Pharmacokinetic studies with PET.
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[1] Z. Lee,et al. Regional distribution and kinetics of inhaled pharmaceuticals. , 2000, Current pharmaceutical design.
[2] C. Halldin,et al. Variability in D2‐dopamine receptor density and affinity: A PET study with [11C]raclopride in man , 1995, Synapse.
[3] H. Herzog,et al. Whole-body distribution and dosimetry of O-(2-[18F]fluoroethyl)-l-tyrosine , 2003, European Journal of Nuclear Medicine and Molecular Imaging.
[4] B. Långström,et al. Synthesis of 11C-amides using [11C]carbon monoxide and in situ activated amines by palladium-mediated carboxaminations. , 2003, Organic & biomolecular chemistry.
[5] Julian C. Matthews,et al. Pharmacokinetic assessment of novel anti-cancer drugs using spectral analysis and positron emission tomography: A feasibility study , 1998, Cancer Chemotherapy and Pharmacology.
[6] B. Kinsey,et al. Studies with [11C]alprazolam: an agonist for the benzodiazepine receptor. , 1995, Nuclear medicine and biology.
[7] A. Harris,et al. Use of positron emission tomography in pharmacokinetic studies to investigate therapeutic advantage in a phase I study of 120-hour intravenous infusion XR5000. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[8] M. Lubberink,et al. Pharmacokinetics and red cell utilization of iron(III) hydroxide–sucrose complex in anaemic patients: a study using positron emission tomography , 1999, British journal of haematology.
[9] B. Gulyás,et al. Drug distribution in man: a positron emission tomography study after oral administration of the labelled neuroprotective drug vinpocetine , 2002, European Journal of Nuclear Medicine and Molecular Imaging.
[10] A. Klimowicz,et al. Application of cutaneous microdialysis to evaluate metronidazole and its main metabolite concentrations in the skin after a single oral dose , 2003, Journal of clinical pharmacy and therapeutics.
[11] T. Jones,et al. In vivo pharmacokinetics and pharmacodynamics in drug development using positron-emission tomography. , 2001, Drug discovery today.
[12] E. Minar,et al. Penetration of Moxifloxacin into Healthy and Inflamed Subcutaneous Adipose Tissues in Humans , 2003, Antimicrobial Agents and Chemotherapy.
[13] U. Ungerstedt,et al. Blood-brain barrier transport of morphine in patients with severe brain trauma. , 2004, British journal of clinical pharmacology.
[14] Christer Halldin,et al. Differentiation of extrastriatal dopamine D2 receptor density and affinity in the human brain using PET , 2004, NeuroImage.
[15] T Jones,et al. Pharmacokinetic evaluation of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in patients by positron emission tomography. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[16] Donald F. Smith,et al. Biodistribution and radiation dosimetry of [N-methyl-11C]mirtazapine, an antidepressant affecting adrenoceptors. , 2003, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
[17] Magnus Dahlbom,et al. Radiation dose estimates in humans for (11)C-acetate whole-body PET. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[18] D. Heald,et al. Biodistribution and kinetics of nasal carbon-11-triamcinolone acetonide. , 1998, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[19] S. Osman,et al. Metabolic activation of temozolomide measured in vivo using positron emission tomography. , 2003, Cancer research.
[20] M. Bergström,et al. 11C-harmine as a tracer for monoamine oxidase A (MAO-A): in vitro and in vivo studies. , 1997, Nuclear medicine and biology.
[21] Christer Halldin,et al. PET-characterization of [carbonyl-11C]WAY-100635 binding to 5-HT1A receptors in the primate brain , 1997, Psychopharmacology.
[22] A Sundin,et al. Demonstration of [11C] 5-hydroxy-L-tryptophan uptake and decarboxylation in carcinoid tumors by specific positioning labeling in positron emission tomography. , 2000, Nuclear medicine and biology.
[23] Sven Valind,et al. Deposition and Disposition of [11C]Zanamivir Following Administration as an Intranasal Spray , 1999, Clinical pharmacokinetics.
