Thiazolopyrimidine Inhibitors of 2‐Methylerythritol 2,4‐Cyclodiphosphate Synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum
暂无分享,去创建一个
F. Diederich | W. Eisenreich | A. Bacher | J. Kaiser | S. Lauw | F. Rohdich | M. Fischer | T. Gräwert | M. Groll | W. Schweizer | J. Alonso-Gómez | S. Wittlin | B. Illarionov | Julie G Geist | V. Illarionova | C. Scheurer
[1] W. V. Van Voorhis,et al. Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene. , 2010, Molecular and biochemical parasitology.
[2] C. Barry. Unorthodox approach to the development of a new antituberculosis therapy. , 2009, The New England journal of medicine.
[3] Gary Taubes,et al. The Bacteria Fight Back , 2008, Science.
[4] G. Sheldrick. A short history of SHELX. , 2008, Acta crystallographica. Section A, Foundations of crystallography.
[5] W. Hunter,et al. The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery , 2007, BMC Structural Biology.
[6] M. Bergua,et al. Biosynthesis of isoprenoids in plants: Structure of the 2C‐methyl‐d‐erithrytol 2,4‐cyclodiphosphate synthase from Arabidopsis thaliana. Comparison with the bacterial enzymes , 2007, Protein science : a publication of the Protein Society.
[7] William N. Hunter,et al. The Non-mevalonate Pathway of Isoprenoid Precursor Biosynthesis* , 2007, Journal of Biological Chemistry.
[8] F. Diederich,et al. Structure‐Based Design and Synthesis of the First Weak Non‐Phosphate Inhibitors for IspF, an Enzyme in the Non‐Mevalonate Pathway of Isoprenoid Biosynthesis , 2007 .
[9] N. Berova,et al. Application of electronic circular dichroism in configurational and conformational analysis of organic compounds. , 2007, Chemical Society reviews.
[10] D. Pompliano,et al. Drugs for bad bugs: confronting the challenges of antibacterial discovery , 2007, Nature Reviews Drug Discovery.
[11] Markus Fischer,et al. Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods. , 2006, The Journal of organic chemistry.
[12] C. Kappe,et al. Microwave-assisted solution phase synthesis of dihydropyrimidine C5 amides and esters , 2006 .
[13] A. Bacher,et al. Fluoreszierende Inhibitoren von IspF, einem Enzym im “Nicht‐Mevalonat‐Biosyntheseweg” der Isoprenoide und möglichen Ziel einer Antimalariatherapie , 2006 .
[14] F. Diederich,et al. Fluorescent inhibitors for IspF, an enzyme in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy. , 2006, Angewandte Chemie.
[15] D. Bussiere,et al. Structure of 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase from Shewanella oneidensis at 1.6 A: identification of farnesyl pyrophosphate trapped in a hydrophobic cavity. , 2004, Acta crystallographica. Section D, Biological crystallography.
[16] Wolfgang Eisenreich,et al. Biosynthesis of isoprenoids: a bifunctional IspDF enzyme from Campylobacter jejuni. , 2004, European journal of biochemistry.
[17] A. Bacher,et al. Biosynthesis of isoprenoids via the non-mevalonate pathway , 2004, Cellular and Molecular Life Sciences CMLS.
[18] S. Yokoyama,et al. Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis. , 2003, Acta crystallographica. Section D, Biological crystallography.
[19] Jochen Wiesner,et al. Fosmidomycin for malaria , 2002, The Lancet.
[20] E. Eisenstein,et al. Structure of 2C‐methyl‐D‐erythrol‐2,4‐cyclodiphosphate synthase from Haemophilus influenzae: Activation by conformational transition , 2002, Proteins.
[21] Charles S Bond,et al. Structure of 2C-methyl-d-erythritol 2,4- cyclodiphosphate synthase: An essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[22] D. Cane,et al. Structure and Mechanism of 2-C-Methyl-d-erythritol 2,4-Cyclodiphosphate Synthase , 2002, The Journal of Biological Chemistry.
[23] S. Steinbacher,et al. Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids. , 2002, Journal of molecular biology.
[24] C. Kappe,et al. The Biginelli dihydropyrimidone synthesis using polyphosphate ester as a mild and efficient cyclocondensation/dehydration reagent , 2001 .
[25] W. Eisenreich,et al. Biosynthesis of terpenoids. 2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) from Plasmodium falciparum. , 2001, European journal of biochemistry.
[26] W. Eisenreich,et al. Deoxyxylulose phosphate pathway to terpenoids. , 2001, Trends in plant science.
[27] S. Saraç,et al. Studies on Synthesis, Chromatographic Resolution, and Antiinflammatory Activities of Some 2‐Thioxo‐1,2,3,4‐tetrahydropyrimidines and Their Condensed Derivatives , 2000, Archiv der Pharmazie.
[28] W. Eisenreich,et al. Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[29] D. Cane. Biosynthesis Meets Bioinformatics , 2000, Science.
[30] Maria Cristina Burla,et al. SIR97: a new tool for crystal structure determination and refinement , 1999 .
[31] P. Kuzmič,et al. Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. , 1996, Analytical biochemistry.
[32] C. Kappe. 100 years of the biginelli dihydropyrimidine synthesis , 1993 .