Pharmacokinetic studies with PET.

[1]  Z. Lee,et al.  Regional distribution and kinetics of inhaled pharmaceuticals. , 2000, Current pharmaceutical design.

[2]  C. Halldin,et al.  Variability in D2‐dopamine receptor density and affinity: A PET study with [11C]raclopride in man , 1995, Synapse.

[3]  H. Herzog,et al.  Whole-body distribution and dosimetry of O-(2-[18F]fluoroethyl)-l-tyrosine , 2003, European Journal of Nuclear Medicine and Molecular Imaging.

[4]  B. Långström,et al.  Synthesis of 11C-amides using [11C]carbon monoxide and in situ activated amines by palladium-mediated carboxaminations. , 2003, Organic & biomolecular chemistry.

[5]  Julian C. Matthews,et al.  Pharmacokinetic assessment of novel anti-cancer drugs using spectral analysis and positron emission tomography: A feasibility study , 1998, Cancer Chemotherapy and Pharmacology.

[6]  B. Kinsey,et al.  Studies with [11C]alprazolam: an agonist for the benzodiazepine receptor. , 1995, Nuclear medicine and biology.

[7]  A. Harris,et al.  Use of positron emission tomography in pharmacokinetic studies to investigate therapeutic advantage in a phase I study of 120-hour intravenous infusion XR5000. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[8]  M. Lubberink,et al.  Pharmacokinetics and red cell utilization of iron(III) hydroxide–sucrose complex in anaemic patients: a study using positron emission tomography , 1999, British journal of haematology.

[9]  B. Gulyás,et al.  Drug distribution in man: a positron emission tomography study after oral administration of the labelled neuroprotective drug vinpocetine , 2002, European Journal of Nuclear Medicine and Molecular Imaging.

[10]  A. Klimowicz,et al.  Application of cutaneous microdialysis to evaluate metronidazole and its main metabolite concentrations in the skin after a single oral dose , 2003, Journal of clinical pharmacy and therapeutics.

[11]  T. Jones,et al.  In vivo pharmacokinetics and pharmacodynamics in drug development using positron-emission tomography. , 2001, Drug discovery today.

[12]  E. Minar,et al.  Penetration of Moxifloxacin into Healthy and Inflamed Subcutaneous Adipose Tissues in Humans , 2003, Antimicrobial Agents and Chemotherapy.

[13]  U. Ungerstedt,et al.  Blood-brain barrier transport of morphine in patients with severe brain trauma. , 2004, British journal of clinical pharmacology.

[14]  Christer Halldin,et al.  Differentiation of extrastriatal dopamine D2 receptor density and affinity in the human brain using PET , 2004, NeuroImage.

[15]  T Jones,et al.  Pharmacokinetic evaluation of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in patients by positron emission tomography. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[16]  Donald F. Smith,et al.  Biodistribution and radiation dosimetry of [N-methyl-11C]mirtazapine, an antidepressant affecting adrenoceptors. , 2003, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[17]  Magnus Dahlbom,et al.  Radiation dose estimates in humans for (11)C-acetate whole-body PET. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[18]  D. Heald,et al.  Biodistribution and kinetics of nasal carbon-11-triamcinolone acetonide. , 1998, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[19]  S. Osman,et al.  Metabolic activation of temozolomide measured in vivo using positron emission tomography. , 2003, Cancer research.

[20]  M. Bergström,et al.  11C-harmine as a tracer for monoamine oxidase A (MAO-A): in vitro and in vivo studies. , 1997, Nuclear medicine and biology.

[21]  Christer Halldin,et al.  PET-characterization of [carbonyl-11C]WAY-100635 binding to 5-HT1A receptors in the primate brain , 1997, Psychopharmacology.

[22]  A Sundin,et al.  Demonstration of [11C] 5-hydroxy-L-tryptophan uptake and decarboxylation in carcinoid tumors by specific positioning labeling in positron emission tomography. , 2000, Nuclear medicine and biology.

[23]  Sven Valind,et al.  Deposition and Disposition of [11C]Zanamivir Following Administration as an Intranasal Spray , 1999, Clinical pharmacokinetics.

