The biological foundation of the genetic association of TOMM40 with late-onset Alzheimer's disease.
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A. Saunders | S. Luo | W. Gottschalk | M. Mihovilovic | Kahli Zeitlow | Lefko Charlambous | Isaac Ng | Sonal Gagrani | Daniel L. Rock | A. D. Roses
[1] A. Roses,et al. TOMM40′523 variant and cognitive decline in older persons with APOE ε3/3 genotype , 2017, Neurology.
[2] Enrico Calzia,et al. Metabolic Characterization of Intact Cells Reveals Intracellular Amyloid Beta but Not Its Precursor Protein to Reduce Mitochondrial Respiration , 2016, PloS one.
[3] W. Voos,et al. Protein quality control at the mitochondrion. , 2016, Essays in biochemistry.
[4] G. Cenini,et al. Amyloid β-peptides interfere with mitochondrial preprotein import competence by a coaggregation process , 2016, bioRxiv.
[5] Jon Valla,et al. Altered Energy Metabolism Pathways in the Posterior Cingulate in Young Adult Apolipoprotein E ɛ4 Carriers , 2016, Journal of Alzheimer's disease : JAD.
[6] J. Quinn,et al. A TOMM40 poly-T variant modulates gene expression and is associated with vocabulary ability and decline in nonpathologic aging , 2016, Neurobiology of Aging.
[7] D. Bredesen,et al. Direct Transcriptional Effects of Apolipoprotein E , 2016, The Journal of Neuroscience.
[8] A. Roses,et al. A genetics-based biomarker risk algorithm for predicting risk of Alzheimer's disease , 2016, Alzheimer's & dementia.
[9] J. Louis,et al. Evidence of Distinct Channel Conformations and Substrate Binding Affinities for the Mitochondrial Outer Membrane Protein Translocase Pore Tom40* , 2015, The Journal of Biological Chemistry.
[10] D. Petranovic,et al. Amyloid-β peptide-induced cytotoxicity and mitochondrial dysfunction in yeast. , 2015, FEMS yeast research.
[11] J. Laczó,et al. The effect of TOMM40 on spatial navigation in amnestic mild cognitive impairment , 2015, Neurobiology of Aging.
[12] F. Metzger,et al. Amyloid-β peptide induces mitochondrial dysfunction by inhibition of preprotein maturation. , 2014, Cell metabolism.
[13] Jae Hoon Kim,et al. Abstract 2456: Overexpression of TOM40 (translocase in the outer mitochondrial membrane 40) inhibits the cell proliferation, invasion and migration abilities in ovarian cancer cell lines , 2014 .
[14] Michael W. Lutz,et al. The cis-regulatory effect of an Alzheimer’s disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes , 2014, Alzheimer's & Dementia.
[15] A. Roses,et al. The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes , 2014, European Neuropsychopharmacology.
[16] R. Swerdlow,et al. The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives. , 2014, Biochimica et biophysica acta.
[17] B. Kuster,et al. Mass-spectrometry-based draft of the human proteome , 2014, Nature.
[18] Sean C. Taylor,et al. The Design of a Quantitative Western Blot Experiment , 2014, BioMed research international.
[19] D. German,et al. Elevated serum pesticide levels and risk for Alzheimer disease. , 2014, JAMA neurology.
[20] R. Swerdlow,et al. Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines. , 2013, Human molecular genetics.
[21] C. Chinopoulos. Which way does the citric acid cycle turn during hypoxia? The critical role of α‐ketoglutarate dehydrogenase complex , 2013, Journal of neuroscience research.
[22] D. Valenti,et al. Mitochondrial respiratory chain Complexes I and IV are impaired by β-amyloid via direct interaction and through Complex I-dependent ROS production, respectively. , 2013, Mitochondrion.
[23] M. Beal,et al. The negative impact of α‐ketoglutarate dehydrogenase complex deficiency on matrix substrate‐level phosphorylation , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[24] T. Berkelman,et al. A Defined Methodology for Reliable Quantification of Western Blot Data , 2013, Molecular Biotechnology.
[25] Brian Spencer,et al. TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson’s Disease , 2013, PloS one.
[26] A. Roses,et al. Using Genetics to Enable Studies on the Prevention of Alzheimer's Disease , 2013, Clinical pharmacology and therapeutics.
[27] A. Roses,et al. Longitudinal modeling of cognitive aging and the TOMM40 effect , 2012, Alzheimer's & Dementia.
