The impact of immune response on endochondral bone regeneration

[1]  F. O'Brien,et al.  An endochondral ossification approach to early stage bone repair: Use of tissue‐engineered hypertrophic cartilage constructs as primordial templates for weight‐bearing bone repair , 2018, Journal of tissue engineering and regenerative medicine.

[2]  Jessica Nulty,et al.  3D printed microchannel networks to direct vascularisation during endochondral bone repair. , 2018, Biomaterials.

[3]  Y. Li,et al.  Local delivery of fingolimod from three‐dimensional scaffolds impacts islet graft efficacy and microenvironment in a murine diabetic model , 2018, Journal of tissue engineering and regenerative medicine.

[4]  H. KiernanCaoimhe,et al.  The Immune Response to Allogeneic Differentiated Mesenchymal Stem Cells in the Context of Bone Tissue Engineering , 2017 .

[5]  Y. Ridwan,et al.  Mesenchymal stem cell-mediated endochondral ossification utilising micropellets and brief chondrogenic priming. , 2017, European cells & materials.

[6]  Jonathan C. Bernhard,et al.  Tissue-engineered hypertrophic chondrocyte grafts enhanced long bone repair. , 2017, Biomaterials.

[7]  W. Dhert,et al.  Local induction of inflammation affects bone formation. , 2017, European cells & materials.

[8]  F. Claas,et al.  B Cell Immunity in Solid Organ Transplantation , 2017, Front. Immunol..

[9]  G. Benichou,et al.  Allorecognition by T Lymphocytes and Allograft Rejection , 2016, Front. Immunol..

[10]  M. Yen,et al.  Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials , 2016, Journal of Biomedical Science.

[11]  C. Voermans,et al.  The Potential of Mesenchymal Stromal Cells as Treatment for Severe Steroid-Refractory Acute Graft-Versus-Host Disease: A Critical Review of the Literature , 2016, Transplantation.

[12]  L. McNamara,et al.  Endochondral Priming: A Developmental Engineering Strategy for Bone Tissue Regeneration. , 2016, Tissue engineering. Part B, Reviews.

[13]  N. Rouas-Freiss,et al.  Mesenchymal Stem Cells Derived from Human Bone Marrow and Adipose Tissue Maintain Their Immunosuppressive Properties After Chondrogenic Differentiation: Role of HLA-G. , 2016, Stem cells and development.

[14]  M. Ferrante,et al.  Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial , 2016, The Lancet.

[15]  P. Brama,et al.  Allogeneic chondrogenically differentiated human mesenchymal stromal cells do not induce immunogenic responses from T lymphocytes in vitro. , 2016, Cytotherapy.

[16]  P. Bourgine,et al.  Fat‐Derived Stromal Vascular Fraction Cells Enhance the Bone‐Forming Capacity of Devitalized Engineered Hypertrophic Cartilage Matrix , 2016, Stem cells translational medicine.

[17]  W. Fibbe,et al.  Unraveling mechanisms of mesenchymal stromal cell–mediated immunomodulation through patient monitoring and product characterization , 2016, Annals of the New York Academy of Sciences.

[18]  R. Atoui,et al.  Immunotolerant Properties of Mesenchymal Stem Cells: Updated Review , 2015, Stem cells international.

[19]  Jean Kanitakis,et al.  Immunopathology of rejection: do the rules of solid organ apply to vascularized composite allotransplantation? , 2015, Current opinion in organ transplantation.

[20]  F. O'Brien,et al.  Recapitulating endochondral ossification: a promising route to in vivo bone regeneration , 2015, Journal of tissue engineering and regenerative medicine.

[21]  M. Romano,et al.  The Human Mesenchymal Stromal Cell-Derived Osteocyte Capacity to Modulate Dendritic Cell Functions Is Strictly Dependent on the Culture System , 2015, Journal of immunology research.

