HIV-1 transcriptional regulation in the central nervous system and implications for HIV cure research

[1]  B. Brew,et al.  Update on HIV Dementia and HIV-Associated Neurocognitive Disorders , 2014, Current Neurology and Neuroscience Reports.

[2]  M. Churchill,et al.  HIV-1 Entry and Trans-Infection of Astrocytes Involves CD81 Vesicles , 2014, PloS one.

[3]  Suha M. Saleh,et al.  Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells , 2013, AIDS.

[4]  S. Lewin,et al.  The search for an HIV cure: tackling latent infection. , 2013, The Lancet. Infectious diseases.

[5]  M. Churchill,et al.  Where does HIV hide? A focus on the central nervous system , 2013, Current opinion in HIV and AIDS.

[6]  M. Churchill,et al.  The NRTIs Lamivudine, Stavudine and Zidovudine Have Reduced HIV-1 Inhibitory Activity in Astrocytes , 2013, PloS one.

[7]  E. Masliah,et al.  Molecular and pathologic insights from latent HIV-1 infection in the human brain , 2013, Neurology.

[8]  M. Churchill,et al.  Is specific HIV eradication from the brain possible or needed? , 2013, Expert opinion on biological therapy.

[9]  S. Lewin,et al.  Comparison of HDAC inhibitors in clinical development , 2013, Human vaccines & immunotherapeutics.

[10]  M. Churchill,et al.  Reduced basal transcriptional activity of central nervous system-derived HIV type 1 long terminal repeats. , 2012, AIDS research and human retroviruses.

[11]  R. Siliciano,et al.  Redefining the viral reservoirs that prevent HIV-1 eradication. , 2012, Immunity.

[12]  P. Kubes,et al.  Immune surveillance in the central nervous system , 2012, Nature Neuroscience.

[13]  J. Eron,et al.  Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy , 2012, Nature.

[14]  S. Deeks.  HIV: Shock and kill , 2012, Nature.

[15]  M. Lederman,et al.  Towards an HIV cure: a global scientific strategy , 2012, Nature Reviews Immunology.

[16]  I. Sadowski,et al.  The Suv39H1 methyltransferase inhibitor chaetocin causes induction of integrated HIV‐1 without producing a T cell response , 2011, FEBS letters.

[17]  M. Law,et al.  Does use of antiretroviral therapy regimens with high central nervous system penetration improve survival in HIV‐infected adults? , 2011, HIV medicine.

[18]  H. Sørensen,et al.  Impact of Non-HIV and HIV Risk Factors on Survival in HIV-Infected Patients on HAART: A Population-Based Nationwide Cohort Study , 2011, PloS one.

[19]  R. Siliciano,et al.  Disulfiram Reactivates Latent HIV-1 in a Bcl-2-Transduced Primary CD4+ T Cell Model without Inducing Global T Cell Activation , 2011, Journal of Virology.

[20]  D. Kolson,et al.  Development of co-selected single nucleotide polymorphisms in the viral promoter precedes the onset of human immunodeficiency virus type 1-associated neurocognitive impairment , 2011, Journal of NeuroVirology.

[21]  D. Fuchs,et al.  Treatment Intensification Has no Effect on the HIV-1 Central Nervous System Infection in Patients on Suppressive Antiretroviral Therapy , 2010, Journal of acquired immune deficiency syndromes.

[22]  Michael J. Taylor,et al.  HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy , 2010, Neurology.

[23]  C. Van Lint,et al.  HIV Persistence and the Prospect of Long-Term Drug-Free Remissions for HIV-Infected Individuals , 2010, Science.

[24]  C. Van Lint,et al.  HIV‐1 regulation of latency in the monocyte‐macrophage lineage and in CD4+ T lymphocytes , 2010, Journal of leukocyte biology.

[25]  T. Okamoto,et al.  Involvement of Histone H3 Lysine 9 (H3K9) Methyltransferase G9a in the Maintenance of HIV-1 Latency and Its Reactivation by BIX01294* , 2010, The Journal of Biological Chemistry.

