GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects
暂无分享,去创建一个
S. Watkins | J. Olefsky | T. Imamura | D. Oh | E. Bae | Saswata Talukdar | H. Morinaga | Wuqiang Fan | Wendell J. Lu | Pingping Li | WuQiang Fan
[1] M. Caron,et al. A β-Arrestin/Green Fluorescent Protein Biosensor for Detecting G Protein-coupled Receptor Activation* , 1997, The Journal of Biological Chemistry.
[2] Masataka Harada,et al. Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40 , 2003, Nature.
[3] J. Kim,et al. Membrane-proximal region of the carboxyl terminus of the gonadotropin-releasing hormone receptor (GnRHR) confers differential signal transduction between mammalian and nonmammalian GnRHRs. , 2005, Molecular endocrinology.
[4] G. Tsujimoto,et al. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120 , 2005, Nature Medicine.
[5] Yue Sun,et al. Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways. , 2004, Molecular cell.
[6] S. Watkins,et al. Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism , 2008, Cell.
[7] I. Verma,et al. Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. , 2009, Cell metabolism.
[8] AC Tose. Cell , 1993, Cell.
[9] H. Tian,et al. Medium-chain Fatty Acids as Ligands for Orphan G Protein-coupled Receptor GPR84* , 2006, Journal of Biological Chemistry.
[10] Daniel B. McClatchy,et al. Functional specialization of β-arrestin interactions revealed by proteomic analysis , 2007, Proceedings of the National Academy of Sciences.
[11] B. Dahiyat,et al. JNK and Tumor Necrosis Factor-α Mediate Free Fatty Acid-induced Insulin Resistance in 3T3-L1 Adipocytes* , 2005, Journal of Biological Chemistry.
[12] J. Schölmerich,et al. Defining high-fat-diet rat models: metabolic and molecular effects of different fat types. , 2006, Journal of molecular endocrinology.
[13] M. Karin,et al. JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. , 2007, Cell metabolism.
[14] J. Olefsky,et al. Insulin sensitivity: modulation by nutrients and inflammation. , 2008, The Journal of clinical investigation.
[15] M. Caron,et al. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. , 1999, Science.
[16] J. Olefsky,et al. Glucocorticoids and Thiazolidinediones Interfere with Adipocyte-mediated Macrophage Chemotaxis and Recruitment* , 2009, The Journal of Biological Chemistry.
[17] Yue Sun,et al. Identification of β-Arrestin2 as a G Protein-Coupled Receptor-Stimulated Regulator of NF-κB Pathways , 2004 .
[18] R. Surabhi,et al. TAK1 is Critical for IκB Kinase-mediated Activation of the NF-κB Pathway , 2003 .
[19] M. Scadeng,et al. Bone marrow–specific Cap gene deletion protects against high-fat diet–induced insulin resistance , 2007, Nature Medicine.
[20] D. Underhill. Faculty Opinions recommendation of Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. , 2006 .
[21] John W. Adams,et al. G Alpha-q / 11 Protein Plays a Key Role in Insulin-Induced Glucose Transport in 3 T 3L 1 Adipocytes , 1999 .
[22] L. Ma,et al. Direct and differential interaction of beta-arrestins with the intracellular domains of different opioid receptors. , 2001, Molecular pharmacology.
[23] G. Shulman,et al. n-3 Fatty Acids Preserve Insulin Sensitivity In Vivo in a Peroxisome Proliferator–Activated Receptor-α–Dependent Manner , 2007, Diabetes.
[24] G. Shulman,et al. Differential effects of safflower oil versus fish oil feeding on insulin-stimulated glycogen synthesis, glycolysis, and pyruvate dehydrogenase flux in skeletal muscle: a 13C nuclear magnetic resonance study. , 1999, Diabetes.
[25] A. Polozova,et al. Role of Liver and Plasma Lipoproteins in Selective Transport of n-3 Fatty Acids to Tissues: A Comparative Study of 14C-DHA and 3H-Oleic Acid Tracers , 2007, Journal of Molecular Neuroscience.
[26] S. Akira,et al. TLR signaling. , 2006, Current topics in microbiology and immunology.
[27] R. Lefkowitz,et al. The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. , 2002, Journal of cell science.
[28] V. Arroyo,et al. Obesity‐induced insulin resistance and hepatic steatosis are alleviated by ω‐3 fatty acids: a role for resolvins and protectins , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[29] U. Gether. Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. , 2000, Endocrine reviews.
[30] Weimin He,et al. Muscle-specific Pparg deletion causes insulin resistance , 2003, Nature Medicine.
[31] L. Tartaglia,et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. , 2003, The Journal of clinical investigation.
[32] R. Lefkowitz,et al. Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking. , 2001, Current opinion in cell biology.
[33] I. Kaji,et al. Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions. , 2008, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
[34] Laura Herrero,et al. Obesity, inflammation, and insulin resistance. , 2007, Gastroenterology.
[35] G. Tsujimoto,et al. The regulation of adipogenesis through GPR120. , 2007, Biochemical and biophysical research communications.
[36] J. Fornwald,et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules , 2006, British journal of pharmacology.
[37] C. Glass,et al. A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways* , 2007, Journal of Biological Chemistry.
[38] B. Fredholm,et al. Signalling from adenosine receptors to mitogen-activated protein kinases. , 2003, Cellular signalling.
[39] A. Baron,et al. Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans. , 1988, The American journal of physiology.
[40] G. Shulman,et al. n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner. , 2007, Diabetes.
[41] A. Saltiel,et al. Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes , 2008, Diabetes.
[42] J. Olefsky,et al. SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes , 2008, Molecular and Cellular Biology.
[43] J. Olefsky,et al. Myosin 5a Is an Insulin-Stimulated Akt2 (Protein Kinase Bβ) Substrate Modulating GLUT4 Vesicle Translocation , 2007, Molecular and Cellular Biology.
[44] R. Surabhi,et al. TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway. , 2003, Journal of molecular biology.
[45] M. Desai,et al. Obesity is associated with macrophage accumulation in adipose tissue. , 2003, The Journal of clinical investigation.
[46] A Ulloa-Aguirre,et al. Structure-activity relationships of G protein-coupled receptors. , 1999, Archives of medical research.
[47] Michel Bouvier,et al. Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with beta-arrestin and their trafficking patterns. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[48] I. Verma,et al. Suppression of PPAR-γ attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes , 2007 .
[49] J. Folch,et al. A simple method for the isolation and purification of total lipides from animal tissues. , 1957, The Journal of biological chemistry.
[50] Dorothy D. Sears,et al. FOXO1 Transrepresses Peroxisome Proliferator-activated Receptor γ Transactivation, Coordinating an Insulin-induced Feed-forward Response in Adipocytes* , 2009, Journal of Biological Chemistry.
[51] D. Hwang,et al. Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids. , 2003, Journal of lipid research.