Tissue amino acid profiles are characteristic of tumor type, malignant phenotype, and tumor progression in pancreatic tumors

[1]  R. Dahlstrom,et al.  Challenges and opportunities , 2021, Foundations of a Sustainable Economy.

[2]  M. V. Vander Heiden,et al.  Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions , 2017, Nature Communications.

[3]  C. Lyssiotis,et al.  Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer. , 2017, Cancer cell.

[4]  N. Hiraoka,et al.  Determination of Amino Acids in Human Pancreas Tissue Sections Using Liquid Chromatography Tandem Mass Spectrometry , 2016 .

[5]  P. Carmeliet,et al.  Meta‐analysis of clinical metabolic profiling studies in cancer: challenges and opportunities , 2016, EMBO molecular medicine.

[6]  L. Cantley,et al.  Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion , 2016, Nature.

[7]  T. Welling,et al.  GM-CSF Mediates Mesenchymal-Epithelial Cross-talk in Pancreatic Cancer. , 2016, Cancer discovery.

[8]  R. Jain,et al.  Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy. , 2016, Cancer discovery.

[9]  Liang Zhao,et al.  Tissue amino acid profile could be used to differentiate advanced adenoma from colorectal cancer. , 2016, Journal of pharmaceutical and biomedical analysis.

[10]  D. Tuveson,et al.  The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1 , 2015, Cell.

[11]  K. Ross,et al.  Transcriptional control of the autophagy-lysosome system in pancreatic cancer , 2015, Nature.

[12]  Makoto Ueno,et al.  A Novel Multivariate Index for Pancreatic Cancer Detection Based On the Plasma Free Amino Acid Profile , 2015, PloS one.

[13]  M. V. Vander Heiden,et al.  Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. , 2015, Cancer research.

[14]  G. Wahl,et al.  Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy , 2014, Cell.

[15]  X. Wang,et al.  Metabolic Profiles are Principally Different between Cancers of the Liver, Pancreas and Breast , 2014, International journal of biological sciences.

[16]  D. Xie,et al.  A Distinct Metabolic Signature of Human Colorectal Cancer with Prognostic Potential , 2014, Clinical Cancer Research.

[17]  G. Kristiansen,et al.  Tissue metabolite profiling identifies differentiating and prognostic biomarkers for prostate carcinoma , 2013, International journal of cancer.

[18]  Xin Lu,et al.  Metabolic characterization of hepatocellular carcinoma using nontargeted tissue metabolomics. , 2013, Cancer research.

[19]  L. Cantley,et al.  Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance , 2013, Cell cycle.

[20]  Christian M. Metallo,et al.  Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells , 2013, Nature.

[21]  John M. Asara,et al.  Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway , 2013, Nature.

[22]  I. Liu,et al.  Taurine homeostasis requires de novo synthesis via cysteine sulfinic acid decarboxylase during zebrafish early embryogenesis , 2013, Amino Acids.

[23]  N. Sunaga,et al.  Prognostic significance of L-type amino-acid transporter 1 expression in surgically resected pancreatic cancer , 2012, British Journal of Cancer.

[24]  J. Siegel,et al.  Characterization of alpha-amino-n-butyric acid correlations in sepsis. , 2011, Translational research : the journal of laboratory and clinical medicine.

[25]  Masakazu Yamamoto,et al.  Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas , 2011, Scientific reports.

[26]  A. Maitra,et al.  Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development , 2011, Science Translational Medicine.

[27]  Marc Liesa,et al.  Pancreatic cancers require autophagy for tumor growth. , 2011, Genes & development.

[28]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[29]  António S. Barros,et al.  Can nuclear magnetic resonance (NMR) spectroscopy reveal different metabolic signatures for lung tumours? , 2010, Virchows Archiv.

[30]  J. Gregory,et al.  Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease. , 2010, Journal of hepatology.

[31]  C. Thompson,et al.  Glutamine addiction: a new therapeutic target in cancer. , 2010, Trends in biochemical sciences.

[32]  Guro F Giskeødegård,et al.  Discrimination of patients with microsatellite instability colon cancer using 1H HR MAS MR spectroscopy and chemometric analysis. , 2010, Journal of proteome research.

[33]  R. Deberardinis,et al.  Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer , 2010, Oncogene.

[34]  M. Tomita,et al.  Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. , 2009, Cancer research.

[35]  M. Hiasa,et al.  Immunohistochemical localization of D-aspartate in islets of Langerhans. , 2006, Biological & pharmaceutical bulletin.

[36]  マーク エス. マランドロ,,et al.  New therapeutic target in cancer , 2003 .

[37]  R. Ball,et al.  Threonine dehydrogenase is a minor degradative pathway of threonine catabolism in adult humans. , 2000, American journal of physiology. Endocrinology and metabolism.

[38]  S. Snyder,et al.  D-aspartate localizations imply neuronal and neuroendocrine roles. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[39]  K. Rückert,et al.  [Classification of pancreatic cancer]. , 1985, Deutsche medizinische Wochenschrift.

[40]  M. Yudkoff,et al.  On the clinical significance of the plasma alpha-amino-n-butyric acid:leucine ratio. , 1979, The American journal of clinical nutrition.

[41]  Y. Okada,et al.  High concentration of GABA and high glutamate decarboxylase activity in rat pancreatic islets and human insulinoma. , 1976, Science.

[42]  J. Vang,et al.  Amino acid and alpha-keto acid concentrations in plasma and blood of the liverless dog. , 1965, The American journal of physiology.

[43]  M. Ramam,et al.  The Background of Structure and Function , 1940 .

[44]  A. Jemal,et al.  Cancer statistics, 2016 , 2016, CA: a cancer journal for clinicians.

[45]  Setsuo Hirohashi,et al.  CXCL17 and ICAM2 are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis. , 2011, Gastroenterology.

[46]  Ståle B. Kristoffersen,et al.  Utilization in , 2011 .

[47]  G. Collins The next generation. , 2006, Scientific American.

[48]  E. Berg,et al.  World Health Organization Classification of Tumours , 2002 .

[49]  N. Dubrawsky Cancer statistics , 1989, CA: a cancer journal for clinicians.

[50]  L. Sobin,et al.  TNM Classification of Malignant Tumours , 1987, UICC International Union Against Cancer.