Crystal structure and chemical inhibition of essential schistosome host-interactive virulence factor carbonic anhydrase SmCA

[1]  Richard Barnett,et al.  Schistosomiasis , 2018, The Lancet.

[2]  R. McKenna,et al.  Crystallography and Its Impact on Carbonic Anhydrase Research , 2018, International journal of medicinal chemistry.

[3]  A. Da'dara,et al.  Intravascular Schistosoma mansoni Cleave the Host Immune and Hemostatic Signaling Molecule Sphingosine-1-Phosphate via Tegumental Alkaline Phosphatase , 2018, Front. Immunol..

[4]  A. Da'dara,et al.  The Essential Ectoenzyme SmNPP5 from the Human Intravascular Parasite Schistosoma mansoni is an ADPase and a Potent Inhibitor of Platelet Aggregation , 2018, Thrombosis and Haemostasis.

[5]  C. Supuran,et al.  Heterocyclic periphery in the design of carbonic anhydrase inhibitors: 1,2,4-Oxadiazol-5-yl benzenesulfonamides as potent and selective inhibitors of cytosolic hCA II and membrane-bound hCA IX isoforms. , 2018, Bioorganic chemistry.

[6]  C. Supuran,et al.  An Overview of the Bacterial Carbonic Anhydrases , 2017, Metabolites.

[7]  Q. Wang,et al.  The human blood parasite Schistosoma mansoni expresses extracellular tegumental calpains that cleave the blood clotting protein fibronectin , 2017, Scientific Reports.

[8]  Tae Yoon Park,et al.  Engineering de novo disulfide bond in bacterial α-type carbonic anhydrase for thermostable carbon sequestration , 2016, Scientific Reports.

[9]  C. Supuran How many carbonic anhydrase inhibition mechanisms exist? , 2016, Journal of enzyme inhibition and medicinal chemistry.

[10]  D. Ashour,et al.  Carbonic anhydrase enzyme as a potential therapeutic target for experimental trichinellosis , 2016, Parasitology Research.

[11]  A. Da'dara,et al.  Schistosomes Enhance Plasminogen Activation: The Role of Tegumental Enolase , 2015, PLoS pathogens.

[12]  C. Supuran,et al.  Ascaris lumbricoides β carbonic anhydrase: a potential target enzyme for treatment of ascariasis , 2015, Parasites & Vectors.

[13]  P. Herzig,et al.  Esterase activity of carbonic anhydrases serves as surrogate for selecting antibodies blocking hydratase activity , 2015, Journal of enzyme inhibition and medicinal chemistry.

[14]  C. Supuran,et al.  The η-class carbonic anhydrases as drug targets for antimalarial agents , 2015, Expert opinion on therapeutic targets.

[15]  C. Supuran,et al.  Ethylene bis-imidazoles are highly potent and selective activators for isozymes VA and VII of carbonic anhydrase, with a potential nootropic effect. , 2014, Chemical communications.

[16]  A. Da'dara,et al.  Schistosome tegumental ecto-apyrase (SmATPDase1) degrades exogenous pro-inflammatory and pro-thrombotic nucleotides , 2014, PeerJ.

[17]  C. D. Boone,et al.  Structural and catalytic characterization of a thermally stable and acid-stable variant of human carbonic anhydrase II containing an engineered disulfide bond. , 2013, Acta crystallographica. Section D, Biological crystallography.

[18]  W. Sly,et al.  Structure, function and applications of carbonic anhydrase isozymes. , 2013, Bioorganic & medicinal chemistry.

[19]  C. Supuran,et al.  Inhibition of the alpha- and beta-carbonic anhydrases from the gastric pathogen Helycobacter pylori with anions , 2013, Journal of enzyme inhibition and medicinal chemistry.

[20]  T. Geary,et al.  Macrocyclic lactone anthelmintics: spectrum of activity and mechanism of action. , 2012, Current pharmaceutical biotechnology.

[21]  A. Da'dara,et al.  Metabolite movement across the schistosome surface , 2012, Journal of Helminthology.

[22]  J. Sznajder,et al.  Elevated CO2 Levels Cause Mitochondrial Dysfunction and Impair Cell Proliferation* , 2011, The Journal of Biological Chemistry.

[23]  S. Tzipori,et al.  Tegumental Phosphodiesterase SmNPP-5 Is a Virulence Factor for Schistosomes , 2011, Infection and Immunity.

[24]  Claudiu T Supuran,et al.  Carbonic anhydrase inhibitors and activators for novel therapeutic applications. , 2011, Future medicinal chemistry.

[25]  Randy J. Read,et al.  Overview of the CCP4 suite and current developments , 2011, Acta crystallographica. Section D, Biological crystallography.

[26]  N. Pannu,et al.  REFMAC5 for the refinement of macromolecular crystal structures , 2011, Acta crystallographica. Section D, Biological crystallography.

[27]  J. Thomas-Oates,et al.  Enzymatic Shaving of the Tegument Surface of Live Schistosomes for Proteomic Analysis: A Rational Approach to Select Vaccine Candidates , 2011, PLoS neglected tropical diseases.

[28]  K. Gilmour Perspectives on carbonic anhydrase. , 2010, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

[29]  F. Verrey,et al.  The Tegument of the Human Parasitic Worm Schistosoma mansoni as an Excretory Organ: The Surface Aquaporin SmAQP Is a Lactate Transporter , 2010, PloS one.

[30]  P. Emsley,et al.  Features and development of Coot , 2010, Acta crystallographica. Section D, Biological crystallography.

