Pulmonary periarterial inflammation in fatal asthma

Background To date, little information has been available about pulmonary artery pathology in asthma. The pulmonary artery supplies the distal parts of the lungs and likely represents a site of immunological reaction in allergic inflammation. The objective of this study was to describe the inflammatory cell phenotype of pulmonary artery adventitial inflammation in lung tissue from patients who died of asthma.

[1]  J. Erjefält,et al.  Novel site-specific mast cell subpopulations in the human lung , 2009, Thorax.

[2]  Seung Yong Park,et al.  Mast cells can mediate vascular permeability through regulation of the PI3K-HIF-1alpha-VEGF axis. , 2008, American journal of respiratory and critical care medicine.

[3]  C. Carvalho,et al.  Aerobic conditioning and allergic pulmonary inflammation in mice. II. Effects on lung vascular and parenchymal inflammation and remodeling. , 2008, American journal of physiology. Lung cellular and molecular physiology.

[4]  E. Chilvers,et al.  Advances in neutrophil biology: clinical implications. , 2008, Chest.

[5]  A. James,et al.  Extracellular matrix components and regulators in the airway smooth muscle in asthma , 2008, European Respiratory Journal.

[6]  C. Brightling,et al.  Inflammatory cell microlocalisation and airway dysfunction: cause and effect? , 2007, European Respiratory Journal.

[7]  J. Alcorn,et al.  Transforming Growth Factor-β1 Suppresses Airway Hyperresponsiveness in Allergic Airway Disease , 2007 .

[8]  A. Chetta,et al.  Chymase-positive mast cells play a role in the vascular component of airway remodeling in asthma. , 2007, The Journal of allergy and clinical immunology.

[9]  D. Radzioch,et al.  Chronic asthma-induced airway remodeling is prevented by toll-like receptor-7/8 ligand S28463. , 2007, American journal of respiratory and critical care medicine.

[10]  E. Edston,et al.  Differential accumulation of pulmonary and cardiac mast cell-subsets and eosinophils between fatal anaphylaxis and asthma death: a postmortem comparative study. , 2007, Forensic science international.

[11]  K. Rabe,et al.  Differential distribution of inflammatory cells in large and small airways in smokers , 2006, Journal of Clinical Pathology.

[12]  J. Alcorn,et al.  Transforming growth factor-beta1 suppresses airway hyperresponsiveness in allergic airway disease. , 2007, American Journal of Respiratory and Critical Care Medicine.

[13]  L. Fabbri,et al.  Epithelial damage and angiogenesis in the airways of children with asthma. , 2006, American journal of respiratory and critical care medicine.

[14]  Yuchiao Chang,et al.  Regional pulmonary perfusion, inflation, and ventilation defects in bronchoconstricted patients with asthma. , 2006, American journal of respiratory and critical care medicine.

[15]  N. Suttorp,et al.  Allergic lung inflammation induces pulmonary vascular hyperresponsiveness , 2006, European Respiratory Journal.

[16]  S. Holgate,et al.  The role of the mast cell in the pathophysiology of asthma. , 2006, The Journal of allergy and clinical immunology.

[17]  E. Chi,et al.  Reversal of allergen-induced airway remodeling by CysLT1 receptor blockade. , 2006, American journal of respiratory and critical care medicine.

[18]  R. Pabst,et al.  Leukocyte Infiltration of the Periarterial Space of the Lung after Allergen Provocation in a Rat Asthma Model , 2006, Pathobiology.

[19]  A. Foresi,et al.  Vascular endothelial growth factor up‐regulation and bronchial wall remodelling in asthma , 2005, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[20]  D M Hyde,et al.  Airway generation‐specific differences in the spatial distribution of immune cells and cytokines in allergen‐challenged rhesus monkeys , 2005, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[21]  K. Rabe,et al.  Expression of the anaphylatoxin receptors C3aR and C5aR is increased in fatal asthma. , 2005, The Journal of allergy and clinical immunology.

[22]  P. Saldiva,et al.  Inflammatory cell mapping of the respiratory tract in fatal asthma , 2005, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[23]  S. Wenzel,et al.  Relationship of small airway chymase-positive mast cells and lung function in severe asthma. , 2005, American journal of respiratory and critical care medicine.

[24]  Hiroshi Tanaka,et al.  Quantitative analysis of bronchial wall vascularity in the medium and small airways of patients with asthma and COPD. , 2005, Chest.

[25]  J. Erjefält,et al.  Allergen exposure of mouse airways evokes remodeling of both bronchi and large pulmonary vessels. , 2005, American journal of respiratory and critical care medicine.

[26]  H. Saito.  Role of mast cell proteases in tissue remodeling. , 2005, Chemical immunology and allergy.

[27]  R. Pabst.  The Periarterial Space in the Lung: Its Important Role in Lung Edema, Transplantation, and Microbial or Allergic Inflammation , 2004, Pathobiology.