[22]  Q. Cui,et al.  Interactions between MSCs and Immune Cells: Implications for Bone Healing , 2015, Journal of immunology research.

[23]  GaliliUri,et al.  Avoiding detrimental human immune response against Mammalian extracellular matrix implants. , 2015 .

[24]  R. Poulsom,et al.  Low-dose TNF augments fracture healing in normal and osteoporotic bone by up-regulating the innate immune response , 2015, EMBO molecular medicine.

[25]  G. Vunjak‐Novakovic,et al.  Immune modulation as a therapeutic strategy in bone regeneration , 2015, Journal of Experimental Orthopaedics.

[26]  D. Hu,et al.  The Multifaceted Role of the Vasculature in Endochondral Fracture Repair , 2015, Front. Endocrinol..

[27]  S. Both,et al.  Effects of in vitro chondrogenic priming time of bone-marrow-derived mesenchymal stromal cells on in vivo endochondral bone formation. , 2015, Acta biomaterialia.

[28]  D. Coutu,et al.  Tissue Engineering of Rat Bladder Using Marrow-Derived Mesenchymal Stem Cells and Bladder Acellular Matrix , 2014, PloS one.

[29]  K. von der Mark,et al.  Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice , 2014, PLoS genetics.

[30]  Yongwon Choi,et al.  Biology of the RANKL–RANK–OPG System in Immunity, Bone, and Beyond , 2014, Front. Immunol..

[31]  Yoshinobu Watanabe,et al.  Bone regeneration in a massive rat femur defect through endochondral ossification achieved with chondrogenically differentiated MSCs in a degradable scaffold. , 2014, Biomaterials.

[32]  J. Murphy,et al.  Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned? , 2014, Stem Cell Research & Therapy.

[33]  Liu Yang,et al.  Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation , 2014, Proceedings of the National Academy of Sciences.

[34]  B. Hallgrímsson,et al.  Stem Cell–Derived Endochondral Cartilage Stimulates Bone Healing by Tissue Transformation , 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[35]  J. Fisher,et al.  Immunogenicity of undifferentiated and differentiated allogeneic mouse mesenchymal stem cells , 2014, Journal of tissue engineering.

[36]  G. Shaw,et al.  Chondrogenic differentiation increases antidonor immune response to allogeneic mesenchymal stem cell transplantation. , 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

[37]  J. Karp,et al.  Mesenchymal stem cells: immune evasive, not immune privileged , 2014, Nature Biotechnology.

[38]  H. Weinans,et al.  Chondrogenically differentiated mesenchymal stromal cell pellets stimulate endochondral bone regeneration in critical-sized bone defects. , 2014, European cells & materials.

[39]  D. Kreisel,et al.  Innate immune cells in transplantation , 2014, Current opinion in organ transplantation.

[40]  S. Chatterjea,et al.  Suppression of the immune system as a critical step for bone formation from allogeneic osteoprogenitors implanted in rats , 2013, Journal of cellular and molecular medicine.

[41]  R. Pacifici.  Osteoimmunology and Its Implications for Transplantation , 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[42]  Y. Kato,et al.  Age-dependent decrease in the chondrogenic potential of human bone marrow mesenchymal stromal cells expanded with fibroblast growth factor-2. , 2013, Cytotherapy.

[43]  D W Hutmacher,et al.  Autologous vs. allogenic mesenchymal progenitor cells for the reconstruction of critical sized segmental tibial bone defects in aged sheep. , 2013, Acta biomaterialia.

[44]  R. Faccio,et al.  The Interplay between the Bone and the Immune System , 2013, Clinical & developmental immunology.

[45]  Kylie A Alexander,et al.  Unraveling macrophage contributions to bone repair. , 2013, BoneKEy reports.

[46]  Navrag B. Singh,et al.  Terminally Differentiated CD8+ T Cells Negatively Affect Bone Regeneration in Humans , 2013, Science Translational Medicine.