[31]  C. King Parasites and poverty: the case of schistosomiasis. , 2010, Acta tropica.

[32]  Wolfgang Kabsch,et al.  Integration, scaling, space-group assignment and post-refinement , 2010, Acta crystallographica. Section D, Biological crystallography.

[33]  Alexei Vagin,et al.  Molecular replacement with MOLREP. , 2010, Acta crystallographica. Section D, Biological crystallography.

[34]  Sandra D. Melman,et al.  Reduced Susceptibility to Praziquantel among Naturally Occurring Kenyan Isolates of Schistosoma mansoni , 2009, PLoS neglected tropical diseases.

[35]  P. Skelly,et al.  Purinergic signaling and immune modulation at the schistosome surface? , 2009, Trends in parasitology.

[36]  J. Sznajder,et al.  Elevated CO2 levels affect development, motility, and fertility and extend life span in Caenorhabditis elegans , 2009, Proceedings of the National Academy of Sciences.

[37]  C. Supuran,et al.  Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans. , 2008, Journal of molecular biology.

[38]  Malcolm K. Jones,et al.  Discovering new schistosome drug targets: the role of transcriptomics. , 2008, Current drug targets.

[39]  A. Miele,et al.  Will new antischistosomal drugs finally emerge? , 2008, Trends in parasitology.

[40]  C. King,et al.  The unacknowledged impact of chronic schistosomiasis , 2008, Chronic illness.

[41]  C. Supuran Carbonic anhydrases--an overview. , 2008, Current pharmaceutical design.

[42]  Claudiu T. Supuran,et al.  Carbonic anhydrases: novel therapeutic applications for inhibitors and activators , 2008, Nature Reviews Drug Discovery.

[43]  C. Shoemaker,et al.  Amino Acid Transport in Schistosomes , 2007, Journal of Biological Chemistry.

[44]  C. Shoemaker,et al.  Optimizing gene suppression in schistosomes using RNA interference. , 2007, Molecular and biochemical parasitology.

[45]  Luc Kestens,et al.  Human schistosomiasis , 2006, The Lancet.

[46]  S. Verjovski-Almeida,et al.  The tegument surface membranes of the human blood parasite Schistosoma mansoni: A proteomic analysis after differential extraction , 2006, Proteomics.

[47]  R. Wilson,et al.  Proteins Exposed at the Adult Schistosome Surface Revealed by Biotinylation*S , 2006, Molecular & Cellular Proteomics.

[48]  J. Muñoz,et al.  Failure of standard treatment with praziquantel in two returned travelers with Schistosoma haematobium infection. , 2006, The American journal of tropical medicine and hygiene.

[49]  P. Skelly,et al.  Making sense of the schistosome surface. , 2006, Advances in parasitology.

[50]  C. King,et al.  Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis , 2005, The Lancet.

[51]  Conrad C. Huang,et al.  UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..

[52]  D. Cioli,et al.  Sex- and stage-related sensitivity of Schistosoma mansoni to in vivo and in vitro praziquantel treatment. , 2004, International journal for parasitology.

[53]  G. Coles,et al.  Schistosomiasis control: keep taking the tablets. , 2004, Trends in parasitology.

[54]  C. Supuran,et al.  Carbonic Anhydrase Inhibitors. Inhibition of Cytosolic Isozymes I and II and Transmembrane, Cancer-associated Isozyme IX with Anions , 2003, Journal of enzyme inhibition and medicinal chemistry.

[55]  Andrea Scozzafava,et al.  Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives. , 2003, Journal of medicinal chemistry.

[56]  G. Coles Drug resistance or tolerance in schistosomes? , 2002, Trends in parasitology.

[57]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[58]  C. Shoemaker,et al.  Schistosoma mansoni Proteases Sm31 (Cathepsin B) and Sm32 (Legumain) Are Expressed in the Cecum and Protonephridia of Cercariae , 2001, The Journal of parasitology.

[59]  V S Lamzin,et al.  ARP/wARP and molecular replacement. , 2001, Acta crystallographica. Section D, Biological crystallography.

[60]  S. Xiao,et al.  In vitro and in vivo effect of levopraziquantel, dextropraziquantel versus racemic praziquantel on different developmental stages of Schistosoma japonicum. , 1998, Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases.

[61]  J. Barrett,et al.  Changes in cuticular permeability associated with recovery from anhydrobiosis in the plant parasitic nematode, Ditylenchus dipsaci , 1988, Parasitology.

[62]  C. Fletcher,et al.  Schistosoma mansoni: chemotherapy of infections of different ages. , 1986, Experimental parasitology.

[63]  K. Warren The Secret of the Immunopathogenesis of Schistosomiasis: IN VIVO Models , 1982, Immunological reviews.

[64]  A. Simpson,et al.  Properties of a series of tegumental membrane-bound phosphohydrolase activities of Schistosoma mansoni. , 1981, The Biochemical journal.

[65]  D. McLaren,et al.  Blood flukes have a double outer membrane , 1977, Nature.

[66]  R. Wilson,et al.  The tegument of Schistosoma mansoni: a histochemical investigation , 1976, Parasitology.

[67]  D. Storm,et al.  The catalytic versatility of erythrocyte carbonic anhydrase. IV. Kinetic studies of enzyme-catalyzed hydrolyses of para-nitrophenly esters. , 1968, Biochemistry.

[68]  Y. Pocker,et al.  The catalytic versatility of erythrocyte carbonic anhydrase. 3. Kinetic studies of the enzyme-catalyzed hydrolysis of p-nitrophenyl acetate. , 1967, Biochemistry.