25-Hydroxycholesterols in innate and adaptive immunity

[1]  D. Russell,et al.  25-Hydroxycholesterol suppresses interleukin-1–driven inflammation downstream of type I interferon , 2014, Science.

[2]  A. Bittner,et al.  Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation , 2014, Proceedings of the National Academy of Sciences.

[3]  M. Hattori,et al.  Foxp3(+) T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis. , 2014, Immunity.

[4]  A. Sher,et al.  Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk , 2014, Nature.

[5]  E. Gold,et al.  25-Hydroxycholesterol acts as an amplifier of inflammatory signaling , 2014, Proceedings of the National Academy of Sciences.

[6]  C. Mineo,et al.  The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha. , 2014, Cell metabolism.

[7]  D. Voehringer,et al.  B‐cell‐intrinsic STAT6 signaling controls germinal center formation , 2014, European journal of immunology.

[8]  M. Rosenkilde,et al.  Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. , 2014, Journal of medicinal chemistry.

[9]  K. Seuwen,et al.  Transcriptional regulation and functional characterization of the oxysterol/EBI2 system in primary human macrophages. , 2014, Biochemical and biophysical research communications.

[10]  G. Belz,et al.  A murid gamma-herpesviruses exploits normal splenic immune communication routes for systemic spread. , 2014, Cell host & microbe.

[11]  M. Arita.  Phosphatidylinositol‐4 kinase III beta and oxysterol‐binding protein accumulate unesterified cholesterol on poliovirus‐induced membrane structure , 2014, Microbiology and immunology.

[12]  F. Bushman,et al.  The Major Cellular Sterol Regulatory Pathway Is Required for Andes Virus Infection , 2014, PLoS pathogens.

[13]  A. Avenell,et al.  Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and systemic lupus erythematosus , 2014, Arthritis Research & Therapy.

[14]  J. Banchereau,et al.  The Antigen Presenting Cells Instruct Plasma Cell Differentiation , 2014, Front. Immunol..

[15]  R. Johnston,et al.  EBI2 Is a Negative Regulator of Type I Interferons in Plasmacytoid and Myeloid Dendritic Cells , 2013, PloS one.

[16]  Joon-No Lee,et al.  Sufficient production of geranylgeraniol is required to maintain endotoxin tolerance in macrophages , 2013, Journal of Lipid Research.

[17]  G. Drin,et al.  A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP , 2013, Cell.

[18]  C. Glass,et al.  25-Hydroxycholesterol Activates the Integrated Stress Response to Reprogram Transcription and Translation in Macrophages* , 2013, The Journal of Biological Chemistry.

[19]  C. Glass,et al.  Sterols and oxysterols in immune cell function , 2013, Nature Immunology.

[20]  R. Brink,et al.  B cell localization: regulation by EBI2 and its oxysterol ligand. , 2013, Trends in immunology.

[21]  J. Sharpe,et al.  Naive B-cell trafficking is shaped by local chemokine availability and LFA-1-independent stromal interactions. , 2013, Blood.

[22]  J. Cyster,et al.  EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture , 2013, eLife.

[23]  M. Shinohara,et al.  The role of interferon‐β in the treatment of multiple sclerosis and experimental autoimmune encephalomyelitis – in the perspective of inflammasomes , 2013, Immunology.

[24]  G. Karupiah,et al.  The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells , 2013, Nature Immunology.

[25]  Jae U. Jung,et al.  The Antiviral Effector IFITM3 Disrupts Intracellular Cholesterol Homeostasis to Block Viral Entry , 2013, Cell Host & Microbe.

[26]  U. Diczfalusy.  On the formation and possible biological role of 25-hydroxycholesterol. , 2013, Biochimie.

[27]  M. Rosenkilde,et al.  Small molecule antagonism of oxysterol-induced Epstein–Barr virus induced gene 2 (EBI2) activation☆ , 2013, FEBS open bio.

[28]  Wan-Wan Lin,et al.  HMG‐CoA reductase inhibitors activate caspase‐1 in human monocytes depending on ATP release and P2X7 activation , 2013, Journal of leukocyte biology.

[29]  T. Wakita,et al.  Oxysterol-Binding Protein Family I Is the Target of Minor Enviroxime-Like Compounds , 2013, Journal of Virology.

[30]  G. Cheng,et al.  Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol. , 2013, Immunity.

[31]  Kevin A. Robertson,et al.  The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response , 2013, Immunity.

[32]  T. Lovenberg,et al.  Identification of Structural Motifs Critical for Epstein-Barr Virus-Induced Molecule 2 Function and Homology Modeling of the Ligand Docking Site , 2012, Molecular Pharmacology.

