The multifunctional Staufen proteins: conserved roles from neurogenesis to synaptic plasticity

Highlights • Staufen (Stau) proteins have evolutionarily conserved functions in the brain.• Stau proteins asymmetrically segregate mRNAs during mouse and fly neurogenesis.• Stau proteins regulate synaptic plasticity and memory formation in flies and mammals.• Stau proteins have roles in translation, localisation, and ribonucleoprotein formation.• New data indicate that mammalian Stau1 and Stau2 can both stabilise and destabilise target mRNAs.

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