Senile Osteoporosis

Age-related changes ofthe femoral bone mass in several strains of the senescence-accelerated mouse (SAM) were investigated. Microdensitometrically, all strains exhibited essentially the same patterns ofage changes, that is, bone mass corrected by the diameter of the shaft reached the peak value when the mice were 4 or 5 months ofage and then fell linearly with age up to over 20 months of age. Two strains, SAM-R/3 and SAM-P/6, which originated from the same ancestry on pedigree, had a significantly lower peak bone mass than other strains (SAM-R/1, SAM-

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