Degeneration of patellar cartilage in patients with recurrent patellar dislocation following conservative treatment: evaluation with delayed gadolinium-enhanced magnetic resonance imaging of cartilage.

OBJECTIVE To examine the characteristics of cartilage degeneration in patients with recurrent patellar dislocation (RPD) following conservative treatment using delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC). DESIGN This study evaluated three groups of knees: group I, 35 knees from both knees of patients with bilateral RPD and dislocated side knees of patients with unilateral RPD; group II, 15 non-dislocated side knees of patients with unilateral RPD; and group III, 20 knees from both knees of healthy volunteers. Differences in post-contrast T1 [T1(Gd)] of cartilage at both medial and lateral facets between groups I, II and III were analyzed. For group I, possible relationships were evaluated between T1(Gd) of cartilage and patient age, length of time between the initial dislocation and MRI and the total number of dislocations between the initial dislocation and MRI for both medial and lateral facets. RESULTS The mean T1(Gd) of cartilage at medial facets for groups I, II and III were 411+/-46ms, 465+/-38ms and 490+/-29ms, respectively; there were significant differences between these means (P<0.05). The mean T1(Gd) of cartilage at lateral facets for groups I, II and III were 426+/-53ms, 466+/-45ms and 510+/-36ms, respectively; there were also significant differences between these means (P<0.05). Significant correlations were observed between T1(Gd) of cartilage for both medial and lateral facets and length of time between the initial dislocation and MRI (P<0.05). No other correlations were significant. CONCLUSION dGEMRIC may be a useful method to monitor glycosaminoglycan concentration in patients with RPD following conservative treatment.

[1]  L. White,et al.  Imaging of patellofemoral disorders. , 2004, Clinical radiology.

[2]  Takayuki Obata,et al.  Effect of multislice acquisition on T1 and T2 measurements of articular cartilage at 3T , 2007, Journal of magnetic resonance imaging : JMRI.

[3]  M. Deimling,et al.  Three‐dimensional delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) for in vivo evaluation of reparative cartilage after matrix‐associated autologous chondrocyte transplantation at 3.0T: Preliminary results , 2007 .

[4]  D. Burstein,et al.  Gd‐DTPA2− as a measure of cartilage degradation , 1996, Magnetic resonance in medicine.

[5]  K. T. Scott,et al.  Protocol issues for delayed Gd(DTPA)2–‐enhanced MRI (dGEMRIC) for clinical evaluation of articular cartilage , 2001, Magnetic resonance in medicine.

[6]  Charles A McKenzie,et al.  Delayed gadolinium-enhanced magnetic resonance imaging of cartilage in knee osteoarthritis: findings at different radiographic stages of disease and relationship to malalignment. , 2005, Arthritis and rheumatism.

[7]  E. Nomura,et al.  Cartilage Lesions of the Patella in Recurrent Patellar Dislocation , 2004, The American journal of sports medicine.

[8]  F Eckstein,et al.  A non-invasive technique for 3-dimensional assessment of articular cartilage thickness based on MRI. Part 2: Validation using CT arthrography. , 1997, Magnetic resonance imaging.

[9]  J. Goodfellow,et al.  Patello-femoral joint mechanics and pathology. 2. Chondromalacia patellae. , 1976, The Journal of bone and joint surgery. British volume.

[10]  D. Burstein,et al.  Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRI , 1999, Magnetic resonance in medicine.

[11]  Carl Johan Tiderius,et al.  Delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) in early knee osteoarthritis , 2003, Magnetic resonance in medicine.

[12]  E. Roos,et al.  Positive effects of moderate exercise on glycosaminoglycan content in knee cartilage: a four-month, randomized, controlled trial in patients at risk of osteoarthritis. , 2005, Arthritis and rheumatism.

[13]  H. Potter,et al.  Magnetic Resonance Imaging of Articular Cartilage in the Knee. An Evaluation with Use of Fast-Spin-Echo Imaging* , 1998, The Journal of bone and joint surgery. American volume.

[14]  J. B. Kneeland,et al.  Effect of intersection spacing on MR image contrast and study time. , 1986, Radiology.

[15]  G E Santyr,et al.  Magnetization transfer effects in multislice MR imaging. , 1993, Magnetic resonance imaging.

[16]  Felix Eckstein,et al.  Accuracy and precision of quantitative assessment of cartilage morphology by magnetic resonance imaging at 3.0T. , 2005, Arthritis and rheumatism.

[17]  P. Loff,et al.  Die habituelle Patellarluxation als präarthrotische Deformität , 1969 .

[18]  R M Rose,et al.  Is chondromalacia patellae a separate clinical entity? , 1978, The Journal of bone and joint surgery. British volume.

[19]  H. Imhof,et al.  The role of relaxation times in monitoring proteoglycan depletion in articular cartilage , 1999, Journal of magnetic resonance imaging : JMRI.

[20]  P. Leander,et al.  Delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC): intra‐ and interobserver variability in standardized drawing of regions of interest , 2004, Acta radiologica.

[21]  D Resnick,et al.  Magnetic resonance imaging of articular cartilage: an overview. , 1998, Topics in magnetic resonance imaging : TMRI.

[22]  J. Svensson,et al.  dGEMRIC (delayed gadolinium‐enhanced MRI of cartilage) indicates adaptive capacity of human knee cartilage , 2004, Magnetic resonance in medicine.

[23]  C. Ficat [Cartilage of the patella]. , 1980, Revue de chirurgie orthopedique et reparatrice de l'appareil moteur.

[24]  T. Stammberger,et al.  Determination of 3D cartilage thickness data from MR imaging: Computational method and reproducibility in the living , 1999, Magnetic resonance in medicine.

[25]  J. Insall,et al.  Chondromalacia Patellae. A prospective study. , 1976, The Journal of bone and joint surgery. American volume.

[26]  A. Maroudas,et al.  Topographical Variation of Glycosaminoglycan Content in Normal and Fibrillated Tissue , 2022 .

[27]  D. Burstein,et al.  Hip dGEMRIC in asymptomatic volunteers and patients with early osteoarthritis: The influence of timing after contrast injection , 2007, Magnetic resonance in medicine.

[28]  Pottumarthi Prasad,et al.  Three-Dimensional T1 Mapping for dGEMRIC at 3.0 T Using the Look Locker Method , 2006, Investigative radiology.

[29]  A. Heywood RECURRENT DISLOCATION OF THE PATELLA , 1961 .

[30]  E. Mcnally,et al.  Assessment of patellar maltracking using combined static and dynamic MRI , 2000, European Radiology.

[31]  D. Burstein,et al.  Glycosaminoglycan in articular cartilage: in vivo assessment with delayed Gd(DTPA)(2-)-enhanced MR imaging. , 1997, Radiology.

[32]  L. Sharma,et al.  dGEMRIC as a function of BMI. , 2006, Osteoarthritis and cartilage.

[33]  F Eckstein,et al.  Non-invasive determination of cartilage thickness throughout joint surfaces using magnetic resonance imaging. , 1997, Journal of biomechanics.