[24] A. Geppert,et al. Target site penetration of fosfomycin in critically ill patients. , 2003, The Journal of antimicrobial chemotherapy.
[25] M. Bergström,et al. In vitro and in vivo primate evaluation of carbon-11-etomidate and carbon-11-metomidate as potential tracers for PET imaging of the adrenal cortex and its tumors. , 1998, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[26] Zhenghong Lee,et al. PET imaging-based evaluation of aerosol drugs and their delivery devices: nasal and pulmonary studies , 2002, IEEE Transactions on Medical Imaging.
[27] P. Price,et al. Pharmacokinetics of radiolabelled anticancer drugs for positron emission tomography. , 2003, Current pharmaceutical design.
[28] G Kilpatrick,et al. Brain uptake and receptor binding of two [11C]labelled selective high affinity NK1-antagonists, GR203040 and GR205171 — PET studies in rhesus monkey , 2000, Neuropharmacology.
[29] M. Bergström,et al. Autoradiography with positron emitting isotopes in positron emission tomography tracer discovery. , 2003, Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging.
[30] N. Alpert,et al. Pharmacokinetics of [18F]fleroxacin in patients with acute exacerbations of chronic bronchitis and complicated urinary tract infection studied by positron emission tomography , 1996, Antimicrobial agents and chemotherapy.
[31] K. Markides,et al. Compounds labelled with short-lived beta(+)-emitting radionuclides and some applications in life sciences. The importance of time as a parameter. , 1999, Acta chemica Scandinavica.
[32] K. Yajima,et al. Measurement of brain concentration of FK960 for development of a novel antidementia drug: a PET study in conscious rhesus monkeys. , 2003, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[33] M. Klimas. Positron emission tomography and drug discovery: contributions to the understanding of pharmacokinetics, mechanism of action and disease state characterization. , 2002, Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging.
[34] B. Långstrom,et al. Synthesis of [11C]/(13C)amines via carbonylation followed by reductive amination. , 2004, Organic & biomolecular chemistry.
[35] A A Lammertsma,et al. Evaluation of [O-methyl-3H]WAY-100635 as an in vivo radioligand for 5-HT1A receptors in rat brain. , 1994, European journal of pharmacology.
[36] M. Dolovich,et al. Measuring total and regional lung deposition using inhaled radiotracers. , 2001, Journal of Aerosol Medicine.
[37] N. Alpert,et al. Pharmacokinetics of [18F]Trovafloxacin in Healthy Human Subjects Studied with Positron Emission Tomography , 1998, Antimicrobial Agents and Chemotherapy.
[38] Richard E Carson,et al. Biodistribution, radiation dose estimates, and in vivo Pgp modulation studies of 18F-paclitaxel in nonhuman primates. , 2003, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[39] B. Långström,et al. Photoinitiated carbonylation with [(11)C]carbon monoxide using amines and alkyl iodides. , 2004, The Journal of organic chemistry.
[40] Bengt Långström,et al. Positron emission tomography microdosing: a new concept with application in tracer and early clinical drug development , 2003, European Journal of Clinical Pharmacology.
[41] M. Bergström,et al. In vivo demonstration of enzyme activity in endocrine pancreatic tumors: decarboxylation of carbon-11-DOPA to carbon-11-dopamine. , 1996, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[42] Joost Bart,et al. PET Studies on P-glycoprotein function in the blood-brain barrier: how it affects uptake and binding of drugs within the CNS. , 2004, Current pharmaceutical design.
[43] B. Gulyás,et al. Brain Uptake and Plasma Metabolism of [11C]Vinpocetine: A Preliminary PET Study in a Cynomolgus Monkey , 1999, Journal of neuroimaging : official journal of the American Society of Neuroimaging.
[44] W Vaalburg,et al. Carbon-11-labeled daunorubicin and verapamil for probing P-glycoprotein in tumors with PET. , 1996, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[45] L. Sanderson,et al. PLASMA PHARMACOKINETICS AND METABOLISM OF THE HISTONE DEACETYLASE INHIBITOR TRICHOSTATIN A AFTER INTRAPERITONEAL ADMINISTRATION TO MICE , 2004, Drug Metabolism and Disposition.