[47]  B. Mahdi,et al.  A glow of HLA typing in organ transplantation , 2013, Clinical and Translational Medicine.

[48]  P. Bourgine,et al.  Engineering of a functional bone organ through endochondral ossification , 2013, Proceedings of the National Academy of Sciences.

[49]  K. English.  Mechanisms of mesenchymal stromal cell immunomodulation , 2013, Immunology and cell biology.

[50]  F. Lin,et al.  Mesenchymal stem cells are injured by complement after their contact with serum. , 2012, Blood.

[51]  Ali Khademhosseini,et al.  Vascularized bone tissue engineering: approaches for potential improvement. , 2012, Tissue engineering. Part B, Reviews.

[52]  O. Joffre,et al.  Cross-presentation by dendritic cells , 2012, Nature Reviews Immunology.

[53]  Marco Antonio Ayala García,et al.  The Major Histocompatibility Complex in Transplantation , 2012, Journal of transplantation.

[54]  K. Wood,et al.  Regulatory immune cells in transplantation , 2012, Nature Reviews Immunology.

[55]  P. Buchwald,et al.  Feasibility of localized immunosuppression: 3. Preliminary evaluation of organosilicone constructs designed for sustained drug release in a cell transplant environment using dexamethasone. , 2012, Die Pharmazie.

[56]  Lutz Claes,et al.  Fracture healing under healthy and inflammatory conditions , 2012, Nature Reviews Rheumatology.

[57]  Lonnie D Shea,et al.  Tissue engineering tools for modulation of the immune response. , 2011, BioTechniques.

[58]  J. Simon,et al.  Immune responses to implants - a review of the implications for the design of immunomodulatory biomaterials. , 2011, Biomaterials.

[59]  P. Nilsson,et al.  Innate immunity activation on biomaterial surfaces: a mechanistic model and coping strategies. , 2011, Advanced drug delivery reviews.

[60]  Christopher H Evans,et al.  Barriers to the clinical translation of orthopedic tissue engineering. , 2011, Tissue engineering. Part B, Reviews.

[61]  Antonios G Mikos,et al.  Harnessing and modulating inflammation in strategies for bone regeneration. , 2011, Tissue engineering. Part B, Reviews.

[62]  Rozalia Dimitriou,et al.  Bone regeneration: current concepts and future directions , 2011, BMC medicine.

[63]  K. Brown,et al.  Coexpression of Donor Peptide/Recipient MHC Complex and Intact Donor MHC: Evidence for a Link between the Direct and Indirect Pathways , 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[64]  G. Duda,et al.  Human Early Fracture Hematoma Is Characterized by Inflammation and Hypoxia , 2011, Clinical orthopaedics and related research.

[65]  R. Hagen,et al.  Adipose tissue-derived stem cells show both immunogenic and immunosuppressive properties after chondrogenic differentiation. , 2011, Cytotherapy.

[66]  F. O'Brien,et al.  In-vivo generation of bone via endochondral ossification by in-vitro chondrogenic priming of adult human and rat mesenchymal stem cells , 2011, BMC musculoskeletal disorders.

[67]  James M. Anderson,et al.  Biocompatibility of implants: lymphocyte/macrophage interactions , 2011, Seminars in Immunopathology.

[68]  M. Feldmann,et al.  TNF-α promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells , 2011, Proceedings of the National Academy of Sciences.

[69]  J. Malda,et al.  Modulating endochondral ossification of multipotent stromal cells for bone regeneration. , 2010, Tissue engineering. Part B, Reviews.

[70]  G. Duda,et al.  Fracture healing is accelerated in the absence of the adaptive immune system , 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[71]  W. Wong,et al.  Intercellular Exchange of Surface Molecules and its Physiological Relevance , 2010, Archivum Immunologiae et Therapiae Experimentalis.

[72]  G. Duda,et al.  The early fracture hematoma and its potential role in fracture healing. , 2010, Tissue engineering. Part B, Reviews.