[26]  Libin Rong,et al.  Modeling HIV persistence, the latent reservoir, and viral blips. , 2009, Journal of theoretical biology.

[27]  M. Churchill,et al.  Extensive astrocyte infection is prominent in human immunodeficiency virus–associated dementia , 2009, Annals of neurology.

[28]  E. Verdin,et al.  Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation , 2009, PLoS pathogens.

[29]  Yujie Liu,et al.  CCAAT/enhancer-binding proteins and the pathogenesis of retrovirus infection. , 2009, Future microbiology.

[30]  Steven Wolinsky,et al.  High frequency of defective vpu compared with tat and rev genes in brain from patients with HIV type 1-associated dementia. , 2007, AIDS research and human retroviruses.

[31]  A. Knezevich,et al.  Suv39H1 and HP1γ are responsible for chromatin‐mediated HIV‐1 transcriptional silencing and post‐integration latency , 2007, The EMBO journal.

[32]  B. Melchior,et al.  CNS immune privilege: hiding in plain sight , 2006, Immunological reviews.

[33]  Matthias Cavassini,et al.  CD4-guided scheduled treatment interruptions compared with continuous therapy for patients infected with HIV-1: results of the Staccato randomised trial , 2006, The Lancet.

[34]  M. Churchill,et al.  Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues , 2006, Journal of NeuroVirology.

[35]  J. Clements,et al.  Mechanism for the establishment of transcriptional HIV latency in the brain in a simian immunodeficiency virus-macaque model. , 2006, The Journal of infectious diseases.

[36]  J. Howard,et al.  Low TRBP Levels Support an Innate Human Immunodeficiency Virus Type 1 Resistance in Astrocytes by Enhancing the PKR Antiviral Response , 2005, Journal of Virology.

[37]  M. Thomson,et al.  IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART. , 2005, The Journal of clinical investigation.

[38]  M. Churchill,et al.  Astrocyte specific viral strains in HIV dementia , 2004, Annals of neurology.

[39]  Yujie Liu,et al.  Specific sequence configurations of HIV-1 LTR G/C box array result in altered recruitment of Sp isoforms and correlate with disease progression , 2004, Journal of Neuroimmunology.

[40]  F. Krebs,et al.  High-affinity interaction between HIV-1 Vpr and specific sequences that span the C/EBP and adjacent NF-kappaB sites within the HIV-1 LTR correlate with HIV-1-associated dementia. , 2004, DNA and cell biology.

[41]  B. Brew,et al.  Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification , 2004, Journal of leukocyte biology.

[42]  B. Korber,et al.  Genetic and Functional Analysis of Full-Length Human Immunodeficiency Virus Type 1 env Genes Derived from Brain and Blood of Patients with AIDS , 2003, Journal of Virology.

[43]  D. Purcell,et al.  Astrocyte infection by HIV-1: mechanisms of restricted virus replication, and role in the pathogenesis of HIV-1-associated dementia. , 2003, Current HIV research.

[44]  R. Siliciano,et al.  Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells , 2003, Nature Medicine.

[45]  R. Beschorner.  Human brain parenchymal microglia express CD14 and CD45 and are productively infected by HIV-1 in HIV-1 encephalitis. , 2003, Brain pathology.

[46]  Kuan-Teh Jeang,et al.  Tat and Trans-activation-responsive (TAR) RNA-independent Induction of HIV-1 Long Terminal Repeat by Human and Murine Cyclin T1 Requires Sp1* , 2003, The Journal of Biological Chemistry.

[47]  G. Bren,et al.  NF-κB cis-Acting Motifs of the Human Immunodeficiency Virus (HIV) Long Terminal Repeat Regulate HIV Transcription in Human Macrophages , 2001, Journal of Virology.

[48]  M. Boyd,et al.  Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART. , 2001, Blood.

