Cell cycle reentry triggers hyperploidization and synaptic dysfunction followed by delayed cell death in differentiated cortical neurons

[1]  Pedro D. Maia,et al.  Modeling cognitive deficits following neurodegenerative diseases and traumatic brain injuries with deep convolutional neural networks , 2016, Brain and Cognition.

[2]  A. Rábano,et al.  Neuronal tetraploidization in the cerebral cortex correlates with reduced cognition in mice and precedes and recapitulates Alzheimer's-associated neuropathology , 2017, Neurobiology of Aging.

[3]  F. Gage,et al.  Genomic Mosaicism in Neurons and Other Cell Types , 2017, Neuromethods.

[4]  Steven L Jones,et al.  Axon Initial Segment Cytoskeleton: Architecture, Development, and Role in Neuron Polarity , 2016, Neural plasticity.

[5]  J. Jankowsky,et al.  Amyloid-β plaques disrupt axon initial segments , 2016, Experimental Neurology.

[6]  M. Evans,et al.  Rapid Modulation of Axon Initial Segment Length Influences Repetitive Spike Firing , 2015, Cell reports.

[7]  J. Frade,et al.  Neuronal cell cycle: the neuron itself and its circumstances , 2015, Cell cycle.

[8]  Yan Zhang,et al.  Selective filtering defect at the axon initial segment in Alzheimer’s disease mouse models , 2014, Proceedings of the National Academy of Sciences.

[9]  E. Masliah,et al.  Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease. , 2014, Biochemical pharmacology.

[10]  Yan Zhang,et al.  miR-342-5p decreases ankyrin G levels in Alzheimer's disease transgenic mouse models. , 2014, Cell reports.

[11]  L. Greene,et al.  Neuronal apoptosis at the G1/S cell cycle checkpoint , 2001, Cell and Tissue Research.

[12]  R. B. Richardson p53 mutations associated with aging-related rise in cancer incidence rates , 2013, Cell cycle.

[13]  J. Frade,et al.  Genetic Evidence for p75NTR-Dependent Tetraploidy in Cortical Projection Neurons from Adult Mice , 2013, The Journal of Neuroscience.

[14]  M. Memo,et al.  p53 at the crossroads between cancer and neurodegeneration. , 2012, Free radical biology & medicine.

[15]  J. Kong,et al.  Oxidative stress in neurodegenerative diseases , 2012, Neural regeneration research.

[16]  J. Trimmer,et al.  Cdk-mediated phosphorylation of the Kvb2 auxiliary subunit regulates Kv1 channel axonal targeting , 2011 .

[17]  G. Hardingham,et al.  The influence of synaptic activity on neuronal health , 2011, Current Opinion in Neurobiology.

[18]  J. Trimmer,et al.  Cdk-mediated phosphorylation of the Kvβ2 auxiliary subunit regulates Kv1 channel axonal targeting , 2011, The Journal of cell biology.

[19]  R. Bergamaschi,et al.  More or LESS , 2011, Techniques in Coloproctology.

[20]  I. Forsythe,et al.  SYMPOSIUM REVIEW: Going native: voltage‐gated potassium channels controlling neuronal excitability , 2010, The Journal of physiology.

[21]  H. Vinters,et al.  Synapse loss in dementias , 2010, Journal of neuroscience research.

[22]  Matthew N. Rasband,et al.  The axon initial segment and the maintenance of neuronal polarity , 2010, Nature Reviews Neuroscience.

[23]  T. Arendt,et al.  Selective cell death of hyperploid neurons in Alzheimer's disease. , 2010, The American journal of pathology.

[24]  M. Grubb,et al.  Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability , 2010, Nature.

[25]  K. Herrup The involvement of cell cycle events in the pathogenesis of Alzheimer's disease , 2010, Alzheimer's Research & Therapy.

[26]  J. Frade,et al.  A novel hypothesis for Alzheimer disease based on neuronal tetraploidy induced by p75NTR , 2010, Cell cycle.

[27]  M. Laiho,et al.  Differential sensitivity of the inner ear sensory cell populations to forced cell cycle re‐entry and p53 induction , 2010, Journal of neurochemistry.

[28]  S. M. Morillo,et al.  Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor , 2009, Proceedings of the National Academy of Sciences.

[29]  Li-Huei Tsai,et al.  Alternative Functions of Core Cell Cycle Regulators in Neuronal Migration, Neuronal Maturation, and Synaptic Plasticity , 2009, Neuron.

[30]  T. Arendt,et al.  Aneuploidy and DNA Replication in the Normal Human Brain and Alzheimer's Disease , 2007, The Journal of Neuroscience.