[73]  Ivan Martin,et al.  Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering , 2010, Proceedings of the National Academy of Sciences.

[74]  P. Kasten,et al.  Transplantation of human mesenchymal stem cells in a non-autogenous setting for bone regeneration in a rabbit critical-size defect model. , 2010, Acta biomaterialia.

[75]  J.Z. Xu,et al.  Immunological Study of Allogeneic Mesenchymal Stem Cells during Bone Formation , 2009, The Journal of international medical research.

[76]  C. Chu,et al.  Donor sex and age influence the chondrogenic potential of human femoral bone marrow stem cells. , 2009, Osteoarthritis and cartilage.

[77]  M. Maitz,et al.  Blood coagulation on biomaterials requires the combination of distinct activation processes. , 2009, Biomaterials.

[78]  L. Moretta,et al.  MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2. , 2009, Blood.

[79]  C. H. Coyle,et al.  Sustained hypoxia enhances chondrocyte matrix synthesis , 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[80]  Kyriacos A Athanasiou,et al.  Success rates and immunologic responses of autogenic, allogenic, and xenogenic treatments to repair articular cartilage defects. , 2009, Tissue engineering. Part B, Reviews.

[81]  J. Ryan,et al.  Cell contact, prostaglandin E2 and transforming growth factor beta 1 play non‐redundant roles in human mesenchymal stem cell induction of CD4+CD25Highforkhead box P3+ regulatory T cells , 2008, Clinical and experimental immunology.

[82]  J. Edwards,et al.  Exploring the full spectrum of macrophage activation , 2008, Nature Reviews Immunology.

[83]  Aaron Schindeler,et al.  Bone remodeling during fracture repair: The cellular picture. , 2008, Seminars in cell & developmental biology.

[84]  Y. Nagase,et al.  Pivotal Role of Bcl-2 Family Proteins in the Regulation of Chondrocyte Apoptosis* , 2008, Journal of Biological Chemistry.

[85]  R. Lechler,et al.  Pathways of major histocompatibility complex allorecognition. , 2008, Current opinion in organ transplantation.

[86]  David F. Williams.  On the mechanisms of biocompatibility. , 2008, Biomaterials.

[87]  James M. Anderson,et al.  Foreign body reaction to biomaterials. , 2008, Seminars in immunology.

[88]  F. Shapiro,et al.  Bone development and its relation to fracture repair. The role of mesenchymal osteoblasts and surface osteoblasts. , 2008, European cells & materials.

[89]  C. V. van Blitterswijk,et al.  Donor variation and loss of multipotency during in vitro expansion of human mesenchymal stem cells for bone tissue engineering , 2007, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[90]  F. Djouad,et al.  Mesenchymal Stem Cells Inhibit the Differentiation of Dendritic Cells Through an Interleukin‐6‐Dependent Mechanism , 2007, Stem cells.

[91]  Wei-Ping Qian,et al.  B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo. , 2007, Blood.

[92]  Chueh Shangkai,et al.  Transplantation of allogeneic chondrocytes cultured in fibroin sponge and stirring chamber to promote cartilage regeneration. , 2007, Tissue engineering.

[93]  Xi Chen,et al.  Chondrogenic Differentiation Alters the Immunosuppressive Property of Bone Marrow‐Derived Mesenchymal Stem Cells, and the Effect Is Partially due to the Upregulated Expression of B7 Molecules , 2007, Stem cells.

[94]  P. Kasten,et al.  Comparison of immunological properties of bone marrow stromal cells and adipose tissue-derived stem cells before and after osteogenic differentiation in vitro. , 2007, Tissue engineering.

[95]  M. Scherer,et al.  Roles of neutrophil‐mediated inflammatory response in the bony repair of injured growth plate cartilage in young rats , 2006, Journal of leukocyte biology.

[96]  Y. Kadono,et al.  Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction , 2006, The Journal of experimental medicine.

