Axilla surface area for males and females: measured distribution.

With the recent introduction of exposure-based Quantitative Risk Assessment (QRA) as an approach to the evaluation, of materials in finished consumer products that are potential dermal sensitizers, the need for robust exposure data was clearly identified. The objective of this current study is to provide a value for the axilla surface area (SA) that is statistically derived and can be used in dermal sensitization QRA for ingredients of personal care products meant for use on the axilla. The axilla surface area measured for 60 men and 60 women resulted in a median surface area for a single axilla of 64.5 cm(2) for females and 135.5 cm(2) for males. These participants were representative of the United States population in their range of heights and weights. Furthermore, combining these surface area data with measured use data from this and other studies has enabled calculations of consumer exposure to solid APDO products on a dose/unit area/day basis (9.1 mg/cm(2)/d).

[1]  M. F. Fuller,et al.  Practical Nonparametric Statistics; Nonparametric Statistical Inference , 1973 .

[2]  A. Kligman.  The identification of contact allergens by human assay. II. Factors influencing the induction and measurement of allergic contact dermatitis. , 1966, The Journal of investigative dermatology.

[3]  S. Shapiro,et al.  An Analysis of Variance Test for Normality (Complete Samples) , 1965 .

[4]  D. D. Bois,et al.  CLINICAL CALORIMETRY: TENTH PAPER A FORMULA TO ESTIMATE THE APPROXIMATE SURFACE AREA IF HEIGHT AND WEIGHT BE KNOWN , 1916 .

[5]  H. Maibach,et al.  Influence of area of application of allergen on sensitization in contact dermatitis , 1992, Contact dermatitis.

[6]  R. Winkelmann.  Some unusual histochemical properties of kangaroo skin. , 1966, The Journal of investigative dermatology.

[7]  Howard I. Maibach,et al.  Models in dermatology , 1987 .

[8]  A. M. Api,et al.  Exposure data for cosmetic products: lipstick, body lotion, and face cream. , 2005, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[9]  W. J. Conover,et al.  Practical Nonparametric Statistics , 1972 .

[10]  G F Gerberick,et al.  The importance of exposure estimation in the assessment of skin sensitization risk , 2000, Contact dermatitis.

[11]  J A Mattar,et al.  A simple calculation to estimate body surface area in adults and its correlation with the Du Bois formula. , 1989, Critical care medicine.

[12]  H. Costeff.  A simple empirical formula for calculating approximate surface area in children. , 1966, Archives of disease in childhood.

[13]  Anne Marie Api,et al.  Exposure data for personal care products: hairspray, spray perfume, liquid foundation, shampoo, body wash, and solid antiperspirant. , 2006, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[14]  Wen-Ko Chiou,et al.  The 3D scanner for measuring body surface area: a simplified calculation in the Chinese adult. , 2003, Applied ergonomics.

[15]  A. Kligman,et al.  Allergic contact dermatitis in the guinea pig : identifications of contact allergens , 1970 .

[16]  Wilfried De Backer,et al.  Body surface area in normal-weight, overweight, and obese adults. A comparison study. , 2006, Metabolism: clinical and experimental.

[17]  E. Livingston,et al.  Body surface area prediction in normal-weight and obese patients. , 2001, American journal of physiology. Endocrinology and metabolism.

[18]  C McNamara,et al.  Probabilistic modelling of European consumer exposure to cosmetic products. , 2007, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[19]  J. Konz,et al.  Exposure factors handbook , 1989 .

[20]  G. Schwartz,et al.  Geometric method for measuring body surface area: a height-weight formula validated in infants, children, and adults. , 1978, The Journal of pediatrics.

[21]  G Frank Gerberick,et al.  Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients. , 2008, Regulatory toxicology and pharmacology : RTP.

[22]  S. Tsai,et al.  Psoriasis vulgaris in Chinese individuals is associated with PSORS1C3 and CDSN genes , 2006, The British journal of dermatology.

[23]  G Frank Gerberick,et al.  Application of the risk assessment paradigm to the induction of allergic contact dermatitis. , 2003, Regulatory toxicology and pharmacology : RTP.

[24]  S. Felter,et al.  Understanding fragrance allergy using an exposure‐based risk assessment approach , 2001, Contact dermatitis.

[25]  E. Boyd,et al.  The Growth of the Surface Area of the Human Body. , 1935 .

[26]  Bremmer Hj,et al.  Cosmetics Fact Sheet. To assess the risks for the consumer. Updated version for ConsExpo 4 , 2006 .

[27]  D. DuBois,et al.  A formula to estimate the approximate surface area if height and weight be known , 1989 .

[28]  C McNamara,et al.  European consumer exposure to cosmetic products, a framework for conducting population exposure assessments. , 2007, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[29]  G Frank Gerberick,et al.  A review of the scientific basis for uncertainty factors for use in quantitative risk assessment for the induction of allergic contact dermatitis , 2002, Contact dermatitis.

[30]  E. Gehan,et al.  Estimation of human body surface area from height and weight. , 1970, Cancer chemotherapy reports.

[31]  P. Friedmann,et al.  The effect of altering area of application and dose per unit area on sensitization by DNCB , 1986, The British journal of dermatology.

[32]  Mosteller Rd.  Simplified Calculation of Body-Surface Area , 1987 .

[33]  More on simplified calculation of body-surface area. , 1988 .