STRATOS 1 and 2: considerations in clinical trial design for a fully human monoclonal antibody in severe asthma
暂无分享,去创建一个
C. Brightling | R. Panettieri | G. Colice | K. Ranade | Ulf Sjobring | AnnaMaria Péterffy | G. Tornling | Sami Z. Daoud | Sally Hollis
[1] P. O'Byrne,et al. Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial. , 2015, The Lancet. Respiratory medicine.
[2] E. Bateman,et al. Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials. , 2015, The Lancet. Respiratory medicine.
[3] G. Rodrigo,et al. What is the role of tiotropium in asthma?: a systematic review with meta-analysis. , 2015, Chest.
[4] Y. Nakano,et al. Using exhaled nitric oxide and serum periostin as a composite marker to identify severe/steroid-insensitive asthma. , 2014, American journal of respiratory and critical care medicine.
[5] Tom Doel,et al. Computational modeling of the obstructive lung diseases asthma and COPD , 2014, Journal of Translational Medicine.
[6] Ian D Pavord,et al. Mepolizumab treatment in patients with severe eosinophilic asthma. , 2014, The New England journal of medicine.
[7] Kian Fan Chung,et al. Defining Phenotypes in Asthma: A Step Towards Personalized Medicine , 2014, Drugs.
[8] Christopher R. Gignoux,et al. Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease. , 2014, The Journal of allergy and clinical immunology.
[9] R. Maciuca,et al. Efficacy and Safety of Lebrikizumab in Severe Uncontrolled Asthma: Results from the Lute and Verse Phase II Randomized, Double-Blind, Placebo-Controlled Trials , 2014 .
[10] R. Townley,et al. Role of periostin, FENO, IL-13, lebrikzumab, other IL-13 antagonist and dual IL-4/IL-13 antagonist in asthma , 2014, Expert opinion on biological therapy.
[11] E. Bleecker,et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma , 2013, European Respiratory Journal.
[12] J. Corren. Role of Interleukin-13 in Asthma , 2013, Current Allergy and Asthma Reports.
[13] W. Busse,et al. Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study. , 2013, American journal of respiratory and critical care medicine.
[14] M. Caruso,et al. Disabling inflammatory pathways with biologics and resulting clinical outcomes in severe asthma , 2013, Expert opinion on biological therapy.
[15] J. Matthews,et al. Redefining approaches to asthma: developing targeted biologic therapies. , 2013, Advances in pharmacology.
[16] M. Holtzman,et al. IL-13-induced airway mucus production is attenuated by MAPK13 inhibition. , 2012, The Journal of clinical investigation.
[17] Monica Kraft,et al. IL-13 in asthma and allergic disease: asthma phenotypes and targeted therapies. , 2012, The Journal of allergy and clinical immunology.
[18] S. Mosesova,et al. Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. , 2011, The Journal of allergy and clinical immunology.
[19] C. Brightling,et al. A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma , 2012, European Respiratory Journal.
[20] Frank Koentgen,et al. Preclinical development of CAT-354, an IL-13 neutralizing antibody, for the treatment of severe uncontrolled asthma , 2012, British journal of pharmacology.
[21] S. Holgate. Trials and tribulations in identifying new biologic treatments for asthma. , 2012, Trends in immunology.
[22] Robert A Silverman,et al. Effect of asthma exacerbations on health care costs among asthmatic patients with moderate and severe persistent asthma. , 2012, The Journal of allergy and clinical immunology.
[23] Yuichiro J Suzuki,et al. Oxidant signaling for interleukin-13 gene expression in lung smooth muscle cells. , 2012, Free radical biology & medicine.
[24] M. Miwa,et al. Interleukin-13-induced activation of signal transducer and activator of transcription 6 is mediated by an activation of Janus kinase 1 in cultured human bronchial smooth muscle cells , 2012 .
[25] S. Gupta,et al. Computed tomography scans in severe asthma: utility and clinical implications , 2012, Current opinion in pulmonary medicine.
[26] Y. Chiba,et al. Interleukin-13-induced activation of signal transducer and activator of transcription 6 is mediated by an activation of Janus kinase 1 in cultured human bronchial smooth muscle cells , 2012, Pharmacological reports : PR.
[27] Pascal Barbry,et al. Distinct epithelial gene expression phenotypes in childhood respiratory allergy , 2011, European Respiratory Journal.
[28] Nicola A Hanania,et al. Lebrikizumab treatment in adults with asthma. , 2011, The New England journal of medicine.
[29] D. Price,et al. Leukotriene antagonists as first-line or add-on asthma-controller therapy. , 2011, The New England journal of medicine.
[30] W. Busse,et al. Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy , 2011, Annals of Internal Medicine.
[31] L. Boulet,et al. Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma. , 2011, American journal of respiratory and critical care medicine.
