Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, α-glycosidase, and carbonic anhydrase inhibitors of novel benzenesulfonamides incorporating 1,3,5-triazine structural motifs.

[1]  Yeliz Demir,et al.  Sulfonamides incorporating ketene N,S‐acetal bioisosteres as potent carbonic anhydrase and acetylcholinesterase inhibitors , 2020, Archiv der Pharmazie.

[2]  Yeliz Demir,et al.  Calcium channel blockers: molecular docking and inhibition studies on carbonic anhydrase I and II isoenzymes , 2020, Journal of biomolecular structure & dynamics.

[3]  Yeliz Demir,et al.  Molecular Docking Studies and Inhibition Properties of Some Antineoplastic Agents against Paraoxonase-I. , 2020, Anti-cancer agents in medicinal chemistry.

[4]  C. Supuran,et al.  Sulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profile , 2020, Journal of enzyme inhibition and medicinal chemistry.

[5]  C. Supuran,et al.  Synthesis, characterisation, biological evaluation and in silico studies of sulphonamide Schiff bases , 2020, Journal of enzyme inhibition and medicinal chemistry.

[6]  M. Işık,et al.  Bioactivities of Hypericum Perforatum L and Equisetum Arvense L fractions obtained with different solvents , 2019 .

[7]  Yeliz Demir,et al.  New Isoindole‐1,3‐dione Substituted Sulfonamides as Potent Inhibitors of Carbonic Anhydrase and Acetylcholinesterase: Design, Synthesis, and Biological Evaluation , 2019 .

[8]  J. Hedner,et al.  Carbonic anhydrase, obstructive sleep apnea and hypertension: Effects of intervention , 2019, Journal of sleep research.

[9]  M. Topal.  Secondary Metabolites of Ethanol Extracts of Pinus sylvestris Cones from Eastern Anatolia and Their Antioxidant, Cholinesterase and α-Glucosidase Activities , 2019 .

[10]  Yeliz Demir,et al.  Benzenesulfonamide derivatives containing imine and amine groups: Inhibition on human paraoxonase and molecular docking studies. , 2019, International journal of biological macromolecules.

[11]  Ş. Beydemir,et al.  AChE mRNA expression as a possible novel biomarker for the diagnosis of coronary artery disease and Alzheimer’s disease, and its association with oxidative stress , 2019, Archives of physiology and biochemistry.

[12]  Yeliz Demir,et al.  Molecular docking and investigation of 4-(benzylideneamino)- and 4-(benzylamino)-benzenesulfonamide derivatives as potent AChE inhibitors , 2019, Chemical Papers.

[13]  Ö. Küfrevioğlu,et al.  In Vitro and In Silico Studies on the Toxic Effects of Antibacterial Drugs as Human Serum Paraoxonase 1 Inhibitor , 2019, ChemistrySelect.

[14]  M. Işık.  The Binding Mechanisms and Inhibitory Effect of Intravenous Anesthetics on AChE In Vitro and In Vivo: Kinetic Analysis and Molecular Docking , 2019, Neurochemical Research.

[15]  Yeliz Demir,et al.  Synthesis, biological evaluation and in silico studies of novel N-substituted phthalazine sulfonamide compounds as potent carbonic anhydrase and acetylcholinesterase inhibitors. , 2019, Bioorganic chemistry.

[16]  Cüneyt Türkeş.  A potential risk factor for paraoxonase 1: in silico and in‐vitro analysis of the biological activity of proton‐pump inhibitors , 2019, The Journal of pharmacy and pharmacology.

[17]  Ş. Beydemir,et al.  Inhibition of Human Serum Paraoxonase-I with Antimycotic Drugs: In Vitro and In Silico Studies , 2019, Applied Biochemistry and Biotechnology.

[18]  A. Yalçın,et al.  Gadolinium-based contrast agents: in vitro paraoxonase 1 inhibition, in silico studies , 2019, Drug and chemical toxicology.

[19]  Cüneyt Türkeş.  Inhibition Effects of Phenolic Compounds on Human Serum Paraoxonase-1 Enzyme , 2019, Journal of the Institute of Science and Technology.

