Interlead heterogeneity of R‐ and T‐wave morphology in standard 12‐lead ECGs predicts sustained ventricular tachycardia/fibrillation and arrhythmic death in patients with cardiomyopathy

Nonuniformities in depolarization and repolarization morphology are critical factors in ventricular arrhythmogenesis.

[1]  R. Verrier,et al.  Selective late sodium current blockade with GS-458967 markedly reduces ischemia-induced atrial and ventricular repolarization alternans and ECG heterogeneity. , 2014, Heart rhythm.

[2]  K. Lee,et al.  Prediction of Long-Term Outcomes by Signal-Averaged Electrocardiography in Patients With Unsustained Ventricular Tachycardia, Coronary Artery Disease, and Left Ventricular Dysfunction , 2001, Circulation.

[3]  H. Huikuri,et al.  Tracking interlead heterogeneity of R- and T-wave morphology to disclose latent risk for sudden cardiac death. , 2017, Heart rhythm.

[4]  Juan Pablo Martínez,et al.  Microvolt T-wave alternans physiological basis, methods of measurement, and clinical utility--consensus guideline by International Society for Holter and Noninvasive Electrocardiology. , 2011, Journal of the American College of Cardiology.

[5]  R. Verrier,et al.  Inhibition of the cardiac late sodium current with eleclazine protects against ischemia-induced vulnerability to atrial fibrillation and reduces atrial and ventricular repolarization abnormalities in the absence and presence of concurrent adrenergic stimulation. , 2016, Heart rhythm.

[6]  G. Kay,et al.  Prophylactic implantable cardioverter-defibrillator therapy in patients with left ventricular systolic dysfunction: a pooled analysis of 10 primary prevention trials. , 2004, Journal of the American College of Cardiology.

[7]  Hervé Rix,et al.  The effect of precordial lead displacement on ECG morphology , 2013, Medical & Biological Engineering & Computing.

[8]  A. Moss,et al.  Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. Multicenter Automatic Defibrillator Implantation Trial Investigators. , 1996, The New England journal of medicine.

[9]  L. Horowitz,et al.  Recurrent Sustained Ventricular Tachycardia: 1. Mechanisms , 1978, Circulation.

[10]  R. Verrier,et al.  Protective zone and the determination of vulnerability to ventricular fibrillation. , 1978, The American journal of physiology.

[11]  R. Verrier,et al.  Tracking cardiac electrical instability by computing interlead heterogeneity of T-wave morphology. , 2003, Journal of applied physiology.

[12]  Tuomas V Kenttä,et al.  Prediction of sudden cardiac death with automated high-throughput analysis of heterogeneity in standard resting 12-lead electrocardiograms. , 2016, Heart rhythm.

[13]  D. Mossman.  Three-way ROCs , 1999, Medical decision making : an international journal of the Society for Medical Decision Making.

[14]  A. Moss,et al.  QRS Fragmentation and the Risk of Sudden Cardiac Death in MADIT II , 2012, Journal of cardiovascular electrophysiology.

[15]  Mark D. Huffman,et al.  Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association , 2016, Circulation.

[16]  Marek Malik,et al.  Respiratory rate predicts outcome after acute myocardial infarction: a prospective cohort study. , 2013, European heart journal.

[17]  Mark E. Anderson,et al.  Sudden Cardiac Death Prediction and Prevention: Report From a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop , 2010, Circulation.

[18]  M. R. Spiegel.  Mathematical handbook of formulas and tables , 1968 .

[19]  Mark E. Josephson,et al.  Crescendo in Depolarization and Repolarization Heterogeneity Heralds Development of Ventricular Tachycardia in Hospitalized Patients With Decompensated Heart Failure , 2012, Circulation. Arrhythmia and electrophysiology.

[20]  Hideki Hayashi,et al.  The dynamics of cardiac fibrillation. , 2005, Circulation.

[21]  K. Lee,et al.  A randomized study of the prevention of sudden death in patients with coronary artery disease. Multicenter Unsustained Tachycardia Trial Investigators. , 1999, The New England journal of medicine.

[22]  M. Janse,et al.  Experimental models of ventricular tachycardia and fibrillation caused by ischemia and infarction. , 1992, Circulation.

[23]  Katerina Hnatkova,et al.  Ventricular gradient and nondipolar repolarization components increase at higher heart rate. , 2004, American journal of physiology. Heart and circulatory physiology.

[24]  R. Verrier,et al.  Low doses of ranolazine and dronedarone in combination exert potent protection against atrial fibrillation and vulnerability to ventricular arrhythmias during acute myocardial ischemia. , 2013, Heart rhythm.

[25]  John A Spertus,et al.  Fragmented QRS and Mortality Risk in Patients With Left Ventricular Dysfunction , 2010, Circulation. Arrhythmia and electrophysiology.

[26]  J. Oss,et al.  IMPROVED SURVIVAL WITH AN IMPLANTED DEFIBRILLATOR IN PATIENTS WITH CORONARY DISEASE AT HIGH RISK FOR VENTRICULAR ARRHYTHMIA , 1996 .