[28] T. Endo,et al. The Tom40 assembly process probed using the attachment of different intramitochondrial sorting signals , 2012, Molecular biology of the cell.
[29] A. Roses,et al. A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging , 2012, Alzheimer's & Dementia.
[30] F. LaFerla,et al. Swedish Alzheimer Mutation Induces Mitochondrial Dysfunction Mediated by HSP60 Mislocalization of Amyloid Precursor Protein (APP) and Beta-Amyloid* , 2012, The Journal of Biological Chemistry.
[31] R. Swerdlow. Mitochondria and cell bioenergetics: increasingly recognized components and a possible etiologic cause of Alzheimer's disease. , 2012, Antioxidants & redox signaling.
[32] S. Bulik,et al. Corrigendum to “Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced α-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species” , 2012, International journal of cell biology.
[33] K. Krishnan,et al. Downregulation of TOMM40 expression in the blood of Alzheimer disease subjects compared with matched controls. , 2012, Journal of psychiatric research.
[34] L. Bekris,et al. Functional Analysis of APOE Locus Genetic Variation Implicates Regional Enhancers in the Regulation of Both TOMM40 and APOE , 2011, Journal of Human Genetics.
[35] Robert C. Green,et al. The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ɛ3/ɛ3 genotype , 2011, Alzheimer's & Dementia.
[36] M. Selbach,et al. Global quantification of mammalian gene expression control , 2011, Nature.
[37] M. Brand,et al. Assessing mitochondrial dysfunction in cells , 2011, The Biochemical journal.
[38] Lucia Pagani,et al. Amyloid-Beta Interaction with Mitochondria , 2011, International journal of Alzheimer's disease.
[39] S. Franken,et al. Mitochondrial enzymes are protected from stress-induced aggregation by mitochondrial chaperones and the Pim1/LON protease , 2011, Molecular biology of the cell.
[40] Dimitrios Kapogiannis,et al. Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease , 2011, The Lancet Neurology.
[41] M. Mann,et al. Defining the transcriptome and proteome in three functionally different human cell lines , 2010, Molecular systems biology.
[42] R. Mahley,et al. Apolipoprotein E4 Domain Interaction Mediates Detrimental Effects on Mitochondria and Is a Potential Therapeutic Target for Alzheimer Disease* , 2010, The Journal of Biological Chemistry.
[43] G. McKhann,et al. Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model , 2010, Proceedings of the National Academy of Sciences.
[44] A. Roses,et al. TOMM40, APOE, and age of onset of Alzheimer's disease , 2010, Alzheimer's & Dementia.
[45] S. Yan,et al. Role of mitochondrial amyloid-beta in Alzheimer's disease. , 2010, Journal of Alzheimer's disease : JAD.
[46] K. Welsh-Bohmer,et al. Occupational exposure to pesticides increases the risk of incident AD , 2010, Neurology.
[47] A. Roses. An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease. , 2010, Archives of neurology.
[48] Wayne F. Patton,et al. A Live-Cell Fluorescence Microplate Assay Suitable for Monitoring Vacuolation Arising from Drug or Toxic Agent Treatment , 2010, Journal of biomolecular screening.
[49] F. Gunn-Moore,et al. The consequences of mitochondrial amyloid beta-peptide in Alzheimer's disease. , 2010, The Biochemical journal.
[50] A. Roses,et al. Genetic variation at a single locus and age of onset for Alzheimer's disease , 2010, Alzheimer's & Dementia.
[51] A D Roses,et al. A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease , 2009, The Pharmacogenomics Journal.
[52] Seongman Kang,et al. Intracellular amyloid beta interacts with SOD1 and impairs the enzymatic activity of SOD1: implications for the pathogenesis of amyotrophic lateral sclerosis , 2009, Experimental & Molecular Medicine.
[53] R. Hamilton,et al. Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease , 2009, Proceedings of the National Academy of Sciences.
[54] T. Lithgow,et al. Importing Mitochondrial Proteins: Machineries and Mechanisms , 2009, Cell.
[55] Anna Lisa Maniero,et al. Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species. , 2009, Biochimica et biophysica acta.
[56] Jayne E. Telford,et al. Complex I Is Rate-limiting for Oxygen Consumption in the Nerve Terminal* , 2009, Journal of Biological Chemistry.
[57] Michael P. Murphy,et al. How mitochondria produce reactive oxygen species , 2008, The Biochemical journal.
