On the Automation of the Tear Film Non-invasive Break-up Test

Dry eye syndrome (DES) is a common disorder of the tear film, affecting a significant percentage of the population. The Non Invasive Break-Up Time (NIBUT) is a clinical test used for the diagnosis of DES. In this work, we propose a methodology for the semi-automatic computation of the NIBUT test. We tested our methodology on a dataset composed of 15 videos manually annotated and high success rates were obtained. The promising results of this approach mean a step forward on the development of computer aided tools for DES assessment.

[1]  M A Lemp,et al.  Tear physiology and dry eyes. , 1977, Survey of ophthalmology.

[2]  C. Kee,et al.  The significance of tear film break-up time in the diagnosis of dry eye syndrome. , 1988, Korean journal of ophthalmology : KJO.

[3]  Manuel G. Penedo,et al.  Analysis of parameters for the automatic computation of the tear film break-up time test based on CCLRU standards , 2014, Comput. Methods Programs Biomed..

[4]  Keiichi Abe,et al.  Topological structural analysis of digitized binary images by border following , 1985, Comput. Vis. Graph. Image Process..

[5]  J. Guillon,et al.  Non-invasive Tearscope Plus routine for contact lens fitting. , 1998, Contact lens & anterior eye : the journal of the British Contact Lens Association.

[6]  Ming-Kuei Hu,et al.  Visual pattern recognition by moment invariants , 1962, IRE Trans. Inf. Theory.

[7]  P. Aragona,et al.  Meibomian gland dysfunction and ocular discomfort in video display terminal workers , 2008, Eye.

[8]  Angus McFadyen,et al.  Dry eye diagnosis. , 2008, Investigative ophthalmology & visual science.

[9]  M. Lemp Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. , 1995, The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc.

[10]  P Cho,et al.  Reliability of the Tear Break-Up Time Technique of Assessing Tear Stability and the Locations of the Tear Break-Up in Hong Kong Chinese , 1992, Optometry and vision science : official publication of the American Academy of Optometry.