A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan.

[1]  B. Merry Molecular mechanisms linking calorie restriction and longevity. , 2002, The international journal of biochemistry & cell biology.

[2]  Raymond Y. N. Lee,et al.  Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway , 2001, Current Biology.

[3]  Andrzej Bartke,et al.  Longevity: Extending the lifespan of long-lived mice , 2001, Nature.

[4]  M. Willingham,et al.  Growth hormone increases regional coronary blood flow and capillary density in aged rats. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[5]  A. Bartke,et al.  Reduced Levels of Thyroid Hormones, Insulin, and Glucose, and Lower Body Core Temperature in the Growth Hormone Receptor/Binding Protein Knockout Mouse , 2001, Experimental biology and medicine.

[6]  C. Kenyon,et al.  Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling , 2001, Nature Genetics.

[7]  Richard A. Miller,et al.  Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[8]  C. Kenyon A Conserved Regulatory System for Aging , 2001, Cell.

[9]  E. Hafen,et al.  Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein , 2001, Science.

[10]  V. Longo,et al.  Regulation of Longevity and Stress Resistance by Sch9 in Yeast , 2001, Science.

[11]  A. Bartke,et al.  Prolonged longevity of hypopituitary dwarf mice , 2001, Experimental Gerontology.

[12]  S. Bennett,et al.  Insulin-like growth factor-1 selectively increases glucose utilization in brains of aged animals. , 2001, Endocrinology.

[13]  A. Flyvbjerg,et al.  Growth hormone treatment increases transmural colonic growth in GH-deficient dwarf rats. , 2000, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[14]  W. Willett,et al.  A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women. , 2000, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[15]  A. Bartke,et al.  Effects of growth hormone on hypothalamic catalase and Cu/Zn superoxide dismutase1 , 2000 .

[16]  W. Sonntag,et al.  Chronic [D-Ala2]-growth hormone-releasing hormone administration attenuates age-related deficits in spatial memory. , 2000, The journals of gerontology. Series A, Biological sciences and medical sciences.

[17]  D. Ingram,et al.  Studies of aging in ames dwarf mice: Effects of caloric restriction , 2000, Journal of the American Aging Association.

[18]  S. Bennett,et al.  Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals. , 1999, The journals of gerontology. Series A, Biological sciences and medical sciences.

[19]  R. Miller,et al.  Kleemeier award lecture: are there genes for aging? , 1999, The journals of gerontology. Series A, Biological sciences and medical sciences.

[20]  A. Bode,et al.  Does growth hormone prevent or accelerate aging? , 1998, Experimental Gerontology.

[21]  J. Apfeld,et al.  Cell Nonautonomy of C. elegans daf-2 Function in the Regulation of Diapause and Life Span , 1998, Cell.

[22]  G. Ruvkun,et al.  Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. , 1998, Genes & development.

[23]  W. Sonntag,et al.  Insulin-like growth factor-1 ameliorates age-related behavioral deficits , 1998, Neuroscience.

[24]  J. French,et al.  Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. , 1997, Cancer research.

[25]  Wei Wu,et al.  Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism , 1996, Nature.

[26]  Andrzej Bartke,et al.  Dwarf mice and the ageing process , 1996, Nature.

[27]  F. Sánchez‐Franco,et al.  Growth hormone induces somatostatin and insulin-like growth factor I gene expression in the cerebral hemispheres of aging rats. , 1996, Endocrinology.

[28]  R. Castillo,et al.  Regulation of Postjatal Intestinal Maturation by Growth Hormone: Studies in Rats with Isolated Growth Hormone Deficiency , 1996, Pediatric Research.

[29]  H. Werner,et al.  The role of the insulin-like growth factor system in human cancer. , 1996, Advances in cancer research.

[30]  H. Yamamoto,et al.  Enzymatic conversion of IGF-I to des(1-3)IGF-I in rat serum and tissues: a further potential site of growth hormone regulation of IGF-I action. , 1995, The Journal of endocrinology.

[31]  P. Kelly,et al.  Expression of prolactin and growth hormone receptor genes and their isoforms in the gastrointestinal tract. , 1995, The American journal of physiology.

[32]  P. Amstad,et al.  Blockade of the insulin‐like growth‐factor‐I receptor inhibits growth of human colorectal cancer cells: Evidence of a functional IGF‐II‐mediated autocrine loop , 1994, International journal of cancer.

[33]  H. Kolb,et al.  Human osteosarcoma (U‐2 OS) cells express both insulin‐like growth factor‐I (IGF‐I) receptors and insulin‐like growth factor‐II/mannose‐6‐phosphate (IGF‐II/M6P) receptors and synthesize IGF‐II: Autocrine growth stimulation by IGF‐II via the IGF‐I receptor , 1994, Journal of cellular physiology.

[34]  S. Hirschfeld,et al.  Human osteosarcoma cell lines are dependent on insulin-like growth factor I for in vitro growth. , 1994, Cancer research.

