Sleep deprivation impairs long-term potentiation in rat hippocampal slices.

To determine if 12-h sleep deprivation disrupts neural plasticity, we compared long-term potentiation (LTP) in five sleep-deprived and five control rats. Thirty minutes after tetanus population spike amplitude increased 101 +/- 15% in 16 slices from sleep deprived rats and 139 +/- 14% in 14 slices from control rats. This significant (P < 0.05) reduction of LTP, the first demonstration that the sleep deprivation protocol impairs plasticity in adult rats, may be due to several factors. Reduced LTP may indicate that sleep provides a period of recuperation for cellular processes underlying neural plasticity. Alternatively, the stress of sleep deprivation, as indicated by elevated blood corticosterone levels, or other non-sleep-specific factors of deprivation may contribute to the LTP reduction.

[1]  M. Stryker,et al.  Sleep Enhances Plasticity in the Developing Visual Cortex , 2001, Neuron.

[2]  J. Horne,et al.  Prefrontal neuropsychological effects of sleep deprivation in young adults--a model for healthy aging? , 2000, Sleep.

[3]  G. Tononi,et al.  Differential Expression of Plasticity-Related Genes in Waking and Sleep and Their Regulation by the Noradrenergic System , 2000, The Journal of Neuroscience.

[4]  Maria L. Thomas,et al.  Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity , 2000, Journal of sleep research.

[5]  J. Born,et al.  Early sleep triggers memory for early visual discrimination skills , 2000, Nature Neuroscience.

[6]  G. Tononi,et al.  Gene expression in the brain across the sleep–waking cycle 1 1 Published on the World Wide Web on 30 October 2000. , 2000, Brain Research.

[7]  Bruce S. McEwen,et al.  The neurobiology of stress: from serendipity to clinical relevance. , 2000, Brain research.

[8]  D. Rapp,et al.  Exercise influences spatial learning in the radial arm maze , 2000, Physiology & Behavior.

[9]  R. Nicoll,et al.  Long-term potentiation--a decade of progress? , 1999, Science.

[10]  J. Sarvey,et al.  Acute cold stress leading to elevated corticosterone neither enhances synaptic efficacy nor impairs LTP in the dentate gyrus of freely moving rats , 1998, Brain Research.

[11]  M. Mishkin,et al.  Positive Correlations Between Cerebral Protein Synthesis Rates and Deep Sleep in Macaca mulatta , 1997, The European journal of neuroscience.

[12]  Donna H. Ryan,et al.  Sleep Deprivation by the “Flower Pot” Technique and Spatial Reference Memory , 1997, Physiology & Behavior.

[13]  H. Roffwarg,et al.  Rapid eye movement sleep deprivation in kittens amplifies LGN cell-size disparity induced by monocular deprivation. , 1996, Brain research. Developmental brain research.

[14]  I. Feinberg,et al.  Noncompetitive NMDA channel blockade during waking intensely stimulates NREM delta. , 1996, The Journal of pharmacology and experimental therapeutics.

[15]  Carlyle T. Smith,et al.  Sleep states and memory processes , 1995, Behavioural Brain Research.

[16]  D. Diamond,et al.  Inverted‐U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation , 1992, Hippocampus.

[17]  P. Ramm,et al.  Rates of cerebral protein synthesis are linked to slow wave sleep in the rat , 1990, Physiology & Behavior.

[18]  H C Thode,et al.  Gamma distribution model describes maturational curves for delta wave amplitude, cortical metabolic rate and synaptic density. , 1990, Journal of theoretical biology.

[19]  C. Bramham,et al.  Synaptic plasticity in the hippocampus is modulated by behavioral state , 1989, Brain Research.

[20]  Richard F. Thompson,et al.  Inescapable versus escapable shock modulates long-term potentiation in the rat hippocampus. , 1989, Science.

[21]  J. Horne.  Sleep loss and "divergent" thinking ability. , 1988, Sleep.

[22]  S Levine,et al.  Behavioral stress impairs long-term potentiation in rodent hippocampus. , 1987, Behavioral and neural biology.

[23]  A. Borbély,et al.  Sleep EEG in the rat as a function of prior waking. , 1986, Electroencephalography and clinical neurophysiology.

[24]  I Feinberg,et al.  Changes in sleep cycle patterns with age. , 1974, Journal of psychiatric research.

[25]  A. Borbély.  A two process model of sleep regulation. , 1982, Human neurobiology.

[26]  G. Moruzzi.  The Functional Significance of Sleep with Particular Regard to the Brain Mechanisms Underlying Consciousness , 1965 .