[58] Dariya S. Glazer,et al. The FEATURE framework for protein function annotation: modeling new functions, improving performance, and extending to novel applications , 2008, BMC Genomics.
[59] B. Winblad,et al. The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae , 2008, Proceedings of the National Academy of Sciences.
[60] Winnie S. Liang,et al. Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons , 2008, Proceedings of the National Academy of Sciences.
[61] C. Moraes,et al. Transcriptional co-expression and co-regulation of genes coding for components of the oxidative phosphorylation system , 2008, BMC Genomics.
[62] Vadim Zinchuk,et al. Quantitative Colocalization Analysis of Multicolor Confocal Immunofluorescence Microscopy Images: Pushing Pixels to Explore Biological Phenomena , 2007, Acta histochemica et cytochemica.
[63] D. Galati,et al. Accumulation of Amyloid Precursor Protein in the Mitochondrial Import Channels of Human Alzheimer’s Disease Brain Is Associated with Mitochondrial Dysfunction , 2006, The Journal of Neuroscience.
[64] F. Nargang,et al. Effect of Mutations in Tom40 on Stability of the Translocase of the Outer Mitochondrial Membrane (TOM) Complex, Assembly of Tom40, and Import of Mitochondrial Preproteins* , 2006, Journal of Biological Chemistry.
[65] Dmitri B Papkovsky,et al. The use of a fluorescence-based oxygen uptake assay in the analysis of cytotoxicity. , 2006, Toxicology in vitro : an international journal published in association with BIBRA.
[66] Dmitri B Papkovsky,et al. Investigation of drug-induced mitochondrial toxicity using fluorescence-based oxygen-sensitive probes. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.
[67] M. Beal,et al. The role of mitochondria in inherited neurodegenerative diseases , 2006, Journal of neurochemistry.
[68] J. Quinn,et al. Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. , 2006, Human molecular genetics.
[69] R. Mahley,et al. Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[70] X. Chen,et al. Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease , 2005 .
[71] S. Kaul,et al. Activation of Wild Type p53 Function by Its Mortalin-binding, Cytoplasmically Localizing Carboxyl Terminus Peptides* , 2005, Journal of Biological Chemistry.
[72] Xi Chen,et al. ABAD enhances Aβ‐induced cell stress via mitochondrial dysfunction , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[73] D. Stojanovski,et al. Dissection of the Mitochondrial Import and Assembly Pathway for Human Tom40* , 2005, Journal of Biological Chemistry.
[74] B. Winblad,et al. Nicastrin, Presenilin, APH-1, and PEN-2 Form Active γ-Secretase Complexes in Mitochondria* , 2004, Journal of Biological Chemistry.
[75] Masao Sakaguchi,et al. Membrane-embedded C-terminal Segment of Rat Mitochondrial TOM40 Constitutes Protein-conducting Pore with Enriched β-Structure* , 2004, Journal of Biological Chemistry.
[76] M. Beal,et al. Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[77] Rodrigue Rossignol,et al. Energy Substrate Modulates Mitochondrial Structure and Oxidative Capacity in Cancer Cells , 2004, Cancer Research.
[78] Charles L. Hoppel,et al. Production of Reactive Oxygen Species by Mitochondria , 2003, Journal of Biological Chemistry.
[79] U. F. Rasmussen,et al. Oxygen solubilities of media used in electrochemical respiration measurements. , 2003, Analytical biochemistry.
[80] B. Schönfisch,et al. Machinery for protein sorting and assembly in the mitochondrial outer membrane , 2003, Nature.
[81] T. Lithgow,et al. Tom40, the import channel of the mitochondrial outer membrane, plays an active role in sorting imported proteins , 2003, The EMBO journal.
[82] F. Nargang,et al. Characterization of Neurospora crassa Tom40-deficient Mutants and Effect of Specific Mutations on Tom40 Assembly* , 2003, The Journal of Biological Chemistry.
[83] M. Duchen,et al. β-Amyloid Fragment 25–35 Causes Mitochondrial Dysfunction in Primary Cortical Neurons , 2002, Neurobiology of Disease.
[84] M. L. Genova,et al. Control of oxidative phosphorylation by Complex I in rat liver mitochondria: implications for aging. , 2002, Biochimica et biophysica acta.
[85] J. Land,et al. β‐Amyloid inhibits integrated mitochondrial respiration and key enzyme activities , 2001, Journal of neurochemistry.
[86] W. Neupert,et al. Structural requirements of Tom40 for assembly into preexisting TOM complexes of mitochondria. , 2001, Molecular biology of the cell.
