012, Stem cells and development.

[42]  M. Štimpfel,et al.  Potential Stemness of Frozen-Thawed Testicular Biopsies without Sperm in Infertile Men Included into the In Vitro Fertilization Programme , 2012, Journal of biomedicine & biotechnology.

[43]  D. Bhartiya,et al.  Very small embryonic-like stem cells with maximum regenerative potential get discarded during cord blood banking and bone marrow processing for autologous stem cell therapy. , 2012, Stem cells and development.

[44]  N. Skakkebæk,et al.  Pathogenesis of testicular carcinoma in situ and germ cell cancer: still more questions than answers. , 2011 .

[45]  A. Wilkie,et al.  OCT2, SSX and SAGE1 reveal the phenotypic heterogeneity of spermatocytic seminoma reflecting distinct subpopulations of spermatogonia , 2011, The Journal of pathology.

[46]  H. Stoop,et al.  A pathologist's view on the testis biopsy. , 2011, International journal of andrology.

[47]  D. Bhartiya,et al.  Newer Insights Into Premeiotic Development of Germ Cells in Adult Human Testis Using Oct-4 as a Stem Cell Marker , 2010, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[48]  A. Agarwal,et al.  Is male infertility a forerunner to cancer? , 2010, International braz j urol : official journal of the Brazilian Society of Urology.

[49]  Dong-Myung Shin,et al.  Molecular characterization of isolated from murine adult tissues very small embryonic/epiblast like stem cells (VSELs) , 2010, Molecules and cells.

[50]  Dong-Myung Shin,et al.  Epiblast/Germ Line Hypothesis of Cancer Development Revisited: Lesson from the Presence of Oct-4+ Cells in Adult Tissues , 2010, Stem Cell Reviews and Reports.

[51]  J. Chan,et al.  Increased risk of testicular germ cell cancer among infertile men. , 2009, Archives of internal medicine.

[52]  James W Lillard,et al.  Very small embryonic‐like stem cells are present in adult murine organs: ImageStream‐based morphological analysis and distribution studies , 2008, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[53]  P. Rožman,et al.  Putative stem cells with an embryonic character isolated from the ovarian surface epithelium of women with no naturally present follicles and oocytes. , 2008, Differentiation; research in biological diversity.

[54]  L. Salmaso,et al.  Analysis of single nucleotide polymorphisms of FSH receptor gene suggests association with testicular cancer susceptibility. , 2008, Endocrine-related cancer.

[55]  M. Ratajczak,et al.  Very Small Embryonic-Like (VSEL) Stem Cells: Purification from Adult Organs, Characterization, and Biological Significance , 2008, Stem Cell Reviews.

[56]  M. Ratajczak,et al.  Hunt for pluripotent stem cell -- regenerative medicine search for almighty cell. , 2008, Journal of autoimmunity.

[57]  R. Czajka,et al.  Morphological and molecular characterization of novel population of CXCR4+ SSEA-4+ Oct-4+ very small embryonic-like cells purified from human cord blood – preliminary report , 2007, Leukemia.

[58]  E. R. Meyts.  Developmental model for the pathogenesis of testicular carcinoma in situ: genetic and environmental aspects , 2006 .

[59]  J Ratajczak,et al.  A population of very small embryonic-like (VSEL) CXCR4+SSEA-1+Oct-4+ stem cells identified in adult bone marrow , 2006, Leukemia.

[60]  Stefan Wagner,et al.  Pluripotency of spermatogonial stem cells from adult mouse testis , 2006, Nature.

[61]  M. Oshimura,et al.  Generation of Pluripotent Stem Cells from Neonatal Mouse Testis , 2004, Cell.

[62]  N. Skakkebaek,et al.  Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects , 2001, Human reproduction.

[63]  J. Olsen,et al.  Risk of testicular cancer in men with abnormal semen characteristics: cohort study , 2000, BMJ : British Medical Journal.

[64]  L. Looijenga,et al.  Genomic imprinting in testicular germ cell tumours , 1998, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[65]  G. T. te Meerman,et al.  Pathogenesis of adult testicular germ cell tumors. A cytogenetic model. , 1990, Cancer genetics and cytogenetics.

[66]  P. W. Adams,et al.  VITAMIN B6, DEPRESSION, AND ORAL CONTRACEPTION , 1974 .

[67]  N. Skakkebæk.  POSSIBLE CARCINOMA-IN-SITU OF THE TESTIS , 1972 .