[24]  A. Geppert,et al.  Target site penetration of fosfomycin in critically ill patients. , 2003, The Journal of antimicrobial chemotherapy.

[25]  M. Bergström,et al.  In vitro and in vivo primate evaluation of carbon-11-etomidate and carbon-11-metomidate as potential tracers for PET imaging of the adrenal cortex and its tumors. , 1998, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[26]  Zhenghong Lee,et al.  PET imaging-based evaluation of aerosol drugs and their delivery devices: nasal and pulmonary studies , 2002, IEEE Transactions on Medical Imaging.

[27]  P. Price,et al.  Pharmacokinetics of radiolabelled anticancer drugs for positron emission tomography. , 2003, Current pharmaceutical design.

[28]  G Kilpatrick,et al.  Brain uptake and receptor binding of two [11C]labelled selective high affinity NK1-antagonists, GR203040 and GR205171 — PET studies in rhesus monkey , 2000, Neuropharmacology.

[29]  M. Bergström,et al.  Autoradiography with positron emitting isotopes in positron emission tomography tracer discovery. , 2003, Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging.

[30]  N. Alpert,et al.  Pharmacokinetics of [18F]fleroxacin in patients with acute exacerbations of chronic bronchitis and complicated urinary tract infection studied by positron emission tomography , 1996, Antimicrobial agents and chemotherapy.

[31]  K. Markides,et al.  Compounds labelled with short-lived beta(+)-emitting radionuclides and some applications in life sciences. The importance of time as a parameter. , 1999, Acta chemica Scandinavica.

[32]  K. Yajima,et al.  Measurement of brain concentration of FK960 for development of a novel antidementia drug: a PET study in conscious rhesus monkeys. , 2003, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[33]  M. Klimas Positron emission tomography and drug discovery: contributions to the understanding of pharmacokinetics, mechanism of action and disease state characterization. , 2002, Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging.

[34]  B. Långstrom,et al.  Synthesis of [11C]/(13C)amines via carbonylation followed by reductive amination. , 2004, Organic & biomolecular chemistry.

[35]  A A Lammertsma,et al.  Evaluation of [O-methyl-3H]WAY-100635 as an in vivo radioligand for 5-HT1A receptors in rat brain. , 1994, European journal of pharmacology.

[36]  M. Dolovich,et al.  Measuring total and regional lung deposition using inhaled radiotracers. , 2001, Journal of Aerosol Medicine.

[37]  N. Alpert,et al.  Pharmacokinetics of [18F]Trovafloxacin in Healthy Human Subjects Studied with Positron Emission Tomography , 1998, Antimicrobial Agents and Chemotherapy.

[38]  Richard E Carson,et al.  Biodistribution, radiation dose estimates, and in vivo Pgp modulation studies of 18F-paclitaxel in nonhuman primates. , 2003, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[39]  B. Långström,et al.  Photoinitiated carbonylation with [(11)C]carbon monoxide using amines and alkyl iodides. , 2004, The Journal of organic chemistry.

[40]  Bengt Långström,et al.  Positron emission tomography microdosing: a new concept with application in tracer and early clinical drug development , 2003, European Journal of Clinical Pharmacology.

[41]  M. Bergström,et al.  In vivo demonstration of enzyme activity in endocrine pancreatic tumors: decarboxylation of carbon-11-DOPA to carbon-11-dopamine. , 1996, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[42]  Joost Bart,et al.  PET Studies on P-glycoprotein function in the blood-brain barrier: how it affects uptake and binding of drugs within the CNS. , 2004, Current pharmaceutical design.

[43]  B. Gulyás,et al.  Brain Uptake and Plasma Metabolism of [11C]Vinpocetine: A Preliminary PET Study in a Cynomolgus Monkey , 1999, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[44]  W Vaalburg,et al.  Carbon-11-labeled daunorubicin and verapamil for probing P-glycoprotein in tumors with PET. , 1996, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[45]  L. Sanderson,et al.  PLASMA PHARMACOKINETICS AND METABOLISM OF THE HISTONE DEACETYLASE INHIBITOR TRICHOSTATIN A AFTER INTRAPERITONEAL ADMINISTRATION TO MICE , 2004, Drug Metabolism and Disposition.

