What the deep sea can tell us about microwaves

Background microwaves are ubiquitous in our modern, urban environment. The thermal effects of these electromagnetic fields on biological matter have been well-researched. However, possible non-thermal effects remain a controversial subject. Our work utilizes the bioluminescent marine organism, Vibrio fischeri, as a novel biosensor to probe the effects of low power, pulsed magnetic and electric 2.45 GHz microwave fields. The ultimate aim of this project is to microscopically image these biological effects in real-time using custom-made luminophores in mammalian cells, to elucidate the mode of action of microwaves at the molecular level.

[1]  J. W. Hastings,et al.  Mechanism of bacterial bioluminescence: 4a,5-dihydroflavin analogs as models for luciferase hydroperoxide intermediates and the effect of substituents at the 8-position of flavin on luciferase kinetics. , 1993, Biochemistry.

[2]  Waheed-uz-Zaman,et al.  Microwave chemistry: Effect of ions on dielectric heating in microwave ovens , 2015 .

[3]  George L. Carlo,et al.  Polarization: A Key Difference between Man-made and Natural Electromagnetic Fields, in regard to Biological Activity , 2015, Scientific Reports.

[4]  J. Walleczek,et al.  Electromagnetic field effects on cells of the immune system: the role of calcium signaling 1 , 1992, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[5]  W. R. Adey Biological effects of electromagnetic fields , 1993, Journal of cellular biochemistry.

[6]  A. Pilla Electromagnetic fields instantaneously modulate nitric oxide signaling in challenged biological systems. , 2012, Biochemical and biophysical research communications.

[7]  Dimitris J. Panagopoulos,et al.  Mechanism for action of electromagnetic fields on cells. , 2002, Biochemical and biophysical research communications.

[8]  Brian N. Ellison,et al.  Biological effects of millimeter-wave radiation: A high-throughput screening system , 2003 .

[9]  Dimitris J. Panagopoulos,et al.  A mechanism for action of oscillating electric fields on cells. , 2000, Biochemical and biophysical research communications.

[10]  M. Pall Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects , 2013, Journal of cellular and molecular medicine.

[11]  Wei-Hai Fang,et al.  Understanding bacterial bioluminescence: a theoretical study of the entire process, from reduced flavin to light emission. , 2014, Chemistry.

[12]  David E. Clapham,et al.  A Superfamily of Voltage-gated Sodium Channels in Bacteria* , 2004, Journal of Biological Chemistry.

[13]  Adrian Porch,et al.  Microwave properties of nanodiamond particles , 2013 .

[14]  M. Pall Scientific evidence contradicts findings and assumptions of Canadian Safety Panel 6: microwaves act through voltage-gated calcium channel activation to induce biological impacts at non-thermal levels, supporting a paradigm shift for microwave/lower frequency electromagnetic field action , 2015, Reviews on environmental health.