[20]  Cüneyt Türkeş.  Investigation of Potential Paraoxonase-I Inhibitors by Kinetic and Molecular Docking Studies: Chemotherapeutic Drugs. , 2019, Protein and peptide letters.

[21]  Suleyman Akocak,et al.  Design, synthesis and biological evaluation of 1,3-diaryltriazene-substituted sulfonamides as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors , 2019, Journal of the Turkish Chemical Society, Section A: Chemistry.

[22]  Yeliz Demir,et al.  Anti-diabetic Properties of Calcium Channel Blockers: Inhibition Effects on Aldose Reductase Enzyme Activity , 2019, Applied Biochemistry and Biotechnology.

[23]  I. Gulcin,et al.  Synthesis and biological evaluation of novel tris-chalcones as potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and α-glycosidase inhibitors. , 2019, Bioorganic chemistry.

[24]  C. Supuran,et al.  Discovery of new ureido benzenesulfonamides incorporating 1,3,5-triazine moieties as carbonic anhydrase I, II, IX and XII inhibitors. , 2019, Bioorganic & medicinal chemistry.

[25]  C. Supuran,et al.  Design, synthesis and biological evaluation of novel ureido benzenesulfonamides incorporating 1,3,5-triazine moieties as potent carbonic anhydrase IX inhibitors. , 2019, Bioorganic chemistry.

[26]  C. Supuran,et al.  Activation of α-, β-, γ- δ-, ζ- and η- class of carbonic anhydrases with amines and amino acids: a review , 2019, Journal of enzyme inhibition and medicinal chemistry.

[27]  Fevzi Topal.  Anticholinergic and antidiabetic effects of isoeugenol from clove (Eugenia caryophylata) oil , 2019, International Journal of Food Properties.

[28]  M. Topal.  The inhibition profile of sesamol against α-glycosidase and acetylcholinesterase enzymes , 2019, International Journal of Food Properties.

[29]  C. Supuran,et al.  Novel sulfonamides incorporating 1,3,5-triazine and amino acid structural motifs as inhibitors of the physiological carbonic anhydrase isozymes I, II and IV and tumor-associated isozyme IX. , 2018, Bioorganic chemistry.

[30]  I. Gulcin,et al.  Antidiabetic potential: In vitro inhibition effects of bromophenol and diarylmethanones derivatives on metabolic enzymes , 2018, Archiv der Pharmazie.

[31]  P. Taslimi,et al.  Investigation of the effects of cephalosporin antibiotics on glutathione S-transferase activity in different tissues of rats in vivo conditions in order to drug development research , 2018, Drug and chemical toxicology.

[32]  P. Bednarski,et al.  Hybrid Molecules Composed of 2,4-Diamino-1,3,5-triazines and 2-Imino-Coumarins and Coumarins. Synthesis and Cytotoxic Properties , 2018, Molecules.

[33]  C. Supuran,et al.  Novel sulfonamide incorporating piperazine, aminoalcohol and 1,3,5-triazine structural motifs with carbonic anhydrase I, II and IX inhibitory action. , 2018, Bioorganic chemistry.

[34]  C. Supuran,et al.  Synthesis and biological evaluation of novel N,N'-diaryl cyanoguanidines acting as potent and selective carbonic anhydrase II inhibitors. , 2018, Bioorganic chemistry.

[35]  I. Gulcin,et al.  Synthesis and discovery of potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and α‐glycosidase enzymes inhibitors: The novel N,N′‐bis‐cyanomethylamine and alkoxymethylamine derivatives , 2018, Journal of biochemical and molecular toxicology.

[36]  C. Supuran,et al.  Design and synthesis of novel 1,3-diaryltriazene-substituted sulfonamides as potent and selective carbonic anhydrase II inhibitors. , 2018, Bioorganic chemistry.

[37]  I. Gulcin,et al.  Synthesis and biological evaluation of phloroglucinol derivatives possessing α‐glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase inhibitory activity , 2018, Archiv der Pharmazie.

[38]  C. Supuran,et al.  Discovery of novel 1,3-diaryltriazene sulfonamides as carbonic anhydrase I, II, VII, and IX inhibitors , 2018, Journal of enzyme inhibition and medicinal chemistry.

