Long‐term remission of recurrent parvovirus‐B associated anemia in a renal transplant recipient induced by treatment with immunoglobulin and positive seroconversion

Abstract: Parvovirus B‐19 (PVB)‐related recurrent anemia is reported in a renal transplant recipient with long‐term remission induced by intravenous immunoglobulin and decreasing immunosuppression. Positive plasma polymerase chain reaction (PCR) and intense bone marrow infection were present at diagnosis, despite the absence of serum immunoglobulin IgG and IgM antibodies to the virus. Seroconversion against the virus was followed by long‐term remission while the plasma PCR for PVB remained positive. This case illustrates the absence of serum antibodies in an immunosuppressed host despite florid infection with the virus. Positive seroconversion in a naïve subject is associated with long‐term remission even in the presence of detectable viral DNA copies in the plasma.

[1]  M. Mihatsch,et al.  Acute renal failure in a renal allograft recipient treated with intravenous immunoglobulin. , 2002, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[2]  S. Choi,et al.  A Case of Persistent Anemia in a Renal Transplant Recipient: Association with Parvovirus B19 Infection , 2002, Scandinavian journal of infectious diseases.

[3]  E. Kraus,et al.  Pure red cell aplasia caused by Parvovirus B19 infection in solid organ transplant recipients: a case report and review of literature , 2000, Clinical transplantation.

[4]  D. Middleton,et al.  Parvovirus B19 in kidney transplant patients. , 2000, Transplantation.

[5]  P. Li,et al.  Parvovirus B19 infection causing red cell aplasia in renal transplantation on tacrolimus. , 1999, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[6]  F. Keller,et al.  Osmotic nephrosis due to high-dose immunoglobulin therapy containing sucrose (but not with glycine) in a patient with immunoglobulin A nephritis. , 1996, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[7]  J. Saldanha,et al.  Detection of human parvovirus B19 DNA in plasma pools and blood products derived from these pools: implications for efficiency and consistency of removal of B19 DNA during manufacture , 1996, British journal of haematology.

[8]  Y. Yoto,et al.  Large‐scale screening for human parvovirus B19 DNA in clinical specimens by dot blot hybridization and polymerase chain reaction , 1995, Journal of medical virology.

[9]  Y. Yoto,et al.  Incidence of human parvovirus B19 DNA detection in blood donors , 1995, British journal of haematology.

[10]  M. Brophy,et al.  Acute Renal Failure After Administration of Intravenous Immunoglobulin: Review of the Literature and Case Report , 1995, Pharmacotherapy.

[11]  M. Rudnick,et al.  Acute renal failure after intravenous immunoglobulin therapy. , 1994, The Journal of rheumatology.

[12]  N. Young,et al.  Erythrocyte P antigen: cellular receptor for B19 parvovirus. , 1993, Science.

[13]  T. Starzl,et al.  PARVOVIRUS B19 INFECTION IN PEDIATRIC TRANSPLANT PATIENTS , 1993, Transplantation.

[14]  P. Simmonds,et al.  Detection of parvovirus B19 in donated blood: a model system for screening by polymerase chain reaction , 1993, Journal of clinical microbiology.

[15]  Y. Yoto,et al.  Retrospective study on the influence of human parvovirus B19 infection among children with malignant diseases. , 1993, Acta haematologica.

[16]  P. Ao Renal failure and intravenous immunoglobulin. , 1992 .

[17]  A. Phillips Renal failure and intravenous immunoglobulin. , 1992, Clinical nephrology.

[18]  T. Török Parvovirus B19 and human disease. , 1992, Advances in internal medicine.

[19]  B. Piraino,et al.  Pulmonary and renal toxicity of intravenous immunoglobulin. , 1991, Clinical nephrology.

[20]  D. W. Jenkins,et al.  Pure red-cell aplasia of 10 years' duration due to persistent parvovirus B19 infection and its cure with immunoglobulin therapy. , 1989, The New England journal of medicine.

[21]  B. Cohen,et al.  The prevalence of antibody to human parvovirus B19 in England and Wales. , 1988, Journal of medical microbiology.