[33]  David C. Wilson,et al.  Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease , 2012, Nature.

[34]  J. Gustafsson,et al.  Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. , 2012, Immunity.

[35]  A. Baíllo,et al.  EBI2 regulates CXCL13‐mediated responses by heterodimerization with CXCR5 , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[36]  T. Frimurer,et al.  Molecular Characterization of Oxysterol Binding to the Epstein-Barr Virus-induced Gene 2 (GPR183)* , 2012, The Journal of Biological Chemistry.

[37]  V. Chukkapalli,et al.  Lipids at the interface of virus-host interactions. , 2012, Current opinion in microbiology.

[38]  M. Ichinose,et al.  25-hydroxycholesterol enhances cytokine release and toll-like receptor 3 response in airway epithelial cells , 2012, Respiratory Research.

[39]  R. D. Du Pasquier,et al.  Type I IFN-mediated regulation of IL-1 production in inflammatory disorders , 2012, Cellular and Molecular Life Sciences.

[40]  S. Crotty,et al.  Bcl6 and Maf Cooperate To Instruct Human Follicular Helper CD4 T Cell Differentiation , 2012, The Journal of Immunology.

[41]  R. Moritz,et al.  ATF3 protects against atherosclerosis by suppressing 25-hydroxycholesterol–induced lipid body formation , 2012, The Journal of experimental medicine.

[42]  G. Núñez,et al.  Sensing and reacting to microbes through the inflammasomes , 2012, Nature Immunology.

[43]  John A. Todd,et al.  Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes , 2012, Human molecular genetics.

[44]  G. Cheng,et al.  Systematic identification of type I and type II interferon-induced antiviral factors , 2012, Proceedings of the National Academy of Sciences.

[45]  Hugh Rosen,et al.  Crystal Structure of a Lipid G Protein–Coupled Receptor , 2012, Science.

[46]  M. David,et al.  Immunomodulatory functions of type I interferons , 2012, Nature Reviews Immunology.

[47]  R. Brink,et al.  EBI2 Operates Independently of but in Cooperation with CXCR5 and CCR7 To Direct B Cell Migration and Organization in Follicles and the Germinal Center , 2011, The Journal of Immunology.

[48]  B. Vickery,et al.  An Interferon-Inducible Neutrophil-Driven Blood Transcriptional Signature in Human Tuberculosis , 2011, Pediatrics.

[49]  J. Cyster,et al.  EBI2 Guides Serial Movements of Activated B Cells and Ligand Activity Is Detectable in Lymphoid and Nonlymphoid Tissues , 2011, The Journal of Immunology.

[50]  L. Karlsson,et al.  Oxysterols direct B-cell migration through EBI2 , 2011, Nature.

[51]  P. Schultz,et al.  Oxysterols direct immune cell migration via EBI2 , 2011, Nature.

[52]  T. Schwartz,et al.  Ligand Modulation of the Epstein-Barr Virus-induced Seven-transmembrane Receptor EBI2 , 2011, The Journal of Biological Chemistry.

[53]  N. Heaton,et al.  Multifaceted roles for lipids in viral infection , 2011, Trends in Microbiology.

[54]  Dan R. Littman,et al.  Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity , 2011, Nature.

[55]  Kevin A. Robertson,et al.  Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis , 2011, PLoS biology.

[56]  Pedro Romero,et al.  Type I interferon inhibits interleukin-1 production and inflammasome activation. , 2011, Immunity.

[57]  Nathan A. Baker,et al.  25-Hydroxycholesterol increases the availability of cholesterol in phospholipid membranes. , 2011, Biophysical journal.

[58]  R. Berland,et al.  Listeria monocytogenes Infection Induces Prosurvival Metabolic Signaling in Macrophages , 2011, Infection and Immunity.

[59]  Kiwon Park,et al.  Cholesterol 25‐hydroxylase production by dendritic cells and macrophages is regulated by type I interferons , 2010, Journal of leukocyte biology.

[60]  J. McDonald,et al.  Editorial: 25‐Hydroxycholesterol: a new life in immunology , 2010, Journal of leukocyte biology.

[61]  J. Cyster.  B cell follicles and antigen encounters of the third kind , 2010, Nature Immunology.

[62]  Kai Simons,et al.  Revitalizing membrane rafts: new tools and insights , 2010, Nature Reviews Molecular Cell Biology.

[63]  G. Trinchieri,et al.  Type I interferon: friend or foe? , 2010, The Journal of experimental medicine.

[64]  Martin Vingron,et al.  A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk , 2010, Nature.

[65]  Yong Li,et al.  Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma. , 2010, Molecular endocrinology.

[66]  V. Pascual,et al.  A genomic approach to human autoimmune diseases. , 2010, Annual review of immunology.