[39]  I. Gulcin,et al.  Antidiabetic potential: in vitro inhibition effects of some natural phenolic compounds on α‐glycosidase and α‐amylase enzymes , 2017, Journal of biochemical and molecular toxicology.

[40]  C. Supuran,et al.  Synthesis and biological evaluation of novel aromatic and heterocyclic bis-sulfonamide Schiff bases as carbonic anhydrase I, II, VII and IX inhibitors. , 2017, Bioorganic & medicinal chemistry.

[41]  I. Gülçin,et al.  Phenolic compounds inhibit the aldose reductase enzyme from the sheep kidney , 2017, Journal of biochemical and molecular toxicology.

[42]  S. Alwasel,et al.  Synthesis, carbonic anhydrase I and II isoenzymes inhibition properties, and antibacterial activities of novel tetralone‐based 1,4‐benzothiazepine derivatives , 2017, Journal of biochemical and molecular toxicology.

[43]  I. Gülçin,et al.  Inhibition properties of some flavonoids on carbonic anhydrase I and II isoenzymes purified from human erythrocytes , 2017, Journal of biochemical and molecular toxicology.

[44]  I. Gülçin,et al.  Oxidative stress and mRNA expression of acetylcholinesterase in the leukocytes of ischemic patients. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[45]  A. Naderi,et al.  Antioxidant Activity, Acetylcholinesterase, and Carbonic Anhydrase Inhibitory Properties of Novel Ureas Derived from Phenethylamines , 2016, Archiv der Pharmazie.

[46]  C. Supuran,et al.  Synthesis of N-alkyl (aril)-tetra pyrimidine thiones and investigation of their human carbonic anhydrase I and II inhibitory effects , 2016, Journal of enzyme inhibition and medicinal chemistry.

[47]  I. Gulcin,et al.  Synthesis, carbonic anhydrase I and II inhibition studies of the 1,3,5-trisubstituted-pyrazolines , 2016, Journal of enzyme inhibition and medicinal chemistry.

[48]  N. Negm,et al.  Fluorescein dye derivatives and their nanohybrids: Synthesis, characterization and antimicrobial activity. , 2016, Journal of photochemistry and photobiology. B, Biology.

[49]  Vijay Luxami,et al.  Synthesis and in vitro evaluation of novel triazine analogues as anticancer agents and their interaction studies with bovine serum albumin , 2016 .

[50]  C. Supuran,et al.  The effects of some bromophenols on human carbonic anhydrase isoenzymes , 2016, Journal of enzyme inhibition and medicinal chemistry.

[51]  I. Gulcin,et al.  Synthesis of 4,5-disubstituted-2-thioxo-1,2,3,4-tetrahydropyrimidines and investigation of their acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase I/II inhibitory and antioxidant activities , 2016, Journal of enzyme inhibition and medicinal chemistry.

[52]  C. Supuran,et al.  Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions , 2016, Journal of enzyme inhibition and medicinal chemistry.

[53]  C. Supuran,et al.  PEGylated Bis-Sulfonamide Carbonic Anhydrase Inhibitors Can Efficiently Control the Growth of Several Carbonic Anhydrase IX-Expressing Carcinomas. , 2016, Journal of medicinal chemistry.

[54]  I. Gulcin,et al.  The synthesis of some β-lactams and investigation of their metal-chelating activity, carbonic anhydrase and acetylcholinesterase inhibition profiles , 2016, Journal of enzyme inhibition and medicinal chemistry.

[55]  I. Gulcin,et al.  Synthesis and bioactivity studies on new 4-(3-(4-Substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl) benzenesulfonamides , 2016, Journal of enzyme inhibition and medicinal chemistry.

[56]  I. Gulcin,et al.  Synthesis of some tetrahydropyrimidine-5-carboxylates, determination of their metal chelating effects and inhibition profiles against acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase , 2016, Journal of enzyme inhibition and medicinal chemistry.

[57]  Ş. Beydemir,et al.  In vitro inhibitory effects of palonosetron hydrochloride, bevacizumab and cyclophosphamide on purified paraoxonase-I (hPON1) from human serum. , 2016, Environmental toxicology and pharmacology.

