Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways

[1]  S. Mirarab,et al.  Sequence Analysis , 2020, Encyclopedia of Bioinformatics and Computational Biology.

[2]  P. Sivaramakrishnan,et al.  Microbial Genetic Composition Tunes Host Longevity , 2018, Cell.

[3]  D. Yoon,et al.  Measurement of Intracellular ROS in Caenorhabditis elegans Using 2',7'-Dichlorodihydrofluorescein Diacetate. , 2018, Bio-protocol.

[4]  J. V. Van Raamsdonk,et al.  Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans , 2018, PLoS genetics.

[5]  J. V. Van Raamsdonk,et al.  Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson’s disease models , 2017, Scientific Reports.

[6]  Renee M. Brielmann,et al.  Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging. , 2017, Cell reports.

[7]  J. V. Van Raamsdonk,et al.  Uncoupling of oxidative stress resistance and lifespan in long‐lived isp‐1 mitochondrial mutants in Caenorhabditis elegans , 2017, Free radical biology & medicine.

[8]  L. Livshits,et al.  Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans , 2017, Aging cell.

[9]  Emily Machiela,et al.  Oxidative stress is increased in C. elegans models of Huntington’s disease but does not contribute to polyglutamine toxicity phenotypes , 2016, Neurobiology of Disease.

[10]  D. Nomura,et al.  Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response , 2016, Cell.

[11]  Cole M. Haynes,et al.  The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR , 2016, Current Biology.

[12]  P. Brookes,et al.  The Mitochondrial Unfolded Protein Response Protects against Anoxia in Caenorhabditis elegans , 2016, PloS one.

[13]  Alfred L. Fisher,et al.  DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans , 2016, PLoS genetics.

[14]  J. V. Van Raamsdonk,et al.  Aging causes decreased resistance to multiple stresses and a failure to activate specific stress response pathways , 2016, Aging.

[15]  Guangchuang Yu,et al.  ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization. , 2016, Molecular bioSystems.

[16]  Dana L. Miller,et al.  Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span , 2015, Science.

[17]  J. V. Van Raamsdonk,et al.  Delaying aging is neuroprotective in Parkinson’s disease: a genetic analysis in C. elegans models , 2015, npj Parkinson's Disease.

[18]  G. Ruvkun,et al.  Dialogue between E. coli free radical pathways and the mitochondria of C. elegans , 2015, Proceedings of the National Academy of Sciences.

[19]  S. Hekimi,et al.  Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan , 2015, PLoS genetics.

[20]  Cole M. Haynes,et al.  Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection , 2014, Nature.

[21]  M. Kaeberlein,et al.  The mitochondrial unfolded protein response and increased longevity: Cause, consequence, or correlation? , 2014, Experimental Gerontology.

[22]  S. Hekimi,et al.  The Intrinsic Apoptosis Pathway Mediates the Pro-Longevity Response to Mitochondrial ROS in C. elegans , 2014, Cell.

[23]  M. Kaeberlein,et al.  Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans , 2014, Nature Communications.

[24]  J. Auwerx,et al.  The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease , 2014, Journal of Experimental Biology.

[25]  Ronald G. Tepper,et al.  PQM-1 Complements DAF-16 as a Key Transcriptional Regulator of DAF-2-Mediated Development and Longevity , 2013, Cell.

[26]  Robert W. Williams,et al.  Mitonuclear protein imbalance as a conserved longevity mechanism , 2013, Nature.

[27]  M. Pilon,et al.  The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway , 2013, Proceedings of the National Academy of Sciences.

[28]  Shu Liu,et al.  Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response , 2013, PLoS genetics.

[29]  Cole M. Haynes,et al.  Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation , 2012, Science.

[30]  Cole M. Haynes,et al.  Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2 , 2012, PLoS genetics.

[31]  S. Hekimi,et al.  Superoxide dismutase is dispensable for normal animal lifespan , 2012, Proceedings of the National Academy of Sciences.

[32]  S. Hekimi,et al.  FUdR causes a twofold increase in the lifespan of the mitochondrial mutant gas-1 , 2011, Mechanisms of Ageing and Development.

[33]  M. Kaeberlein,et al.  HIF‐1 modulates longevity and healthspan in a temperature‐dependent manner , 2011, Aging cell.

[34]  A. Dillin,et al.  The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity , 2011, Cell.

[35]  Seung-Jae V. Lee,et al.  Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity , 2010, Current Biology.

[36]  Siegfried Hekimi,et al.  A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans , 2010, PLoS biology.

[37]  S. Hekimi,et al.  Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans , 2010, Aging cell.

[38]  H. Daniel,et al.  Caenorhabditiselegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1 , 2010, Biogerontology.

[39]  Cole M. Haynes,et al.  The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. , 2010, Molecular cell.

[40]  Z. Zhai,et al.  The HIF-1 Hypoxia-Inducible Factor Modulates Lifespan in C. elegans , 2009, PloS one.

[41]  Michael P. Cary,et al.  A Regulated Response to Impaired Respiration Slows Behavioral Rates and Increases Lifespan in Caenorhabditis elegans , 2009, PLoS genetics.

[42]  S. Hekimi,et al.  Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans , 2009, PLoS genetics.

[43]  Cole M. Haynes,et al.  ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans. , 2007, Developmental cell.

[44]  Cole M. Haynes,et al.  Ubiquitin-Like Protein 5 Positively Regulates Chaperone Gene Expression in the Mitochondrial Unfolded Protein Response , 2006, Genetics.

[45]  F. Urano,et al.  Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones , 2004, Journal of Cell Science.

[46]  Y. Dong,et al.  Systematic functional analysis of the Caenorhabditis elegans genome using RNAi , 2003, Nature.

[47]  Andrew G Fraser,et al.  Rates of Behavior and Aging Specified by Mitochondrial Function During Development , 2002, Science.

[48]  Cynthia Kenyon,et al.  Timing Requirements for Insulin/IGF-1 Signaling in C. elegans , 2002, Science.

[49]  M. Ryan,et al.  A mitochondrial specific stress response in mammalian cells , 2002, The EMBO journal.

[50]  T. Johnson,et al.  daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans , 2001, Current Biology.

[51]  S. Hekimi,et al.  Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. , 2001, Developmental cell.

[52]  B. Lakowski,et al.  Determination of Life-Span in Caenorhabditis elegans by Four Clock Genes , 1996, Science.

[53]  S. Hekimi,et al.  Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. , 1995, Genetics.

[54]  Aaron T. L. Lun,et al.  It's DE-licious: A Recipe for Differential Expression Analyses of RNA-seq Experiments Using Quasi-Likelihood Methods in edgeR , 2016, Statistical Genomics.

[55]  J. Greally,et al.  Open Access Method , 2009 .