[67]  S. Crovella,et al.  The inhibition of mevalonate pathway induces upregulation of NALP3 expression: new insight in the pathogenesis of mevalonate kinase deficiency , 2010, European Journal of Human Genetics.

[68]  J. Tschopp,et al.  The Inflammasomes , 2010, Cell.

[69]  D. Golenbock,et al.  Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide , 2009, Journal of Lipid Research.

[70]  D. Russell,et al.  25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production , 2009, Proceedings of the National Academy of Sciences.

[71]  Scott N. Mueller,et al.  Stromal cell contributions to the homeostasis and functionality of the immune system , 2009, Nature Reviews Immunology.

[72]  R. Brink,et al.  Antigen Affinity Controls Rapid T-Dependent Antibody Production by Driving the Expansion Rather than the Differentiation or Extrafollicular Migration of Early Plasmablasts1 , 2009, The Journal of Immunology.

[73]  C. Mackay,et al.  Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. , 2009, Immunity.

[74]  D. Russell,et al.  CYP7B1: One Cytochrome P450, Two Human Genetic Diseases, and Multiple Physiological Functions* , 2009, The Journal of Biological Chemistry.

[75]  J. Cyster,et al.  EBV induced molecule-2 mediates B cell segregation between outer and center follicle , 2009, Nature.

[76]  M. Labow,et al.  Cholesterol biosynthesis modulation regulates dengue viral replication. , 2009, Virology.

[77]  T. Manser,et al.  Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles. , 2009, Immunity.

[78]  I. Björkhem.  Are side-chain oxidized oxysterols regulators also in vivo? Published, JLR Papers in Press, October 23, 2008. , 2009, Journal of Lipid Research.

[79]  Seth L Masters,et al.  Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*). , 2009, Annual review of immunology.

[80]  M. Katze,et al.  Impaired Cholesterol Biosynthesis in a Neuronal Cell Line Persistently Infected with Measles Virus , 2009, Journal of Virology.

[81]  Xianlin Han,et al.  Side Chain Oxygenated Cholesterol Regulates Cellular Cholesterol Homeostasis through Direct Sterol-Membrane Interactions* , 2009, Journal of Biological Chemistry.

[82]  H. Waterham,et al.  HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation. , 2008, Blood.

[83]  M. Rosenkilde,et al.  Structural Motifs of Importance for the Constitutive Activity of the Orphan 7TM Receptor EBI2: Analysis of Receptor Activation in the Absence of an Agonist , 2008, Molecular Pharmacology.

[84]  Peter Tontonoz,et al.  Integration of metabolism and inflammation by lipid-activated nuclear receptors , 2008, Nature.

[85]  Elina Ikonen,et al.  Cellular cholesterol trafficking and compartmentalization , 2008, Nature Reviews Molecular Cell Biology.

[86]  R. Parton,et al.  Cholesterol manipulation by West Nile virus perturbs the cellular immune response. , 2007, Cell host & microbe.

[87]  K. Korach,et al.  27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen , 2007, Nature Medicine.

[88]  H. Waterham,et al.  A role for geranylgeranylation in interleukin‐1β secretion , 2006 .

[89]  Y. Yamauchi,et al.  Cholesterol sensing, trafficking, and esterification. , 2006, Annual review of cell and developmental biology.

[90]  R. Mebius,et al.  New Insights into the Cell Biology of the Marginal Zone of the Spleen , 2006, International Review of Cytology.

[91]  T. Schwartz,et al.  Molecular Pharmacological Phenotyping of EBI2 , 2006, Journal of Biological Chemistry.

[92]  Kathleen A. Kennedy,et al.  Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4 , 2006, Nature.

[93]  Joseph L. Goldstein,et al.  Protein Sensors for Membrane Sterols , 2006, Cell.

[94]  T. Banks,et al.  Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells. , 2005, Immunity.

[95]  井出 智広.  Sterol regulatory element-binding proteinsは肝臓のインスリン受容体基質-2を介したインスリンシグナルを抑制する , 2005 .

[96]  R. Cantor,et al.  Systemic lupus erythematosus genome scan: support for linkage at 1q23, 2q33, 16q12-13, and 17q21-23 and novel evidence at 3p24, 10q23-24, 13q32, and 18q22-23. , 2004, Arthritis and rheumatism.

[97]  M. Chow,et al.  Cholesterol Removal by Methyl-β-Cyclodextrin Inhibits Poliovirus Entry , 2004, Journal of Virology.

[98]  D. Russell.  The enzymes, regulation, and genetics of bile acid synthesis. , 2003, Annual review of biochemistry.