[49]  Sandy D. Westerheide,et al.  The p65 (RelA) Subunit of NF-κB Interacts with the Histone Deacetylase (HDAC) Corepressors HDAC1 and HDAC2 To Negatively Regulate Gene Expression , 2001, Molecular and Cellular Biology.

[50]  B. Peterlin,et al.  NF-κB Binds P-TEFb to Stimulate Transcriptional Elongation by RNA Polymerase II , 2001 .

[51]  D. Aunis,et al.  Functional Interactions between C/EBP, Sp1, and COUP-TF Regulate Human Immunodeficiency Virus Type 1 Gene Transcription in Human Brain Cells , 2000, Journal of Virology.

[52]  E. Major,et al.  Nonproductive human immunodeficiency virus type 1 infection of human fetal astrocytes: independence from CD4 and major chemokine receptors. , 1999, Virology.

[53]  Achim Leutz,et al.  A C/EBPβ Isoform Recruits the SWI/SNF Complex to Activate Myeloid Genes , 1999 .

[54]  G. Suske.  The Sp-family of transcription factors. , 1999, Gene.

[55]  E. Wintersberger,et al.  Histone Deacetylase 1 Can Repress Transcription by Binding to Sp1 , 1999, Molecular and Cellular Biology.

[56]  M. Churchill,et al.  Diminished Production of Human Immunodeficiency Virus Type 1 in Astrocytes Results from Inefficient Translation ofgag, env, and nef mRNAs despite Efficient Expression of Tat and Rev , 1999, Journal of Virology.

[57]  K. Webster,et al.  Hypoxia Regulates β-Enolase and Pyruvate Kinase-M Promoters by Modulating Sp1/Sp3 Binding to a Conserved GC Element* , 1998, The Journal of Biological Chemistry.

[58]  Anthony S. Fauci,et al.  Induction of HIV-1 Replication in Latently Infected CD4+ T Cells Using a Combination of Cytokines , 1998, The Journal of experimental medicine.

[59]  G. Nabel,et al.  HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[60]  K. Klempnauer,et al.  Interaction and functional collaboration of p300 and C/EBPbeta , 1997, Molecular and cellular biology.

[61]  R. Gaynor,et al.  In Vitro Chromatin Assembly of the HIV-1 Promoter , 1997, The Journal of Biological Chemistry.

[62]  C. Van Lint,et al.  Transcriptional activation and chromatin remodeling of the HIV‐1 promoter in response to histone acetylation. , 1996, The EMBO journal.

[63]  O. Narayan,et al.  Interaction of Virion Protein Vpr of Human Immunodeficiency Virus Type 1 with Cellular Transcription Factor Sp1 and trans-Activation of Viral Long Terminal Repeat (*) , 1995, The Journal of Biological Chemistry.

[64]  M. Beato,et al.  Functional Analyses of the Transcription Factor Sp4 Reveal Properties Distinct from Sp1 and Sp3 (*) , 1995, The Journal of Biological Chemistry.

[65]  K. Calame,et al.  C/EBP proteins activate transcription from the human immunodeficiency virus type 1 long terminal repeat in macrophages/monocytes , 1995, Journal of virology.

[66]  J. Church.  HIV-1 INFECTION OF SUBCORTICAL ASTROCYTES IN THE PEDIATRIC CENTRAL NERVOUS SYSTEM , 1995, Pediatrics.

[67]  Margaret A. Johnson,et al.  Distinct HIV‐1 long terminal repeat quasispecies present in nervous tissues compared to that in lung, blood and lymphoid tissues of an AIDS patient , 1995, AIDS.

[68]  G. Kreutzberg,et al.  Microglia: Intrinsic immuneffector cell of the brain , 1995, Brain Research Reviews.

[69]  D. Weiner,et al.  Extracellular Vpr protein increases cellular permissiveness to human immunodeficiency virus replication and reactivates virus from latency , 1995, Journal of virology.

[70]  R. Roeder,et al.  Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators , 1995, Science.

