Machine learning-powered antibiotics phenotypic drug discovery

[1]  Elias Mossialos,et al.  Incentivising innovation in antibiotic drug discovery and development: progress, challenges and next steps , 2017, The Journal of Antibiotics.

[2]  P. Moja,et al.  Antibacterial agents in clinical development: an analysis of the antibacterial clinical development pipeline, including tuberculosis , 2017 .

[3]  Matthew A Cooper,et al.  Chemical philanthropy: a path forward for antibiotic discovery? , 2016, Future medicinal chemistry.

[4]  E. Brown,et al.  Antibacterial drug discovery in the resistance era , 2016, Nature.

[5]  Tse Hsien Koh,et al.  In Vitro Activities of Ceftazidime-Avibactam, Aztreonam-Avibactam, and a Panel of Older and Contemporary Antimicrobial Agents against Carbapenemase-Producing Gram-Negative Bacilli , 2015, Antimicrobial Agents and Chemotherapy.

[6]  Lisa McWilliams,et al.  Novel Antibacterial Targets and Compounds Revealed by a High-Throughput Cell Wall Reporter Assay , 2015, Journal of bacteriology.

[7]  J. Reymond The chemical space project. , 2015, Accounts of chemical research.

[8]  Felice C. Lightstone,et al.  Tricyclic GyrB/ParE (TriBE) Inhibitors: A New Class of Broad-Spectrum Dual-Targeting Antibacterial Agents , 2013, PloS one.

[9]  Wei Zheng,et al.  Phenotypic screens as a renewed approach for drug discovery. , 2013, Drug discovery today.

[10]  K. Pogliano,et al.  Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules , 2013, Proceedings of the National Academy of Sciences.

[11]  Jindan Zhou,et al.  EcoGene 3.0 , 2012, Nucleic Acids Res..

[12]  Michael C. Hout,et al.  Multidimensional Scaling , 2003, Encyclopedic Dictionary of Archaeology.

[13]  L. Silver Challenges of Antibacterial Discovery , 2011, Clinical Microbiology Reviews.

[14]  Serban Nacu,et al.  Fast and SNP-tolerant detection of complex variants and splicing in short reads , 2010, Bioinform..

[15]  Jean-Luc Wolfender,et al.  Modern approaches in the search for new lead antiparasitic compounds from higher plants. , 2009, Current drug targets.

[16]  Max Kuhn,et al.  Building Predictive Models in R Using the caret Package , 2008 .

[17]  B. Williams,et al.  Mapping and quantifying mammalian transcriptomes by RNA-Seq , 2008, Nature Methods.

[18]  Klaus Klumpp,et al.  Characterization of the Metabolic Activation of Hepatitis C Virus Nucleoside Inhibitor β-d-2′-Deoxy-2′-fluoro-2′-C-methylcytidine (PSI-6130) and Identification of a Novel Active 5′-Triphosphate Species* , 2007, Journal of Biological Chemistry.

[19]  H. Mori,et al.  Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection , 2006, Molecular systems biology.

[20]  Hinrich W. H. Göhlmann,et al.  A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis , 2005, Science.

[21]  U. Alon,et al.  Just-in-time transcription program in metabolic pathways , 2004, Nature Genetics.

[22]  Leo Breiman,et al.  Random Forests , 2001, Machine Learning.

[23]  B. Ligon,et al.  Penicillin: its discovery and early development. , 2004, Seminars in pediatric infectious diseases.

[24]  David L. Pompliano,et al.  Regulated Expression of the Escherichia coli lepB Gene as a Tool for Cellular Testing of Antimicrobial Compounds That Inhibit Signal Peptidase I In Vitro , 2002, Antimicrobial Agents and Chemotherapy.

[25]  U. Alon,et al.  Ordering Genes in a Flagella Pathway by Analysis of Expression Kinetics from Living Bacteria , 2001, Science.

[26]  Stefan Sperlich,et al.  Generalized Additive Models , 2014 .

[27]  R J Heath,et al.  Mechanism of Triclosan Inhibition of Bacterial Fatty Acid Synthesis* , 1999, The Journal of Biological Chemistry.

[28]  John M. Barnard,et al.  Chemical Similarity Searching , 1998, J. Chem. Inf. Comput. Sci..

[29]  R. Tibshirani,et al.  Generalized additive models for medical research , 1995, Statistical methods in medical research.

[30]  P. Sasieni,et al.  Generalized additive models. T. J. Hastie and R. J. Tibshirani, Chapman and Hall, London, 1990. No. of Pages: xv + 335. Price: £25. ISBN: 0‐412‐34390‐8 , 1992 .

[31]  J. H. Ward Hierarchical Grouping to Optimize an Objective Function , 1963 .