BIOTRANSFORMATION OF α-SANTONIN

AbstractBacillus cereus UI-1477 was able to convert α-santonin into one major metabolite with a 64% yield. The structure of the obtained metabolite was suggested with 1D and 2D 1H-, 13C-NMR as 1,2-dihydrosantonin. Biological evaluation showed a complete loss of both anthelmintic and antimicrobial activity of 1,2-dihydrosantonin in comparison to α-santonin.

[1]  R. Rogers,et al.  Preparation, characterization, and antiviral activity of microbial metabolites of stemodin. , 1991, Journal of natural products.

[2]  C. D. Hufford,et al.  Microbial transformations of stemodin, a Stemodia diterpene , 1991 .

[3]  A. Mikami,et al.  Studies on the terpenoids and related alicyclic compounds. XXXVI: Chemical and microbiological transformations of l-α-santonin into 8-epiartemisin , 1986 .

[4]  A. Clark,et al.  Antimicrobial activity of phenolic constituents of Magnolia grandiflora L. , 1981, Journal of pharmaceutical sciences.

[5]  K. Yamakawa,et al.  Chemical Transformation of a-Santonin into Sesquiterpene a-Methylene-g-lactones, Douflanine, and Ludovicin A and B , 1978 .

[6]  K. Yamakawa,et al.  Chemical Transformation of a-Santonin into Balchanin, Colartin, and Arbusculin A, B, C, and E , 1977 .

[7]  K. Yamakawa,et al.  Studies on the Terpenoids and related Alicyclic Compounds. VIII. Chemical Transformation of α-Santonin into Arsantin and Arsanin , 1976 .

[8]  YamakawaKoji,et al.  TRANSPOSITION OF LACTONE IN SESQUITERPENE LACTONE: CHEMICAL TRANSFORMATION OF α-SANTONIN INTO SESQUITERPENE α-METHYLENE-γ-LACTONE, YOMOGIN , 1976 .

[9]  K. Yamakawa,et al.  Chemical transformation of α-santonin into sesquiterpene α-methylene-γ-lactones, tuberiferine and artecalin , 1975 .

[10]  S. R. Jain,et al.  THERAPEUTIC UTILITY OF OCIMUM BASILICUM VAR. ALBUM , 1972, Planta medica.

[11]  R. Beukers,et al.  Microbial Conversion as a Tool in the Preparation of Drugs , 1972 .

[12]  A. A. Miles,et al.  Topley and Wilson's Principles of Bacteriology and Immunity , 1946, The Indian Medical Gazette.