Magnetic resonance imaging of brain function

New techniques for imaging of brain function are described, which utilize magnetic resonance imaging. Echo-planar imaging (EPI), the preferred method, is introduced and technical issues are discussed. Two recent approaches for measurement of blood flow are explained: contrast agent bolus tracking and black blood perfusion. An intrinsic contrast technique, which utilizes the paramagnetism of deoxyhemoglobin, is presented. Results from experiments on functional imaging of the human brain are shown, and the specific advantages of MRI for this purpose are discussed.

[1]  S. Ogawa,et al.  Oxygenation‐sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields , 1990, Magnetic resonance in medicine.

[2]  J. Binder,et al.  Functional magnetic resonance imaging of complex human movements , 1993, Neurology.

[3]  Scott T. Grafton,et al.  Parceling of mesial frontal motor areas during ideation and movement using functional magnetic resonance imaging at 1.5 tesla , 1994, Annals of neurology.

[4]  R. Turner,et al.  Functional mapping of the human visual cortex at 4 and 1.5 tesla using deoxygenation contrast EPI , 1993, Magnetic resonance in medicine.

[5]  B. Rosen,et al.  Functional mapping of the human visual cortex by magnetic resonance imaging. , 1991, Science.

[6]  J. Binder,et al.  Functional magnetic resonance imaging of human auditory cortex , 1994, Annals of neurology.

[7]  R. S. Hinks,et al.  Time course EPI of human brain function during task activation , 1992, Magnetic resonance in medicine.

[8]  Karl J. Friston,et al.  Analysis of functional MRI time‐series , 1994, Human Brain Mapping.

[9]  E C Wong,et al.  Processing strategies for time‐course data sets in functional mri of the human brain , 1993, Magnetic resonance in medicine.

[10]  R. Turner,et al.  Echo-planar imaging: magnetic resonance imaging in a fraction of a second. , 1991, Science.

[11]  R. Turner,et al.  Echo‐planar time course MRI of cat brain oxygenation changes , 1991, Magnetic resonance in medicine.

[12]  G. Radda,et al.  Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field. , 1982, Biochimica et biophysica acta.