A novel patient-derived tumorgraft model with TRAF1-ALK anaplastic large-cell lymphoma translocation
暂无分享,去创建一个
S. Pileri | R. Rabadán | B. Falini | G. Inghirami | E. Lasorsa | E. Ficarra | J. Iqbal | R. Piva | A. Barreca | B. Ruggeri | L. Shultz | S. Aime | F. Abate | T. Tousseyn | I. Kwee | F. Bertoni | M. Ponzoni | P. Piccaluga | S. Aliberti | M. Gaudiano | R. Crescenzo | L. Cerchietti | A. Rinaldi | D. Longo | M. Todaro | E. Tiacci | F. Tabbò | M. Boi | D. Novero | M. Cheng | I. Wlodarska | I. Landra | R. Machiorlatti | F. D. Giacomo | K. Messana | J. A. Krogt | C. Abele | L. Bessone | A. Acquaviva | B. Pera-Gresely | W. Chan
[1] I. Lossos,et al. Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas , 2014, Nature Genetics.
[2] L. Staudt,et al. Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma. , 2012, Blood.
[3] M. Kalos,et al. The potent oncogene NPM-ALK mediates malignant transformation of normal human CD4(+) T lymphocytes. , 2013, The American journal of pathology.
[4] Sumit Middha,et al. Novel TRAF1‐ALK fusion identified by deep RNA sequencing of anaplastic large cell lymphoma , 2013, Genes, chromosomes & cancer.
[5] A. Rosenwald,et al. PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma. , 2013, Blood.
[6] G. Gaidano,et al. Genome‐wide high resolution DNA profiling of hairy cell leukaemia , 2013, British journal of haematology.
[7] L. Meltesen,et al. Dual ALK and MYC Rearrangements Leading to an Aggressive Variant of Anaplastic Large Cell Lymphoma , 2013, Journal of pediatric hematology/oncology.
[8] S. Pileri,et al. Abstract 3853: Humanized NOD/Scid/IL2g-/- tumor grafts recapitulate primary anaplastic large cell lymphoma. , 2013 .
[9] D. Rossi,et al. The PD-1/PD-L1 axis contributes to T-cell dysfunction in chronic lymphocytic leukemia , 2012, Haematologica.
[10] S. Pileri,et al. PDGFR blockade is a rational and effective therapy for NPM-ALK–driven lymphomas , 2012, Nature Medicine.
[11] D. Greiner,et al. Humanized mice for immune system investigation: progress, promise and challenges , 2012, Nature Reviews Immunology.
[12] David I. Smith,et al. Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas. , 2012, Blood.
[13] D. Brat,et al. Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma , 2012, Science.
[14] Enrico Macii,et al. Bellerophontes: an RNA-Seq data analysis framework for chimeric transcripts discovery based on accurate fusion model , 2012, Bioinform..
[15] Francesco Bertoni,et al. Identification of a 3-gene model as a powerful diagnostic tool for the recognition of ALK-negative anaplastic large-cell lymphoma. , 2012, Blood.
[16] K. Savage,et al. Anaplastic large cell lymphoma, ALK-positive. , 2012, Critical reviews in oncology/hematology.
[17] J. Cigudosa,et al. Preclinical activity of LBH589 alone or in combination with chemotherapy in a xenogeneic mouse model of human acute lymphoblastic leukemia , 2011, Leukemia.
[18] Aik Choon Tan,et al. Patient-derived tumour xenografts as models for oncology drug development , 2012, Nature Reviews Clinical Oncology.
[19] G. Inghirami,et al. ALK Signaling and Target Therapy in Anaplastic Large Cell Lymphoma , 2012, Front. Oncol..
[20] R. Palmer,et al. Anaplastic lymphoma kinase in human cancer. , 2012, Critical reviews in oncogenesis.
[21] J. Cigudosa,et al. Preclinical activity of LBH 589 alone or in combination with chemotherapy in a xenogeneic mouse model of human acute lymphoblastic leukemia , 2012 .
[22] David I. Smith,et al. Genome-wide analysis reveals recurrent structural abnormalities of TP 63 and other p 53-related genes in peripheral T-cell lymphomas Running head : Genome-wide analysis of T-cell lymphomas , 2012 .
[23] G. Inghirami,et al. CEP-28122, a Highly Potent and Selective Orally Active Inhibitor of Anaplastic Lymphoma Kinase with Antitumor Activity in Experimental Models of Human Cancers , 2011, Molecular Cancer Therapeutics.
[24] Christopher A. Maher,et al. ChimeraScan: a tool for identifying chimeric transcription in sequencing data , 2011, Bioinform..
[25] Qiang Yu,et al. Context-specific regulation of NF-κB target gene expression by EZH2 in breast cancers. , 2011, Molecular cell.
[26] Süleyman Cenk Sahinalp,et al. deFuse: An Algorithm for Gene Fusion Discovery in Tumor RNA-Seq Data , 2011, PLoS Comput. Biol..
[27] F. Sigaux,et al. Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse , 2011 .
