Baseline cardiovascular risk in the INSIGHT Strategic Timing of AntiRetroviral Treatment trial

Introduction— The Strategic Timing of AntiRetroviral Treatment (START) trial has recruited antiretroviral-naïve individuals with high CD4 cell counts from all world regions. We describe the distribution of cardiovascular (CVD) risk factors, overall and by geographic region, at study baseline. Methods— The distribution of CVD risk factors was assessed and compared by geographic region among START participants who had baseline electrocardiogram (n=4019; 11% North America; 36% Europe/Australia/Israel; 26% South America; 4% Asia; 23% Africa; median age 36 years; 26% females). Results— About 58.3% (n=2344) of the participants had at least one CVD risk factor and 18.9% (n=761) had two or more. The most common CVD risk factors were current smoking (32%), hypertension (19.3%) and obesity (16.5%). There were significant differences in the prevalence of CVD risk factors among geographic regions. The prevalence of at least one risk factor across regions was as follows: 70.0% North America, 65.1% Europe/Australia/Israel, 49.4% South America, 37.0% Asia, and 55.8% Africa (p-value<0.001). Significant regional differences were also observed when risk factors were used as part of the Framingham and D:A:D risk scores or used to define favourable risk profile. Conclusions— CVD risk factors are common among START participants, and their distribution varies by geographic region. Better understanding of how and why CVD risk factors develop in people with HIV and their geographical distributions could shed light on appropriate strategies for CVD prevention and may inform the interpretation of the results of START as CVD is expected to be a major fraction of the primary endpoints observed. baseline of risk factors, overall and by geographic region, in HIV-positive individuals enrolled in the Strategic the distribution of CVD risk