Improvement of Platelet Function Following Plateletpheresis in Patients with Myeloproliferative Diseases

Four patients with myeloproliferative diseases and acute hemorrhagic or thrombotic complications of thrombocytosis were treated with plateletpheresis by discontinuous‐flow centrifufation. Reduction of platelet counts was achieved rapidly, without complications and was associated with clinical improvement. In all four cases, abnormal platelet aggregation testing was present before pheresis, but improved immediately after pheresis. Platelet‐sizing data obtained in one case suggested that during the pheresis procedure, a population of larger volume platelets was selectively removed. The efficacy of plateletpheresis in these clinical situations may be related to the selective removal of a large abnormal platelet population.

[1]  E. Berkman,et al.  Management of Chronic Myelocytic Leukemia in Pregnancy by Cell Pheresis , 1978, Transfusion.

[2]  S. Karpatkin.  Heterogeneity of human platelets. VI. Correlation of platelet function with platelet volume. , 1978, Blood.

[3]  K. Wu.  Platelet hyperaggregability and thrombosis in patients with thrombocythemia. , 1978, Annals of internal medicine.

[4]  E. Taft,et al.  Plateletpheresis in the management of thrombocytosis. , 1977, Blood.

[5]  J. Wharton,et al.  Defective Platelet Lipid Peroxidation in Myeloproliferative Disorders: A Possible Defect of Prostaglandin Synthesis , 1977, British journal of haematology.

[6]  H. Gralnick,et al.  Heterogeneity of human whole blood platelet subpopulations. I. Relationship between buoyant density, cell volume, and ultrastructure. , 1977, Blood.

[7]  D. Penington,et al.  Megakaryocytes and the Heterogeneity of Circulating Platelets , 1976, British journal of haematology.

[8]  D. Penington,et al.  Platelet Density and Size: the Interpretation of Heterogeneity , 1976, British journal of haematology.

[9]  B. Greenberg,et al.  Successful Control of Life‐Threatening Thrombocytosis with a Blood Processor , 2003, Transfusion.

[10]  A. D. Ginsburg.  Platelet function in patients with high platelet counts. , 1975, Annals of internal medicine.

[11]  L. Wasserman,et al.  Abnormalities of platelet function in patients with polycythemia vera. , 1973, Cancer research.

[12]  S. Inceman,et al.  PLATELET DEFECTS IN THE MYELOPROLIFERATIVE DISORDERS , 1972, Annals of the New York Academy of Sciences.

[13]  S. Zucker,et al.  Classification of thrombocytosis based on platelet function tests: correlation with hemorrhagic and thrombotic complications. , 1972, The Journal of laboratory and clinical medicine.

[14]  R. Rundles,et al.  Hemorrhagic thrombocythemia; control of postsplenectomy thrombocytosis with melphalan. , 1970, Blood.

[15]  C. Mielke,et al.  The standardized normal Ivy bleeding time and its prolongation by aspirin. , 1969, Blood.

[16]  P. Mannucci,et al.  Platelet Volume and Shape in Relation to Aggregation and Adhesion , 1967, British journal of haematology.