[46] R. Colin Garner,et al. Big physics, small doses: the use of AMS and PET in human microdosing of development drugs , 2003, Nature Reviews Drug Discovery.
[47] A. Nordberg,et al. Regional deposition of inhaled 11C‐nicotine vapor in the human airway as visualized by positron emission tomography , 1995, Clinical pharmacology and therapeutics.
[48] B. Långström,et al. Absorption of L-DOPA from the proximal small intestine studied in the rhesus monkey by positron emission tomography. , 1999, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[49] P. Price,et al. PET for in vivo pharmacokinetic and pharmacodynamic measurements. , 2002, European journal of cancer.
[50] Z. Lee,et al. Mapping PET-measured triamcinolone acetonide (TAA) aerosol distribution into deposition by airway generation. , 2000, International journal of pharmaceutics.
[51] Nathaniel M. Alpert,et al. Pharmacokinetic Imaging , 2002, Clinical pharmacokinetics.
[52] Ming-fang Wang,et al. Radiation dosimetry of O-(3-[18F]fluoropropyl)-L-tyrosine as oncologic PET tracer based on the mice distribution data. , 2004, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
[53] R. Myers,et al. Comparative biodistribution and metabolism of carbon-11-labeled N-[2-(dimethylamino)ethyl]acridine-4-carboxamide and DNA-intercalating analogues. , 2001, Cancer research.
[54] A. Lammertsma,et al. Transport across the blood-brain barrier: stereoselectivity and PET-tracers. , 2004, Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging.
[55] N. Alpert,et al. The role of positron emission tomography in pharmacokinetic analysis. , 1997, Drug metabolism reviews.
[56] B. Långström,et al. Aryl triflates and [11C]/(13C)carbon monoxide in the synthesis of 11C-/13C-amides. , 2003, The Journal of organic chemistry.
[57] Bengt Långström,et al. [11C]Carbon Monoxide in Selenium-Mediated Synthesis of 11C-Carbamoyl Compounds , 2002 .
[58] R D Combes,et al. Early microdose drug studies in human volunteers can minimise animal testing: Proceedings of a workshop organised by Volunteers in Research and Testing. , 2003, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[59] Z. Lee,et al. Pulmonary distribution and kinetics of inhaled [11C]triamcinolone acetonide. , 2000, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[60] H. Croxatto,et al. Pharmacokinetics and metabolism of RU 486. , 1987, Journal of steroid biochemistry.
[61] Cancer Research UK procedures in manufacture and toxicology of radiotracers intended for Pre-phase I positron emission tomography studies in cancer patients , 2002, British Journal of Cancer.
[62] B. Kiss,et al. PET studies on the brain uptake and regional distribution of [11C]vinpocetine in human subjects , 2002, Acta neurologica Scandinavica.
[63] M. Bergström,et al. Synthesis of some 11C-labelled MAO-A inhibitors and their in vivo uptake kinetics in rhesus monkey brain. , 1997, Nuclear medicine and biology.
[64] D J Brooks,et al. Comparison of Methods for Analysis of Clinical [11C]Raclopride Studies , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[65] N. Alpert,et al. Pharmacokinetics of fleroxacin as studied by positron emission tomography and [18F]fleroxacin. , 1993, The American journal of medicine.
[66] F. Fazio,et al. 11C-Radiosynthesis and preliminary human evaluation of the disposition of the ACE inhibitor [11C]zofenoprilat. , 2004, Bioorganic & medicinal chemistry.
[67] H. Eichler,et al. Concentrations of Gemifloxacin at the Target Site in Healthy Volunteers after a Single Oral Dose , 2004, Antimicrobial Agents and Chemotherapy.
[68] R. Frackowiak,et al. Measurement of Cerebral Monoamine Oxidase B Activity Using L-[11C]Deprenyl and Dynamic Positron Emission Tomography , 1991, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.