[32] E. R. Sutherland,et al. Tiotropium bromide step-up therapy for adults with uncontrolled asthma. , 2010, The New England journal of medicine.
[33] T. Lasserson,et al. Addition of long-acting beta2-agonists to inhaled corticosteroids versus same dose inhaled corticosteroids for chronic asthma in adults and children. , 2010, The Cochrane database of systematic reviews.
[34] S. Agee,et al. Analytical validation of a highly sensitive microparticle-based immunoassay for the quantitation of IL-13 in human serum using the Erenna immunoassay system. , 2009, Journal of immunological methods.
[35] Salman Siddiqui,et al. IL-13 expression by blood T cells and not eosinophils is increased in asthma compared to non-asthmatic eosinophilic bronchitis , 2009, BMC pulmonary medicine.
[36] I. Pavord,et al. An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. , 2009, American journal of respiratory and critical care medicine.
[37] C. Morimoto,et al. Revisiting an old acquaintance: CD26 and its molecular mechanisms in T cell function. , 2008, Trends in immunology.
[38] S. Wenzel,et al. IL‐13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells , 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
[39] A Simon Pickard,et al. Use of a preference-based measure of health (EQ-5D) in COPD and asthma. , 2008, Respiratory medicine.
[40] I. Pavord,et al. Increased sputum and bronchial biopsy IL-13 expression in severe asthma. , 2008, The Journal of allergy and clinical immunology.
[41] E. Bleecker,et al. Assessing productivity loss and activity impairment in severe or difficult-to-treat asthma. , 2008, Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research.
[42] J. Stankova,et al. Interleukin-4 and Interleukin-13 Enhance Human Bronchial Smooth Muscle Cell Proliferation , 2008, International Archives of Allergy and Immunology.
[43] Yee Hwa Yang,et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids , 2007, Proceedings of the National Academy of Sciences.
[44] C. Lam,et al. Increased Expression of Plasma and CD4+ T Lymphocyte Costimulatory Molecule CD26 in Adult Patients with Allergic Asthma , 2007, Journal of Clinical Immunology.
[45] X. Badia,et al. Asthma control in patients with asthma and allergic rhinitis receiving add-on montelukast therapy for 12 months: a retrospective observational study , 2007, Current medical research and opinion.
[46] J. Ceuppens,et al. Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients , 2006, Thorax.
[47] M. Kondo,et al. Elimination of IL-13 reverses established goblet cell metaplasia into ciliated epithelia in airway epithelial cell culture. , 2006, Allergology international : official journal of the Japanese Society of Allergology.
[48] Klas Svensson,et al. Measurement properties and interpretation of three shortened versions of the asthma control questionnaire. , 2005, Respiratory medicine.
[49] I. Pavord,et al. Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis. , 2004, The Journal of allergy and clinical immunology.
[50] D. Price,et al. Randomised controlled trial of montelukast plus inhaled budesonide versus double dose inhaled budesonide in adult patients with asthma , 2003, Thorax.
[51] Brigit VanGraafeiland,et al. National Asthma Education and Prevention Program. , 2002, The Nurse practitioner.
[52] N. Thomson,et al. Immuno‐regulatory cytokines in asthma: IL‐15 and IL‐13 in induced sputum , 2001, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
[53] W. Busse,et al. Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma. , 2001, The Journal of allergy and clinical immunology.
[54] R. Hubbard,et al. Adverse effects of oral corticosteroids in relation to dose in patients with lung disease , 2001, Thorax.
[55] V. Casolaro,et al. Interleukin-13 upregulates eotaxin expression in airway epithelial cells by a STAT6-dependent mechanism. , 2001, American journal of respiratory cell and molecular biology.
[56] F. Symon,et al. HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Interleukin-13 induces PSGL-1/P–selectin–dependent adhesion of eosinophils, , 2022 .
[57] T. Casale,et al. Once-daily fexofenadine HCl improves quality of life and reduces work and activity impairment in patients with seasonal allergic rhinitis. , 1999, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
[58] G H Guyatt,et al. Development and validation of a questionnaire to measure asthma control. , 1999, The European respiratory journal.
[59] A. Buist,et al. Validation of a standardized version of the Asthma Quality of Life Questionnaire. , 1999, Chest.
[60] R. Homer,et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. , 1999, The Journal of clinical investigation.
[61] T. Mosmann,et al. Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells. , 1999, Journal of immunology.
[62] D B Corry,et al. Requirement for IL-13 independently of IL-4 in experimental asthma. , 1998, Science.
[63] S. Durham,et al. Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma. , 1997, The Journal of allergy and clinical immunology.
[64] R. Martin,et al. Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy. , 1997, American journal of respiratory and critical care medicine.
[65] T. Kotsimbos,et al. Interleukin-13 and interleukin-4 are coexpressed in atopic asthma. , 1996, Proceedings of the Association of American Physicians.
[66] R. Coffman,et al. IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells. , 1995, Journal of immunology.