Thioredoxin overexpression in both the cytosol and mitochondria accelerates age-related disease and shortens lifespan in male C57BL/6 mice

[1]  Daxesh P. Patel,et al.  Metabolic profiling by gas chromatography-mass spectrometry of energy metabolism in high-fat diet-fed obese mice , 2017, PloS one.

[2]  Shuai Jiang,et al.  Succinate in the cancer-immune cycle. , 2017, Cancer letters.

[3]  S. Postovalov,et al.  A new two-sample test for choosing between log-rank and Wilcoxon tests with right-censored data , 2015 .

[4]  Inder M. Verma,et al.  NF-κB, an Active Player in Human Cancers , 2014, Cancer Immunology Research.

[5]  J. Yodoi,et al.  Thioredoxin/Txnip: Redoxisome, as a Redox Switch for the Pathogenesis of Diseases , 2014, Front. Immunol..

[6]  J. Schmid,et al.  The complexity of NF-κB signaling in inflammation and cancer , 2013, Molecular Cancer.

[7]  Dean P. Jones,et al.  Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice. , 2011, The journals of gerontology. Series A, Biological sciences and medical sciences.

[8]  Rebecca SY Wong,et al.  Apoptosis in cancer: from pathogenesis to treatment , 2011, Journal of experimental & clinical cancer research : CR.

[9]  Dean P. Jones,et al.  Increased Inflammatory Signaling and Lethality of Influenza H1N1 by Nuclear Thioredoxin-1 , 2011, PloS one.

[10]  K. Tominaga,et al.  The anti-tumor effects of calorie restriction are correlated with reduced oxidative stress in ENU-induced gliomas , 2011, Pathobiology of aging & age related diseases.

[11]  G. Semenza.  Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics , 2010, Oncogene.

[12]  A. Bartke,et al.  Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[13]  C. Epstein,et al.  The overexpression of major antioxidant enzymes does not extend the lifespan of mice , 2008, Aging cell.

[14]  M. Milburn,et al.  Analysis of the adult human plasma metabolome. , 2008, Pharmacogenomics.

[15]  E. Rankin,et al.  The role of hypoxia-inducible factors in tumorigenesis , 2008, Cell Death and Differentiation.

[16]  V. Pérez,et al.  Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress. , 2008, Free radical biology & medicine.

[17]  Y. Huang,et al.  Endothelial‐specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesions , 2007, The American journal of pathology.

[18]  Ruvie Lou Maria Custodio Martinez,et al.  Diagnostics for Choosing between Log-Rank and Wilcoxon Tests , 2007 .

[19]  C. Hsieh,et al.  Thioredoxin‐ASK1 complex levels regulate ROS‐mediated p38 MAPK pathway activity in livers of aged and long‐lived Snell dwarf mice , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[20]  Dean P. Jones,et al.  Nuclear and mitochondrial compartmentation of oxidative stress and redox signaling. , 2006, Annual review of pharmacology and toxicology.

[21]  J. K. Kundu,et al.  International Conference on Diet , Nutrition , and Cancer Redox-Sensitive Transcription Factors as Prime Targets for Chemoprevention with Anti-Inflammatory and Antioxidative Phytochemicals 1 – 3 , 2005 .

[22]  J. Nelson,et al.  Housing density does not influence the longevity effect of calorie restriction. , 2005, The journals of gerontology. Series A, Biological sciences and medical sciences.

[23]  M. Emond,et al.  Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria , 2005, Science.

[24]  David B. Allison,et al.  Statistical methods for testing effects on “maximum lifespan” , 2004, Mechanisms of Ageing and Development.

[25]  Andreas Sommer,et al.  NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression , 2004 .

[26]  G. Semenza.  Targeting HIF-1 for cancer therapy , 2003, Nature Reviews Cancer.

[27]  R. Bronson,et al.  Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. , 2003, The journals of gerontology. Series A, Biological sciences and medical sciences.

[28]  G. Powis,et al.  The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis. , 2002, Cancer research.

[29]  Tadashi Hirakawa,et al.  Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span. , 2002, Antioxidants & redox signaling.

[30]  J. Yodoi,et al.  Enhanced resistancy of thioredoxin-transgenic mice against influenza virus-induced pneumonia. , 2002, Immunology letters.

[31]  Elias S. J. Arnér,et al.  Physiological functions of thioredoxin and thioredoxin reductase. , 2000, European journal of biochemistry.

[32]  D. Mustacich,et al.  The role of the redox protein thioredoxin in cell growth and cancer. , 2000, Free radical biology & medicine.

[33]  N. Brot,et al.  Peptide methionine sulfoxide reductase: biochemistry and physiological role. , 2000, Biopolymers.

[34]  H. J. Kim,et al.  Characterization of three isoforms of mammalian peroxiredoxin that reduce peroxides in the presence of thioredoxin. , 1999, Diabetes research and clinical practice.

[35]  K. Nozaki,et al.  Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[36]  E. Stadtman,et al.  Methionine residues may protect proteins from critical oxidative damage , 1999, Mechanisms of Ageing and Development.

[37]  S. Rhee,et al.  Isoforms of mammalian peroxiredoxin that reduce peroxides in presence of thioredoxin. , 1999, Methods in enzymology.

[38]  C. Epstein,et al.  Increased Oxidative Damage Is Correlated to Altered Mitochondrial Function in Heterozygous Manganese Superoxide Dismutase Knockout Mice* , 1998, The Journal of Biological Chemistry.

[39]  Kohei Miyazono,et al.  Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1 , 1998, The EMBO journal.

[40]  J. Gustafsson,et al.  Cloning and Expression of a Novel Mammalian Thioredoxin* , 1997, The Journal of Biological Chemistry.

[41]  W. Dröge,et al.  Distinct effects of glutathione disulphide on the nuclear transcription factor kappa B and the activator protein-1. , 1994, European journal of biochemistry.

[42]  Niels Keiding,et al.  Statistical Models Based on Counting Processes , 1993 .

[43]  W. Leonard,et al.  Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[44]  R. Bronson,et al.  Reduction in rate of occurrence of age related lesions in dietary restricted laboratory mice. , 1991, Growth, development, and aging : GDA.

[45]  T. Curran,et al.  Redox regulation of fos and jun DNA-binding activity in vitro. , 1990, Science.

[46]  K. Arai,et al.  ATL‐derived factor (ADF), an IL‐2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol‐reduction in the IL‐2 receptor induction. , 1989, The EMBO journal.

[47]  E. Stadtman,et al.  The isolation and purification of a specific "protector" protein which inhibits enzyme inactivation by a thiol/Fe(III)/O2 mixed-function oxidation system. , 1988, The Journal of biological chemistry.

[48]  Y. Sun,et al.  A simultaneous visualization of the antioxidant enzymes glutathione peroxidase and catalase on polyacrylamide gels. , 1988, Free radical research communications.

[49]  N. Brot,et al.  Enzymatic reduction of protein-bound methionine sulfoxide. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[50]  J. Pages,et al.  Characteristics of the antigenic determinants revealed by hybridoma-made monoclonal antibodies against the Fc fragment of rabbit IgG , 1979 .

[51]  I. Fridovich,et al.  Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. , 1971, Analytical biochemistry.

[52]  W. Leonard,et al.  Modulation of transcription factor NF-cB binding activity by oxidation-reduction in vitro , 2022 .