[28] H. Moritake,et al. C‐MYC rearrangement may induce an aggressive phenotype in anaplastic lymphoma kinase positive anaplastic large cell lymphoma: Identification of a novel fusion gene ALO17/C‐MYC , 2011, American journal of hematology.
[29] A. Rosenwald,et al. Treatment and prognosis of mature T-cell and NK-cell lymphoma: an analysis of patients with T-cell lymphoma treated in studies of the German High-Grade Non-Hodgkin Lymphoma Study Group. , 2010, Blood.
[30] N. Amariglio,et al. TNF Activates a NF-κB–Regulated Cellular Program in Human CD45RA– Regulatory T Cells that Modulates Their Suppressive Function , 2010, The Journal of Immunology.
[31] Enzo Medico,et al. Gene expression profiling uncovers molecular classifiers for the recognition of anaplastic large-cell lymphoma within peripheral T-cell neoplasms. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[32] M Paulli,et al. Gene expression profiling of isolated tumour cells from anaplastic large cell lymphomas: insights into its cellular origin, pathogenesis and relation to Hodgkin lymphoma , 2009, Leukemia.
[33] B. Falini,et al. Anaplastic large cell lymphoma: changes in the World Health Organization classification and perspectives for targeted therapy , 2009, Haematologica.
[34] R. Dalla‐Favera,et al. Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma , 2009, Nature.
[35] K. Anderson,et al. Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells. , 2009, Blood.
[36] J. Nardone,et al. The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL. , 2009, Blood.
[37] K. Garber. From human to mouse and back: 'tumorgraft' models surge in popularity. , 2009, Journal of the National Cancer Institute.
[38] G. Roodman,et al. Increased signaling through p62 in the marrow microenvironment increases myeloma cell growth and osteoclast formation. , 2008, Blood.
[39] M. Djokic. ALK− anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project , 2009 .
[40] L. Staudt,et al. Stromal gene signatures in large-B-cell lymphomas. , 2008, The New England journal of medicine.
[41] Mark Shackleton,et al. Efficient tumour formation by single human melanoma cells , 2008 .
[42] J. Tao,et al. Bone marrow stromal cells prevent apoptosis of lymphoma cells by upregulation of anti-apoptotic proteins associated with activation of NF-κB (RelB/p52) in non-Hodgkin's lymphoma cells , 2007, Leukemia.
[43] Lauren B. Smith,et al. Highly aggressive ALK-positive anaplastic large cell lymphoma with a leukemic phase and multi-organ involvement: a report of three cases and a review of the literature , 2007, Annals of Hematology.
[44] Dale L. Greiner,et al. Humanized mice in translational biomedical research , 2007, Nature Reviews Immunology.
[45] S. Monaco,et al. Pediatric ALK+ anaplastic large cell lymphoma with t(3;8)(q26.2;q24) translocation and c‐myc rearrangement terminating in a leukemic phase , 2007, American journal of hematology.
[46] Michael Q. Zhang,et al. TRED: a transcriptional regulatory element database, new entries and other development , 2007, Nucleic Acids Res..
[47] J. Tao,et al. Bone marrow stromal cells prevent apoptosis of lymphoma cells by upregulation of anti-apoptotic proteins associated with activation of NF-kappaB (RelB/p52) in non-Hodgkin's lymphoma cells. , 2007, Leukemia.
[48] Limin Fu,et al. FLAME, a novel fuzzy clustering method for the analysis of DNA microarray data , 2007, BMC Bioinformatics.
[49] R. Hruban,et al. An In vivo Platform for Translational Drug Development in Pancreatic Cancer , 2006, Clinical Cancer Research.
[50] M. Pierotti,et al. The TFG protein, involved in oncogenic rearrangements, interacts with TANK and NEMO, two proteins involved in the NF‐κB pathway , 2006, Journal of cellular physiology.
[51] J. Mesirov,et al. GenePattern 2.0 , 2006, Nature Genetics.
[52] R. Taulli,et al. Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas. , 2006, Blood.
[53] H. Stein,et al. Elevated NF-κB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large-cell, and other peripheral T-cell lymphomas , 2005 .
[54] J. Benítez,et al. Differential expression of NF-κB pathway genes among peripheral T-cell lymphomas , 2005, Leukemia.
[55] Pablo Tamayo,et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[56] T. Golub,et al. NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes. , 2005, Blood.
[57] H. Stein,et al. Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large-cell, and other peripheral T-cell lymphomas. , 2005, Blood.
[58] Toshiki Watanabe,et al. The NPM-ALK oncoprotein abrogates CD30 signaling and constitutive NF-kappaB activation in anaplastic large cell lymphoma. , 2004, Cancer cell.
[59] P. Marynen,et al. Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large‐cell lymphoma and inflammatory myofibroblastic tumor , 2002, Genes, chromosomes & cancer.
[60] D. Levy,et al. Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death , 2002, Oncogene.
[61] R. Siebert,et al. Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide biosynthesis. , 2000, Blood.
[62] B. Dörken,et al. High-level nuclear NF-kappa B and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells. , 1996, Blood.