[31]  Peter Davies,et al.  Conditional Neuronal Simian Virus 40 T Antigen Expression Induces Alzheimer-Like Tau and Amyloid Pathology in Mice , 2007, The Journal of Neuroscience.

[32]  F. Schmitt,et al.  Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment , 2006, Neurobiology of Aging.

[33]  Xiongwei Zhu,et al.  Apoptosis in Alzheimer disease: a mathematical improbability. , 2006, Current Alzheimer research.

[34]  Raman M. Das,et al.  A robust system for RNA interference in the chicken using a modified microRNA operon. , 2006, Developmental biology.

[35]  T. Arendt,et al.  The expression of cell cycle proteins in neurons and its relevance for Alzheimer's disease. , 2005, Current drug targets. CNS and neurological disorders.

[36]  Kevin A. Burns,et al.  Hypoxia-Ischemia Induces DNA Synthesis without Cell Proliferation in Dying Neurons in Adult Rodent Brain , 2004, The Journal of Neuroscience.

[37]  Esther B. E. Becker,et al.  Cell cycle regulation of neuronal apoptosis in development and disease , 2004, Progress in Neurobiology.

[38]  M. Bear,et al.  Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression , 2003, Neuron.

[39]  T. Arendt Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the ‘Dr. Jekyll and Mr. Hyde concept’ of Alzheimer’s disease or the yin and yang of neuroplasticity , 2003, Progress in Neurobiology.

[40]  Karl Herrup,et al.  Neuronal Cell Death Is Preceded by Cell Cycle Events at All Stages of Alzheimer's Disease , 2003, The Journal of Neuroscience.

[41]  C. Winters,et al.  Glutamate-induced transient modification of the postsynaptic density , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[42]  B. Edgar,et al.  Endoreplication Cell Cycles More for Less , 2001, Cell.

[43]  K. Herrup,et al.  DNA Replication Precedes Neuronal Cell Death in Alzheimer's Disease , 2001, The Journal of Neuroscience.

[44]  K. Jellinger,et al.  Problems of cell death in neurodegeneration and Alzheimer's Disease. , 2001, Journal of Alzheimer's disease : JAD.

[45]  Hans Förstl The Lewy body variant of Alzheimer’s disease: clinical, pathophysiological and conceptual issues , 1999, European Archives of Psychiatry and Clinical Neuroscience.

[46]  Hans Förstl,et al.  Clinical features of Alzheimer’s disease , 1999, European Archives of Psychiatry and Clinical Neuroscience.

[47]  K. Herrup,et al.  Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer’s Disease Brain , 1998, The Journal of Neuroscience.

[48]  MB Kennedy,et al.  PSD-95 is associated with the postsynaptic density and not with the presynaptic membrane at forebrain synapses , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[49]  J. Decaprio,et al.  Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation , 1995, Molecular and cellular biology.

[50]  V. Caviness,et al.  The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wall , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[51]  H. Orr,et al.  In Vivo Viability of Postmitotic Purkinje Neurons Requires pRb Family Member Function , 1995, Molecular and Cellular Neuroscience.

[52]  A. Chumakov,et al.  T-antigen of sv40 blocks p53 transactivation but not p53 specific binding to DNA. , 1994, International journal of oncology.

[53]  M. Cynader,et al.  Activity-dependent expression and distribution of M1 muscarinic ACh receptors in visual cortex neuronal cultures , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[54]  O. Isacson,et al.  On neuronal health , 1993, Trends in Neurosciences.

[55]  R. Palmiter,et al.  Oncogene expression in retinal horizontal cells of transgenic mice results in a cascade of neurodegeneration , 1993, Neuron.

[56]  H. Orr,et al.  Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice , 1992, Neuron.

[57]  J. Vermeulen,et al.  NMDA receptor levels in chronically depolarized long-term neonatal rat neocortical explants , 1992, International Journal of Developmental Neuroscience.

[58]  R. J. Mullen,et al.  NeuN, a neuronal specific nuclear protein in vertebrates. , 1992, Development.

[59]  M. Al-Ubaidi,et al.  Photoreceptor degeneration induced by the expression of simian virus 40 large tumor antigen in the retina of transgenic mice. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[60]  Matthew H. Kaufman,et al.  The Atlas of Mouse Development , 1992 .

[61]  A. Tolkovsky,et al.  The Death Programme in Cultured Sympathetic Neurones Can Be Suppressed at the Posttranslational Level by Nerve Growth Factor, Cyclic AMP, and Depolarization , 1991, Journal of neurochemistry.

[62]  H. M. Geller,et al.  Both survival and development of spontaneously active rat hypothalamic neurons in dissociated culture are dependent on membrane depolarization. , 1991, Brain research. Developmental brain research.