Biochemical pathways to α-ketoglutarate, a multi-faceted metabolite

[1]  V. Appanna,et al.  Metabolic manipulation by Pseudomonas fluorescens: a powerful stratagem against oxidative and metal stress. , 2020, Journal of medical microbiology.

[2]  V. Appanna,et al.  Metabolic adaptation and NADPH homeostasis evoked by a sulfur-deficient environment in Pseudomonas fluorescens , 2019, Antonie van Leeuwenhoek.

[3]  V. Appanna,et al.  Isocitrate Lyase and Succinate Semialdehyde Dehydrogenase Mediate the Synthesis of α-Ketoglutarate in Pseudomonas fluorescens , 2019, Front. Microbiol..

[4]  Xiaolan Fan,et al.  Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK , 2019, Aging.

[5]  Liuqin He,et al.  The Antioxidative Function of Alpha-Ketoglutarate and Its Applications , 2018, BioMed research international.

[6]  W. Cai,et al.  Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin. , 2018, Biochemistry.

[7]  F. Ahmad,et al.  Alpha ketoglutarate nanoparticles: A potentially effective treatment for cyanide poisoning , 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[8]  Yongqing Hou,et al.  Dietary α-ketoglutarate supplementation improves hepatic and intestinal energy status and anti-oxidative capacity of Cherry Valley ducks. , 2017, Animal science journal = Nihon chikusan Gakkaiho.

[9]  A. Wilde,et al.  Ethylene production in Synechocystis sp. PCC 6803 promotes phototactic movement. , 2017, Microbiology.

[10]  A. Barbul,et al.  Proline Precursors and Collagen Synthesis: Biochemical Challenges of Nutrient Supplementation and Wound Healing. , 2017, The Journal of nutrition.

[11]  V. Appanna,et al.  Metabolic defence against oxidative stress: the road less travelled so far , 2017, Journal of applied microbiology.

[12]  V. Sieber,et al.  In vitro metabolic engineering for the production of α-ketoglutarate. , 2017, Metabolic engineering.

[13]  V. Appanna,et al.  The role of glutamine synthetase in energy production and glutamine metabolism during oxidative stress , 2017, Antonie van Leeuwenhoek.

[14]  V. Appanna,et al.  Manganese orchestrates a metabolic shift leading to the increased bioconversion of glycerol into α-ketoglutarate. , 2016 .

[15]  Xing Fu,et al.  AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis. , 2016, Cell metabolism.

[16]  V. Appanna,et al.  Phospho-transfer networks and ATP homeostasis in response to an ineffective electron transport chain in Pseudomonas fluorescens. , 2016, Archives of biochemistry and biophysics.

[17]  H. Bayır,et al.  Therapies targeting lipid peroxidation in traumatic brain injury , 2016, Brain Research.

[18]  U. Gaur,et al.  Alpha-Ketoglutarate: Physiological Functions and Applications , 2016, Biomolecules & therapeutics.

[19]  T. Horvath,et al.  Mitochondrial ROS Signaling in Organismal Homeostasis , 2015, Cell.

[20]  V. Appanna,et al.  Brain metabolism and Alzheimer’s disease: The prospect of a metabolite-based therapy , 2015, The journal of nutrition, health & aging.

[21]  K. Storey,et al.  Alpha-ketoglutarate attenuates toxic effects of sodium nitroprusside and hydrogen peroxide in Drosophila melanogaster. , 2015, Environmental toxicology and pharmacology.

[22]  Guoyao Wu,et al.  Dietary supplementation with glutamate precursor α-ketoglutarate attenuates lipopolysaccharide-induced liver injury in young pigs , 2015, Amino Acids.

[23]  C. Schofield,et al.  Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation , 2014, Proceedings of the National Academy of Sciences.

[24]  V. Appanna,et al.  Mitochondrial lactate metabolism is involved in antioxidative defense in human astrocytoma cells , 2014, Journal of neuroscience research.

[25]  Ling Tao,et al.  Ethylene-forming enzyme and bioethylene production , 2014, Biotechnology for Biofuels.

[26]  C. ThomasSean,et al.  Mitochondrial Biogenesis and Energy Production in Differentiating Murine Stem Cells: A Functional Metabolic Study , 2014 .

[27]  V. Appanna,et al.  Mitochondrial biogenesis and energy production in differentiating murine stem cells: a functional metabolic study. , 2014, Cellular reprogramming.

[28]  G. Barth,et al.  Engineering the α-ketoglutarate overproduction from raw glycerol by overexpression of the genes encoding NADP+-dependent isocitrate dehydrogenase and pyruvate carboxylase in Yarrowia lipolytica , 2013, Applied Microbiology and Biotechnology.

[29]  Abdelwahab Omri,et al.  Hydrogen peroxide stress provokes a metabolic reprogramming in Pseudomonas fluorescens: enhanced production of pyruvate. , 2013, Journal of biotechnology.

[30]  K. Rhee,et al.  Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis , 2013, Proceedings of the National Academy of Sciences.

[31]  V. Appanna,et al.  The Metabolic Reprogramming Evoked by Nitrosative Stress Triggers the Anaerobic Utilization of Citrate in Pseudomonas fluorescens , 2011, PloS one.

[32]  V. Appanna,et al.  Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders. , 2011, Journal of inorganic biochemistry.

