Prevalence of Chronic Sputum and Associated Factors in Korean Adults

Chronic sputum is a troublesome symptom in many respiratory diseases. The prevalence of chronic sputum varies from 1.2% to 13% according to the country. The purpose of this study was to estimate the prevalence of chronic sputum and to find its associated factors in a general Korean population. We analyzed the data of the Korea National Health and Nutrition Examination Survey 2010 and 2011. A total number of 6,783 subjects aged 40 yr or more were enrolled in this study with 3,002 men and 3,781 women. As a result, the prevalence of chronic sputum was 6.3% (n=430). Significant risk factors for chronic sputum by multivariate analysis were: age (≥70 yr) (odds ratio [OR], 1.954; 95% confidence interval [CI], 1.308-2.917), current smoking (OR, 4.496; 95% CI, 3.001-6.734), chronic obstructive pulmonary disease (COPD) (OR, 1.483; 95% CI, 1.090-2.018), and tuberculosis (OR, 1.959; 95% CI, 1.307-2.938). In conclusion, the prevalence of chronic sputum in Korea was in the intermediate range compared with other countries. Smoking is a preventable risk factor identified in this study, and major respiratory diseases, such as COPD and tuberculosis, should be considered in subjects with chronic sputum. Graphical Abstract

[1]  Kyungdo Han,et al.  Parathyroid hormone, vitamin D levels and urine albumin excretion in older persons: the 2011 Korea National Health and Nutrition Examination Survey (KNHANES) , 2014, Clinical endocrinology.

[2]  Seong-Woo Choi,et al.  The Association Between the Socioeconomic Status and Thyroid Cancer Prevalence; Based on the Korean National Health and Nutrition Examination Survey 2010-2011 , 2013, Journal of Korean medical science.

[3]  W. Bishai,et al.  Procollagen III N-terminal propeptide and desmosine are released by matrix destruction in pulmonary tuberculosis. , 2013, The Journal of infectious diseases.

[4]  Sang Min Park,et al.  Prevalence of and factors associated with osteoporosis among Korean cancer survivors: a cross-sectional analysis of the Fourth and Fifth Korea National Health and Nutrition Examination Surveys. , 2013, Asian Pacific journal of cancer prevention : APJCP.

[5]  R. Kozu,et al.  Longitudinal study of respiratory function and symptoms in a non-smoking group of long-term officially-acknowledged victims of pollution-related illness , 2013, BMC Public Health.

[6]  J. Poorolajal,et al.  Prevalence of Oral Mucosal Lesions in Male Smokers and Nonsmokers , 2013, Chonnam medical journal.

[7]  Yunjung Choi,et al.  Relationship between serum 25-hydroxyvitamin D and lung function among Korean adults in Korea National Health and Nutrition Examination Survey (KNHANES), 2008-2010. , 2013, The Journal of clinical endocrinology and metabolism.

[8]  Yong Chul Lee,et al.  A Multicenter Study of Pertussis Infection in Adults with Coughing in Korea: PCR-Based Study , 2012, Tuberculosis and respiratory diseases.

[9]  Y. Oh,et al.  Comorbidities of Chronic Obstructive Pulmonary Disease in Koreans: A Population-Based Study , 2012, Journal of Korean medical science.

[10]  A. Menezes,et al.  The chronic bronchitis phenotype in subjects with and without COPD: the PLATINO study , 2012, European Respiratory Journal.

[11]  D. Cole,et al.  Global burden of chronic pulmonary aspergillosis as a sequel to pulmonary tuberculosis. , 2011, Bulletin of the World Health Organization.

[12]  P. Mahesh,et al.  Prevalence of chronic cough, chronic phlegm & associated factors in Mysore, Karnataka, India , 2011, The Indian journal of medical research.

[13]  E. Bronkhorst,et al.  Risk factors for aspiration pneumonia in frail older people: a systematic literature review. , 2011, Journal of the American Medical Directors Association.