[58]  I. Gulcin,et al.  Inhibitory effects of isatin Mannich bases on carbonic anhydrases, acetylcholinesterase, and butyrylcholinesterase , 2016, Journal of enzyme inhibition and medicinal chemistry.

[59]  Ş. Beydemir,et al.  Human serum paraoxonase-1 (hPON1): in vitro inhibition effects of moxifloxacin hydrochloride, levofloxacin hemihidrate, cefepime hydrochloride, cefotaxime sodium and ceftizoxime sodium , 2015, Journal of enzyme inhibition and medicinal chemistry.

[60]  Recep Demir,et al.  Changes in the anti-oxidant system in adult epilepsy patients receiving anti-epileptic drugs , 2015, Archives of physiology and biochemistry.

[61]  M. Ilies,et al.  Next-generation primary sulfonamide carbonic anhydrase inhibitors , 2014 .

[62]  Ş. Beydemir,et al.  Inhibition Effects of Gemcitabine Hydrochloride, Acyclovir, and 5-Fluorouracil on Human Serum Paraoxonase-1 (hPON1): In Vitro , 2014 .

[63]  I. Gülçin,et al.  Rosmarinic acid: a potent carbonic anhydrase isoenzymes inhibitor , 2014 .

[64]  Ş. Beydemir,et al.  Effect of calcium channel blockers on paraoxonase-1 (PON1) activity and oxidative stress , 2014, Pharmacological reports : PR.

[65]  C. Supuran,et al.  Inhibition of human carbonic anhydrase isoforms I-XIV with sulfonamides incorporating fluorine and 1,3,5-triazine moieties. , 2013, Bioorganic & medicinal chemistry.

[66]  E. Şahin,et al.  Synthesis and paroxonase activities of novel bromophenols , 2013, Journal of enzyme inhibition and medicinal chemistry.

[67]  C. Supuran,et al.  Novel sulfamides as potential carbonic anhydrase isoenzymes inhibitors. , 2013, Bioorganic & medicinal chemistry.

[68]  I. Gülçin,et al.  Phenolic compounds as antioxidants: carbonic anhydrase isoenzymes inhibitors. , 2013, Mini reviews in medicinal chemistry.

[69]  S. Ok,et al.  Inhibitory effect of novel pyrazole carboxamide derivatives on human carbonic anhydrase enzyme , 2013, Journal of enzyme inhibition and medicinal chemistry.

[70]  C. Supuran.  Structure-based drug discovery of carbonic anhydrase inhibitors , 2012, Journal of enzyme inhibition and medicinal chemistry.

[71]  Claudiu T. Supuran,et al.  Interfering with pH regulation in tumours as a therapeutic strategy , 2011, Nature Reviews Drug Discovery.

[72]  C. Supuran,et al.  Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis. , 2011, Journal of medicinal chemistry.

[73]  G. Bland,et al.  Erythrocyte Total Carbonic Anhydrase Esterase Activity in African American Obese Children: Reduction Starts at a Young Age , 2009, Biochemical Genetics.

[74]  Claudiu T. Supuran,et al.  Carbonic anhydrases: novel therapeutic applications for inhibitors and activators , 2008, Nature Reviews Drug Discovery.

[75]  D. Ekinci,et al.  Some drugs inhibit in vitro hydratase and esterase activities of human carbonic anhydrase-I and II. , 2007, Pharmacological reports : PR.

[76]  V. Headings,et al.  Decreased total carbonic anhydrase esterase activity and decreased levels of carbonic anhydrase 1 isozyme in erythrocytes of type II diabetic patients , 2007, Biochemical Genetics.

[77]  H. Soreq,et al.  Acetylcholinesterase — new roles for an old actor , 2001, Nature Reviews Neuroscience.

[78]  W. L. Jorgensen,et al.  Prediction of Properties from Simulations: Free Energies of Solvation in Hexadecane, Octanol, and Water , 2000 .

[79]  M. F. Sugrue.  Pharmacological and ocular hypotensive properties of topical carbonic anhydrase inhibitors , 2000, Progress in Retinal and Eye Research.

[80]  K. Courtney,et al.  A new and rapid colorimetric determination of acetylcholinesterase activity. , 1961, Biochemical pharmacology.

[81]  F. Lombardo,et al.  Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. , 2001, Advanced drug delivery reviews.