Two-Phase Flow in Minichannels: Hydrodynamics, Pressure Drop, and Residence Time Distribution

Two-phase flow in mini-channels (1 mm × 1.5 mm × 430 mm and 1.5 mm × 0.5 mm × 430 mm serpentine channel geometry) made in different materials (SS 316, PMMA and Teflon) was studied at different flow rate ratio (0.66, 1.0 and 1.56) of the two immiscible fluids. A dual syringe pump was used to pump the fluids (air−water and water-kerosene) through the channels. For characterization of the two phase flow, experiments were carried out to measure the slug size distribution and relevant hydrodynamic properties, pressure drop across a single serpentine unit (i.e., one sinusoidal unit that includes two 180° return bends connected by a straight portion of 20 mm) and also the residence time distribution of water. In all the cases, the effect of material of fabrication on the hydrodynamics was significant. Apart from flow rates and flow rate ratio of the two fluids, the slug size distribution was seen to have a strong effect of the channel orientation (vertical, horizontal) and also the flow direction (up-flow and do...

[1]  Rustem F Ismagilov,et al.  Using microfluidics to observe the effect of mixing on nucleation of protein crystals. , 2005, Journal of the American Chemical Society.

[2]  Santosh V. Krishnamurthy,et al.  Gas-liquid two-phase flow across a bank of micropillars , 2007 .

[3]  Yong Wang,et al.  Review of developments in portable hydrogen production using microreactor technology. , 2004, Chemical reviews.

[4]  K. Jensen,et al.  Integrated continuous microfluidic liquid-liquid extraction. , 2007, Lab on a chip.

[5]  H. Löwe,et al.  Chemistry in microstructured reactors. , 2004, Angewandte Chemie.

[6]  Paul Watts,et al.  Benchmarking of Microreactor Applications , 2004 .

[7]  K. Jensen,et al.  Multistep continuous-flow microchemical synthesis involving multiple reactions and separations. , 2007, Angewandte Chemie.

[8]  N. Zuber,et al.  Average volumetric concentration in two-phase flow systems , 1965 .

[9]  B. W. Webb,et al.  Characterization of frictional pressure drop for liquid flows through microchannels , 2002 .

[10]  Duu-Jong Lee,et al.  Residence time distribution for electrokinetic flow through a microchannel comprising a bundle of cylinders. , 2007, Journal of colloid and interface science.

[11]  Helen Song,et al.  Reactions in droplets in microfluidic channels. , 2006, Angewandte Chemie.

[12]  Dirk Janasek,et al.  A novel method for determining residence time distribution in intricately structured microreactors. , 2008, Lab on a chip.

[13]  M. Matlosz,et al.  Gas-phase residence time distribution in a falling-film microreactor , 2006 .

[14]  F. Irlinger,et al.  Microfluidic Module System with Piezo Driven Microvalve for Synthesis of Radiopharmaceutical Products , 2007, 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[15]  Paul Watts,et al.  The application of micro reactors to synthetic chemistry , 2001 .

[16]  J. Hsu,et al.  Residence time distribution of a cylindrical microreactor. , 2005, Journal of Physical Chemistry B.

[17]  Dominique M. Roberge,et al.  Microreactor Technology: A Revolution for the Fine Chemical and Pharmaceutical Industries? , 2005 .

[18]  A. Gavriilidis,et al.  A model for predicting axial mixing during gas–liquid Taylor flow in microchannels at low Bodenstein numbers , 2004 .

[19]  Takashi Okazoe,et al.  Versatile Gas/Liquid Microreactors for Industry , 2005 .

[20]  Andreas Kirschning,et al.  Continuous flow techniques in organic synthesis. , 2003, Chemistry.

[21]  N. Kockmann,et al.  Microreactor Technology and Continuous Processes in the Fine Chemical and Pharmaceutical Industry: Is the Revolution Underway? , 2008 .

[22]  Asterios Gavriilidis,et al.  Experimental studies of nitrobenzene hydrogenation in a microstructured falling film reactor , 2004 .

[23]  K. Jensen,et al.  Photochemical reactions and on-line UV detection in microfabricated reactors. , 2001, Lab on a chip.

[24]  Saif A. Khan,et al.  Microfluidic synthesis of colloidal silica. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[25]  Patricia Short.  MICROREACTORS HIT THE MAJOR LEAGUES: Suppliers of microreactor technology aim BEYOND SPECIALTY NICHES at industrial markets , 2008 .

[26]  Alan H. Epstein,et al.  Design of a silicon-based microscale trickle-bed system for singlet-oxygen production , 2008 .

[27]  Vivek V. Ranade,et al.  Hydrodynamics and liquid phase residence time distribution in mesh microreactor , 2007 .

[28]  Thomas Gervais,et al.  Mass transport and surface reactions in microfluidic systems , 2006 .

[29]  Robert Hu,et al.  Influence of horizontal return bend on the two-phase flow pattern in small diameter tubes , 2004 .

[30]  J. Zemel,et al.  Liquid transport in micron and submicron channels , 1990 .

[31]  Saif A. Khan,et al.  Transport and reaction in microscale segmented gas-liquid flow. , 2004, Lab on a chip.

[32]  J. Welty,et al.  Pressure Drop Measurements in a Microchannel , 1998, Micro-Electro-Mechanical Systems (MEMS).

[33]  Peter H Seeberger,et al.  Microreactors as tools for synthetic chemists-the chemists' round-bottomed flask of the 21st century? , 2006, Chemistry.

[34]  Dionisios G. Vlachos,et al.  Novel micromixers driven by flow instabilities: Application to post‐reactors , 2005 .

[35]  Klavs F. Jensen,et al.  Measurement of residence time distribution in microfluidic systems , 2005 .

[36]  Paul Watts,et al.  Continuous Flow Reactors, a Tool for the Modern Synthetic Chemist , 2008 .