Evidence for general cognitive ability (g) in heterogeneous stock mice and an analysis of potential confounds

The heterogeneous stock (HS) is a genetically outbred line of mice established more than 30 years ago from an 8‐way cross of C57BL/6, BALB/c, RIII, AKR, DBA/2, I, A/J and C3H inbred mouse strains. The present study compared the performance of 40 HS mice across a battery of diverse cognitive tasks under a variety of motivations. Indices of emotionality were also included in order to assess their influence on performance. All measures of ability loaded positively on an unrotated first principal component that accounted for 31% of the variance, suggesting the presence of a common factor of general cognitive ability (g) underlying all tasks. A first factor derived from anxiety indices correlated nonsignificantly with all cognitive tasks and nonsignificantly with this g factor, supporting the hypothesis that the factor is cognitive rather than temperamental in nature. The factor was also robust in relation to outliers and sex differences, accounting for 28% of the variance after removal of outlier individuals and also after correcting for variance owing to sex differences. A general cognitive ability (g) appears to underlie the performance of HS mice on a battery tapping diverse cognitive demands.

[1]  Edward L. Thorndike,et al.  Learning without awareness of what is being learned or intent to learn it. , 1934 .

[2]  Britt Anderson,et al.  Evidence from the rat for a general factor that underlies cognitive performance and that relates to brain size: intelligence? , 1993, Neuroscience Letters.

[3]  A. Jensen,et al.  The g factor , 1996, Nature.

[4]  Ian J. Deary,et al.  Looking down on human intelligence , 2000 .

[5]  Robert Plomin,et al.  The genetics of G in human and mouse , 2001, Nature Reviews Neuroscience.

[6]  David I. Mostofsky,et al.  Brain mechanisms in problem solving and intelligence , 1991 .

[7]  G. Lindzey,et al.  Contributions to behavior-genetic analysis : the mouse as a prototype , 1970 .

[8]  J. Wehner,et al.  Inheritance of spatial learning ability in inbred mice: a classical genetic analysis. , 1989, Behavioral neuroscience.

[9]  Francis M. Crinella,et al.  Brain mechanisms in problem solving and intelligence: A replication and extension , 1995 .

[10]  N. Brody.  Intelligence, 2nd ed. , 1992 .

[11]  David P Wolfer,et al.  Genetically modified mice and cognition , 1998, Current Opinion in Neurobiology.

[12]  Philip A. Vernon,et al.  The neuropsychology and psychophysiology of human intelligence , 2004 .

[13]  R. E. Brown,et al.  Developing standardized behavioral tests for knockout and mutant mice. , 2000, ILAR journal.

[14]  Book Reviews,et al.  Looking Down on Human Intelligence: From Psychometrics to the Brain , 2001 .

[15]  W. Meredith,et al.  The use of isogenic and heterogenic mouse stocks in behavioral research. P. 3-22. In g. Lindzey & d. D. Thiessen (ed.), Contrib. To behavior-genetic , 1970 .

[16]  H E ROSVOLD,et al.  A closed-field intelligence test for rats. , 1951, Canadian journal of psychology.

[17]  Richard Paylor,et al.  The use of behavioral test batteries: Effects of training history , 2001, Physiology & Behavior.

[18]  P. Livesey.  A consideration of the neural basis of intelligent behavior: comparative studies. , 1970, Behavioral science.

[19]  J. R. Royce.  The factorial analysis of animal behavior. , 1950, Psychological bulletin.

[20]  C. Locurto,et al.  Individual Differences and a Spatial Learning Factor in Two Strains of Mice ( Mus musculus ) , 2004 .

[21]  R. Morris.  Developments of a water-maze procedure for studying spatial learning in the rat , 1984, Journal of Neuroscience Methods.

[22]  William J. Hauser,et al.  A Replication and Extension , 1978 .

[23]  Allan Collins,et al.  Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies , 1997, Psychopharmacology.

[24]  R. Gerlai.  A new continuous alternation task in T-maze detects hippocampal dysfunction in mice A strain comparison and lesion study , 1998, Behavioural Brain Research.

[25]  Wim E Crusio.  Chapter 4.4 Methodological considerations for testing learning in mice , 1999 .

[26]  David W. Fulker,et al.  High-resolution mapping of quantitative trait loci in outbred mice , 1999, Nature Genetics.

[27]  Heritable variation for latent inhibition and its correlation with reversal learning in honeybees (Apis mellifera). , 2000, Journal of comparative psychology.