[71]  L. Lania,et al.  Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1. , 1994, Nucleic acids research.

[72]  D. Weiner,et al.  Serum Vpr regulates productive infection and latency of human immunodeficiency virus type 1. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[73]  A. Emili,et al.  Species-specific interaction of the glutamine-rich activation domains of Sp1 with the TATA box-binding protein. , 1994, Molecular and cellular biology.

[74]  G. Nabel,et al.  A cooperative interaction between NF‐kappa B and Sp1 is required for HIV‐1 enhancer activation. , 1993, The EMBO journal.

[75]  A. Baldwin,et al.  Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation , 1993, Molecular and cellular biology.

[76]  M. Beato,et al.  Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes. , 1992, Nucleic acids research.

[77]  C. Kufta,et al.  Specific tropism of HIV-1 for microglial cells in primary human brain cultures. , 1990, Science.

[78]  G. Nabel,et al.  Activation of HIV gene expression during monocyte differentiation by induction of NF-kB , 1989, Nature.

[79]  P. Armbruster,et al.  Creating Superheavy Elements , 1989 .

[80]  D. Baltimore,et al.  I kappa B: a specific inhibitor of the NF-kappa B transcription factor. , 1988, Science.

[81]  Robert Tjian,et al.  Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain , 1987, Cell.

[82]  G. Nabel,et al.  An inducible transcription factor activates expression of human immunodeficiency virus in T cells , 1987, Nature.

[83]  C. Wiley,et al.  Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[84]  R. Tjian,et al.  Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1. , 1986, Science.

[85]  Gundo Weiler,et al.  Global Update on HIV Treatment 2013: Results, Impact and Opportunities , 2013 .

[86]  F. Krebs,et al.  Structural and functional evolution of human immunodeficiency virus type 1 long terminal repeat CCAAT/enhancer binding protein sites and their use as molecular markers for central nervous system disease progression , 2011, Journal of NeuroVirology.

[87]  J. McArthur,et al.  HIV-1 LTR C/EBP binding site sequence configurations preferentially encountered in brain lead to enhanced C/EBP factor binding and increased LTR-specific activity , 2011, Journal of NeuroVirology.

[88]  T. Burdo,et al.  Region-specific distribution of human immunodeficiency virus type 1 long terminal repeats containing specific configurations of CCAAT/enhancer-binding protein site II in brains derived from demented and nondemented patients , 2011, Journal of NeuroVirology.

[89]  E. De Clercq,et al.  NF-kappaB: the inducible factors of HIV-1 transcription and their inhibitors. , 2009, Mini reviews in medicinal chemistry.

[90]  I. Grant,et al.  Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system. , 2008, Archives of neurology.

[91]  J. Alam,et al.  NF-κB site-mediated negative regulation of the HIV-1 promoter by CCAAT/enhancer binding proteins in brain-derived cells , 2007, Journal of Molecular Neuroscience.

[92]  Francisco González-Scarano,et al.  The neuropathogenesis of AIDS , 2005, Nature Reviews Immunology.

[93]  B. Peterlin,et al.  NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II. , 2001, Molecular cell.

[94]  J. Glass,et al.  Localization of HIV-1 DNA and tumor necrosis factor-alpha mRNA in human brain using polymerase chain reaction in situ hybridization and immunocytochemistry. , 2000, Methods in molecular biology.

[95]  R. Siliciano,et al.  Reservoirs for HIV-1: mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy. , 2000, Annual review of immunology.

[96]  A. Leutz,et al.  A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes. , 1999, Molecular cell.

[97]  A. Kleinschmidt,et al.  Restricted expression of HIV1 in human astrocytes: molecular basis for viral persistence in the CNS. , 1994, Research in virology.

[98]  G. Nabel,et al.  An inducible transcription factor activates expression of human immunodeficiency virus in T cells , 1990, Nature.

[99]  A. Emili,et al.  the TATA box-binding protein . glutamine-rich activation domains of Sp 1 with Species-specific interaction of the , 2022 .