[14]  Y. Oh,et al.  Prevalence of chronic obstructive pulmonary disease in Korea: The fourth Korean National Health and Nutrition Examination Survey, 2008 , 2011, Respirology.

[15]  Jae Seung Lee,et al.  Relation between Subjective Symptoms and Rhinolaryngoscopic Findings or Sputum Eosinophilia in Chronic Cough Patients , 2010 .

[16]  P. Davies,et al.  Tuberculosis, bronchiectasis and chronic airflow obstruction , 2010, Respirology.

[17]  C. Carlsten,et al.  Respiratory disease associated with solid biomass fuel exposure in rural women and children: systematic review and meta-analysis , 2009, Thorax.

[18]  M. Lee,et al.  Cigarette Smoking and Risk of Lung Cancer in Korean Men: The Seoul Male Cancer Cohort Study , 2007, Journal of Korean medical science.

[19]  A. Nissinen,et al.  Thirty-year cumulative incidence of chronic bronchitis and COPD in relation to 30-year pulmonary function and 40-year mortality: a follow-up in middle-aged rural men. , 2006, Chest.

[20]  P. Nilsson,et al.  Mortality in GOLD stages of COPD and its dependence on symptoms of chronic bronchitis , 2005, Respiratory research.

[21]  N. Anthonisen The British hypothesis revisited , 2004, European Respiratory Journal.

[22]  G. Viegi,et al.  Chronic cough and phlegm in young adults , 2003, European Respiratory Journal.

[23]  M. DeLegge,et al.  Aspiration pneumonia: incidence, mortality, and at-risk populations. , 2002, JPEN. Journal of parenteral and enteral nutrition.

[24]  S. Hurd,et al.  Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. , 2001, American journal of respiratory and critical care medicine.

[25]  M. Miravitlles,et al.  Factors Associated with Increased Risk of Exacerbation and Hospital Admission in a Cohort of Ambulatory COPD Patients: A Multiple Logistic Regression Analysis , 2000, Respiration.

[26]  R. Hurt,et al.  Trends in smoking-related diseases. Why smoking cessation is still the best medicine. , 1998, Postgraduate medicine.

[27]  T. Seemungal,et al.  Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. , 1998, American journal of respiratory and critical care medicine.

[28]  Kim Wd Lung mucus: a clinician's view , 1997 .

[29]  J. Vestbo,et al.  Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity. Copenhagen City Heart Study Group. , 1996, American journal of respiratory and critical care medicine.

[30]  R. Kronmal,et al.  Prevalence and Correlates of Respiratory Symptoms and Disease in the Elderly , 1994 .

[31]  M. Cosio,et al.  Morphological and cellular basis for airflow limitation in smokers. , 1994, The European respiratory journal.

[32]  J. Lundgren,et al.  Mucus secretion and inflammation. , 1992, Pulmonary pharmacology.

[33]  Young-Wook Kim,et al.  Relationship between serum 25-hydroxyvitamin D and lung function among Korean adults , 2015 .

[34]  D. Jarvis,et al.  Incidence of chronic obstructive pulmonary disease in a cohort of young adults according to the presence of chronic cough and phlegm. , 2007, American journal of respiratory and critical care medicine.

[35]  F. Martinez,et al.  Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. , 2007, American journal of respiratory and critical care medicine.

[36]  Christine Jenkins,et al.  GOLD SCIENTIFIC COMMITTEE. GLOBAL STRATEGY FOR THE DIAGNOSIS, MANAGEMENT, AND PREVENTION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE. NHLBI/WHO GLOBAL INITIATIVE FOR CHRONIC OBSTRUCTIVE LUNG DISEASE (COLD) WORKSHOP SUMMARY , 2001 .

[37]  W. D. Kim,et al.  Lung mucus: a clinician's view. , 1997, The European respiratory journal.

[38]  R. Kronmal,et al.  Prevalence and correlates of respiratory symptoms and disease in the elderly. Cardiovascular Health Study. , 1994, Chest.