A Randomized, Controlled Trial of Doxycycline and Rifampin for Patients with Alzheimer's Disease

Objectives: To assess whether doxycycline and rifampin have a therapeutic role in patients with Alzheimer's disease (AD).

[1]  G. Forloni,et al.  Anti‐amyloidogenic activity of tetracyclines: studies in vitro , 2001, FEBS letters.

[2]  T. Quinn,et al.  Failure to detect Chlamydia pneumoniae in coronary atheromas of patients undergoing atherectomy. , 1996, The Journal of infectious diseases.

[3]  S. Asano,et al.  Inhibition of Amyloid Protein Aggregation and Neurotoxicity by Rifampicin , 1996, The Journal of Biological Chemistry.

[4]  H. Beppu,et al.  Donepezil for mild and moderate Alzheimer's disease. , 2000 .

[5]  D. Nochlin,et al.  Failure to detect Chlamydia pneumoniae in brain tissues of Alzheimer’s disease , 1999, Neurology.

[6]  A. Burns Clinical diagnosis of Alzheimer's disease , 1991 .

[7]  T. Standish,et al.  Improved Reliability of the Standardized Alzheimer's Disease Assessment Scale (SADAS) Compared with the Alzheimer's Disease Assessment Scale (ADAS) , 1996, Journal of the American Geriatrics Society.

[8]  J. Ramírez Isolation of Chlamydia pneumoniae from the Coronary Artery of a Patient with Coronary Atherosclerosis , 1996, Annals of Internal Medicine.

[9]  Nicole A. Lazar,et al.  Statistical Analysis With Missing Data , 2003, Technometrics.

[10]  T. L. Brink,et al.  Screening tests for geriatric depression , 1982 .

[11]  J. Gnarpe,et al.  Demonstration of Chlamydia pneumoniae in patients with chronic pharyngitis. , 1997, Scandinavian journal of infectious diseases.

[12]  H. Mori,et al.  Rifampicin prevents the aggregation and neurotoxicity of amyloid beta protein in vitro. , 1994, Biochemical and biophysical research communications.

[13]  W. Solbach,et al.  Failure To Detect Chlamydia pneumoniaein Brain Sections of Alzheimer's Disease Patients , 2000, Journal of Clinical Microbiology.

[14]  S. Asano,et al.  Inhibition of Amyloid Protein Aggregation and Neurotoxicity by Rifampicin , 1996, The Journal of Biological Chemistry.

[15]  A. Easton,et al.  Evidence that Chlamydia pneumoniae causes pneumonia and bronchitis. , 1993, The Journal of infectious diseases.

[16]  M. Lawton,et al.  Assessment of older people: self-maintaining and instrumental activities of daily living. , 1969, The Gerontologist.

[17]  D. Appelt,et al.  Identification and localization of Chlamydia pneumoniae in the Alzheimer's brain , 1998, Medical Microbiology and Immunology.

[18]  L. Jackson,et al.  Chlamydia pneumoniae (TWAR) , 1995, Clinical microbiology reviews.

[19]  J. Sloane,et al.  Evidence for local production of acute phase response apolipoprotein serum amyloid A in Alzheimer's disease brain , 1997, Neuroscience Letters.

[20]  G. Guyatt,et al.  Validity and reliability of the Dysfunctional Behaviour Rating Instrument , 1991, Acta psychiatrica Scandinavica.

[21]  L. Lue,et al.  Modeling microglial activation in Alzheimer’s disease with human postmortem microglial cultures , 2001, Neurobiology of Aging.

[22]  C. Gaydos,et al.  Comparison of an Industry-Derived LCx Chlamydia pneumoniae PCR Research Kit to In-House Assays Performed in Five Laboratories , 2002, Journal of Clinical Microbiology.

[23]  P. Eikelenboom,et al.  Inflammatory mechanisms in Alzheimer's disease. , 1994, Trends in pharmacological sciences.

[24]  A. Tenner Complement in Alzheimer’s disease: opportunities for modulating protective and pathogenic events , 2001, Neurobiology of Aging.