Evaluating metabolites in patients with major depressive disorder who received cognitive therapy and healthy controls using short echo MRSI at 7

mindfulness-based Tesla. of N -acetyl aspartate (NAA)/tCr in the left ACC, myo-inositol/tCr in the right insula, and glutathione/tCr in the left putamen were significantly decreased. At baseline, the severity of depression was negatively correlated with my-inositol/tCr in the left insula and putamen. The improve-ment in depression severity was significantly associated with changes in NAA/tCr in the left ACC. Conclusions This study has successfully evaluated regional differences in metabolites for patients with MDD who received MBCT treatment and in controls using 7 Tesla MRSI. its efficacy in reducing depressive recurrence [2] and treat-ing acute [3], chronic [4], and treatment-resistant depression [5] as an augmentation. These findings make MBCT treatment a potential valuable stand-alone treatment for MDD. Abstract Objectives Our aim was to evaluate differences in metabolite levels between unmedicated patients with major depressive disorder (MDD) and healthy controls, to assess changes in metabolites in patients after they completed an 8-week course of mindfulness-based cognitive therapy (MBCT), and to exam the correlation between metabolites and depression severity.

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