A formula for human retinal ganglion cell receptive field density as a function of visual field location.

In the human eye, all visual information must traverse the retinal ganglion cells. The most numerous subclass, the midget retinal ganglion cells, are believed to underlie spatial pattern vision. Thus the density of their receptive fields imposes a fundamental limit on the spatial resolution of human vision. This density varies across the retina, declining rapidly with distance from the fovea. Modeling spatial vision of extended or peripheral targets thus requires a quantitative description of midget cell density throughout the visual field. Through an analysis of published data on human retinal topography of cones and ganglion cells, as well as analysis of prior formulas, we have developed a new formula for midget retinal ganglion cell density as a function of position in the monocular or binocular visual field.

[1]  N Drasdo,et al.  Non-linear projection of the retinal image in a wide-angle schematic eye. , 1974, The British journal of ophthalmology.

[2]  William H. Merigan,et al.  Spatio-temporal vision of macaques with severe loss of Pβ retinal ganglion cells , 1986, Vision Research.

[3]  L. Thibos,et al.  Retinal limits to the detection and resolution of gratings. , 1987, Journal of the Optical Society of America. A, Optics and image science.

[4]  S. Schein Anatomy of macaque fovea and spatial densities of neurons in foveal representation , 1988, The Journal of comparative neurology.

[5]  Christine A. Curcio,et al.  The spatial resolution capacity of human foveal retina , 1989, Vision Research.

[6]  W. Merigan,et al.  Spatial resolution across the macaque retina , 1990, Vision Research.

[7]  B. Boycott,et al.  Retinal ganglion cell density and cortical magnification factor in the primate , 1990, Vision Research.

[8]  A. Hendrickson,et al.  Human photoreceptor topography , 1990, The Journal of comparative neurology.

[9]  C. Curcio,et al.  Topography of ganglion cells in human retina , 1990, The Journal of comparative neurology.

[10]  H. Kolb,et al.  Midget ganglion cells of the parafovea of the human retina: A Study by electron microscopy and serial section reconstructions , 1991, The Journal of comparative neurology.

[11]  R. Hess,et al.  Human peripheral spatial resolution for achromatic and chromatic stimuli: limits imposed by optical and retinal factors. , 1991, The Journal of physiology.

[12]  D. Dacey,et al.  Dendritic field size and morphology of midget and parasol ganglion cells of the human retina. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[13]  D. Dacey The mosaic of midget ganglion cells in the human retina , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[14]  Paul R. Martin,et al.  Comparison of photoreceptor spatial density and ganglion cell morphology in the retina of human, macaque monkey, cat, and the marmoset Callithrix jacchus , 1996, The Journal of comparative neurology.

[15]  J. Sjöstrand,et al.  Morphometric study of the displacement of retinal ganglion cells subserving cones within the human fovea , 1999, Graefe's Archive for Clinical and Experimental Ophthalmology.

[16]  J. Sjöstrand,et al.  Quantitative estimations of foveal and extra-foveal retinal circuitry in humans , 1999, Vision Research.

[17]  Peter G. J. Barten,et al.  Contrast sensitivity of the human eye and its e ects on image quality , 1999 .

[18]  L N Thibos,et al.  Relationship between acuity for gratings and for tumbling-E letters in peripheral vision. , 1999, Journal of the Optical Society of America. A, Optics, image science, and vision.

[19]  David A. Atchison,et al.  Optics of the Human Eye , 2023 .

[20]  J. Sjöstrand,et al.  Resolution, separation of retinal ganglion cells, and cortical magnification in humans , 2001, Vision Research.

[21]  Kareem M. Ahmad,et al.  Cell density ratios in a foveal patch in macaque retina , 2003, Visual Neuroscience.

[22]  Johan Sjöstrand,et al.  The relation between resolution measurements and numbers of retinal ganglion cells in the same human subjects , 2005, Vision Research.

[23]  N. Drasdo,et al.  The length of Henle fibers in the human retina and a model of ganglion receptive field density in the visual field , 2007, Vision Research.

[24]  E. Rossi,et al.  The relationship between visual resolution and cone spacing in the human fovea , 2009, Nature Neuroscience.

[25]  Toco Y P Chui,et al.  Variation of cone photoreceptor packing density with retinal eccentricity and age. , 2011, Investigative ophthalmology & visual science.

[26]  I. Rentschler,et al.  Peripheral vision and pattern recognition: a review. , 2011, Journal of vision.