[87] J. R. Smith,et al. Extramitochondrial localization of mortalin/mthsp70/PBP74/GRP75. , 2000, Biochemical and biophysical research communications.
[88] A. Nunomura,et al. Mitochondrial abnormalities in Alzheimer disease , 2000, Neurobiology of Aging.
[89] S. Papa,et al. Low Reserve of Cytochrome c Oxidase Capacity in Vivo in the Respiratory Chain of a Variety of Human Cell Types* , 1998, The Journal of Biological Chemistry.
[90] C. Oliveira,et al. Mitochondrial function impairment induced by amyloid β‐peptide on PC12 cells , 1998 .
[91] B. Soltys,et al. Cloning and some novel characteristics of mitochondrial Hsp70 from Chinese hamster cells. , 1997, Experimental cell research.
[92] A. Norin,et al. Preferential Interaction of a Novel Tumor Surface Protein (p38.5) with Naive Natural Killer Cells , 1997, The Journal of experimental medicine.
[93] R. Margreiter,et al. Oxygen dependence of respiration in coupled and uncoupled endothelial cells. , 1996, The American journal of physiology.
[94] David F Wilson,et al. Calibration of oxygen-dependent quenching of the phosphorescence of Pd-meso-tetra (4-carboxyphenyl) porphine: a phosphor with general application for measuring oxygen concentration in biological systems. , 1996, Analytical biochemistry.
[95] S. Thibodeau,et al. Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. , 1996, The New England journal of medicine.
[96] J. Haines,et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. , 1993, Science.
[97] A. Moreno,et al. Mitochondrial bioenergetics as affected by DDT. , 1991, Biochimica et biophysica acta.
[98] D. Vestweber,et al. A yeast mitochondrial outer membrane protein essential for protein import and cell viability , 1990, Nature.
[99] J. Breslow,et al. Expression of the human apolipoprotein E gene is regulated by multiple positive and negative elements. , 1988, The Journal of biological chemistry.
[100] H. Westerhoff,et al. Quantification of the contribution of various steps to the control of mitochondrial respiration. , 1982, The Journal of biological chemistry.
[101] R. Wu. Regulatory mechanisms in carbohydrate metabolism. V. Limiting factors of glycolysis in HeLa cells. , 1959, The Journal of biological chemistry.
[102] Tih-Shih Lee,et al. TOMM40 alterations in Alzheimer's disease over a 2-year follow-up period. , 2015, Journal of Alzheimer's disease : JAD.
[103] E. Greenfield,et al. Antibodies : a laboratory manual , 2014 .
[104] Tih-Shih Lee,et al. Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease. , 2013, Journal of Alzheimer's disease : JAD.
[105] R. Zeh. Neurological and molecular biological characterisation of the mutant mouse line Tom40 , 2013 .
[106] C. Graff,et al. Biochemical studies of poly-T variants in the Alzheimer's disease associated TOMM40 gene. , 2012, Journal of Alzheimer's disease : JAD.
[107] Jason J. Corneveaux,et al. Reduced posterior cingulate mitochondrial activity in expired young adult carriers of the APOE ε4 allele, the major late-onset Alzheimer's susceptibility gene. , 2010, Journal of Alzheimer's disease : JAD.
[108] P. Reddy,et al. Differential expression of oxidative phosphorylation genes in patients with Alzheimer’s disease , 2007, NeuroMolecular Medicine.
[109] H. Anandatheerthavarada,et al. Mitochondrial Translocation of Amyloid Precursor Protein and its Cleaved Products: Relevance to Mitochondrial Dysfunction in Alzheimer's Disease , 2007, Reviews in the neurosciences.
[110] A. Eckert,et al. Mitochondrial dysfunction induced by disease relevant AbetaPP and tau protein mutations. , 2006, Journal of Alzheimer's disease : JAD.
[111] O. Pereira-smith,et al. 3D Reconstruction and Localization of Mortalin by Deconvolution Microscopy , 2002 .
[112] R. Brigelius-Flohé,et al. ATP‐sensitive association of mortalin with the IL‐1 receptor type I , 1999, BioFactors.
[113] M A Pericak-Vance,et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. , 1993, Neurology.
[114] M. Michikawa,et al. Molecular Neurodegeneration Apolipoprotein E4 (1–272) Fragment Is Associated with Mitochondrial Proteins and Affects Mitochondrial Function in Neuronal Cells , 2022 .