[35]  Adrian V. Lee,et al.  Processing of insulin-like growth factor-II (IGF-II) by human breast cancer cells , 1994, Molecular and Cellular Endocrinology.

[36]  C. Kenyon,et al.  A C. elegans mutant that lives twice as long as wild type , 1993, Nature.

[37]  E. Catsafados,et al.  The synthetic retinoid fenretinide lowers plasma insulin-like growth factor I levels in breast cancer patients. , 1993, Cancer research.

[38]  D. Bevan,et al.  Insulin-like growth factor-I and human lung fibroblast-derived insulin-like growth factor-I stimulate the proliferation of human lung carcinoma cells in vitro. , 1993, Cancer research.

[39]  R. Furlanetto,et al.  Effects of insulin-like growth factor receptor inhibition on human melanomas in culture and in athymic mice. , 1993, Cancer research.

[40]  D. Clemmons,et al.  The insulin-like growth factors. , 1993, Annual review of physiology.

[41]  A. Bartke,et al.  Premature ageing in transgenic mice expressing different growth hormone genes. , 1993, Journal of reproduction and fertility. Supplement.

[42]  J. McCubrey,et al.  Growth-promoting effects of insulin-like growth factor-1 (IGF-1) on hematopoietic cells: overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency of murine factor-dependent cells by a ligand-dependent mechanism , 1991 .

[43]  M R Rose,et al.  Evolution of senescence: late survival sacrificed for reproduction. , 1991, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[44]  C. Osborne,et al.  Regulation of breast cancer growth by insulin-like growth factors , 1990, The Journal of Steroid Biochemistry and Molecular Biology.

[45]  Larry W. Swanson,et al.  Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1 , 1990, Nature.

[46]  T. Johnson,et al.  Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging. , 1990, Science.

[47]  D. Rudman,et al.  Effects of human growth hormone in men over 60 years old. , 1990, The New England journal of medicine.

[48]  M. Niwa,et al.  Partial characterization of insulin-like growth factor I in primary human lung cancers using immunohistochemical and receptor autoradiographic techniques. , 1990, Cancer research.

[49]  W. Rutter,et al.  Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation , 1990, Molecular and cellular biology.

[50]  W. Daughaday A Personal History of the Origin of the Somatomedin Hypothesis and Recent Challenges to Its Validity , 2015, Perspectives in biology and medicine.

[51]  T. Gansler,et al.  Antibody to type I insulinlike growth factor receptor inhibits growth of Wilms' tumor in culture and in athymic mice. , 1989, The American journal of pathology.

[52]  C. Osborne,et al.  Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor. , 1989, Cancer research.

[53]  M. Israel,et al.  Autonomous growth of a human neuroblastoma cell line is mediated by insulin-like growth factor II. , 1989, The Journal of clinical investigation.

[54]  R. Weindruch,et al.  The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. , 1986, The Journal of nutrition.

[55]  R. Palmiter,et al.  Metallothionein-human GH fusion genes stimulate growth of mice. , 1983, Science.

[56]  Blizzard Rm,et al.  Low somatomedin-C levels in older men rise in response to growth hormone administration. , 1981 .

[57]  M. Kutner,et al.  Impaired growth hormone secretion in the adult population: relation to age and adiposity. , 1981, The Journal of clinical investigation.

[58]  J. Florini,et al.  Effect of rat age on serum levels of growth hormone and somatomedins , 1981, Mechanisms of Ageing and Development.

[59]  R. Steger,et al.  Decreased pulsatile release of growth hormone in old male rats. , 1980, Endocrinology.

[60]  B. Charlesworth,et al.  A test of evolutionary theories of senescence , 1980, Nature.

[61]  L. Lichtenberger,et al.  Pituitary-Induced Alterations in Gastrin Levels and Gastrointestinal Growth in Normal and Genetically Dwarf Mice , 1979, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[62]  W. Beamer,et al.  Inherited ateliotic dwarfism in mice. Characteristics of the mutation, little, on chromosome 6. , 1976, The Journal of heredity.

[63]  L. Martinet,et al.  Preliminary results on plasma progesterone levels during pregnancy and superfetation in the hare, Lepus Europaeus. , 1976, Journal of reproduction and fertility.

[64]  H. Roffwarg,et al.  Age-related change in the twenty-four-hour spontaneous secretion of growth hormone. , 1972, The Journal of clinical endocrinology and metabolism.

[65]  P. Gorden,et al.  Abscence of sleep-related growth hormone peaks in aged normal subjects and in acromegaly. , 1972, The Journal of clinical endocrinology and metabolism.

[66]  G. Snell DWARF, A NEW MENDELIAN RECESSIVE CHARACTER OF THE HOUSE MOUSE. , 1929, Proceedings of the National Academy of Sciences of the United States of America.