[97]  Thomas Aigner,et al.  Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. , 2006, Arthritis and rheumatism.

[98]  R. Willemze,et al.  Mesenchymal Stem Cells Inhibit Generation and Function of Both CD34+-Derived and Monocyte-Derived Dendritic Cells1 , 2006, The Journal of Immunology.

[99]  E. Vogler,et al.  Autoactivation of blood factor XII at hydrophilic and hydrophobic surfaces. , 2006, Biomaterials.

[100]  Robyn L Stanfield,et al.  How TCRs bind MHCs, peptides, and coreceptors. , 2006, Annual review of immunology.

[101]  Y. Kadono,et al.  Osteoimmunology: interplay between the immune system and bone metabolism. , 2006, Annual review of immunology.

[102]  H. Ouyang,et al.  The Immunogenicity and Immunomodulatory Function of Osteogenic Cells Differentiated from Mesenchymal Stem Cells , 2006, The Journal of Immunology.

[103]  I. Shapiro,et al.  Fate of the hypertrophic chondrocyte: microenvironmental perspectives on apoptosis and survival in the epiphyseal growth plate. , 2005, Birth defects research. Part C, Embryo today : reviews.

[104]  Eleftherios Tsiridis,et al.  Bone substitutes: an update. , 2005, Injury.

[105]  Miya Ishihara,et al.  Tissue engineering of articular cartilage using an allograft of cultured chondrocytes in a membrane-sealed atelocollagen honeycomb-shaped scaffold (ACHMS scaffold). , 2005, Journal of biomedical materials research. Part B, Applied biomaterials.

[106]  A. Gross,et al.  Long-Term Followup of the Use of Fresh Osteochondral Allografts for Posttraumatic Knee Defects , 2005, Clinical orthopaedics and related research.

[107]  Yan Wang,et al.  Microarray analysis of proliferative and hypertrophic growth plate zones identifies differentiation markers and signal pathways. , 2004, Bone.

[108]  Rui L Reis,et al.  Bone tissue engineering: state of the art and future trends. , 2004, Macromolecular bioscience.

[109]  Ulrich Göbel,et al.  bloodjournal.hematologylibrary.org at PENN STATE UNIVERSITY on February 20, 2013. For personal use , 2004 .

[110]  G. Dellgren,et al.  Xenoreactivity and engraftment of human mesenchymal stem cells transplanted into infarcted rat myocardium. , 2004, The Journal of thoracic and cardiovascular surgery.

[111]  J. Wetterö,et al.  Oxygen radical production in neutrophils interacting with platelets and surface-immobilized plasma proteins: role of tyrosine phosphorylation. , 2003, Journal of biomedical materials research. Part A.

[112]  O. Ringdén,et al.  HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. , 2003, Experimental hematology.

[113]  M. Walsh,et al.  Biology of the TRANCE axis. , 2003, Cytokine & growth factor reviews.

[114]  Thomas A Einhorn,et al.  Fracture healing as a post‐natal developmental process: Molecular, spatial, and temporal aspects of its regulation , 2003, Journal of cellular biochemistry.

[115]  T. Strom,et al.  Allogeneic stem cells, clinical transplantation, and the origins of regenerative medicine. , 2002, Transplantation proceedings.

[116]  D. Abramowicz,et al.  Multiple pathways to allograft rejection , 2002, Transplantation.

[117]  J W Eaton,et al.  Molecular basis of biomaterial-mediated foreign body reactions. , 2001, Blood.

[118]  J. Santerre,et al.  Neutrophil‐mediated biodegradation of medical implant materials , 2001, Journal of cellular physiology.

[119]  J M Anderson,et al.  Adsorbed serum proteins responsible for surface dependent human macrophage behavior. , 2000, Journal of biomedical materials research.

[120]  K. Healy,et al.  Protein adsorption and cell attachment to patterned surfaces. , 2000, Journal of biomedical materials research.

