Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease

[1]  L. Gentilucci,et al.  Novel Ligands Targeting α4β1 Integrin: Therapeutic Applications and Perspectives , 2019, Front. Chem..

[2]  K. Hao,et al.  A functional genomics predictive network model identifies regulators of inflammatory bowel disease , 2017, Nature Genetics.

[3]  S. Snapper,et al.  Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages , 2017, Science.

[4]  A. Fichera,et al.  Inflammatory bowel disease surgery in the biologic era. , 2016, World journal of gastrointestinal surgery.

[5]  A. Giordano,et al.  From Inflammation to Cancer in Inflammatory Bowel Disease: Molecular Perspectives. , 2016, Anticancer research.

[6]  G. Kaplan,et al.  The global burden of IBD: from 2015 to 2025 , 2015, Nature Reviews Gastroenterology &Hepatology.

[7]  D. Vestweber,et al.  How leukocytes cross the vascular endothelium , 2015, Nature Reviews Immunology.

[8]  A. K. Hansen,et al.  High-resolution gene expression profiling using RNA sequencing in patients with inflammatory bowel disease and in mouse models of colitis. , 2015, Journal of Crohn's & colitis.

[9]  Qi Zhao,et al.  Identification of Gene Expression Changes from Colitis to CRC in the Mouse CAC Model , 2014, PloS one.

[10]  A. Yoshimura,et al.  IL-1β and TNFα-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis. , 2011, International immunology.

[11]  L. Klampfer,et al.  Cytokines, inflammation and colon cancer. , 2011, Current cancer drug targets.

[12]  J. Clifford,et al.  Temporal genomewide expression profiling of DSS colitis reveals novel inflammatory and angiogenesis genes similar to ulcerative colitis. , 2011, Physiological genomics.

[13]  I. Hishinuma,et al.  The α integrin cytoplasmic motif KXGFFKR is essential for integrin-mediated leukocyte adhesion , 2010 .

[14]  I. Dubchak,et al.  Visualizing genomes: techniques and challenges , 2010, Nature Methods.

[15]  R. Egan,et al.  The Binding Specificity and Selective Antagonism of Vedolizumab, an Anti-α4β7 Integrin Therapeutic Antibody in Development for Inflammatory Bowel Diseases , 2009, Journal of Pharmacology and Experimental Therapeutics.

[16]  Jing Chen,et al.  ToppGene Suite for gene list enrichment analysis and candidate gene prioritization , 2009, Nucleic Acids Res..

[17]  M. Karin,et al.  IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. , 2009, Cancer cell.

[18]  D. Ostanin,et al.  T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade. , 2009, American journal of physiology. Gastrointestinal and liver physiology.

[19]  B. Williams,et al.  Mapping and quantifying mammalian transcriptomes by RNA-Seq , 2008, Nature Methods.

[20]  R. Xavier,et al.  Unravelling the pathogenesis of inflammatory bowel disease , 2007, Nature.

[21]  M. Denis,et al.  Altered Calreticulin expression in human colon cancer: maintenance of Calreticulin expression is associated with mucinous differentiation. , 2007, Oncology reports.

[22]  Stefan Wirtz,et al.  Chemically induced mouse models of intestinal inflammation , 2007, Nature Protocols.

[23]  U. Landegren,et al.  Direct observation of individual endogenous protein complexes in situ by proximity ligation , 2006, Nature Methods.

[24]  M. Aurrand-Lions,et al.  Adhesion mechanisms regulating the migration of monocytes , 2004, Nature Reviews Immunology.

[25]  T. Springer,et al.  Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster , 2003, Nature Structural Biology.

[26]  A. Orr,et al.  Thrombospondin signaling through the calreticulin/LDL receptor-related protein co-complex stimulates random and directed cell migration , 2003, Journal of Cell Science.

[27]  R. Pounder,et al.  A pilot study of treatment of active ulcerative colitis with natalizumab, a humanized monoclonal antibody to alpha‐4 integrin , 2002, Alimentary pharmacology & therapeutics.

[28]  J. Piette,et al.  Calreticulin, a Potential Cell Surface Receptor Involved in Cell Penetration of Anti-DNA Antibodies1 , 2001, The Journal of Immunology.

[29]  A. Whitehead,et al.  Serum amyloid A, the major vertebrate acute-phase reactant. , 1999, European journal of biochemistry.

[30]  Sasaki,et al.  Inhibition of dextran sulphate sodium (DSS)‐induced colitis in mice by intracolonically administered antibodies against adhesion molecules (endothelial leucocyte adhesion molecule‐1 (ELAM‐1) or intercellular adhesion molecule‐1 (ICAM‐1)) , 1999, Clinical and experimental immunology.

[31]  S. Grinstein,et al.  Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion , 1997, Nature.

[32]  S. Dedhar,et al.  Inducible interaction of integrin alpha 2 beta 1 with calreticulin. Dependence on the activation state of the integrin. , 1995, The Journal of biological chemistry.

[33]  M. Ginsberg,et al.  The inner world of cell adhesion: integrin cytoplasmic domains. , 1994, Trends in cell biology.

[34]  S. Dedhar,et al.  Cell attachment to extracellular matrix substrates is inhibited upon downregulation of expression of calreticulin, an intracellular integrin alpha-subunit-binding protein. , 1994, Journal of cell science.

[35]  H. Cooper,et al.  Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin , 1993, Digestive Diseases and Sciences.

[36]  U. Landegren Measurement of cell numbers by means of the endogenous enzyme hexosaminidase. Applications to detection of lymphokines and cell surface antigens. , 1984, Journal of immunological methods.

[37]  I. Hishinuma,et al.  The alpha integrin cytoplasmic motif KXGFFKR is essential for integrin-mediated leukocyte adhesion. , 2010, International Journal of Molecular Medicine.