Improving performance of time-domain optical mammography by Jacobian scaling method

Time-domain optical mammography has attracted many attentions since it can diagnose early breast cancer by efficiently reconstructing optical parameter. However, the currently available image reconstruction algorithms for time-domain optical mammography are badly influenced by different Jacobian magnitudes of absorption coefficient and reduced scattering coefficient. To improve image quality, we proposed an efficient Jacobian scaling method with a relative data type based on generalized pulse spectrum technique. Our simulated and experimental reconstructions show that this Jacobian scaling method can efficiently enhancing the quality of reconstructed image.