[121]  James M. Anderson,et al.  Multinucleated giant cells , 2000, Current opinion in hematology.

[122]  M. Pittenger,et al.  Multilineage potential of adult human mesenchymal stem cells. , 1999, Science.

[123]  J. Buckwalter,et al.  Changes in cell, matrix compartment, and fibrillar collagen volumes between growth‐plate zones , 1998, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[124]  M. Devidas,et al.  The immune microenvironment of human fracture/soft-tissue hematomas and its relationship to systemic immunity. , 1997, The Journal of trauma.

[125]  N. Halperin,et al.  Resurfacing of Goat Articular Cartilage by Chondrocytes Derived From Bone Marrow , 1996, Clinical orthopaedics and related research.

[126]  L. Gerstenfeld,et al.  Expression of bone‐specific genes by hypertrophic chondrocytes: Implications of the complex functions of the hypertrophic chondrocyte during endochondral bone development , 1996, Journal of cellular biochemistry.

[127]  C. Janeway.  Immunobiology: The Immune System in Health and Disease , 1996 .

[128]  S. Moskalewski,et al.  Rejection of cartilage formed by transplanted allogeneic chondrocytes: evaluation with monoclonal antibodies. , 1995, Transplant immunology.

[129]  N. Kawabe,et al.  The repair of full-thickness articular cartilage defects. Immune responses to reparative tissue formed by allogeneic growth plate chondrocyte implants. , 1991, Clinical orthopaedics and related research.

[130]  G. Duda,et al.  Macrophages in bone fracture healing: Their essential role in endochondral ossification. , 2018, Bone.

[131]  H. Weinans,et al.  Inflammation-Induced Osteogenesis in a Rabbit Tibia Model. , 2017, Tissue engineering. Part C, Methods.

[132]  Louis C. Gerstenfeld,et al.  Fracture healing: mechanisms and interventions , 2015, Nature Reviews Rheumatology.

[133]  Jos Malda,et al.  Endochondral bone formation in gelatin methacrylamide hydrogel with embedded cartilage-derived matrix particles. , 2015, Biomaterials.

[134]  J. Babensee,et al.  Macrophage and dendritic cell phenotypic diversity in the context of biomaterials. , 2011, Journal of biomedical materials research. Part A.

[135]  C. Milliman,et al.  Immune evasion by neocartilage-derived chondrocytes: Implications for biologic repair of joint articular cartilage. , 2010, Stem cell research.

[136]  Stefan Milz,et al.  Xenogenic transplantation of human mesenchymal stem cells in a critical size defect of the sheep tibia for bone regeneration. , 2010, Tissue engineering. Part A.

[137]  J. Caetano-Lopes,et al.  Osteoimmunology--the hidden immune regulation of bone. , 2009, Autoimmunity reviews.

[138]  Zhaohui Zheng,et al.  Allogeneic mesenchymal stem cell and mesenchymal stem cell-differentiated chondrocyte suppress the responses of type II collagen-reactive T cells in rheumatoid arthritis. , 2008, Rheumatology.

[139]  E. Mackie,et al.  Endochondral ossification: how cartilage is converted into bone in the developing skeleton. , 2008, The international journal of biochemistry & cell biology.

[140]  Bo Nilsson,et al.  The role of complement in biomaterial-induced inflammation. , 2007, Molecular immunology.

[141]  R. Willemze,et al.  Mesenchymal Stem Cells Inhibit Generation and Function of Both CD34 -Derived and Monocyte-Derived Dendritic Cells , 2006 .

[142]  J. V. van Rood.  Double Role of HLA in Organ Transplantation , 2000, World journal of surgery.

[143]  T. Aigner,et al.  Transplantation of allograft chondrocytes embedded in agarose gel into cartilage defects of rabbits. , 1998, Osteoarthritis and cartilage.

[144]  L. Sherman,et al.  The molecular basis of allorecognition. , 1993, Annual review of immunology.