[33]  V. Appanna,et al.  Hepatic response to aluminum toxicity: dyslipidemia and liver diseases. , 2011, Experimental cell research.

[34]  V. Appanna,et al.  he disruption of l-carnitine metabolism by aluminum toxicity and oxidative tress promotes dyslipidemia in human astrocytic and hepatic cells , 2011 .

[35]  B. Halliwell,et al.  Artefacts in cell culture: α-Ketoglutarate can scavenge hydrogen peroxide generated by ascorbate and epigallocatechin gallate in cell culture media. , 2011, Biochemical and biophysical research communications.

[36]  San-feng Chen,et al.  Metabolic engineering for ethylene production by inserting the ethylene-forming enzyme gene (efe) at the 16S rDNA sites of Pseudomonas putida KT2440. , 2010, Bioresource technology.

[37]  V. Appanna,et al.  Histidine is a source of the antioxidant, alpha-ketoglutarate, in Pseudomonas fluorescens challenged by oxidative stress. , 2010, FEMS microbiology letters.

[38]  W. Qin,et al.  Overexpression of bacterial ethylene-forming enzyme gene in Trichoderma reesei enhanced the production of ethylene , 2010, International journal of biological sciences.

[39]  R. Tulsawani,et al.  Protective role of alpha-ketoglutarate against massive doses of cyanide in rats. , 2009, Journal of environmental biology.

[40]  V. Appanna,et al.  α-Ketoglutarate Dehydrogenase and Glutamate Dehydrogenase Work in Tandem To Modulate the Antioxidant α-Ketoglutarate during Oxidative Stress in Pseudomonas fluorescens , 2009, Journal of bacteriology.

[41]  S. Puiseux-Dao,et al.  Alpha-ketoglutarate abrogates the nuclear localization of HIF-1alpha in aluminum-exposed hepatocytes. , 2009, Biochimie.

[42]  P. Richard,et al.  d-Galacturonic acid catabolism in microorganisms and its biotechnological relevance , 2009, Applied Microbiology and Biotechnology.

[43]  S. Pierzynowski,et al.  Effect of dietary alpha‐ketoglutarate on blood lipid profile during hypercholesterolaemia in rats , 2009, Scandinavian journal of clinical and laboratory investigation.

[44]  C. Rose,et al.  Identifying the direct effects of ammonia on the brain , 2009, Metabolic Brain Disease.

[45]  S. Kalyuzhnyi,et al.  A novel metabolic network leads to enhanced citrate biogenesis in Pseudomonas fluorescens exposed to aluminum toxicity , 2008, Extremophiles.

[46]  V. Appanna,et al.  Aluminum-Induced Mitochondrial Dysfunction Leads to Lipid Accumulation in Human Hepatocytes: A Link to Obesity , 2007, Cellular Physiology and Biochemistry.

[47]  V. Appanna,et al.  The Tricarboxylic Acid Cycle, an Ancient Metabolic Network with a Novel Twist , 2007, PloS one.

[48]  V. Appanna,et al.  The overexpression of NADPH-producing enzymes counters the oxidative stress evoked by gallium, an iron mimetic , 2007, BioMetals.

[49]  .. P.N.Okafor,et al.  The Effects of Cassava Cyanide on the Antioxidant (Glutathione) Status and Some Clinically Important Enzymes of Rats , 2006 .

[50]  U. Stottmeister,et al.  White biotechnology for green chemistry: fermentative 2-oxocarboxylic acids as novel building blocks for subsequent chemical syntheses , 2005, Journal of Industrial Microbiology and Biotechnology.

[51]  V. Appanna,et al.  Overexpression of isocitrate lyase is an important strategy in the survival of Pseudomonas fluorescens exposed to aluminum. , 2004, Biochemical and biophysical research communications.

[52]  B. Buchanan,et al.  A reverse KREBS cycle in photosynthesis: consensus at last , 2004, Photosynthesis Research.

[53]  A. Das,et al.  An evaluation of level of oxidative stress and protein glycation in nondiabetic undialyzed chronic renal failure patients. , 2002, Clinica chimica acta; international journal of clinical chemistry.

[54]  S. Velvizhi,et al.  Effects of alpha-ketoglutarate on antioxidants and lipid peroxidation products in rats treated with ammonium acetate. , 2002, Nutrition.

[55]  N. Kristensen,et al.  Absorption and metabolism of alpha-ketoglutarate in growing pigs. , 2002, Journal of animal physiology and animal nutrition.

[56]  L. Cynober,et al.  Ornithine &agr;-ketoglutarate improves wound healing in severe burn patients: A prospective randomized double-blind trial versus isonitrogenous controls , 2000, Critical care medicine.

[57]  V. Appanna,et al.  Oxalic acid production and aluminum tolerance in Pseudomonas fluorescens. , 1999, Journal of inorganic biochemistry.

[58]  J. Monboisse,et al.  Glutamine increases collagen gene transcription in cultured human fibroblasts. , 1995, Biochimica et biophysica acta.

[59]  I. Robinson,et al.  Biosynthesis of α-Ketoglutarate by the Reductive Carboxylation of Succinate in Bacteroides ruminicola , 1970 .

[60]  D. Feingold,et al.  d-Glucaric Acid and Galactaric Acid Catabolism by Agrobacterium tumefaciens , 1970, Journal of bacteriology.