Primary Diffuse Leptomeningeal Gliomatosis with Signs of Increased Intracranial Pressure and Progressive Meningeal Enhancement on MRI

A 21‐year‐old woman presented with a 5‐month history of meningeal signs and evidence of intracranial hypertension and, as shown by magnetic resonance imaging (MRI), progressively more extensive meningeal enhancement, particularly within the spinal canal. Autopsy disclosed the presence of primary diffuse leptomeningeal gliomatosis with spinal cord predominance, possibly arising within heterotopic leptomeningeal glial tissue in the cervical region. No parenchymal primary lesion was identified. MRI with gadolinium appears to be the imaging modality of choice for the early detection of primary diffuse leptomeningeal neoplasia.

[1]  D. Melanson,et al.  Leptomeningeal gliomatosis: MR findings. , 1993, Journal of computer assisted tomography.

[2]  G. Arendt,et al.  Primary malignant melanoblastosis of the meninges. Clinical, cytologic and neuropathologic findings in a case. , 1988, Acta cytologica.

[3]  J. Sung,et al.  Diffuse leptomeningeal gliomatosis: report of three cases. , 1987, Clinical neuropathology.

[4]  C. Wada,et al.  Primary leptomeningeal ependymoblastoma. Case report. , 1986, Journal of neurosurgery.

[5]  Y. Robitaille,et al.  Primary Diffuse Leptomeningeal Gliomatosis , 1985, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[6]  R. Katakura,et al.  Diffuse form of primary leptomeningeal gliomatosis. Case report. , 1985, Journal of neurosurgery.

[7]  Douglas C. Miller,et al.  Meningeal gliomatosis with “negative” CSF cytology , 1984, Neurology.

[8]  P. Cancilla,et al.  Solitary, Primary Malignant Astrocytoma of the Spinal Leptomeninges , 1983, Journal of neuropathology and experimental neurology.

[9]  K. Ho,et al.  Primary leptomeningeal gliomatosis: symptoms suggestive of meningitis. , 1981, Archives of neurology.

[10]  A. J. Dale,et al.  Meningeal carcinomatosis. Clinical manifestations. , 1974, Archives of neurology.

[11]  J. Kepes,et al.  Primary diffuse malignant lymphoma of the leptomeninges presenting as ”pseudotumor cerebri” , 1971, Neurochirurgia.

[12]  S. M. Sumi,et al.  Primary intracranial leptomeningeal glioma with persistant hypoglycorrhachia. , 1968, Journal of neurology, neurosurgery, and psychiatry.

[13]  J. Korein,et al.  Oligodendrogliomatosis With Intracranial Hypertension , 1957, Neurology.

[14]  I. S. Cooper,et al.  Heterotopic glial nests in the subarachnoid space; histopathologic characteristics, mode of origin and relation to meningeal gliomas. , 1951, Journal of neuropathology and experimental neurology.