[46]  R. Colin Garner,et al.  Big physics, small doses: the use of AMS and PET in human microdosing of development drugs , 2003, Nature Reviews Drug Discovery.

[47]  A. Nordberg,et al.  Regional deposition of inhaled 11C‐nicotine vapor in the human airway as visualized by positron emission tomography , 1995, Clinical pharmacology and therapeutics.

[48]  B. Långström,et al.  Absorption of L-DOPA from the proximal small intestine studied in the rhesus monkey by positron emission tomography. , 1999, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[49]  P. Price,et al.  PET for in vivo pharmacokinetic and pharmacodynamic measurements. , 2002, European journal of cancer.

[50]  Z. Lee,et al.  Mapping PET-measured triamcinolone acetonide (TAA) aerosol distribution into deposition by airway generation. , 2000, International journal of pharmaceutics.

[51]  Nathaniel M. Alpert,et al.  Pharmacokinetic Imaging , 2002, Clinical pharmacokinetics.

[52]  Ming-fang Wang,et al.  Radiation dosimetry of O-(3-[18F]fluoropropyl)-L-tyrosine as oncologic PET tracer based on the mice distribution data. , 2004, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[53]  R. Myers,et al.  Comparative biodistribution and metabolism of carbon-11-labeled N-[2-(dimethylamino)ethyl]acridine-4-carboxamide and DNA-intercalating analogues. , 2001, Cancer research.

[54]  A. Lammertsma,et al.  Transport across the blood-brain barrier: stereoselectivity and PET-tracers. , 2004, Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging.

[55]  N. Alpert,et al.  The role of positron emission tomography in pharmacokinetic analysis. , 1997, Drug metabolism reviews.

[56]  B. Långström,et al.  Aryl triflates and [11C]/(13C)carbon monoxide in the synthesis of 11C-/13C-amides. , 2003, The Journal of organic chemistry.

[57]  Bengt Långström,et al.  [11C]Carbon Monoxide in Selenium-Mediated Synthesis of 11C-Carbamoyl Compounds , 2002 .

[58]  R D Combes,et al.  Early microdose drug studies in human volunteers can minimise animal testing: Proceedings of a workshop organised by Volunteers in Research and Testing. , 2003, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[59]  Z. Lee,et al.  Pulmonary distribution and kinetics of inhaled [11C]triamcinolone acetonide. , 2000, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[60]  H. Croxatto,et al.  Pharmacokinetics and metabolism of RU 486. , 1987, Journal of steroid biochemistry.

[61]  Cancer Research UK procedures in manufacture and toxicology of radiotracers intended for Pre-phase I positron emission tomography studies in cancer patients , 2002, British Journal of Cancer.

[62]  B. Kiss,et al.  PET studies on the brain uptake and regional distribution of [11C]vinpocetine in human subjects , 2002, Acta neurologica Scandinavica.

[63]  M. Bergström,et al.  Synthesis of some 11C-labelled MAO-A inhibitors and their in vivo uptake kinetics in rhesus monkey brain. , 1997, Nuclear medicine and biology.

[64]  D J Brooks,et al.  Comparison of Methods for Analysis of Clinical [11C]Raclopride Studies , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[65]  N. Alpert,et al.  Pharmacokinetics of fleroxacin as studied by positron emission tomography and [18F]fleroxacin. , 1993, The American journal of medicine.

[66]  F. Fazio,et al.  11C-Radiosynthesis and preliminary human evaluation of the disposition of the ACE inhibitor [11C]zofenoprilat. , 2004, Bioorganic & medicinal chemistry.

[67]  H. Eichler,et al.  Concentrations of Gemifloxacin at the Target Site in Healthy Volunteers after a Single Oral Dose , 2004, Antimicrobial Agents and Chemotherapy.

[68]  R. Frackowiak,et al.  Measurement of Cerebral Monoamine Oxidase B Activity Using L-[11C]Deprenyl and Dynamic Positron Emission Tomography , 1991, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.