[Postpartum portal venous system thrombosis in a patient with antiphospholipid syndrome].

INTRODUCTION Antiphospholipid Syndrome (APS) is an immune thrombophylia of unknown etiology which leads to vascular thrombosis and gestational complications. CLINICAL REPORT A 27-year old woman who had been diagnosed APS four years before was admitted in the Emergency Room five days after a spontaneous delivery due to [corrected] pain in the upper right abdominal quadrant. Blood analysis revealed AST and ALT rise and thrombocytopenia. CT scan was suggestive of liver infarction due to venous ischemia. Abdominal eco-doppler diagnosed vena porta left branch thrombosis and compensatory arterial circulation. Treatment included low molecular weight heparin and corticosteroids which led to progressive clinical, laboratory and imagiological recovery. DISCUSSION Portal venous system thrombosis is extremely rare in the absence of local risk factors and the most common and catastrophic complication is intestinal necrosis.

[1]  S. Gaiani,et al.  Thrombosis of the portal venous system. , 2007, Journal of ultrasound.

[2]  S. Iliceto,et al.  Antibody profile and clinical course in primary antiphospholipid syndrome with pregnancy morbidity , 2006, Thrombosis and Haemostasis.

[3]  F. Rosendaal,et al.  Lupus anticoagulants and the risk of a first episode of deep venous thrombosis , 2005, Journal of thrombosis and haemostasis : JTH.

[4]  S. Iliceto,et al.  Antibody profiles for the diagnosis of antiphospholipid syndrome , 2005, Thrombosis and Haemostasis.

[5]  M. Esplin Management of antiphospholipid syndrome during pregnancy. , 2001, Clinical obstetrics and gynecology.

[6]  F. Guillemin,et al.  Meta-analysis of the risk of venous thrombosis in individuals with antiphospholipid antibodies without underlying autoimmune disease or previous thrombosis , 1998, Lupus.

[7]  P. Brill-Edwards,et al.  Antiphospholipid antibodies and venous thromboembolism. , 1995, Blood.

[8]  B. Chong,et al.  Prevalence of lupus anticoagulant and anticardiolipin antibodies in a healthy population. , 1990, Australian and New Zealand journal of medicine.

[9]  Chan Jun-mi,et al.  International Consensus Statement on an Update of the Classification Criteria for Definite Antiphospholipid Syndrome(APS) , 2008 .

[10]  J. Rand The antiphospholipid syndrome. , 2007, Hematology. American Society of Hematology. Education Program.

[11]  M. Petri Classification and Epidemiology of the Antiphospholipid Syndrome , 2002 .

[12]  J. Piette,et al.  Milestones in the Antiphospholipid Syndrome , 2002 .

[13]  E. Harris,et al.  The antiphospholipid syndrome , 1995, Clinical reviews in allergy & immunology.