The impacts of contact lenses on the short- and long-term biochemical parameters of tear films and corneal thickness

Introduction: To investigate the effects of long- and short-term use of different types of contact lenses on corneal metabolism and corneal thickness. Materials and Method: The participants were divided into two groups in the study. In the first group, 20 of the 42 patients were administered a rigid gas-permeable lens (RGPL) with a Dk value of 92x10-11, while the remaining wore a soft contact lens with a water content of 38%. We then explored their Lactate Dehydrogenase (LHD) levels to evaluate the hypoxic effect on tear films in short- (8 hours) and long-term (2nd, 3rd, 5th months) and albumin levels to assess mechanical trauma. In the second group, the corneal thickness was measured using a Haag-Streit optical pachymeter before and at the 8th hour and 2nd month following the first set of lenses, and LDH and albumin values were simultaneously evaluated in tear film. Results: The results yielded no significant increase in tear film LDH and albumin levels in the short- and long-term in both the RGPL and the soft contact lens groups with similar age and sex distribution. In the second part, the corneal thickness measurements resulted in an increase of 5.5% in the RGPL group and 3.63% in the soft lens group at the 8th hour of lens use. However, the groups did not significantly differ by baseline corneal thickness at the 2nd-month follow-up. Similarly, there was no significant increase in LDH and albumin levels in the tear film samples of the same group. Conclusion: The absence of a long-term increase in corneal thickness and no elevated levels of albumin and LDH in tear films indicate that contact lenses fit corneal physiology.

[1]  M. Doughty,et al.  Corneal structure, transparency, thickness and optical density (densitometry), especially as relevant to contact lens wear-a review. , 2019, Contact lens & anterior eye : the journal of the British Contact Lens Association.

[2]  B. Tighe,et al.  The fall and rise of tear albumin levels: a multifactorial phenomenon. , 2013, The ocular surface.

[3]  H. Ichijima,et al.  Effects of Rigid Lens Extended Wear on Lactate Dehydrogenase Activity and Isozymes in Rabbit Tears , 1994, Cornea.

[4]  H. Ichijima,et al.  Effect of Contact-Lens-Induced Hypoxia on Lactate Dehydrogenase Activity and Isozyme in Rabbit Cornea , 1992, Cornea.

[5]  N. Brennan,et al.  Corneal pathophysiology with contact lens wear. , 1990, Survey of ophthalmology.

[6]  K. Polse,et al.  Oxygen tension under a contact lens. , 1979, Investigative ophthalmology & visual science.

[7]  N. V. van Haeringen,et al.  The origin of some enzymes in tear fluid, determined by comparative investigation with two collection methods. , 1976, Experimental eye research.

[8]  J. Friend,et al.  Biochemical Aspects of Contact Lens Wear , 1975 .

[9]  I. L. Kahán,et al.  Lactate dehydrogenase of tears and corneal epithelium. , 1975, Experimental eye research.

[10]  N. V. van Haeringen,et al.  Lactate dehydrogenase in tear fluid. , 1974, Experimental eye research.

[11]  N. V. van Haeringen,et al.  Enzymes of energy-producing metabolism in human tear fluid. , 1974, Experimental eye research.

[12]  E. Sercarz,et al.  Proteins in human tears. I. Immunoelectrophoretic patterns. , 1969, Archives of ophthalmology.

[13]  A. Josephson,et al.  IMMUNOELECTROPHORETIC STUDIES OF THE PROTEIN COMPONENTS OF NORMAL TEARS. , 1964, Journal of immunology.

[14]  Yong Li,et al.  Tear fluid protein biomarkers. , 2013, Advances in clinical chemistry.

[15]  J. Chan,et al.  Corneal thickness. , 2008, Ophthalmology.

[16]  D. Erkan,et al.  Kontakt Lensler: Materyallerin Fiziksel Özellikleri ve Çeşitleri:Derleme. , 2004 .

[17]  S. Klyce,et al.  The effects of contact lenses on the normal physiology and anatomy of the cornea: symposium summary , 1985 .

[18]  L G Carney,et al.  Diurnal variation in human tear enzymes. , 1984, Experimental eye research.

[19]  R. Mandell,et al.  Corneal swelling caused by contact lens wear. , 1970, Archives of ophthalmology.

[20]  R L Sutherland,et al.  Contact Lenses. , 1965, Canadian Medical Association journal.

[21]  M KAJIURA,et al.  [HISTORY OF CONTACT LENSES]. , 1964, Kaiin dayori. [Membership news]. Nippon Kontakuto Renzu Gakkai.

[22]  R. Khoramnia,et al.  MINISECTION: ANTERIOR SEGMENT IMAGING Central and peripheral pachymetrymeasurements according to age using the Pentacam rotating Scheimpflug camera , 2022 .