Surgical treatment of small cell lung cancer ; possible advantage of preoperative chemotherapy

1976年から1991年までに当科で手術を行ない組織学的に肺小細胞癌と診断された46例についてその治療成績についてretrospectiveに検討した.臨床病期は1期19例, II期7例, III期15例, IV期5例で, そのうち術前化学療法を17例に, 術後化学療法を23例に施行した.切除全症例の5年生存率 (5生率) は29%で median survival time (MST) は87週であった.病理病期I期, II期, III期の5生率はそれぞれ39%, 40%, 29%であった.また術前化学療法群と術後化学療法群の5生率はそれぞれ30%, 32%と有意差はなかったが, 術前化学療法群の臨床病期I II期の5生率は80%と良好であった.臨床病期, 病理病期の不一致率が45.7%と高く, より進化した症例が多いことより, 肺小細胞癌の外科治療は1, II, III期にかかわらず, 術前に化学療法を先行することが勧められる.

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