Inactivation of nuclear factor-κB by citrus flavanone hesperidin contributes to apoptosis and chemo-sensitizing effect in Ramos cells.

[1]  S. Kao,et al.  The inhibitory effect of hesperidin on tumor cell invasiveness occurs via suppression of activator protein 1 and nuclear factor-kappaB in human hepatocellular carcinoma cells. , 2010, Toxicology letters.

[2]  J. R. Patil,et al.  Bioactive compounds from Mexican lime ( Citrus aurantifolia ) juice induce apoptosis in human pancreatic cells. , 2009, Journal of agricultural and food chemistry.

[3]  N. Nalini,et al.  Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis. , 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[4]  E. Ignatowicz,et al.  Citrus fruit flavonoids influence on neutrophil apoptosis and oxidative metabolism , 2008, Phytotherapy research : PTR.

[5]  S. Barnes.  Nutritional genomics, polyphenols, diets, and their impact on dietetics. , 2008, Journal of the American Dietetic Association.

[6]  S. Ley,et al.  New insights into NF-kappaB regulation and function. , 2008, Trends in immunology.

[7]  W. Wahli.  A gut feeling of the PXR, PPAR and NF‐κB connection , 2008, Journal of internal medicine.

[8]  Tadashi Hase,et al.  Short-term effects of glucosyl hesperidin and hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive rats. , 2008, Journal of nutritional science and vitaminology.

[9]  J-H Chung,et al.  Apoptotic effect of hesperidin through caspase3 activation in human colon cancer cells, SNU-C4. , 2008, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[10]  Noeris K. Salam,et al.  Novel PPAR‐gamma Agonists Identified from a Natural Product Library: A Virtual Screening, Induced‐Fit Docking and Biological Assay Study , 2007, Chemical biology & drug design.

[11]  A. Krishnan,et al.  Biology of PPARγ in Cancer: A Critical Review on Existing Lacunae , 2007 .

[12]  G. Kroemer,et al.  NF-κB inhibition sensitizes to starvation-induced cell death in high-risk myelodysplastic syndrome and acute myeloid leukemia , 2007, Oncogene.

[13]  Jing Wen,et al.  [6]-Gingerol Induces Cell Cycle Arrest and Cell Death of Mutant p53-expressing Pancreatic Cancer Cells , 2006, Yonsei medical journal.

[14]  H. Chung,et al.  Modulation of the age‐related nuclear factor‐κB (NF‐κB) pathway by hesperetin , 2006, Aging cell.

[15]  O. Wiestler,et al.  Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin , 2006, Apoptosis.

[16]  I. Puddey,et al.  Differential modulation of cell cycle, apoptosis and PPARγ2 gene expression by PPARγ agonists ciglitazone and 9-hydroxyoctadecadienoic acid in monocytic cells , 2006 .

[17]  G. Courtois,et al.  Down-regulating constitutive activation of the NF-kappaB canonical pathway overcomes the resistance of cutaneous T-cell lymphoma to apoptosis. , 2006, Blood.

[18]  S. Orrenius,et al.  Apoptosis: a basic biological phenomenon with wide‐ranging implications in human disease , 2005, Journal of internal medicine.

[19]  M. Salvador,et al.  Antioxidant activity of the flavonoid hesperidin in chemical and biological systems. , 2005, Journal of agricultural and food chemistry.

[20]  S. Kulp,et al.  Thiazolidenediones mediate apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 functions independently of PPARgamma. , 2005, Cancer research.

[21]  R. Taulli,et al.  15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins. , 2005, Blood.

[22]  Lawrence A. Donehower,et al.  Cyclin D1 Repression of Peroxisome Proliferator-Activated Receptor γ Expression and Transactivation , 2003, Molecular and Cellular Biology.

[23]  Kazuki Kanazawa,et al.  Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice. , 2003, The Journal of nutrition.

[24]  W. Wahli,et al.  PPARs: transcriptional effectors of fatty acids and their derivatives , 2002, Cellular and Molecular Life Sciences CMLS.

[25]  R. Phipps,et al.  Human B Lymphocytes and B Lymphomas Express PPAR-γ and Are Killed by PPAR-γ Agonists , 2002 .

[26]  D. Green,et al.  Bax-induced Caspase Activation and Apoptosis via Cytochromec Release from Mitochondria Is Inhibitable by Bcl-xL* , 1999, The Journal of Biological Chemistry.

[27]  J C Reed,et al.  IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. , 1998, Cancer research.

[28]  M. Fiscella,et al.  A p53-independent Pathway for Activation of WAF1/CIP1 Expression Following Oxidative Stress * , 1995, The Journal of Biological Chemistry.

[29]  T. Frey,et al.  Nucleic acid dyes for detection of apoptosis in live cells. , 1995, Cytometry.

[30]  G. Stark,et al.  p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[31]  Muneesh Tewari,et al.  Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase , 1995, Cell.

[32]  Yi-Song Wang,et al.  WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. , 1994, Cancer research.

[33]  J. M. Lee,et al.  p53 mutations increase resistance to ionizing radiation. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[34]  T. Crook,et al.  p53 is frequently mutated in Burkitt's lymphoma cell lines. , 1991, The EMBO journal.

[35]  F. Ranelletti,et al.  Synergistic antiproliferative activity of quercetin and cisplatin on ovarian cancer cell growth. , 1990, Anti-cancer drugs.

[36]  T. Mosmann.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.

[37]  M. Lean,et al.  Polyphenols and health: what compounds are involved? , 2010, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[38]  Xiquan Liang,et al.  Polyphenol antioxidants in citrus juices: in vitro and in vivo studies relevant to heart disease. , 2002, Advances in experimental medicine and biology.

[39]  J. Ross,et al.  Dietary flavonoids: bioavailability, metabolic effects, and safety. , 2002, Annual review of nutrition.

[40]  Myung‐Sook Choi,et al.  Interactive effect of hesperidin and vitamin E supplements on cholesterol metabolism in high cholesterol-fed rats. , 2001, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.