Responses to Leishmania donovani in Mice Deficient in Interleukin-12 (IL-12), IL-12/IL-23, or IL-18

ABSTRACT Interleukin-12 (IL-12) orchestrates acquired resistance in intracellular Leishmania donovani infection in the liver, inducing gamma interferon and, in turn, macrophage activation and parasite killing. Nevertheless, testing in IL-18−/− mice compared to wild-type mice and in IL-12p40−/− compared to IL-12p35−/− mice also suggested both early-acting (IL-18) and late-acting (IL-23) antileishmanial effects independent of IL-12.

[1]  S. Khader,et al.  IL-23 Compensates for the Absence of IL-12p70 and Is Essential for the IL-17 Response during Tuberculosis but Is Dispensable for Protection and Antigen-Specific IFN-γ Responses if IL-12p70 Is Available1 , 2005, The Journal of Immunology.

[2]  C. Hunter.  New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions , 2005, Nature Reviews Immunology.

[3]  P. Gros,et al.  Interleukin-15 Enhances Innate and Adaptive Immune Responses to Blood-Stage Malaria Infection in Mice , 2005, Infection and Immunity.

[4]  H. Murray.  Prevention of Relapse after Chemotherapy in a Chronic Intracellular Infection: Mechanisms in Experimental Visceral Leishmaniasis1 , 2005, The Journal of Immunology.

[5]  R. Pearson,et al.  Immunopathogenesis of infection with the visceralizing Leishmania species. , 2005, Microbial pathogenesis.

[6]  K. Ozato,et al.  Synergistic Activation of Interleukin-12 p35 Gene Transcription by Interferon Regulatory Factor-1 and Interferon Consensus Sequence-binding Protein* , 2004, Journal of Biological Chemistry.

[7]  P. Kaye,et al.  The immunopathology of experimental visceral leishmaniasis , 2004, Immunological reviews.

[8]  P. Kaye,et al.  Immunotherapy with OX40L‐Fc or anti‐CTLA‐4 enhances local tissue responses and killing of Leishmania donovani , 2004, European journal of immunology.

[9]  S. Akira,et al.  Interferon-gamma production and host protective response against Mycobacterium tuberculosis in mice lacking both IL-12p40 and IL-18. , 2004, Microbes and infection.

[10]  H. Murray,et al.  Modulation of T-Cell Costimulation as Immunotherapy or Immunochemotherapy in Experimental Visceral Leishmaniasis , 2003, Infection and Immunity.

[11]  P. Kaye,et al.  Both Interleukin-4 (IL-4) and IL-4 Receptor α Signaling Contribute to the Development of Hepatic Granulomas with Optimal Antileishmanial Activity , 2003, Infection and Immunity.

[12]  D. Foster,et al.  IL-21 in Synergy with IL-15 or IL-18 Enhances IFN-γ Production in Human NK and T Cells1 , 2003, The Journal of Immunology.

[13]  K. HayGlass,et al.  Endogenous IFN‐γ and IL‐18 production directly limit induction of type 2 immunity in vivo , 2002 .

[14]  R. Coffman,et al.  Interleukin-10 (IL-10) in Experimental Visceral Leishmaniasis and IL-10 Receptor Blockade as Immunotherapy , 2002, Infection and Immunity.

[15]  C. Hunter,et al.  Susceptibility of Interleukin-2-Deficient Mice to Toxoplasma gondii Is Associated with a Defect in the Production of Gamma Interferon , 2002, Infection and Immunity.

[16]  I. Orme,et al.  Mice Lacking Bioactive IL-12 Can Generate Protective, Antigen-Specific Cellular Responses to Mycobacterial Infection Only if the IL-12 p40 Subunit Is Present1 , 2002, The Journal of Immunology.

[17]  H. Murray.  Tissue granuloma structure‐function in experimental visceral leishmaniasis , 2001, International journal of experimental pathology.

[18]  J. D. Di Santo,et al.  IL-12-Independent IFN-γ Production by T Cells in Experimental Chagas’ Disease Is Mediated by IL-181 , 2001, The Journal of Immunology.

[19]  H. Murray,et al.  Interleukin-12 regulates the response to chemotherapy in experimental visceral Leishmaniasis. , 2000, The Journal of infectious diseases.

[20]  S. Akira,et al.  Cutting Edge: Selective IL-18 Requirements for Induction of Compartmental IFN-γ Responses During Viral Infection1 , 2000, The Journal of Immunology.

[21]  M. Marino,et al.  Visceral Leishmaniasis in Mice Devoid of Tumor Necrosis Factor and Response to Treatment , 2000, Infection and Immunity.

[22]  J Wagner,et al.  Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. , 2000, Immunity.

[23]  S. Akira,et al.  Genetically Resistant Mice Lacking IL-18 Gene Develop Th1 Response and Control Cutaneous Leishmania major Infection1 , 2000, The Journal of Immunology.

[24]  S. Rodig,et al.  IL‐12 gene‐deficient C57BL / 6 mice are susceptible to Leishmania donovani but have diminished hepatic immunopathology , 2000, European journal of immunology.

[25]  H. Murray,et al.  Roles of Endogenous Gamma Interferon and Macrophage Microbicidal Mechanisms in Host Response to Chemotherapy in Experimental Visceral Leishmaniasis , 2000, Infection and Immunity.

[26]  S. Akira,et al.  Defective NK cell activity and Th1 response in IL-18-deficient mice. , 1998, Immunity.

[27]  P. Kaye,et al.  Neutralization of IL‐12 demonstrates the existence of discrete organ‐specific phases in the control of Leishmania donovani , 1998, European journal of immunology.

[28]  H. Murray.  Endogenous interleukin-12 regulates acquired resistance in experimental visceral leishmaniasis. , 1997, The Journal of infectious diseases.

[29]  Alice P. Taylor,et al.  Intracellular Antimicrobial Activity in the Absence of Interferon-γ: Effect of Interleukin-12 in Experimental Visceral Leishmaniasis in Interferon-γ Gene-disrupted Mice , 1997, The Journal of experimental medicine.

[30]  H. Murray,et al.  Effect of granulocyte-macrophage colony-stimulating factor in experimental visceral leishmaniasis. , 1995, The Journal of clinical investigation.

[31]  H. Murray,et al.  Interleukin 12 is effective treatment for an established systemic intracellular infection: experimental visceral leishmaniasis , 1995, The Journal of experimental medicine.

[32]  G. D. Miralles,et al.  Th1 and Th2 cell-associated cytokines in experimental visceral leishmaniasis , 1994, Infection and immunity.

[33]  G. D. Miralles,et al.  Role and effect of IL-2 in experimental visceral leishmaniasis. , 1993, Journal of immunology.

[34]  C. Hunter,et al.  Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to leishmania donovani infection but develop severe liver immunopathology. , 2006, The American journal of pathology.

[35]  G. Trinchieri.  Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. , 1995, Annual review of immunology.