Incorporating Polygenic Risk Scores and Nongenetic Risk Factors for Breast Cancer Risk Prediction Among Asian Women

Key Points Question How well do breast cancer risk prediction models that incorporate polygenic risk scores (PRSs) and nongenetic risk factors perform for Asian women? Findings In this diagnostic study of 126 894 women, a PRS including 111 genetic variants was developed and tested using data from a prospective cohort study. The PRS was significantly associated with breast cancer risk, and adding 7 nongenetic risk factors improved the model’s accuracy. Meaning These findings support the utility of prediction models in identifying Asian women with high risk of breast cancer.

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