[99]  R. Lahesmaa,et al.  Identification of Novel Genes Regulated by IL-12, IL-4, or TGF-β during the Early Polarization of CD4+ Lymphocytes 1 , 2003, The Journal of Immunology.

[100]  C. Bao,et al.  Protein interaction for an interferon-inducible systemic lupus associated gene, IFIT1. , 2003, Rheumatology.

[101]  R. Lahesmaa,et al.  Identification of Novel Genes Regulated by IL-12, IL-4, or TGF- during the Early Polarization of CD4 Lymphocytes , 2003 .

[102]  J. Goldstein,et al.  Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. , 2003, Molecular cell.

[103]  S. Dikman,et al.  Autoimmune disease complicating antiviral therapy for hepatitis C virus infection. , 2002, Seminars in arthritis and rheumatism.

[104]  L. Wodicka,et al.  Genomic analysis of the host response to hepatitis C virus infection , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[105]  I. Maclennan,et al.  Dendritic cells, BAFF, and APRIL: innate players in adaptive antibody responses. , 2002, Immunity.

[106]  E. Lander,et al.  Human macrophage activation programs induced by bacterial pathogens , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[107]  D. Russell,et al.  Oxysterol biosynthetic enzymes. , 2000, Biochimica et biophysica acta.

[108]  D. Russell,et al.  The bile acid synthetic gene 3β-hydroxy-Δ5-C27-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis , 2000 .

[109]  K. Rajewsky,et al.  EBV-infected B cells in infectious mononucleosis: viral strategies for spreading in the B cell compartment and establishing latency. , 2000, Immunity.

[110]  L. Staudt,et al.  BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. , 2000, Immunity.

[111]  D. Russell,et al.  Disruption of the Oxysterol 7α-Hydroxylase Gene in Mice* , 2000, The Journal of Biological Chemistry.

[112]  M. Kielian,et al.  The Cholesterol Requirement for Sindbis Virus Entry and Exit and Characterization of a Spike Protein Region Involved in Cholesterol Dependence , 1999, Journal of Virology.

[113]  Andrew J. Brown,et al.  Oxysterols and atherosclerosis. , 1999, Atherosclerosis.

[114]  D. Russell,et al.  cDNA Cloning of Mouse and Human Cholesterol 25-Hydroxylases, Polytopic Membrane Proteins That Synthesize a Potent Oxysterol Regulator of Lipid Metabolism* , 1998, The Journal of Biological Chemistry.

[115]  M. Petri,et al.  Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[116]  A. Aubertin,et al.  Oxysterols, but Not Cholesterol, Inhibit Human Immunodeficiency Virus Replication in Vitro , 1998, Antiviral chemistry & chemotherapy.

[117]  D. Mangelsdorf,et al.  An oxysterol signalling pathway mediated by the nuclear receptor LXRα , 1996, Nature.

[118]  D. Morel,et al.  Esterification of oxysterols in human serum: effects on distribution and cellular uptake. , 1996, Journal of lipid research.

[119]  Catherine C. Y. Chang,et al.  Activation of Acyl-Coenzyme A:Cholesterol Acyltransferase by Cholesterol or by Oxysterol in a Cell-free System (*) , 1995, The Journal of Biological Chemistry.

[120]  E. Kieff,et al.  Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors , 1993, Journal of virology.

[121]  H. Stein,et al.  Patterns of Epstein-Barr virus infection in non-neoplastic lymphoid tissue. , 1992, Blood.

[122]  M. Kielian,et al.  Cholesterol is required for infection by Semliki Forest virus , 1991, The Journal of cell biology.

[123]  K. Gibson,et al.  3-Hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured fibroblasts from patients with mevalonate kinase deficiency: differential response to lipid supplied by fetal bovine serum in tissue culture medium. , 1990, Journal of lipid research.

[124]  M. Cervin,et al.  Cholesterol enhances mouse hepatitis virus-mediated cell fusion , 1988, Virology.

[125]  B Lundberg,et al.  Chemical composition and physical state of lipid deposits in atherosclerosis. , 1985, Atherosclerosis.

[126]  S. Miller,et al.  Regulation of cholesterol biosynthesis and esterification by 25-hydroxycholesterol in a macrophage-like cell line: uncoupling by progesterone. , 1984, Journal of lipid research.

[127]  M. Brown,et al.  Cholesterol ester formation in cultured human fibroblasts. Stimulation by oxygenated sterols. , 1975, The Journal of biological chemistry.

[128]  M. Brown,et al.  Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol. , 1974, The Journal of biological chemistry.

[129]  A. Kandutsch,et al.  Inhibition of sterol synthesis in cultured mouse cells by cholesterol derivatives oxygenated in the side chain. , 1974, The Journal of biological chemistry.