[28]  Wayne Mitzner,et al.  Vascular remodeling in the circulations of the lung. , 2004, Journal of applied physiology.

[29]  L. Grinberg,et al.  Abnormal alveolar attachments with decreased elastic fiber content in distal lung in fatal asthma. , 2004, American journal of respiratory and critical care medicine.

[30]  A. Ieni,et al.  Perivascular mast cells in advanced gastric adenocarcinomas: an electron microscopic study. , 2004, Anticancer research.

[31]  Y. Mekori.  The mastocyte: the "other" inflammatory cell in immunopathogenesis. , 2004, The Journal of allergy and clinical immunology.

[32]  S. Anker,et al.  Statins and the Role of Nitric Oxide in Chronic Heart Failure , 2004, Heart Failure Reviews.

[33]  C. Garrard,et al.  The pulmonary physician in critical care • 12: Acute severe asthma in the intensive care unit , 2003, Thorax.

[34]  J. Boyce.  Mast cells: beyond IgE. , 2003, The Journal of allergy and clinical immunology.

[35]  J. Wood,et al.  Mast cells mediate the microvascular inflammatory response to systemic hypoxia. , 2003, Journal of applied physiology.

[36]  F. Symon,et al.  Characterisation of adhesion receptors mediating lymphocyte adhesion to bronchial endothelium provides evidence for a distinct lung homing pathway , 2002, Thorax.

[37]  R. Pabst,et al.  Perivascular capillaries in the lung: an important but neglected vascular bed in immune reactions? , 2002, The Journal of allergy and clinical immunology.

[38]  P. Jeffery,et al.  The effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: a double-blind, placebo-controlled biopsy study. , 2002, American journal of respiratory and critical care medicine.

[39]  N. Aoike,et al.  Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis. , 2001, The Journal of allergy and clinical immunology.

[40]  C. Doerschuk.  Leukocyte trafficking in alveoli and airway passages , 2000, Respiratory research.

[41]  L. Boulet,et al.  Airway hyperresponsiveness, inflammation, and subepithelial collagen deposition in recently diagnosed versus long-standing mild asthma. Influence of inhaled corticosteroids. , 2000, American journal of respiratory and critical care medicine.

[42]  H. Kimura,et al.  Increased expression of mast cell chymase in the lungs of patients with congenital heart disease associated with early pulmonary vascular disease. , 1999, American journal of respiratory and critical care medicine.

[43]  V. Peinado,et al.  Inflammatory reaction in pulmonary muscular arteries of patients with mild chronic obstructive pulmonary disease. , 1999, American journal of respiratory and critical care medicine.

[44]  E. Minshall,et al.  Eotaxin and monocyte chemotactic protein-4 mRNA expression in small airways of asthmatic and nonasthmatic individuals. , 1999, The Journal of allergy and clinical immunology.

[45]  J. Wilson,et al.  Increased vascularity of the bronchial mucosa in mild asthma. , 1997, American journal of respiratory and critical care medicine.

[46]  M. Welle.  Development, significance, and heterogeneity of mast cells with particular regard to the mast cell‐specific proteases chymase and tryptase , 1997, Journal of leukocyte biology.

[47]  Y. Nakamura,et al.  Anti-inflammatory effects of inhaled beclomethasone dipropionate in nonatopic asthmatics. , 1996, The European respiratory journal.

[48]  S. Durham,et al.  Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa. , 1996, American journal of respiratory and critical care medicine.

[49]  M. Ebisawa,et al.  Eosinophil transendothelial migration induced by cytokines. II. Potentiation of eosinophil transendothelial migration by eosinophil-active cytokines. , 1994, Journal of immunology.

[50]  E. Wagner,et al.  Role of the bronchial circulation in ischemia-reperfusion lung injury. , 1994, Journal of applied physiology.

[51]  C E Reed,et al.  Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa? , 1993, The American review of respiratory disease.

[52]  J. Nadel,et al.  Distribution of chymase-containing mast cells in human bronchi. , 1992, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[53]  L. Fabbri,et al.  Quantitative structural analysis of peripheral airways and arteries in sudden fatal asthma. , 1991, The American review of respiratory disease.

[54]  K. Chung,et al.  e of increased airway microvascular permeability and plasma exudation in asthma , 2012 .

[55]  C. Kepley,et al.  Detection of MCT and MCTC types of human mast cells by immunohistochemistry using new monoclonal anti-tryptase and anti-chymase antibodies. , 1989, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[56]  M. Cosio,et al.  Morphologic changes in the muscular pulmonary arteries: relationship to cigarette smoking, airway disease, and emphysema. , 1980, The American review of respiratory disease.

[57]  A. Harcus,et al.  Arteries and Veins , 1975 .

[58]  K. Pump.  Distribution of bronchial arteries in the human lung. , 1972, Chest.

[59]  S. Vasli.  [BRONCHIAL CIRCULATION]. , 1964, Nordisk medicin.